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Validated All-in-One™ qPCR Primer for SRC(NM_005417.4) Search again
Product ID:
HQP017696
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASV, SRC1, THC6, c-SRC, p60-Src
Gene Description:
SRC proto-oncogene, non-receptor tyrosine kinase
Target Gene Accession:
NM_005417.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Gene References into function
- Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
- v-Src's hold over actin and cell adhesions.
- PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism
- The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells
- Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells.
- REVIEW: Arsenic carcinogenicity: relevance of c-Src activation
- Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells
- The p85 subunit of PI 3-kinase activates Src independently of the enzymatic activity of PI 3- kinase. Ligand binding of GPIb, without receptor clustering, is sufficient to activate Src.
- pp60c-src may be involved in stabilization of dynamic HT-29 cell adhesion to ECM components, and this kinase appears to be part of a mechanosensory protein complex during integrin-mediated cell adhesion
- Src activation may contribute to colon tumor progression and metastasis in part by activating Akt-mediated survival pathways that decrease sensitivity of detached cells to anoikis.
- mediation of synergism with epidermal growth factor receptor by STAT5b
- Data report a novel positioning of Src, mediating signals from insulin to phosphatidylinositol 3-kinase and to beta(2)-adrenergic receptor trafficking.
- Mutual interaction of c-Src with EGFR is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review.
- c-Src activation is associated with early stages of breast carcinomas with low aggressiveness.
- src has a role in promoting destruction of c-Cbl and enabling EGFR to evade desensitization as part of an oncogenesis pathway
- c-Src, lacking cysteine at position 520, is resistant to 1 microM N-(9-acridinyl) maleimide (NAM) but sensitive to 5 microM. Changing Phe520 to cysteine made it sensitive to 1 microM. Double mutation in clustered cysteines restored resistance to 5 microM
- Results demonstrate that c-Src and TRAF6 are key mediators of interleukin-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways.
- c-Src regulates NAD(P)H oxidase-derived *O2- generation acutely by stimulating p47phox phosphorylation and translocation and chronically by increasing protein content of gp91phox, p22phox, and p47phox in Ang II-stimulated cells.
- stimulated by HBX protein acting on the mitochondrial transition pore and effecting hepatitis B virus replication.
- involvement of G(i), Src tyrosine kinase and PI3 Kinase, respectively, in TNFalpha production
- v-SRC regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL-ETV6
- role of c-Src on PRL-stimulated proliferation of T47D and MCF7 breast cancer cells
- a triple complex between AR, p85alpha, and Src is required for androgen-stimulated PI3K/Akt activation
- FAK and Src are both important survival factors, playing a role in protecting colon cancer cell lines from Adenovirus-containing FAK-CD (Ad-FAK-CD)-induced apoptosis
- Inhibition of Src signaling results in a marked reduction of pancreatic cancer cellular invasiveness. Src may represent a novel therapeutic target for this deadly cancer.
- Src has an appreciable role in the organization of the Golgi apparatus, which may be linked to its involvement in protein transport from the Golgi apparatus to the endoplasmic reticulum
- SRC tyrosine kinases are activated and have a role in tyrosine phosphorylation of ezrin and activation of p38
- c-src activation of PLCgamma is mediated by GIT1
- The data indicate an increase in the expression and total activity of endogenous p60(c-Src) in several GM-CSF-independent 1 cultured leukemia cell mutants.
- focal adhesion kinase and src are stimulated by G alpha q and platelet activating factor receptor in vascular endothelium
- role of IGF-1R and c-Src in human pancreatic carcinogenesis. Coexpression of both these molecules may play important role in transformation of pancreatic ductal cells.
- data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor
- A novel regulatory network RAFTK/Pyk2, Src and p38 appears to be critical for VEGF-induced endothelial cell migration.
- v-Src and receptor tyrosine kinase ErbB2 activate beta-catenin-TCF-mediated transcription.
