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Validated All-in-One™ qPCR Primer for TIMP1(NM_003254.2) Search again
Product ID:
HQP018092
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CLGI, EPA, EPO, HCI, TIMP, TIMP-1
Gene Description:
TIMP metallopeptidase inhibitor 1
Target Gene Accession:
NM_003254.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].
Gene References into function
- The growth of the primary melanoma cell lines was stimulated by TIMP-1 and inhibited by TIMP-2. In contrast, the growth of the visceral metastatic melanoma cell line was stimulated by TIMP-2.
- All patient groups had higher urinary TIMP-1 concentrations than healthy volunteers.
- 17beta-estradiol had no influence on production in MG-63 cells or human osteoblast cultures
- inhibition of apoptosis of activated hepatic stellar cells mediated via effects on matrix metalloproteinase inhibition
- The role of TIMPs and MMPs in the pathogenesis of atopic dermatitis was studied by evaluating serum levels of TIMP-1 and MMP-3 in AD and controls. TIMP-1 was significantly higher in AD during exacerbation than in nonatopic subjects, but MMP-3 was not.
- Variability of X chromosome inactivation: effect on levels of TIMP1 RNA and role of DNA methylation.
- TIMP-1 expression was increased notably in partially sclerotic glomeruli, and most prominently expressed in tubulointerstitium, mainly in tubular epithelial cells, interstitial cells, and vascular endothelial cells.
- elevation of serum and urine levels in patients with kidney diseases
- TIMP-1 was intensively detected in both stromal and epithelial cells in the menstrual period but the expression decreased in other stages of the menstrual cycle.
- Regulation of TIMP-1 phenotypic expression in Epstein--Barr virus-immortalized B lymphocytes.
- TIMP-1 inhibits the serum deprivation-induced apoptosis in rat mesangial cells, in which Bax might be involved.
- role in activating ras proteins
- enhancement of TIMP-1 is associated with suppression of prostate neoplasm invasiveness caused by staurosporine treatment
- polymorphisms and cerebrospinal fluid levels of this protein in sporadic Alzheimer's disease
- MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD
- This protein is present in normal and azoospermic human semen.
- the association between the positive expression of TIMP-1 and the invasiveness and metastasis was negative.
- Progress curve analysis of MMP inhibition by TIMP-1 shows that it has lower reactivity with MMPs at less acidic conditions than TIMP-4.
- The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis in squamous carcinoma of the cervix.
- TIMP-1 expression is regulated by IL-10 and IL-10 receptor signaling in primary human prostate tumor cell lines.
- TIMP1 may have a role in the pathogenesis of papillary thyroid carcinoma
- association between TIMP-1 and the process of renal scarring in pyelonephritis
- Levels of TIMP-1 were significantly elevated in cerebrospinal fluid samples from all disease groups: Parkinson's, amyotrophic lateral sclerosis, and Huntington's and Alzheimer's disease.
- Significantly lower expression of tissue inhibitor of matrix metalloproteinase-1 was found in follicular fluid of female patients with polycystic ovary syndrome compared with normally ovulating patients
- TIMP-1 protein levels were significantly elevated among Kawasaki disease patients, compared to those of febrile and afebrile controls
- N-TIMP-1 interaction with the catalytic domain of MMP-3 investigation by titration calorimetry and 15N NMR
- expression and regulation by intestinal myofibroblasts in inflammatory bowel disease
- TIMP-1 has a role in inhibiting tumor growth by angiogenesis suppression
- The interaction between MMP-9 and TIMP-1 in the processes of gastric tumor invasion and metastasis is that MMP-9 mainly promotes tumor invasion and metastasis and TIMP-1 inhibits functions of MMP-9.
- IL-10 receptor signaling of TIMP-1 expression is regulated by tyrosine phosphorylation of a novel gene (IL-10E1) in human prostate cells
- multiple roles of MMP-9 and TIMP-1 in progress of inflammation and tissue damage and/or in repair, depending on clinical stages of SLE
- STAT1 and STAT3 may, at least in part, mediate angiotensin II-induced TIMP-1 mRNA expression in human renal proximal tubular epithelial cells, implicating a role of the STAT signaling pathway in pathogenesis of renal tubulointerstitial fibrosis.
- study suggested that, in fibroblasts that were derived from the continent woman, tissue inhibitor of metalloproteinase 1 protein production increases with increasing estrogen levels and that, in stress incontinent fibroblasts, no similar increase occurs
- threonine 98 is critical in initiating MT1-MMP binding and complex stabilization
- Patients with deteriorating heart failure have increased expression of TIMP1 and MMP1 mRNA. Correlation with pro-inflammatory cytokines suggests common pathways of regulation and potential activation by IL-6 and IL1-beta.
