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Validated All-in-One™ qPCR Primer for XRCC1(NM_006297.2) Search again
Product ID:
HQP018562
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
RCC, SCAR26
Gene Description:
X-ray repair cross complementing 1
Target Gene Accession:
NM_006297.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq].
Gene References into function
- XRCC1 is directly involved in the dominant negative activity of a truncated variant of DNA polymerase beta, possibly leading to the genomic instability characteristic of tumor cells.
- The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.
- X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.
- we investigated the association between the repair phenotype of ultraviolet (UV)-induced damage and genotypes of three DNA repair genes, XPC and XPD [involved in nucleotide excision repair (NER)] and XRCC1 [involved in base excision repair (BER)].
- Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair.
- Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population.
- polymorphism and risk of lung cancer in a Chinese population
- When tested in CHO derived XRCC1 'knock out' EM9 cells, co-expression of human papillomavirus 16 E6 with human XRCC1 reduced the ability of the latter protein to correct the methyl methane sulfate sensitivity of XRCC1 mutant CHO cell line EM9.
- XRCC1 polymorphism is associated with gastric cancer
- The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia
- evaluated prostate cancer risk in men with polymorphisms in the XRCC1 gene, a key player in base excision repair, across different strata of antioxidant intake
- The XRCC1 variant allele did not show any effect on the p53 mutation in lung tumors.
- Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer.
- polymorphisms and age-related diseases
- Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
- Cumulative cigarette smoking plays an important role in altering the direction and magnitude of the associations between the XRCC1 and ERCC2 polymorphisms and lung cancer risk.
- the XRCC1 Gln allele is associated with AT to GC mutations in p53 in NSCLC. The XRCC1 gene may play a role in the repair of cigarette smoking-induced DNA damage.
- data presented support a model by which X-ray repair cross complementing protein 1 (XRCC1) will pass on the DNA intermediate from DNA glycosylase hOGG1 to the endonuclease APE1
- High XRCC1 mRNA levels is associated with Clear cell tumors of epithelial ovarian cancer
- XRCC1 polymorphism and risks of breast neoplasms has no apparent association in chinese women.
- These data suggest that XRCC1 Gln399Arg polymorphism plays a limited role in lymphomagenesis.
- XRCC1 co-localizes with proliferating cell nuclear antigen (PCNA) at DNA replication foci, observed exclusively in the S phase of undamaged HeLa cells
- The XRCC1-DNA ligase IIIalpha heterodimer must interact with DNA polymerase beta for efficient base excision repair.
- XRCC1 codon 194, 280, and 399 genotypes do not influence CIN risk in the Taiwanese population
- The polymorphic DNArepair gene, XRCC1 was associated with the risk of esophageal cancer in patients with smoking.
- XRCC1 polymorphism (Arg/94Trp) associated with susceptibility to squamous cell carcinoma of the head and neck in Korean population
- XRCC1 gene polymorphism is associated with higher risk susceptibility of bladder cancer.
- Polymorphism of XRCC1 is associated with colorectal cancer
- Genetic variation in XRCC1 and sun exposure is associated with skin cancer
- poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III utilize an alternative route for DNA double-strand breaks rejoining
- determined the domains of APTX and XRCC1 required for their interaction; findings suggest that APTX, together with XRCC1 and PARP-1, plays an essential role in single-strand DNA break repair
- XRCC1 gene DNA repair capacity found reduced in patients with laryngeal neoplasms.
- exhibits preferential binding to DNA with single-strand breaks with a gap size of <5 nucleotides
- Lack of evidence for a role of the XRCC1 polymorphism in developing breast cancer.
- Preliminary evidence of a role for XRCC1 codon 194 and 399 polymorphisms in the genetic predisposition to breast cancer in Indian women
- The role of a genetic polymorphism of the XRCC1 gene in risk for colorectal cancer was investigated.
- Neither of the two genetic polymorphisms of XRCC1 directly influence breast cancer risk; however, there was a suggestive weak additive interaction between XRCC1 and polycyclic aromatic hydrocarbon-DNA adducts on breast cancer risk among never smokers.
- investigated relationship between genetic polymorphism of XRCC1 & ERCC2 & DNA damage in polycyclic aromatic hydrocarbon exposed workers workers; findings suggest that variant allele of G27466A polymorphism of XRCC1 is associated with increased DNA damage
- These results indicate that the Arg399Gln polymorphism, but not the Arg194Trp or Arg280His polymorphism, influences the ability of XRCC1 to repair DNA.
- genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China
- interaction of XRCC1 with DNA polymerase beta contributes to efficient DNA repair in vivo
- XRCC1 is required for efficient DNA single-strand break repair and genomic stability in human cells.
- XRCC1 is recruited to the repair of alkylated or oxidized bases by the DNA glycosylases recognizing the lesion.
- XRCC1 polymorphism contributes to the etiology of lung cancer
- the XRCC1 280His and XRCC3 241Met alleles affect individual chromosomal aberration levels, most probably via influencing the DNA repair phenotype
- analysis of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein
- Meta-analyses showed a protective effect of XRCC1 194Trp allele for tobacco-related cancers, an association between XRCC1 399Gln/399Gln genotype and tobacco-related cancers, and no association between cancer risk and XRCC1 Arg280His polymorphism.
- XRCC1 variant allele coding Gln amino acid at position 399 was found to be associated with a higher number of DNA breaks as revealed by the comet assay
- Of the three polymorphisms, only the XRCC1 Arg280His allele was associated with increased rheumatoid arthritis risk after adjustment for smoking.
- Polymorphisms of the XRCC1 is associated with breast cancer
- ADPRT Val762Ala and XRCC1 Arg399Gln polymorphisms may not play a role in the etiology of breast cancer.
- XRCC1 stimulates Pol beta strand displacement activity and releases inhibition of Pol beta by DNA-bound Lig III if ligation is prevented.
- results support the hypothesis that genetic variation in XRCC1, particularly in Arg194Trp, may influence postmenopausal breast cancer risk
- XRCC1, XRCC3, GSTM1 and GSTT1 polymorphisms and chromosome damage are higher in welders than in a control group
- XRCC1 Arg399Gln polymorphism may genetically modify the development and progression of testicular germ cell tumors through genomic instability.
- XRCC1 IVS10+141G>A is an intronic polymorphism that is associated with XRCC1 expression, apoptosis and familial breast cancer.
- the APE1 Glu variant, but not an ADPRT variant, may have an effect or interact with XRCC1 in the etiology of cutaneous melanoma or in linkage disequilibrium
- XRCC1 Trp194Trp variant genotype is associated with a reduced risk of developing nasopharyngeal carcinoma in Cantonese population, particularly in males and smokers
- -77T-->C genotype or another variant in linkage disequilibrium influences the cellular response to DNA damage and to breast cancer risk.
- identification of polymorphisms in lung carcinoma of never smokers
- The finding of decreased expression levels for hOGG1 and XRCC1 in gamma-irradiated lymphocytes has not been reported elsewhere.
- The ADPRT and XRCC1 polymorphisms confer host susceptibility to GCA, which might result from reduced ADPRT-XRCC1 interaction and attenuated base excision repair capacity.
- The XRCC1 RNA expression was correlated with microsatellite instability status in colorectal cancer tissues.
- Our results show that the genetic variation in XRCC1, XRCC3 and NBS1 influence lung cancer susceptibility among women, and that combinations of risk alleles in the two HR genes can enhance the effects.
- study suggests a major gene effect of the "T" allele of the C26304T polymorphism modulating the cerebral response to ischemia in non lacunar ischemic stroke, not contriubting to the etiology.
- XRCC1-01, XRCC3-01, and CCND1-01 may be predictive of survival outcome in patients with metastatic breast cancer treated with DNA-damaging chemotherapy
- Increased susceptibility to genotoxic agents with polymorphisms in DNA repair genes XRCC1.
- Polymorphisms in XPD codon 751 and XRCC1 codon 399 were not associated with risk of POAG in a sample of Turkish patients.
- The XRCC1 Arg399Gln polymorphism did modify the relationship between XPD Lys751Gln and esophageal adenocarcinoma risk.
- genetic polymorphisms of XRCC1 as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan
- The polymorphisms of XRCC1 gene may modulate the effects of DNA damages induced by formaldhyde in workers.
- Data suggest that the Arg194Trp and Arg399Gln polymorphisms may be differentially associated with skin cancer risk.
- the polymorphic variants of XRCC1 codon 194 have a role in the development of sporadic late-onset Alzheimer's disease.
- The results have suggested that the XRCC1 gene might be the risk genotype for lung cancer in this population.
- No evidence of an association between polymorphisms in XRCC1 and bladder cancer risk.
- The expression levels of four genes (hMSH2, XRCC1, XPD, MGMT) present in peripheral blood mononuclear cells were significantly correlated with increased risk for esophageal squamous cell carcinoma.