- Ret tyrosine 981 constitutes the major binding site of the Src homology 2 domain of Src and therefore the primary residue responsible for Src activation upon Ret engagement
- EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2
- src and protein kinase C have roles in inducing phosphorylation of p38 mitogen-activated protein kinase in epithelial cells after mechanical pressure
- mechanisms of c-Src activation in human cancer (review)
- both the androgen receptor interacting domains of the coactivator SRC1 and of the corepressor SMRT compete for interaction with the androgen receptor N-terminus
- SH2 and SH3 domains of Src mediate peripheral accumulation of phospho-myosin, leading to integrin adhesion complex assembly, whereas loss of SH2 or SH3 function restores normal regulation of E-cadherin and inhibits vimentin expression
- hTAF(II)68-mediated transactivation is linked to the cytoplasmic Src signal transduction pathway. The hTAF(II)68 protein can associate with the SH3 domains of several cell signaling proteins, including v-Src.
- data suggest that colony-stimulating factor receptor-1R (CSF-1R) disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism
- Src kinase activity is suppressed by RAC1, which regulates G1/S progression
- Src plays an obligatory role in the mechanism for receptor and diacylglycerol activation of TRPC3
- Results provide important insight to the mechanism of SRC transcriptional activation in liver cancer cells.
- A prolactin signalling cascade in W53 cells involves Src kinases that mediate stimulation of c-Myc expression.
- colony stimulating factor 1 receptor phosphorylation was not markedly affected by Src-family kinases (SFK) inhibition, indicating that lack of SFK binding is not responsible for diminished Y559F phosphorylation.
- Src inhibitors inhibited COX-2 induction in Helicobacter pylori infected gastric mucosa cells.
- Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer
- G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor requires c-Src, protein kinase C, and ERK signaling
- c-Src participates in regulating the endocytosis of PDGFbeta receptor-GPCR complexes in response to PDGF.
- c-Src has a role in regulating the dissociation of AP-2 from agonist-occupied AT1R and beta-arrestin during the clathrin-mediated internalization of receptors
- Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta.
- src kinase potentiates tamoxifen agonist action through serine 167-dependent stabilization of estrogen receptor promoter interaction and through elevation of SRC-1 and cAMP response element binding protein-binding protein coactivation of ER
- ERK activation mediated pure pressure-induced proliferative response of aortic smooth muscle cells. This activation was partly mediated by c-Src.
- FRS2-dependent SRC activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity
- there is a complex interplay between PKCalpha, Syk, and Src involving physical interaction, phosphorylation, translocation within the cell, and functional activity regulation
- PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells
- Csk achieves a low K(m) for the substrate Src, not by stabilizing protein-protein interactions but rather by facilitating a fast phosphoryl transfer step
- Src phosphorylates ezrin at tyrosine 477
- Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin.
- Src-dependent ezrin phosphorylation has a role in adhesion-mediated events in epithelial cells
- SRC-1 is a novel Smad3/4 transcriptional partner, facilitating the functional link between Smad3 and p300/CBP.
- Data show that ionizing radiation causes stress-induced activation of insulin-like growth factor-1 receptor-Src-Mek-Erk-Egr-1 signaling that regulates the clusterin pro-survival cascade.
- HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
- data demonstrate that Src tyrosine kinase modulates human airway smooth muscle (ASM) cell proliferation and migration
- results indicated that Src kinase-dependent tyrosine phosphorylation of p47(phox) regulates hyperoxia-induced NADPH oxidase activation and reactive oxygen species production in human pulmonary artery endothelial cells
- a specific cross-talk between TGF-beta1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells
- c-src codon 531 mutation in colorectal cancer is not the cause of c-src activation.
- This review summarizes some of the latest evidence for the role of c-Src in tumorigenesis and particularly in human tumor progression.
- calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K
- dynamin, Cbl, and Src coordinately participate in signaling complexes that are important in the assembly and remodeling of the actin cytoskeleton, leading to changes in osteoclast adhesion, migration, and resorption
- c-Src tyrosine kinase was identified as a binding partner of the BMPR-II C-terminus.
- Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway
- MUC1 is delivered to mitochondria by a mechanism involving activation of the ErbB receptor-->c-Src pathway and transport by the molecular chaperone HSP70/HSP90 complex
- The Src, a proto-oncogene, has been strongly implicated in the growth, progression and metastasis of a number of human cancers.
- Src activity contributes to constitutive and EGF-induced VEGF expression and angiogenic potential in pancreatic cancer cells
- Data report three crystal structures of a dimeric active c-Src kinase domain, in an apo and two ligand complexed forms, with resolutions ranging from 2.9A to 1.95A.
- FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase
- rhMIF induced VCAM-1 and ICAM-1 up-regulation in 12 hours via Src, PI3K, and NFkappaB
- LPC-induced Flk-1/KDR transactivation via c-Src may have important implications for the progression of atherosclerosis
- Data suggest a model in which netrin stimulates UNC5 tyrosine phosphorylation and signaling in a manner dependent on the co-receptor DCC, through the recruitment of Src and FAK kinases.
- Stat3 downregulation in vSrc transformed NIH3T3 cells or in breast cancer lines with activated Src induces apoptosis, but in normal cells Stat3 inhibition at post-confluence causes apoptosis while in sparsely growing cells it induces growth retardation
- Cells with single Src family kinase knockdown show that Src, Fyn and Yes kinases are all required for vascular endothelial growth factor (VEGF) mitogenic signaling.
- Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking
- These studies also raise the possibility that fully active forms of c-Src and Fak in breast tumors.
- IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation
- The results demonstrate that collagen-evoked ectodomain cleavage of DDR1 is mediated in part by Src-dependent activation
- Data show that the interaction between Src and major vault protein (MVP) is critically dependent on Src activity and protein (MVP) tyrosyl phosphorylation, which are induced by epidermal growth factor stimulation.
- Results suggest that c-Src may be involved in the formation of giant cells in cherubism, central giant cell granuloma and giant cell tumors.
- arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src
- These data suggest that FAK might differently regulate apoptosis and focal adhesion formation through site-specific, Src-dependent tyrosine phosphorylation in senescent cells.
- nephrin phosphorylation results in Src kinase activation, recruitment of Nck, and assembly of actin filaments in an Nck-dependent fashion
- Although a key factor in TRAF6-dependent activation of PI 3-kinase, ectopic expression of Src was insufficient for NF-kappaB activation and, in contrast to NF-kappaB, was not inhibited by IRAK2.
- Src activation triggers Caspase-8 phosphorylation on Tyr380 and impairs Fas-induced apoptosis.
- Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner.
- nNOS is a new p60(src) kinase substrate essential for SST5-mediated anti-proliferative action
- the Src/Fak complex has a role in breast cancer tumorigenesis
- Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response
- v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II.
- Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent p85 PI3K and Akt and Erk activation
- Nicotine induces cell proliferation by beta-arrestin-mediated activation of the Src and Rb-Raf-1 pathways om ;img camcer.
- extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway
- A key coactivator for the proper function of HNF4 alpha in human liver and for an integrative control of multiple hepatic genes involved in metabolism and homeostasis.
- Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers. .
- inhibition may be an attractive therapeutic approach for patients with ovarian carcinoma
- Curcumin treatment inhibited v-src gene expression in K562 chronic leukaemia cells.
- steps involving Src association, phosphorylation, and product release are fast, and a structural change in Csk participates in limiting the catalytic cycle
- HSP90 binding to ErbB2 participates in regulation of src kinase activity as well as kinase stability
- data delineate multiple PTH1R structural determinants for ERK1/2 activation and identify mechanism involving proline-rich motifs in receptor C terminus for reciprocal scaffolding of c-Src and beta-arrestin2 with a class II G-protein-coupled receptor
- SHP1 activation, association with Src and dephosphorylation of specific proteins were dependent on extracellular calcium and maintenance of a higher cytosolic calcium plateau.
- These results suggest that dimerization of Src plays an important role in the regulation of Src tyrosine kinase activity.
- Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)
- Src and Rac1 have roles in focal adhesion kinase and ERK mitogenic signaling in epithelial cells
- Stimulation of collagen type I secretion by TGF-beta requires a PKCdelta-Src-ERK1/2 signaling motif.
- Src and focal adhesion kinase mediate cyclic mechanical strain-induced extracellular regulated kinase phosphorylation and proliferation of pulmonary epithelial cells.
- P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells.
- These lines of evidence suggested that a Gq-coupled receptor activates specifically p38 MAPK through lipid rafts and Src kinase activation, in which flotillins positively modulate the Gq signaling.
- results delineate a novel force-activated inside-out Src/PI3K/FAK/Akt pathway by which cancer cells regulate their own adhesion.
- study elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation
- Src plays a crucial role in CUTL1-induced tumor cell migration
- Fak/Src signaling to the PI3-K/Akt-1 and MEK/Erk pathways undergoes a differentiation state-specific uncoupling in enterocytes.
- CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity.
