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Validated All-in-One™ qPCR Primer for SLC2A2(NM_000340.1) Search again
Product ID:
HQP017351
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GLUT2
Gene Description:
solute carrier family 2 member 2
Target Gene Accession:
NM_000340.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq].
Gene References into function
- mutated in patients with fanconi-Bickel syndrome
- Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter.
- polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients.
- Expression is responsible for resistance to alloxan and streptozotocin toxicity.
- We have found GLUT-2 and glucokinase mRNAs in several brain regions, including the ventromedial and arcuate nuclei of the hypothalamus
- SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with impaired glucose tolerance.
- identify Glut2 as a GroPIns transporter in mammals, and define a physiologically relevant cell-permeation mechanism
- kidney of diabetic rats, an initial and transient upregulation of GLUT2 was induced specifically by insulin only.
- recent progress in elucidating the transcriptional regulation of GLUT2 in the liver and pancreatic beta-cells and the relevance to type 2 diabetes.[RREVIEW]
- Data show that glucose transport in human airway epithelial cells in vitro and in vivo utilises GLUT2 transporters, and suggest that these transporters could contribute to glucose uptake/homeostasis in the human airway.
- Our findings show that a genetic variation in GLUT2 is associated with habitual consumption of sugars, suggesting an underlying glucose-sensing mechanism that regulates food intake.