- anti-apoptotic effects of TIMP-1 in human breast epithelial cells through TIMP-1-specific signal transduction pathways
- Imbalanced ratio of TIMP-1:MMP-9 may not only play a role in the pathogenesis of COPD, but also relate to FEV(1.0)% of prediction and RV/TLC%.
- In diseased brain the ability of astrocytes to counteract the destructive effects of MMP through expression of TIMP-1 is diminished by chronic activation. Our studies reveal new opportunities for therapeutics in HIV-associated dementia
- Palpable tumours (T2, T3) expressed significantly more MMP-2 and significantly less MMP-9 than T1c tumours
- A bivariate analysis revealed a strong and highly significant correlation between TIMP-1 and TGF-beta1, which was due to common genetic and environmental sources.
- Our analysis of the entire coding region of TIMP-1, -2, and -3, which are the main inhibitors of metalloproteinase activity in the extracellular matrix, failed to show an association between genetic polymorphisms and an intracranial aneurysm
- exhibits keratinocyte and fibroblast growth factor-like activity and has been described as a cell survival factor in skin
- Authors of this review propose that astrocyte-TIMP-1 may play an important role in central nervous system homeostasis and disease.
- These findings demonstrate that the ability of TIMP-1 to inhibit apoptosis in T-47D cells is mediated by the sequential activation of pertussis toxin-sensitive G protein, c-Src, PI3 kinase, and Akt.
- effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts
- Overexpressed in ulcerative colitis and serve as biological markers.
- blocks transmigration of granulocytes into urine; entrapped and activated granulocytes, protected from apoptosis, might destroy renal parenchyma and contribute to the pathogenesis of renal scarring following acute pyelonephritis
- Tissue from lateral and medial rectus muscles had different levels of expression of TIMP-1 and 2, MMP-2, and BMP-4,which may underlie different characteristics of these extraocular muscles and may influence wound healing after strabismus surgery.
- the pivotal residue of TIMP-1 in metalloproteinase recognition is threonine 98
- TIMP-1 is an important contributor to epithelial neoplastic progression and exerts differential regulation on tissues in a stage-dependent manner.
- TIMP-1 could promote growth of Hodgkin's lymphoma, and may be linked to connective tissue turnover in the nodular sclerosis subtype.
- MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates
- MMP-2, TIMP-1 and TIMP-2 are downregulated in human orthotopic liver transplantation
- TIMP-1 expression correlated with pT stage & was an independent predictor of cause-specific survival. TIMP-1 may influence survival through its effects on tumor proliferation, angiogenesis, and tumor invasion.
- TIMP1 gene transcription is regulated by RUNX1 and RUNX2
- TIMP-1 may have a role in progression of primary breast cancer
- STAT3 directly contributes to the high level of TIMP1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
- Dermal wound healing in red Duroc pigs show unique mRNA expression of HSP47,BMP-1,TIMP1-3 and hypercontracted,hyperpigmented scars.
- marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women
- Plasma levels are increased in type 2 diabetic patients.
- TIMP-1 concentration in hepatocellular carcinoma was higher than in non-neoplastic liver and correlated with the differentiation grade
- HBV affects the malignance of hepatocellular cancer by suppressing TIMP-1.
- Circulating pretreatment MMP-9 and TIMP-1 levels were significantly higher in patients with hypertension
- TIMP-1 may be a key mediator of left ventricular diastolic dysfunction through definition of ventricular matrix composition.
- Data suggest that tissue inhibitor of metalloproteinases-1 (TIMP-1) activates Ras, which then turns on the ERK and phosphatidylinositol 3-kinase signaling pathways to promote cell cycle progression of human aortic smooth muscle cells.
- Validation of TIMP-1 expression in human lymphoma cell lines and primary B-cell tumors with plasmacytic/plasmablastic phenotypes, including multiple myelomas, supports TIMP-1 as an important factor in the pathogenesis of plasmacytic/plasmablastic tumors.
- experiments demonstrate that sphingosine kinase 1/sphingosine-1-phosphate are important components of the transforming growth factor-beta signaling pathway involved in up-regulation of the tissue inhibitor of metalloproteinase-1 (TIMP-1)
- Enhancement of TIMP-1 production by tumor-derived prostaglandin E2 correlates with reduced dendritic cell migration through the tumor extracellular matrix.
- Specifically, increased expression of SERPIN-A (proteinase inhibitor-alpha antitrypsin) and TIMP 1 (tissue inhibitor of metalloproteinase 1) identified these as candidate molecular biomarkers for Papillary Thyroidi Carcinoma.
- Intrinsic TIMP-1 expression in myeloid leukemia cells might impact upon survival or differentiation
- data suggest that TIMP-1 inhibits HDMVEC migration through MMP-dependent stimulation of VE-cadherin and MMP-independent stimulation of PTEN with subsequent dephosphorylation of FAK and cytoskeletal remodeling.
- The expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones.
- This study found an up-regulation of TIMP-1, TIMP-2 and MMP-2 RNA in Duchenne Muscular Dystrophy muscle.
- Over expression of TIMP-1 is associated with nonsmall cell lung carcinoma
- Overexpressing functional TIMP-1- enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9.
- altered MMP/TIMP ratios in maternal blood during gestational hypertension
- in hepatocellular carcinoma cells, fibril- and fixed-collagen have opposite effects on MMP-1 production without affecting TIMP production
- evidence that cell density influences the invasive potential of tumor cells via regulation of MMPs and TIMP-1 and TIMP-2 by AP-1, NF kappa B and CRE transcription factors
- Study suggest that TIMP-1 might be related to both tumor growth and metastasis in head and neck squamous cell carcinoma.
- Significantly elevated tissue inhibitor of metalloproteinase 1 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans
- Oncostatin M regulates TIMP1 through extracellular signal-regulated MAP kinases in cardiac myocytes.
- matrix metallopeptidase 9/TIMP-1 system and beta-chemokines could cooperate in conditions of elevated oxidative stress, which ultimately predisposes hemodialysis patients to accelerated atherosclerosis
- genetic variations in TIMP1 may contribute to pathogenesis of abdominal aortic aneurysm
- Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
- analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor
- a magnetic resonance imaging (MRI) measure of disease activity in multiple sclerosis patients during treatment with rIFNbeta-1a.
- TIMP1 transcripts increased during acute lung injury in mice
- Cardiac expression of TIMP-1 and TIMP-2 is significantly increased in chronic pressure-overloaded human hearts compared with controls and is related to the degree of interstitial fibrosis
- TIMP-1 secretion is profoundly decreased in erythroid cells from fetal livers of transgenic knock-in mice homozygous for a GATA(S310A) gene
- We hereby propose a new method to overproduce human recombinant TIMP-1 by transient expression in HEK293E cells.
- there is a differential association of TIMP-1 with carotid-femoral pulse-wave velocity, intima-media thickness at the common carotid arteries, and carotid plaques
- Homozygous familial hypercholesterolemia patients exhibited significantly elevated level of active TIMP-1.
- results suggest that gingival fibroblast are stimulated by monocytes resulting in enhanced expression of MMP-1 and TIMP-1 and that the enhanced MMP-1 expression, in contrast to TIMP-1, is partly mediated by ICAM-1 and the signal pathway p38 MAPK
- During exacerbation, increased inflammatory burden coincides with an imbalance of the proteinase MMP-9 and its cognate inhibitor TIMP-1
- TIMP-1-mediates cell-cycle arrest via cyclin D1 downregulation & p27KIP1 upregulation. TIMP-1 modulation of these proteins is achieved through differential regulation of protein stability independent of growth factor signaling or cell adhesion.
- Coordinated down-regulation of collagen & TIMP-1 and up-regulation of MMP-1 occurs in fibroblasts exposed to proteasome inhibitors, indicating the proteasome's role in fibrosis and extracellular matrix remodeling.
- Data suggest that tissue expression of TIMP1 could be a useful marker to predict the progression and metastasis of hepatocellular carcinoma.
- We propose that one of the mechanisms involved in TIMP-1 downregulation may be through TGF-signaling in chronic immune activation. These studies show a novel extracellular regulatory loop in astrocyte-TIMP-1 regulation.
- TIMP-1 expression is regulated through multiple mechanisms. Transcriptional control and loss of mRNA stabilization are, however, the most likely primary contributors to chronic downregulation of TIMP-1.
- protein expression levels of TIMP-1 were higher in colorectal tumor tissues than in the corresponding normal tissues
- TIMP-1 and TIMP-2 are major serum factors that stimulate the induction of TIMP-1 mRNA in quiescent human gingival fibroblasts (Gin-1 cells) at mid-G1 (6-9 h after serum stimulation) of the cell cycle, but not that of TIMP-2.
