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Validated All-in-One™ qPCR Primer for CCL17(NM_002987.2) Search again
Product ID:
HQP016636
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
A-152E5.3, ABCD-2, SCYA17, TARC
Gene Description:
C-C motif chemokine ligand 17
Target Gene Accession:
NM_002987.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq].
Gene References into function
- Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies
- TARC may contribute to the pathogenesis of eosinophilic pleural effusions in paragonimiasis.
- TGF-beta(1) might regulate the TARC-related inflammatory processes, which may be important for understanding the pathogenesis of allergic diseases.
- modulation by IL-4
- TARC was found to be highly expressed in the basal epidermis of the lesional skin of atopic dermatitis patients and only slightly in the non-lesional skin.
- Production of TARC by HaCaT cells is phenomenon specific to cell line, and observation on TARC in HaCaT cells can not be generalized. Normal human epidermal keratinocytes do not produce TARC protein in vitro.
- TGF-beta1 inhibited IFN-gamma and TNF-alpha-induced TARC production in HaCaT cells via Smad2/3. Modulation of TGF-beta/Smad signaling pathway may be beneficial for treatment of atopic dermatitis.
- The combination of TNF-alpha with either IL-4 or IL-13 markedly increased both TARC release and the abundance of TARC mRNA in corneal and dermal fibroblasts, but not in lung fibroblasts.
- important role in the production of antigen specific IgE by T-B cell interaction and in the pathogenesis of atopic dermatitis
- Th2 cytokines enhance TARC expression in human airway smooth muscle cells in IL-4Ralpha genotype-dependent fashion.
- The development of SLE is closely related to the elevation of plasma TARC/CCL17 levels.
- Basal expression and colocalization of CCL17 with E-selectin and ICAM-1 in dermal blood vessels serves to recruit T cells to noninflamed human skin and provides a strong cutaneous immunosurveillance system and model interface with the environment.
- selectively induced in EBV-infected B cells by LMP-1 protein
- serum levels correlate with disease severity specific for atopic dermatitis
- IL-4/IL-13 and IFN-gamma induce alternations in the distribution of adherens junctions in a different fashion and thereby contribute to the reciprocal regulation of TARC/MDC production.
- EBV infection induces TARC expression in B cells; EBNA-LP is one of the viral gene products responsible for the induction.
- Serum levels of TARC and MDC in atopic dermatitis patients were significantly higher than those found in normal controls
- primary Th2-dominated inflammatory reaction in atopic dermatitis induced by TARC leads to an augmented skin-specific inflammatory reaction through CTACK.
- IL-4 and IL-13 secreted from embryo during implantation may up-regulate TARC by endometrial epithelial cells. Production of TARC in endometrium may contribute to modulation of immune reaction by regulation of Th2 lymphocyte trafficking and functions.
- the -431C>T SNP of the TARC gene enhances the promoter activity of TARC gene but is not associated with susceptibility to AD in Japanese population
- findings indicate TARC and MDC are actively involved in pathogenesis of atopic dermatitis and their expression, opposite to that of eotaxin, is strongly associated with clinical picture of atopic dermatitis.
- Elevated bronchial mucosal expression of TARC/CCL17 is implicated in asthma pathogenesis; its action is partly through selective development and retention, or recruitment of T helper type 2, not Th1, receptor-bearing cells.
- CCR4 and TARC/CCL17 play role in pathophysiology of cutaneous lupus erythematosus(CLE). Cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE.
- Both a Th1 chemoattractant (CXCL9) and Th2 chemoattractants, CCL17 and CCL22, cooperatively play a role in the development of autoimmune blistering disease.
- Thymus and activation-regulated chemokine (TARC)/CCL17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts (review).
- The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined.
- Ragweed stimulation significantly increased the production of the Th2-associated cytokines IL-5, IL-9 and IL-13, the chemokines CCL17 and CCL22 and the regulatory cytokine IL-10 in allergic patients
- Bexarotene decreases chemotaxis to CCL17.
- Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC.
- Circulating TARC/CCL17 and KL-6 are useful measurements for discriminating acute eosinophilic pneumonia from other causes of acute lung injury.
- In a lung epithelial tumor cell model, respiratory syncytial virus induces the chemokine TARC that has a potential to recruit T helper type 2 (Th2) cells to the lung.
- thymus- and activation-regulated chemokine may have a role in bronchopulmonary aspergillosis in cystic fibrosis patients
- There were no significant differences in CCL17 and CCL22 expression in PBMCs, sera and lesional skins of patients with intrinsic and extrinsic atopic dermatitis.
- Via TARC production, nasal fibroblasts may play an important role in the recruitment of Th2 cells into the sinus mucosa as well as nasal polyps.
- evidence provided that a distal tandem STAT6 element elevates expression from the CCL17 locus approximately twofold.
- Significantly higher CCL17 expression is associated with gastric cancer
- Latent membrane protein 1-expressing tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder were selectively positive for CCL17 and CCL22.
- We investigated whether nasal polyp fibroblasts produce TARC when stimulated with the breakdown products of microorganisms (TLR ligands) and a Th2 cytokine (IL-4).
- TARC overexpression is associated with eosinophilia in T-cell lymphomas.
- The increased level of CCL17 and CCL22 release was important for acute myelogenous leukemia dendritic cell (AML-DC) chemotaxis of normal T cells.
- AMCase induced epithelial cell production of CCL2, CCL17, and CXCL8.
- Report downmodulatory effect of the antihistaminic drug bepotastine on CCL17 expression in human keratinocytes.