- These data suggest that Src-induced u-PAR gene expression and invasion/intravasation in vivo is also mediated via AP-1 region -190/-171, especially bound with c-Jun phosphorylated at Ser(73/63).
- The interplay between palladin, SPIN90 and Src and characterized the role of palladin and SPIN90 in platelet derived growth factor and Src-induced cytoskeletal remodeling, was analyzed.
- These results suggest that palmitoylation of Src-family kinases (SFKs) is critical for SFK localization and trafficking and implicate that two distinct trafficking pathways for SFKs may be involved in SFKs' specific functions.
- E-cadherin signaling is an important activator of c-Src at cell-cell contacts, providing a key input into a signaling pathway where quantitative changes in signal strength may result in qualitative differences in functional outcome.
- These findings support a novel role for RACK1 as a key regulator of cell migration and adhesion dynamics through the regulation of Src activity, and the modulation of paxillin phosphorylation at early adhesions.
- Indirect evidence for an impaired src kinase regulation of I (Ca,L) together with an increased phosphatase activity suggests that a complex alteration in the kinase/phosphatase balance leads to I (Ca,L) dysregulation in chronic AF.
- Activated c-Src may play a role in survival, metastasis, and invasion of malignant pleural mesothelioma
- c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation.
- These results demonstrate that the chimeric strategy is useful for detailed dissection of the mechanistic basis of substrate specificity and regulation of protein tyrosine kinases.
- norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression
- Endothelial Src activity is required for ICAM-mediated tyrosine phosphorylation of vascular endothelial cadherin and for efficient neutrophil migration during passage of leukocytes across the vascular endothelial monolayer.
- Src was identified as Death-associated protein kinase (DAPK) regulator through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression.
- Colorectal cancer cells may develop acquired resistance to cetuximab via altering EGFR levels through ubiquitination and degradation and using Src kinase-mediated cell signaling for cell growth and survival.
- TAE226-induced apoptosis in breast cancer cells with overexpressed SRC.
- analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton
- These observations suggest that within in vivo-like conditions Src may have a leading role in the induction of sustained ERK1/2 activation through the Src/Ras/Raf pathway.
- These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
- human breast cells are a uniquely permissive environment for HGF transactivation by Src/Stat3 which may allow for the inappropriate activation of HGF transcription during the early stages of breast transformation
- This study suggests that (a) PTP1B can act as an important activator of Src in colon cancer cells via dephosphorylation at Y530 of Src and (b) elevated levels of PTP1B can increase tumorigenicity of colon cancer cells by activating Src.
- Brk-mediated STAT5b phosphorylation leads to STAT5b transcriptional activity, and this activity is further increased by kinase active c-Src.
- These data suggest that phosphorylation of PDK1 on Tyr(9), distinct from Tyr(373/376), is important for PDK1/Src complex formation, leading to PDK1 activation.
- Silencing Cdc42 blocks activation of EGFR and Src induced by Ca2+ depletion, resulting in a reduction in E-cadherin degradation
- Col-IV regulates the secretion of MMP-9 via a Src and FAK dependent pathway in MCF-7 cells
- The SRC-STAT5 pathway is essential for decidualization of estrogen-primed human endometrial stromal cells.
- novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
- there is functional conservation between Qr domains of yeast Gal11p and mammalian SRC proteins as direct targets of activator proteins in yeast.
- TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes
- attenuation of the Erk1/2 signaling pathway is essential for andrographolide-mediated inhibition of v-Src transformation
- Association of caspase-8 and Src may help reconcile why a potential tumor suppressor such as caspase-8 is rarely absent in cancers.
- Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway.
- VE-cadherin has a role in modulating c-Src activation in VEGF signaling
- This study analysed whether the serotonin transport mediated by the plasma-membrane transporter SERT is regulated by its Tyr-phosphorylation.
- CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity.
- Src, a nonreceptor tyrosine kinase, is overexpressed in androgen-independent prostate carcinoma
- These data provide direct evidence for increased activation of Src-family tyrosine kinases in the pathogenesis of hyperproliferative epidermal disorders.
- a new signaling connection from ILK to cofilin for dynamic actin polymerization during cell adhesion, depending on the activity of ILK-associated c-Src.