- results suggest that both MMP-9 and TIMP-1 contribute to tissue remodeling in asthma
- High levels of tissue inhibitor of metalloproteinase-1 is associated with recurrence in patients with gastric cancer
- Increase in serum levels eight days after IVIG treatment in neuromuscular disease.
- an increased ratio of MMP-9 to TIMP-1 might be associated with the formation of microcysts and peritumoral edema in microcystic meningioma
- plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism
- metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 may have roles in development of systemic lupus erythomatosus
- These reuslts show a significant association between the expression of the phosphorylated/active form of STAT3 (pSTAT3) and that of TIMP1.
- These findings make plausible the involvement of MMP-9/TIMP-1 imbalance in the invasiveness of the endometrial tissue of patients with endometriosis and the ectopic development of the disease.
- hTIMP-1 reduces aneurysm formation in ApoE(-/-) mice but does not protect them against the development of arterial lesions
- The two genes (MMP3 and TIMP1) may not play a crucial role for high myopia in young Taiwanese men.
- These findings suggest that the +372T>C polymorphism of the TIMP-1 gene is associated with Systemic sclerosis (SSc) in male individuals.
- data indicate a significant positive correlation of TIMP-1 levels and the incidence of positive remodelling of coronary artery or increased plaque burden
- TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis.
- Excessive expression of MMP-1 and TIMP-1 in the diseased colonic mucosa causes excessive hydrolysis of the extracellular matrix (ECM) and ulceration in ulcerative colitis (UC) patients.
- This study proposes a novel mechanism of TIMP-1 regulation, which ensures an increased supply of the inhibitor after brain injury, and limits extracellular matrix degradation.
- analysis of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1
- Increased expression of TIMP-1 may reflect a specific temporal inhibition of collagenolysis and thereby a time-dependent regulation of ECM breakdown in areas surrounding the apex of the follicle.
- The suppressive effect of human recombinant tissue inhibitor of metalloproteinases-1(TIMP-1; rh-TIMP-1) on tumor proliferation using an in vivo xenograft system is reported.
- In the present exploratory study, it showed that elevated tumor tissue TIMP-1 levels were significantly associated with a poor response to chemotherapy of a group of patients with metastatic breast cancer.
- elevated TIMP-1 levels may reflect the degree of hepatic fibrosis and development of portal hypertension with biliary atresia; TIMP-1 may play a role in the pathophysiology of post-Kasai biliary atresia.
- Overexpression of TIMP-1 in beta-cells enhances the replication of pancreatic islets beta-cells and counteracts type 1 diabetes, indicating that the TIMP-1 gene may be a potential target to prevent, or even reverse, type 1 diabetes.
- a TIMP-1 mutant (K26/27/30 + K76 transplant) capable of ECM association.
- Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis.
- Increased TIMP-1 levels in gingival crevicular fluid are associated with the enhanced severity of periodontal inflammation, indicating that it can participate in the regulation of disease progression.
- TIMP-1 and TIMP-2 have a differential relationship with haemostatic proteins and roles in hemostasis and thrombogenesis
- The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells.
- The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported.
- Caspase-3 and the p38alpha MAP kinase were activated during TIMP-1-induced UT-7 cells erythroid differentiation.
- TIMP1 regulates cell proliferation by interacting with the ninth zinc finger domain of PZLF.
- Positive correlation was found between hepatosplenomegaly and the MMP-2/TIMP-1 ratio
- TIMP-1 demonstrated an inhibitory effect on angiogenesis, and may be worthwhile investigating for use as a future therapy for peritoneal dissemination.
- Results showed that the endogenous TIMP1 might be involved in skin development and in maintenance of
- High concentrations of TIMP1-v1+2 mRNA are associated with good prognosis in patients with primary breast cancer.
- The 82 kDa proMMP-9 expressed on the surface of malignant cells may escape inhibition by natural TIMP-1, thereby facilitating cellular invasion in vivo.
- Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response.
- Primary colorectal cancers and metastatic liver lesions showed highly significant differences in MMP-1, -10, -11, and TIMP-1.
- BLood TIMP-1 levels of plasma from healthy blood donors were not significantly diffrent from colorectal patients.
- Expression of TIMP1 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue.
- Allelic composition at the examined SNPs in genes coding for TIMP-1 and MMP-3 affect Crohn's disease susceptibility and/or phenotype, i.e., fistulizing disease, stricture pathogenesis and first disease localisation.
