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Validated All-in-One™ qPCR Primer for TNFRSF1B(NM_001066.2) Search again
Product ID:
HQP018149
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Gene Description:
TNF receptor superfamily member 1B
Target Gene Accession:
NM_001066.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq].
Gene References into function
- induced marked apoptosis in T cells from HIV-infected persons; associated with both alteration of Bcl-2 expression and activation of caspase-8 and caspase-3
- insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in type 2 diabetes mellitus
- Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively.
- mediates ubiquitination and degradation of TRAF2
- TNFRII exon 6 SNP does not seem to be associated with susceptibility to juvenile idiopathic arthritis.
- polymorphism is associated with the incidence of graft-versus-host disease and relapse rate in unrelated bone marrow transplantation (uBMT)
- a possible marker for the early diagnosis of rejection and for prognosis after renal transplantation
- The high level of TNF alpha expression was noted both for typical and sought TNF R2/R7 isoforms and 3) A considerable number of samples displayed higher levels of TNF R2 isoforms than TNF R2/R7 mRNA expression in differentiated thyroid carcinomas
- methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.
- A TNFR2 recessive factor, in linkage disequilibrium with the 196R allele, plays a major role in a subset of families with multiple cases of rheumatoid arthritis.
- Review. Blockade of the p75TNFR may be helpful in treating systemic autoimmunity since its function may be essential for systemic tissue damage.
- in patients with rheumatoid arthritis, preliminary study results showed a trend towards a higher prevalence of the GG genotype for the exon 6 TNFRII polymorphism in the less responsive patients with more aggressive disease
- Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells, suggesting a possible role for TNF-mediated events during co-stimulation.
- Increased levels of this receptor are found in lean nondiabetic offspring of type 2 diabetic subjects.
- Both adipose tissue and blood PAI-1 levels were positively associated with TNFRSF1A and TNFRSF1B in obesity.
- plasma IL-8 was related to body mass index, percentage of body fat, fat mass and soluble TNF-alpha receptor 2
- TNFR2 binds to Etk but is not involved in Etk activation in human cells
- Review: role in signaling in chronic inflammatory disorders
- Elevated serum levels of soluble TNF-alpha receptor type II are strongly associated with the development of acute renal failure in patients with septic shock.
- serum levels elevated in asthmatic patients during acute attack
- No association with narcolepsy in German patients, in contrast with Japanese.
- Plasma sTNFR1 and sTNFR2 were inversely related to insulin sensitivity and might contribute to the development of insulin resistance in glucose-intolerant subjects.
- TNFR2ms 18 may have a protective effect on the development of rheumatoid arthritis in Taiwanese, while TNFR2ms 15 tends to have a precipitating effect.
- An ethnic difference in the TNFR2 promoter variable number of tandem repeats has been found that may be associated with clinical phenotypes in systemic lupus erythematosus.
- TNFR2 activates cytosolic phospholipase A2 (cPLA2) by causing its translocation to plasma membrane and perinuclear subcellular regions and by causing an increase in intracellular calcium that may contribute to the translocation and activation of cPLA2.
- Neither the +36 TNFRSF1A SNP nor the +196 TNFRSF1B SNP is associated with RA severity in a population of Caucasian patients with rheumatoid arthritis.
- levels of sTNFR concentrations were either similar (in sera) or significantly lower (in CM) in the patients with acute HPV infection compared with the controls
- TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis
- Serum levels and Adamantiades-Behcet's disease activity
- TNF-RII plays a unique role among the T cell costimulatory molecules, as TNF-RII ligation can have positive and negative effects on TCR-dependent signaling.
- Deficient expression of TNF-RII mRNA in the endometrium of women at the earliest stages of endometriosis may play a significant role in the pathophysiology of this disease.
- cells pre-stimulated through TNFR-2 prior to subsequent activation of TNFR-1, showed enhanced cell death and recruitment of RIP to the TNFR-1 complex; TNFR-2 signaling may play a role in controlling viral infection
- There is a significant association between exon 10 nt 1668*T-->G tumor necrosis factor receptor 2 gene polymorphism of and susceptibility to MS.
- Association between recipient and donor TNFRII 196R allele status and acute or extensive chronic GVHD incidence, respectively, may reflect reduced circulating sTNFRII.
- The level of the sTNF-R2 was elevated in myelodysplastic syndrome(MDS) patients.
- Distribution of the TNFR2 196 R/R and TNFR1 +36 A/A genotypes in familial rheumatoid arthritis could suggest an interaction between TNFR1 and TNFR2 in the genetic susceptibility for rheumatoid arthritis.
- significantly up-regulated in plasma of HIV seropositive patients who used opiates compared to those who did not.
- Association between the TNFRII 196 M/R gene polymorphism and the functional severity of early rheumatoid arthritis.
- Expression of TNF-receptor 2 (TNF-R2) but not TNF-receptor 1 (TNF-R1) was detected in myeloma cell lines.
- The TNFRII 196R G allele does not appear to be associated with Alzheimer's disease susceptibility in a Japanese population.
- TNFR2 polymorphism is not associated with susceptibility to endometriosis.
- The TNFR2 expression was increased in human leukaemic TF-1 cells by granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin-3 (IL-3), with TNFR1 expression unaffected.
- The mutated form TNFR2(196ARG) shows a reduction of inducible TRAF2 recruitment upon TNF-alpha stimulation
- polymorphism and plasma levels in rheumatoid arthritis
- The data confirm the capacity of TNFR2 to generate an apoptotic cell death signal independent of TNFR1.