- Anoikis causes a down-activation of Fak, Src, Akt-1 and Erk1/2, a loss of Fak-Src association, and a sustained/enhanced activation of p38b, which is required as apoptosis/anoikis driver
- results indicate that Src and E-cadherin may play an important role in epithelial-mesenchymal transformations, invasion, and aggressive clinicopathologic features of head and neck squamous carcinoma
- results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway
- Role of Src kinase in the early action of TCDD through a nongenomic pathway in MCF10A cells is reported.
- Rac1-dependent NADPH oxidases play a critical role in activating c-Src following hypoxia/reoxygenation injury
- These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation, through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration.
- Within the endothelial cell, p11 is required for Src kinase-mediated tyrosine phosphorylation of A2, which signals translocation of both proteins to the cell surface.
- hnRNP K binds to the 3'-untranslated region of the c-Src mRNA and inhibits its translation by blocking 80 S ribosome formation
- Csk serves to maintain the constancy of baseline excitatory synaptic transmission by inhibiting Src kinase-dependent synaptic plasticity in the hippocampus
- A Met/c-Src-mediated signaling pathway is a mediator of EGFR tyrosine phosphorylation and cell growth in the presence of EGFR tyrosine kinase inhibitors.
- These results suggest that Src-family tyrosine kinases, including c-Src and Lyn, are involved in formation of the cortical actin cap, which may serve as a platform of tyrosine phosphorylation signaling.
- c-Src is an important regulator of Nox1 activity
- tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases are regulated by phosphorylation
- Src phosphorylation of Bif-1 suppresses the interaction between Bif-1 and Bax, resulting in the inhibition of Bax activation during anoikis.
- a critical role for a EGF-R-connected p60c-src-kinase-mediated pathway involving STAT3 and contributing to cell survival and proliferation within colorectal carcinomatumours.
- The effect of OGP(10-14) on differentiation of a cancer megakaryoblast cell line and its involvement on RhoA and Src family kinases signaling pathway, was evaluated.
- pp60c-Src TK-activity was selectively induced by VEGF in MM tumor and ECs
- These studies demonstrate positive cross talk between ER, c-Src, EGFR, and STAT5b in ER+ breast cancer cells.
- the Src-specific sites are all required for overexpressed Focal adhesion kinase to inhibit invadopodia formation.
- This study reveals for the first time that alpha-catenin is a key regulator of beta-catenin transcriptional activity and that the status of alpha-catenin expression in tumor tissues might have prognostic value for Src targeted therapy
- expression and activation of c-Src as well as EGF receptor promotes head and neck squamous cell carcinoma progression
- PLCgamma-1 and c-Src activation contribute to HNSCC invasion downstream of EGF receptor
- study shows that TNFR1 associates with Jak2, c-Src, and PI3K in various cell types to engage signaling pathways, activate transcription factors, and modulate gene expression
- Regulation of hERG channels by protein tyrosine kinases modifies the channel activity and thus likely alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons.
- analysis of PAFR activation and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer
- This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis .
- PI3K and Src-ELMO-Dock2 pathways work in parallel to activate Rac2 and modulate chemotaxis in response to a CXCL8 gradient in neutrophils.
- In vascular smooth muscle cells shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation.
- The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
- c-Src is involved in lipoteichoic acid-induced heme oxygenase-1 expression in human cultured tracheal smooth muscle cells.
- data are compatible with a model wherein interaction of MDA-9/syntenin with c-Src promotes the formation of an active FAK/c-Src signaling complex, leading to enhanced tumor cell invasion and metastatic spread
- Src overexpression downregulates alpha3 integrin total protein expression and localization to the cell surface of HCT116 colon cancer cells. This indicates that Src activity may enhance metastasis by altering alpha3 integrin expression.
- Src and ADAM-17-mediated shedding of transforming growth factor-alpha is a mechanism of acute resistance to TRAIL.
- Src and Src-associated signaling pathways are activated in relation to hypoxia in neoplasms
- TCPTP is a negative regulator of SFK, JAK1 and STAT3 signalling during the cell cycle.
- KV11 peptide (from human Apolipoprotein A) suppresses angiogenesis and tumor progression by targeting the c-Src/ERK signaling pathways in VEGF induced cells
- Data suggest that upon phosphorylation, Src is directly translocated from focal adhesions to membrane ruffles, thereby promoting formation of new adhesion complexes.
- the c-Src-Rac1-p38 MAPK pathway is required for activation of Akt in response to radiation and plays a cytoprotective role against radiation in human cancer cells
- Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.