- Plasma TIMP-1 levels are significantly and independently associated with objective response in patients with metastatic colorectal cancer receiving combination chemotherapy.
- Constraining specificity in the N-domain of TIMP1 was studied.
- The median level of TIMP-1 (tissue inhibitor of metalloproteinase 1) was elevated in Juvenile Idiopathic Arthritis (JIA) patients as compared to controls; MMP3/TIMP-1 ratio correlated with measures of disease activity
- The findings suggest that pericellular production of HOCl by phagocytes, generated by the MPO-H2O2-chloride system, is a pathogenic mechanism for impairing TIMP-1 activity during inflammation.
- The present results do not support the current hypothesis that tumour cells contribute substantially to increased plasma TIMP-1 levels observed in patients with colorectal cancer.
- Increased Timp-1 is assopciated with squamous cell laryngeal carcinoma
- Tissue inhibitor of metalloproteinase-1 (TIMP-1), was identified as a target protein for GnT-V in human colon cancer cell WiDr.
- No association between genetic polymorphisms of the TIMP-1 gene and abdominal aortic aneurysm was found, suggesting that variations in the TIMP-1 gene do no contribute to the development of AAA.
- imbalance of serum matrix metallopeptidase 9 and tissue inhibitors of metalloproteinases 1 levels in patients with acute encephalopathy following prolonged febrile seizures may be associated with severe neurological sequelae
- TIMP-1 carries independent prognostic information when measured in blood, especially plasma.
- Patients with larger aortic diameters have increased MMP-2/TIMP-1.
- Abundant peritumoral expression of TIMP-1 in non-immunocompromised patients limits extracellular matrix degradation permissive for cancer cell migration.
- MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression.
- serum level significantly and positively correlated with carotid-femoral pulse wave velocity in hypertensive patients
- FOXO3a (forkhead box O3) increased the expression of MMP-3 (stromelysin-1) but decreased the expression of tissue inhibitors of metalloproteinases-1 (TIMP-1)in human umbilical vein endothelial cells
- Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids. Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers.
- Immunoassays showed significantly elevated content type 1 tissue inhibitor of metalloproteinases in tumors compared to adjacent histologically unchanged mucosa of patients with colorectal cancer.
- MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B
- results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs.
- Fibroblast-derived TIMP-1 acts on endothelial cells in a pro-angiogenic capacity.
- TIMP-1, -2, and -3 are significantly reduced by chorionic gonadotropin in endometrial stromal cells.
- The dysregulated TIMP1 expression is associated with infertility and early pregnancy loss.
- serum OPG, RANKL, MMP-1 and TIMP-1 may have roles in mediating myocardial healing after myocardial infarct
- TIMP-1 interacts with matrix metalloproteinases and regulates matrilysin activity during airway epithelial repair.
- The absolute concentration of TIMP-1 in the airway, rather than its molar ratio with MMP-9, was associated with persistent wheezing.
- MMP-9(matrix metalloproteinase-9) /TIMP-1 (tissue inhibitor of metalloproteinase-1 )ratios of SSPE (subacute sclerosing panencephalitis)patients were significantly higher than controls.
- Atorvastatin does not alter interferon Beta-induced changes of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in patients with multiple sclerosis.
- Higher plasma pro-MMP-9 levels, and higher pro-MMP-9/TIMP-1 ratios in women with gestational hypertension
- hematopoiesis was not adversely affected by TIMP-1 or TIMP-2
- TIMP1 functions as a differentiating and survival factor of GC B cells by modulating CD44 and SHP1 in the late centrocyte/post-GC stage, regardless of EBV infection.
- Tumour invasion in colorectal liver metastasis is associated with increased TIMP-1 RNA and protein levels in both tumour and host cells.
- The T allele at TIMP-1 SNP +372 T/C was found to be associated with an increased risk for surgical recurrence in Crohn's disease.
- Plasma TIMP-1 is a potential marker for predicting tumour progression and for monitoring tumour burden in metastatic breast cancer patients.
- These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion.
- HCMV infection specifically alters the MMP-9/TIMP-1 balance in human macrophages, which in turn reduces MMP-9 activity in infected cells.
- Higher TIMP-1 was associated with carotid stenosis (OR for Quartiles (Q)4 v Q1-3, 1.63, P = .022) and a higher internal carotid media thickness(beta 0.057 +/- 0.025, Q4 v Q1-3, P = .023).
- Serous and mucinous ovarian tumors express different profiles of TIMP-1.
- The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis.