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Validated All-in-One™ qPCR Primer for SUV39H1(NM_003173.3) Search again
Product ID:
HQP017833
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
H3-K9-HMTase 1, KMT1A, MG44, SUV39H
Gene Description:
SUV39H1 histone lysine methyltransferase
Target Gene Accession:
NM_003173.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq].
Gene References into function
- functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases
- The human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects in Drosophila.
- Suv39h1 enhanced MBD1-mediated transcriptional repression via MBD, not the C-terminal transcriptional repression domain of MBD1. MBD1 links to histone deacetylases through Suv39h1, causing methylation and deacetylation of histones for gene inactivation
- We investigated occupancy of ER-alpha promoter by pRb2/p130-E2F4/5-HDAC1-SUV39 H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 complexes, and provided a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of ER-alpha transcription
- SUV39H interacts with Smads and cooperates in BMP-induced repression.
- Kaposi's Sarcoma-Associated Herpesvirus (KSHV)LANA (Latency-associated nuclear antigen)interacts with SUV39H1 histone methyltransferase, a key component of heterochromatin formation, in KSHV-infected cells
- The recruitment of SUV39H1 to heterochromatin is at least partly independent from that of HP1 and that HP1 transiently interacts with SUV39H1 at heterochromatin.
- Interaction between HTLV-1Tax and human SUV39H1 and tethering of SUV39H1 by Tax to the HTLV-1 long terminal repeat
- permanent transcriptional silencing is mediated by the association of PML-RAR with chromatin-modifying enzymes and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3
- The association between RUNX1, histone deacetylases and SUV39H1 provides a molecular mechanism for repression and possibly gene silencing mediated by RUNX1.
- Cabin1 recruits chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress myocyte enhancer factor 2 transcriptional activity
- Suv39H1, HP1gamma and histone H3Lys9 trimethylation play a major role in chromatin-mediated repression of integrated HIV-1 gene expression.
- SUV39H1 is significantly associated with DNMT1, but not with euchromatic promoter methylation in colorectal cancer
- Presence of SUV39H1 enhances Evi1 transcriptional repression in a dose dependent manner.