- the polymorphism of the TNFRII, might not participate in the pathogenesis of SLE in Vietnamese.
- TNFR2 and TNFR2/R7 are dysregulated and have roles in colorectal cancer
- Infliximab reduces solble levels in Crohn disease.
- Genetic variations in these proinflammatory mediators and their receptors appear to influence the susceptibility and severity of the inflammatory response within the eyes of patients during the development of IAU(idiopathic acute anterior uveitis).
- Genetic variation in TNFRII may predict the late onset of breast carcinoma, relapse and death for patients with breast carcinoma
- polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families.
- Increased levels of sTNF-RII were strongly associated with risk of coronary disease among diabetic women, independent of hyperglycemia.
- TNFR2 and TNFR1 signal transduction mechanisms involved in activation of NFkappaB and CMV promoter-enhancer were compared with respect to their susceptibility towards inhibitors of intracellular signaling.
- There is no association with hypertension of TNFRSF1B polymorphism at a hypertension locus on chromosome 1p36.
- Polymorphism of TNFRSF1B gene are associated with iron deficient anemia in patients diagnosed with rheumatoid arthritis.
- TNFR1 and TNFR2 have roles in cell type-specific renal injury
- TNFR2 polymorphism is not associated with bone mineral density in two independent Caucasian populations
- tumor necrosis factor alpha and TNFR1 and TNFR2 have roles in cellular differentiation
- DS-TNFR2 might play a role as a counterpart of the proinflammatory environment associated with insulin resistance.
- Independently associated with brachial-ankle pulse-wave velocity in nonobese Japanese type 2 diabetic patients.
- May have a protective effect in protecting vasodilation in glucose intolerance.
- In summary, the circulating concentration of DS-TNFR2 seems to be inversely linked to metabolic disorders, hinting at a possible anti-inflammatory role.
- 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for systemic lupus erythematosus, especially in the Asian population (Review)
- A genetic difference in TNFR2 promoter variable number of tandem repeats may play a major role in susceptibility to invasive pulmonary aspergillosis
- TNFR2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling
- Positively associated with vascular cell adhesion molecule 1 in type 2 diabetes and insulin resistance
- TNF-RI and -RII promoter gene polymorphisms and variations in protein and gene expression of these receptors are unlikely to play a major role in the development of Alzheimer's disease
- Transmembrane tumor necrosis factor (TNF) and TNF receptor (TNFR)1/2 are interaction partners contributing to TNF-alpha production in monocytes.
- TNF-RII-supported TCR costimulation is defective in common variable immunodeficiency.
- Transplantation of TNFRSF1B-transfected mesenchymal stem cells improved left ventricular function following myocardial infarction.
- study failed to demonstrate an association of TNFR2 T676G polymorphism with primary Sjogren's syndrome
- Genetic variation in TNFRSF1B plays a role in the determination of bone structure in Caucasian postmenopausal women, possibly through effects on osteoblast and osteoclast differentiation.
- Data show that Type D personality is associated with substantially increased TNFR2 and TNF-alpha activity.
- TNFalphaRII levels were assessed in chronic liver diseases as possible marker to assess severity of disease/response to treatment.
- The increase of plasma TNF-alpha in amyotrophic lateral sclerosis (ALS) patients in the presence of a slight increase of sTNFR-1 & -2 supports a functionally significant activation of the TNF system in ALS.
- noticed the largest number of mRNA copies for TNFalpha and TNF R2/R7 in healthy cells at stage III of the disease
- TNF-alpha-308 G/A may be related to susceptibility, whereas -609 TT TNFR1 and 1690 C/T TNFR2 SNPs may be protective to tobacco-related oral squamous cell carcinoma.
- These results suggest that tumour necrosis factor receptor genotypes may be involved in the different responses to infliximab in Japanese patients with Crohn's disease.
- The circulating levels of sTNF-R2 were approximately 60% higher in Trypanosoma cruzi-infected than in non-infected neonates (1,635 +/- 101 and 1,027 +/- 100 pg/mL, respectively) and remained higher at 1 year of age.
- sTNFR1 and sTNFR2 were found at increased plasma concentrations in active Behcet's disease (BD), with the highest concentration in active BD with arthritis.
- Engineered chimeric receptor from TNFRSF1B and Fas protein which could be used to screen for TNFR2-related therapeutic molecules.
- Higher percentage of peritoneal fluid macrophages expressing TNFR1 and TNFR2 proteins in endometriosis suggests dependence of these cells on TNF-alpha stimulation.
- oxidative stress promotes TNFR receptor (TNFR1- and TNFR2) self-interaction and ligand-independent and enhanced ligand-dependent TNF signaling
- statistically significant association between the TNFRSF1B-M196R single nucleotide polymorphism and response to infliximab in a French cohort
- TNFRII was implicated in Graves disease development in the Tunisian population
- These results suggest an important role for Smurf2 binding to TRAF2 in determining specific signalling outputs of TNF-R2.
- Serum levels of sTNFR1 and sTNFR2 were increased in schizophrenic patients when compared with controls (all p < 0.05), but there was no difference in TNF-alpha levels.
- The TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes.
- A downregulated TNFR1-dependent pathway plays a role in plateau-phase acute inflammatory demyelinating polyradiculoneuropathy.
- TNF and a TNFR2 agonist may offer highly targeted therapies, with the latter likely to be less systemically toxic
- Expression of TNFRII might play an important role in the angiogenesis, tumour cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast .
- amniotic fluid TNF-alpha and soluble TNF receptor concentration regulation is affected by race and preterm birth