|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CXCL5(NM_002994.4) Search again
Product ID:
HQP016650
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ENA-78, SCYB5
Gene Description:
C-X-C motif chemokine ligand 5
Target Gene Accession:
NM_002994.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation. [provided by RefSeq].
Gene References into function
- ENA-78 is produced in bronchial epithelial cells in response to RV16 infection
- ENA-78 is present in increased abundance in the amniotic cavity in response to intrauterine infection and may play a role in infection-driven preterm birth and rupture of membranes secondary to leukocyte recruitment and activation.
- During bacterial meningitis, CXCL5 is elevated in cerebrospinal fluid, where it is involved in the recruitment of neutrophils to the central nervous system.
- ENA-78 may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization.
- Peripheral blood monocytes upregulated both tumor ENA-78 and IL-8 mRNA and protein. Alveolar macrophages only upregulated ENA-78 mRNA and protein.
- induced by Rhinovirus infection of primary human airway fibroblasts
- CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide 78
- The platelet-derived chemokines ENA-78 exhibited particular changes after SCT; results suggest that ENA-78 plays a role in hematopoietic conditions in which G-CSF is not involved
- LDL lipoprotein subunit L5 induces human umbilical vein endothelial cells (HUVEC) to express ENA-78.
- IP-10 may play an important role in regulating lymphocytes into the lung and ENA-78 may be associated with lung parenchymal disease in pulmonary sarcoidosis.
- lack of association of ENA-78 polymorphism with giant cell arteritis
- CXCL5 overexpression is associated with late stage gastric cancer
- This is the first report on the influence of CXCL5 gene variants and their relation to expression of CXCL5 protein in human colorectal cancer.
- Stromal endometrial cells produced ENA-78 and IL-8 under cytokine stimulation.
- unveils a proinflammatory pathway centered on kinin B1 receptor activation of CXCL5 leading to leukocyte trafficking
- CXCL5 may play multiple roles in the etiology of both benign and malignant proliferative diseases in the prostate.
- Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients.
- Results reveal that platelet-derived growth factor-B-activated fibroblasts play a key role in the recruitment/migration and differentiation of mesenchymal stem cells and implicate a bFGF- and CXCL5-dependent mechanism in mediating these effects.
- CXCL5/ENA-78 has a role in acute coronary syndrome and the statin response
- patients with type 2 diabetes had higher frequency of carrying the G/C or C/C genotype compared with controls; frequency of allele C was increased in patients with diabetes compared to controls; findings suggest role of CXCL5 in pathogenesis of diabetes