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Validated All-in-One™ qPCR Primer for CXCR5(NM_001716.4) Search again
Product ID:
HQP016959
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BLR1, CD185, MDR15
Gene Description:
C-X-C motif chemokine receptor 5
Target Gene Accession:
NM_001716.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family.
Gene References into function
- structural requirements for the activation of signal transduction pathways by CXCR5
- CXCR5 is a common and early marker for newly generated memory CD4+ T cell subsets during ongoing immune responses.
- Most Natural killer t-cells express receptors for extralymphoid tissue or inflammation-related chemokines (CCR2, CCR5, and CXCR3), while few NKT cells express lymphoid tissue-homing chemokine receptors (CCR7 and CXCR5).
- Data show that blr1 was induced early during cell differentiation and because its overexpression accelerated monocytic differentiation, it may be important for signals controlling cell differentiation.
- Data demonstrate a significant age-dependent difference in the response of osteoblasts to CXCR3 and CXCR5 activation.
- CXCR5 and CXCL13 play an essential role in maintaining B- and T-cells in lymphocytic infiltrates and ectopic follicles in thyroid tissue from patients affected by autoimmunity.
- certain malignant cells use CXCR5/CXCL13 for infiltration, resistance to apoptosis, and inappropriate proliferation
- studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5
- Potenetial role of CXCL13 and its specific receptor CXCR5 in recruitment of B cells in renal allograft rejection.
- Data show that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulated PEG10 expression and function in leukemic B cells.
- elevated levels of CXCL13 could cause impaired or altered trafficking of B cells during HIV infection and could contribute to the previously reported loss of CXCR5
- CCR7 and CXCR5 are differentially expressed on the cell surface of lymphocytes and dendritic cells depending of the stage of cellular differentiation and activation. (review)
- expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production
- Expression of CXCR5 on tumor cells promotes the growth of colon carcinoma cells in the liver.
- CXCR5 plays a role in Chronic lymphocytic leukemia (CLL) cell positioning and cognate interactions between CLL and CXCL13-secreting CD68+ accessory cells in lymphoid tissues.
- CXCR5 is the first chemokine receptor so far identified able to attract in vitro primary metastatic neuroblastoma cells
- Most B cells expressed CXCR5.
- Altered expression of the chemokine receptor-ligand pair, CXCR5/CXCL13, may participate in the establishment of B-cell dysfunctions during HIV-1 infection.