- Polymorphisms of XRCC1 appear to influence the risk of prostate cancer and may modify risks attributable to environmental exposure.
- XRCC1 polymorphisms including genotypes and haplotypes contribute to susceptibility to the development of cervical squamous cell carcinoma.
- this prospective investigation provides suggestive evidence of a favorable effect of the XRCC1399 Gln/Gln genotype on survival in platinum-treated non-small-cell lung cancer and, for the first time, in small-cell lung carcinoma patients also
- XRCC1 codon 399 Gln/Gln genotype might play an important role in DNA repair in esophageal squamous cell carcinoma.
- Multivariate analysis confirmed XRCC1 genotype as a potential breast cancer treatment predictor.
- XRCC1 1915C allele was associated with a lower salivary gland carcinoma (SGC) risk, and the XRCC1 194Trp allele was associated with a higher SGC risk
- The median survival times for oxaliplatin-treated gastric cancer patients with Arg/Arg or Arg/Gln genotypes of XRCC1 gene were significantly longer than others (P=0.03).
- XRCC1 down-regulation in HeLa cells leads to a decrease in the DNA ligase 3 protein level, significantly increased sensitivity to alkylating agents, elevated level of sister chromatid exchange and decrease in the survival of BRCA2-deficient cells.
- Polymorphisms in DNA repair gene XRCC1 may be important in the aetiology of stroke.
- XRCC1 codon 194 tryptophan allele may be contributing factors in the risk of nasopharyngeal carcinoma.
- key role for XRCC1-DNA ligase IIIalpha in maintenance of genomic integrity by nucleotide excision repair in both dividing and nondividing cells
- XRCC1 enhances the capacity of hPNK to discriminate between strand breaks with 5'-OH termini and those with 5'-phosphate termini; and XRCC1 stimulates hPNK activity by displacing hPNK from the phosphorylated DNA product
- The results suggest that the Arg194Trp andArg399Gln polymorphism of XRCC1 gene may not be linked with appearance and development of breast cancer.
- Findings do not support a role of XRCC1 codon 399Gln polymorphism in CML.
- Frequencies of XRCC1 and XPD polymorphisms observed in the present study with other populations revealed a distinctive nature of the South Indian population.
- Arg399Gln polymorphism is associated with increased frequency of p53 mutations in codon 249 among the Guangxi population of China.
- Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population
- proliferating cell nuclear antigen and XRCC1 have distinct kinetic properties with functional consequences for their capacity to respond to successive DNA damage events
- Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein is associated with cancer risk
- This study provided the first evidence that the XPD and XRCC1 polymorphisms contributed to the risk of developing idiopathic azoospermia in a selected Chinese population.
- Thai women with a certain XRCC1 diplotype or homozygous for two or three variant alleles of XRCC1, OGG1, and APEX1 are likely to have an increased susceptibility to breast cancer.
- Our results suggest that menopausal age together with Arg194Trp and Arg399Gln XRCC1 gene polymorphisms might be involved in individual susceptibility to breast cancer.
- Increasing numbers of either XPD or XRCC1 variant alleles were associated with shorter overall survival.
- In a selected Chinese population, AA genotype of Arg399Gln appears to contribute to a decreased risk of idiopathic azoospermia, while we have not any evidence of involvement of XRCC1 T-77C and Arg194Trp polymorphisms in idiopathic azoospermia.
- Evidence that the combination of different DNA repair genes (hOGG1, XRCC1 and XRCC3) and their interaction with environmental genotoxic agents may modulate micronuclei induction.
- It is concluded that CRCC1 399Gln allele may act as a recessive allele and increase the breast cancer risk.
- These preliminary results suggest that XPD Lys751Gln and XRCC1 Arg399Gln polymorphisms may not be a significant risk factor for developing CAD.
- genetic variation in SNPs in XRCC1 and XRCC2 genes, but not XRCC3, may influence breast cancer susceptibility
- benzene exposed workers with the combination of myeloperoxidase G/G genotype and XRCC1(x-ray cross-complementation group 1) Arg/Gln or Gln/Gln genotype showed a significantly increased chromosomal aberration frequency
- It is indicated that the hOGG1 codon 326 and XRCC1 codon 399 polymorphisms are risk factors of bladder cancer.
- Data show that CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins XRCC1, DNA polymerase beta, and DNA ligase III.
