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Validated All-in-One™ qPCR Primer for SOX11(NM_003108.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq].
Gene References into function
- Sox-11 activates transcription more strongly than Sox-2; the transactivation domain of Sox-11 is primarily responsible for this capability
- Sry transgene resucues sex reversal in C57Bl-Dax1-Y gonads
- two novel mutations in SRY gene in the patients with 46,XY female sex reversal.
- the function of SIP-1/NHERF2 as an SRY cofactor during testis determination is conserved between human and mouse
- The phenotype of the twins presented in this report is consistent with what is generally seen in XX SRY+ males: they have normal genitalia.
- The SRY gene variation was detected in two cases of male infertility.
- specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1-positive and - negative MCL may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL.