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Validated All-in-One™ qPCR Primer for SCGB1A1(NM_003357.4) Search again
Product ID:
HQP018411
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1
Gene Description:
secretoglobin family 1A member 1
Target Gene Accession:
NM_003357.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- The effect of G38A may be apparent under stimulation as sex steroids or infections, and homozygotes of the G38A mutation cannot produce sufficient UG in response to stimulation and may be predisposed to IgA nephropathy, especially in childhood.
- Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients.
- is a regulator of the inflammatory process in respiratory diseases
- Lys 43 and Asp 46 in rhUG are critical residues for the sPLA2-inhibitory activity of UG
- In IgA nephropathy, circulating UGB is not reduced and is even increased in IgA-Fn complexes, suggesting a feedback mechanism to downregulate the formation and circulation of IgA1-Fn complexes.
- COUP-transcription factors may play a pivotal role in cell specificity of the human CC10 gene by inhibiting its expression in nonpermissive cells
- CC16*A38G single-nucleotide polymorphism influences bronchial hyperreactivity and might be a genetic determinant of asthma severity in German children.
- results suggest that rP1 inhibits platelet aggregation by participation in the actin polymerization through which store mediated calcium entry is mediated
- G38A polymorphism in the CC10 gene may influence protein expression and be associated with the development of progressive sarcoidosis
- The presence of UG significantly correlated with the expression of estrogen receptor alpha and Progesterone rseceptor in endometrial cancer.
- uteroglobin expression is regulated by progesterone in the normal endometrium but regulation by progesterone receptor is lost in endometrial hyperplasia and carcinoma according to acquirement of tumorigenesis
- Uteroglobin G38A polymorphism had no association with the development of IgA nephropathy.
- Uteroglobin is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repress allergen-induced inflammatory responses.
- Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma.
- These data provide new insights into the role of CC-10 in lung diseases and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.
- CC10 was the most down-regulated gene in human nasal polyp tissues studied by means of DNA microarray
- Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma
- Polymorphism A38G and its role in asthma is studied.
- Reduction in anti-inflammatory activity by CC16 may contribute to the pathogenesis of allergic rhinitis.
- induction of uteroglobin expression has inhibitory effect on COX-2 expression in lung cancer cells via suppression of nuclear factor kappa-B activity
- uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor
- Given that inflammation may lead to functional compromise, these data suggest that early intervention with rhCC10 may enhance SF therapy.
- Subjects with CC16 38AA were more likely to have moderate or severe acute asthma.
- CC10 is detectable in the blood of newborn infants, and a production surge occurs at birth; surge is more pronounced in term infants and may confer them with superior extrauterine pulmonary protection compared with preterm infants
- These results do not support a role for UG in susceptibility to childhood Henoch-Schonlein purpura.
- Uteroglobin induces the development and cellular proliferation of the mouse early embryo.
- The genetic polymorphism in CC16 38 A/G is not associated with susceptibility to COPD in a southern Chinese population of Han nationality.
- The metabolic pathway of CC10 was studied.
- Uteroglobin is present in the human fallopian tube as a secretory protein and appears to be involved in immunosuppressive responses in the fallopian tube.
- Serum Clara cell protein 16(CC16) concentrations decreased in silica-exposed miners and may be a useful biomarker for early diagnosis of silicosis.
- study found that infant frequent wheezing is associated with the CC10 G+38A polymorphism and lower CC10 levels but not infant atopy
- Study provides evidence for the first time for AF-1 binding with uteroglobin(UG)-binding protein, and preliminarily characterized UG-binding protein as a point downstream of AF-1 in mediating ERK phosphorylation.
- Newborn piglets with meconium aspiration syndrome have physiologic dysfunction, inflammatory changes and histologic abnormalities, partially counteracted by a single dose of exogenous surfactant and CC10.
- Uteroglobin interacts with the heparin-binding site of fibronecti(Fn) and propose that small molecules competing for interaction with this site may reduce the level of circulating Fn-IgA complexes in immunoglobulin A (IgA)-nephropathy.
- Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia
- CC16 protein is a peripheral blood biomarker of lung injury in ventilated preterm neonates.
- The CC10 A + 38G SNP may not exert a substantial influence on the development of CRS in the Chinese Han population.
- CC10 may take part in the pathogenesis of CRS and correlates with disease severity. Different cytokines can regulate CC10 expression in nasal mucosa differentially through modulating mRNA stability and certain transcriptional factors expression.
- SCGB1A1 A38G may play a role in the development and persistence of the asthma phenotype in childhood.