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Validated All-in-One™ qPCR Primer for TRPS1(NM_014112.4) Search again
Product ID:
HQP018258
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GC79, LGCR
Gene Description:
transcriptional repressor GATA binding 1
Target Gene Accession:
NM_014112.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein.
Gene References into function
- Review: Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene
- novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes
- homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros
- TRPS1 activity is regulated by RNF4
- Our results suggest a role of TRPS1 in androgen regulation of prostate-specfici antigen gene expression
- TRPS-1 protein and gene were expressed in >90% of early- and late-stage breast cancer, including ductal carcinoma in situ and invasive ductal, lobular, and papillary carcinomas
- We show here that TRPS1 is SUMOylated at multiple sites, both in vivo and in vitro, through interaction with UBC9. Overexpression of wild-type UBC9 enhances TRPS1-mediated transcriptional repression.
- suggests a possible involvement of TRPS1 in oxidative stress, and possibly in apoptosis in androgen-independent DU145 prostate cancer cells
- study reports a family affected by a mild form of trichorhinophalangeal syndrome type I; mutation analysis showed a missense mutation (R952C) in exon 7 of the TRPS1 gene
- The results describe a position effect that downregulates TRPS1 expression as the probable cause of hypertrichosis in Ambras syndrome (a rare form of congenital hypertrichosis with excessive hair on the shoulders, face and ears in humans).
- results suggest a role for TRPS1 in tooth morphogenesis