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Validated All-in-One™ qPCR Primer for THOP1(NM_003249.4) Search again
Product ID:
HQP018073
(click here to view gene annotation page)
Species:
Human
Symbol:
Alias:
EP24.15, MEPD_HUMAN, MP78, TOP
Gene Description:
thimet oligopeptidase 1
Target Gene Accession:
NM_003249.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
Gene References into function
- human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization
- THIMET has a role in degradation of peptides generated by proteasomes
- EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization
- Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs.
- increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.