- No significant association XRCC1 with brain tumors was found for any of the polymorphisms, but indicated possible associations between combinations of XRCC1 and XRCC3 SNPs and the risk of brain tumors.
- No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
- The XRCC1 ARG399Gln polymorphism had consistent associations with survival outcomes in head and neck neoplasms.
- No significant association between the XRCC1 ARG339Gln polymorphism and the risk of esophageal adenocarcinoma, Barrett's esophagus or reflux esophagitis.
- XRCC1 399Gln may enhance the risk of breast cancer.
- Haplotypes of nine single nucleotide polymorphisms in ERCC1, ERCC2 and XRCC1 genes on chromosome 19q13.2-3 is associated with lung cancer
- XRCC1 399 A allele may have a major role in recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy
- The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study.
- The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.
- patients carrying at least one variant XRCC1 Arg399Gln allele have a 2.5-fold increased risk of grade 3 or 4 gastrointestinal toxicity when treated with first-line cisplatin-based chemotherapy.
- XRCC1 Arg399Gln and T-77C polymorphisms may alter the risk of lung cancer in women nonsmokers in China
- combined XRCCs 1-4 polymorphisms associated with oral cancer risk
- for the single nucleotide polymorphism in XRCC1 exon 10 (Arg399Gln, G/A), no remarkable differences for genotype distribution and allele frequencies were observed between breast cancer group and control group in the study
- presence of heat-labile sites has a substantial impact on DSB induction and DSB rejoining rates measured by pulsed-field gel electrophoresis, and heat-labile sites repair is independent of DNA-PKcs, XRCC1 and PARP
- XRCC1 Arg399Gln polymorphism is associated with higher susceptibility to endometriosis and might be a useful biomarker for endometriosis
- single nucleotide polymorphisms in the SOD2, XRCC1 and XRCC3 genes are associated with the development of late radiation injury in patients treated with radiation therapy for prostate adenocarcinoma
- These results suggest that individuals with susceptible metabolic GSTP1 and DNA-repair XRCC1 genotypes may be at increased risk of DNA damage due to pesticide exposure.
- No significant effects of XRCC3 241Met polymorphisms was seen on the initial repair of MMS-induced DNA damage in human lymphocytes.
- The minimal sequence of XRCC1 required for efficient nuclear localization in triple A syndrome, mstNLS, is residues 239-276 aa.
- polymorphism rs25487 might be involved in contributing towards breast cancer susceptibility in North Indian women, while rs1799782 might have protective influence.
- polymorphic variants of the XRCC1 gene are not independent risk factors for Alzheimer's disease
- The role of PI3K/Akt activity and DNA-PKcs on XRCC1 expression/stabilization, was studied.
- the XRCC3 gene TT genotype and the APE1 gene AG genotype might increase the risk of myocardial infarcts
- The association between XRCC1-Arg399Gln polymorphism and ductal carcinoma was statistically significant (P = 0.02).
- Results indicated that XRCC1 R399Q and R194W might not be risk factors to bladder cancer, but the 399QQ genotype decreased susceptibility of bladder cancer under recessive model and homozygote contrast among ever-smokers.
- The XRCC1 polymorphisms, especially the 194Trp allele, may have an effect on DTC development and progression.
- No association was found between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and colorectal cancer risk and progression.
- The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were associated with the response to NAC in patients with cervical cancer. No SNP genotypes were associated with DFS.
- these results indicated that SLE leucocytes repair less efficiently the radiation-induced DNA damage, and DNA repair polymorphic sites may predispose to the development of particular clinical and laboratory features
- Chk2 formed a complex with XRCC1, the BER scaffold protein, and phosphorylated XRCC1 in vivo and in vitro at Thr(284).
- review summarizes the literature and discusses the relevance of XRCC1 polymorphisms and lung cancer risk [review]
- Results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer.
- Our results suggest that XRCC1 T-77C variants (TC + CC) may act as a favorable prognostic indicator of resected NSCLC.
- interactions between DNA repair genes hMLH1, APEX1, MGMT, XRCC1 and XPD and electric transformers and power line distances from the houses of childhood acute leukemia patients revealed gene-environment interaction existed with XRCC1 Ex9+16 A allele
- findings further suggest that the polymorphisms XRCC1 Arg194Trp and Pro206Pro or the haplotype encompassing the variant alleles may contribute to susceptibility of lung cancer in a Chinese population
- The SNP XRCC1 R339Q showed a significant association with glioma risk.
- Variant XRCC1 genotypes are statistically significantly associated with benign breast disease.
- The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma.