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Validated All-in-One™ qPCR Primer for CCL2(NM_002982.3) Search again
Product ID:
HQP016621
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
Gene Description:
C-C motif chemokine ligand 2
Target Gene Accession:
NM_002982.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.
Gene References into function
- Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee.
- These studies demonstrate that PEIPC and PECPC isomers are potent activators of endothelial cells increasing synthesis of IL-8 and MCP-1.
- Contact hypersensitivity are significantly enhanced in the hMCP-1 Tgm, which appears to result from a constitutive activation of LC with the systemic presence of large amount of hMCP-1.
- overexpression in mesangial cells by advanced glycation end products
- Inflammatory cytokines mediate C-C (monocyte chemotactic protein 1) and C-X-C (interleukin 8) chemokine expression in human pleural fibroblasts.
- Increased expression in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty
- Monocyte chemotactic protein-1 and macrophage migration inhibitory factor production by peritoneal macrophages may contribute to paracrine and autocrine activation and to macrophage accumulation in peritoneal cavity of women with endometriosis.
- LPS-stimulated production of MCP-1 was significantly less in infected patients. Serum concentrations of both mediators were higher in infected patients and the highest concentrations of MCP-1 were in patients who died
- Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in smooth muscle cells by differential activation of nuclear factor-kappa B and activator protein-1.
- expression of MCP in aiway epithelial cells after injury enhances cell migration and proliferation
- Fluid shear stress induces the secretion of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells
- plasmin induction of MCP-1 in human monocytes
- Simvastatin reduces expression of the proinflammatory cytokine monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients.
- MCP1 is upregulatied in Peyronie's disease
- Induction of the gene encoding macrophage chemoattractant protein 1 by Orientia tsutsugamushi in human endothelial cells involves activation of transcription factor activator protein 1.
- enhances the migration of bone marrow stromal cells
- upstream signaling events in platelet-induced NF-kappa B activation that induce secretion of NF-kappa B-regulated chemokine MCP-1.
- Toxoplasma gondii tachyzoites induced MCP-1 expression and secretion in infected fibroblasts
- Monocyte chemotactic protein-1 directly induces human vascular smooth muscle proliferation.
- Recipients of renal transplants homozygous for the -2518 G mutation of the MCP-1 gene are at risk for premature kidney graft failure.
- may be a marker of early development of nephropathy in IDDM
- first report of monocyte chemotactic protein-1 expression in mesothelial cells induced by oxidized LDL, and provides direct evidence of inflammatory action of peritoneal fluid of women with endometriosis
- influence of genetic variation in MCP-1 on HIV-1 pathogenesis in large cohorts of HIV-1-infected adults and children
- Circulating ICAM-1, IL-8, and MCP-1 in untreated obstructive sleep apnea were significantly greater than in controls. nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators.
- MCP-1 modulates the differentiation of monocytes into dendritic cells and may thereby inhibit Th1 cell development.
- We used specific pharmacologic inhibitors to identify the signalling molecules which lead to interleukin (IL)-8 and MCP-1 production in human monocytes in response to M. tuberculosis infection
- MCP-1 may play a role in progression of human esophageal carcinoma through its role in angiogenesis
- Results show that high ambient glucose does not affect mesangial monocyte chemoattractant protein-1 release and decreases its chemokine receptor 2 (CCR2) receptor expression.
- homozygosity for G at -2518 in the MCP-1 gene might be a candidate for the genetic marker of Carpal-tunnel syndrome development in Japanese hemodialysis patients
- some heat-stable component of P. gingivalis, including LPS, may be responsible for the induction of IL-8 and MCP-1 in HUVECs by a CD14-dependent mechanism
- The polymorphisms of the MCP-1 and MIP-1A genes do not play a substantial role in genetic predisposition for sarcoidosis or in clinical manifestations of sarcoidosis in this Japanese population.
- mechanism of gamma-Herpesvirus MCP-1 sequestration
- induction of MCP-1 by Porphyromonas gingivalis in endothelial cells could enhance atherosclerosis progression by contributing to the recruitment of monocytes
- A genetic polymorphism in the 5' flanking region of the MCP-1 gene is associated with nephritis in lupus through modulating MCP-1 expression.
- Escherichia coli activates kidney proximal tubular cells to generate MCP-1 that promotes migration of monocytes in vitro.
- IL-10 has two contrasting actions on MCP-1 production of monocytes/macrophages, between the resting and activated conditions.
- results suggest that monocyte chemoattractant protein-1 is produced in renal tubular cells and released into urine in proportion to the degree of proteinuria (albuminuria), and its increased expression in renal tubuli contributes to renal tubular damage
- Myxomas with both high tumor and high stromal MCP-1 expression had a higher macrophage count than other myxomas. In cardiac myxoma, MCP-1 and thymidine phosphorylase may be important angiogenic signals accompanying growth.
- results revealed that Porphyromonas gingivalis induces the expression of IL-8 and MCP-1 mRNAs in vascular endothelial cells, but bacterial proteases degrade both chemokines
- The ability of activated protein C to upregulate the production of MCP-1 is most likely by increasing the stability of MCP-1-mRNA rather than by transcriptional activation via NF-KB
- MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation
- interacts with the transcriptional repression domain of MBD1
- human monocytes require PKCbeta for the chemotactic response to MCP-1
- MCP-1 may play a novel role as a protective agent against the toxic effects of glutamate and HIV-1 tat; neuronal and astrocytic apoptosis in culture was significantly inhibited by co-treatment with MCP-1 or RANTES but not IP-10
- transcription regulated by Tat and the Smad-3 and-4 transcription factors whose activities are induced by the TGFbeta-1 pathway in human astrocytic cells
- Estradiol-bound estrogen receptor beta may inhibit MCP-1 gene expression by inhibiting Sp1 and AP-1 transcriptional activities in keratinocytes.
- CCL2 may represent an autocrine factor important for enhancing HIV-1 virion production likely by affecting the macrophage cytoskeleton.
- a marker for acute rejection after liver transplantation
- MCP-1 polymorphism is slightly associated with the susceptibility to rheumatoid arthritis in patients lacking the HLA shared epitope
- that integrin-mediated cell adhesion to the ECM can induce MCP-1 expression through activation of FAK, and suggest a role for altered extracellular matrix deposition in the progression of glomerular diseases by affecting gene expression.
- Proapoptotic stimuli upregulate MCP-1 expression by vascular smooth muscle cells through caspase- and calpain-dependent release of interleukin-1alpha.
- differential glycosylation allows one to obtain highly effective short-lived CCL2 or less-effective long-lived CCL2 and may thus represent a novel mechanism of adaptation to pathological versus physiological conditions
- ANF mediates the inhibition of TNF-alpha-induced expression of MCP-1.
- MCP-1 mRNA levels were increased by 40-fold in left ventricle of myocardial infarction model mice; a transfected N-terminal deletion mutant of the human MCP-1 gene improved the survival rate and symptomology
- Inheritance of the -2518 MCP-1 G allele, which appears to affect hepatic MCP-1 expression, may predispose HCV patients to more severe hepatic inflammation and fibrosis.
- ROS such as superoxide and H(2)O(2) derived from Rac1-activated NADPH oxidase mediate TNF-alpha-induced MCP-1 expression in endothelial cells.
- Cerebrospinal fluid MCP-1 activity may be a sensitive marker for neuroinflammation in amyotrophic lateral sclerosis.
- Expression in the CNS of transgenic mice is a major pathogenic factor that drives macrophage accumulation in the development of CNS inflammatory disease.
- MCP-1 genotype was an independent determinant of plasma MCP-1 level; findings indicate plasma MCP-1 associated with carotid atherosclerosis; -2518 SNP is associated with plasma level of MCP-1, but was not directly associated with carotid atherosclerosis
- MCP-1 has an effect on astrocytes that is mediated by caveolin-1
- RANTES is more involved than MCP-1 in recruiting inflammatory cells in rhinological disease and may reflect the degree of local inflammation as consequence of the specific chemoattractant properties of RANTES
- MCP-1 is substantially regulated upon monocyte contact with various cell wall components from Gram-positive and Gram-negative bacteria.
- Unlike in cells exposed to proinflammatory cytokines, all three MAPKs (ERK, p38 MAPK, and JNK) were required to induce CCL2 secretion in response to activin.
- Oncostatin M induces CCL-2 expression in osteoblasts. Activation of MEK/ERK and STAT pathways, which leads to c-Fos expression and AP-1-DNA binding, is involved in process. Signaling requires tyrosine kinase and protein kinase C but not COX-2.
- The present study suggests that the MCP1 promoter -2518 polymorphism may not confer susceptibility to BID itself, but could have an influence on the clinical heterogeneity of BID, at least in the Korean population.
- Up-regulation of MCP-1 in myeloma cells which express the relevant receptor C-C chemokine receptor 2.
- Collagen II-reactive T cells in rheumatoid arthritis joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with synoviocytes.
- MCP-1 is induced by 13-hydroperoxyoctadecadienoic acid in the vasculature via activation of NF-kappa B
- The MCP-1 (-2518) gene polymorphism is unlikely to confer genetic susceptibility to Alzheimer's disease in this large Spanish population.
- The capacity of in vitro factors to decrease human islet MCP-1 release suggests strategies to increase the success of islet transplantation.
- Eight tested neuroblastoma cell lines secreted a range of CCL2 (0-21.6 ng/ml.
- Role of the MCP-1 promoter -2518 polymorphism in clinical heterogeneity of schizophrenia.
- an A/G or G/G genotype may predispose to the development of systemic lupus erythematosus and further indicate that the patients with these genotypes may be at higher risk of developing lupus nephritis.
- no association between the MCP-1 -2518 polymorphism and susceptibility to or clinical disease course in multiple sclerosis
- SphK1 mediates TNF-alpha-induced MCP-1 gene expression through a p38 MAPK-dependent pathway and may participate in oscillatory flow-mediated proinflammatory signaling pathway in the vasculature.
- The induction of IL-13 and MCP-1 gene expression by IL-1beta was accompanied by the activation of IL-1 receptor-associated kinase and translocation of the transcription factor NF Kappa B into the nucleus.
- Elevation of MCP-1 in the circulation of peripheral arterial disease(PAD) patients implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology.
- An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic hemodialysis patients.
- Our findings suggest a limited role for CCL2/CCR2 in early active multiple sclerosis
- A strong upregulation of MCP-1 and RANTES was observed in all the cases, mainly in tubular cells, and there was a strong correlation between the expression of these chemokines and NF-kappaB activation in the same cells.
- The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD.
- Single nucleotide polymorphism in this gene supports role for MCP-1 in pathologies associated with hyperinsulinaemia.
- Data suggest that the A-2518G variant of the SCYA2 has not a major role in the pathogenesis of schizophrenia.
- HIV-infected patients with the MCP-1-2518G allele have a 5-fold increased risk for atherosclerosis.
- Two codons of this human gene suppressed hepatic fibrosis in rats, thus providing feasible gene threapy.
- MCP-1, MIP-1beta, and IL-8 elevated in relapsing polychondritis(RP) are proinflammatory chemokines, characteristic of activation of monocytes and macrophages and, in the case of IL-8, also of neutrophils. Role for cell-mediated immune response in RP.
- MCP-1 is involved in the regulation of chemotaxis and function of monocytes during and early after the end of cardiopulmonary bypass
- The surgical team and the enzyme were independently associated with in vitro CCL2/MCP-1 islet release in islet transplantation.
- Role in the development of bronchiolitis associated with influenza and RSV infections in infants and children.
- Association between presence of G at position -2518 in MCP-1 promoter region and presence of arthritis in patients with systemic lupus erythematosus.
- new role of MCP-1 as an arteriogenic factor in hemodialysis patients with cardiovascular disease.
- The A -2518G polymorphism of the MCP-1 gene appears to affect MCP-1 expression of skin fibroblasts of patients with systemic sclerosis; the G/G genotype may predispose patients
- stretching of mesangial cells stimulates their monocyte chemoattractant activity via an NF-kappaB-mediated, MCP-1-dependent pathway
- MCP-1 significantly increased the number of TRAP-positive multinuclear bone-resorbing osteoclasts
- increased CXCL10 especially in hypothyroid patients with a more aggressive disorder, and normal CCL2 serum levels in autoimmune thyroiditis
- MCP-1 expression is upregulated in P. gingivalis-infected endothelial cells via reactive oxygen species, p38 MAP kinase, JNK, NF-kappaB, and AP-1.
- MCP-1 mainly down-regulates the expression of chemotactic genes influencing neutrophilic granulocyte expression
- Lack of involvement of polymorphism at position -2518 (A/G) of the MCP-1 gene on the susceptibility to acute allograft rejection among liver transplantation recipients.
- Our aim was to determine whether the MCP-1 -2518 A/G polymorphism affects the severity of acute pancreatitis
- Increased expression of monocyte chemotactic protein-1 is associated with invasive ductal breast carcinoma
- CCL2 may play role in pathobiology of ovarian cancers
- expression induced in macrophages by SARS-CoV infection
- the production of MCP-1 and IL-8 in vascular endothelial cells was induced by mast cell granules and amplified by tryptase
- IL-8 and MCP-1 may contribute to the pathophysiology of adenomyosis
- results therefore identify MCP-1 as a target of the beta-catenin/TCF/LEF pathway in breast tumour cells, a regulation which could play a key role in breast tumour progression
- These results indicate that interaction between the Arp2/3 complex and WASP stimulates actin polymerization and integrin beta-1-mediated adhesion during MCP-1-induced chemotaxis of THP-1 cells.
- Biologically active MCP-1 secreted into both the uterine lumen and underlying stroma mediates the presence of monocytes, macrophages, and other immune cells in the uterine endometrium.
- findings suggest that monocyte chemotactic protein-1 (MCP-1) may play a role in preterm labor regardless of the presence of intra-amniotic infection (IAI)
- MCP-1/CCR2 may play a role in Ca2+ influx-dependent TF regulation in the monocyte-endothelial cell interaction in the impairment of nitric oxide synthesis
- The results indicate that pulmonary CCR2+ T cells and MCP-1 contribute to the pathogenesis of pediatric ILD and might provide a novel target for therapeutic strategies.
- These results suggest that hypoxia is an important negative regulator of monocyte chemotaxis to the renal inflamed interstitium, by reducing MCP-1 expression.
- MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction
- MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development.
- Human perivascular white adipose tissue has chemotactic properties through the secretion of chemokines
- Basal secretion of IL-8 and MCP-1 was not changed in CTGF-silenced renal cells.
- The transcription factor NF-kappaB, and possibly NF-I, contribute to the upregulation of CCL2 chemokine production during the differentiation of human progenitor cells toward an astrocyte phenotype.
- The level of CCL2 in cultured fibroblasts was increased 3 h post-stimulation by purified or recombinant SAG1.
- MCP-1 is upregulated by oxidized cholesterol.
- no polymorphic sequence deletion in chronic hepatitis C.
- IL-4 up-regulates the expression of MCP-1 and decreases NO bioavailability through activation of NADPH oxidase in endothelial cells
- MCP1 has a role in angiogenesis and tumorigenesis of gastric carcinoma
- the MCP-1-induced TRAP(+)/CTR(+) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity
- Our data suggest that the CCL2 -2518A>G polymorphism may play a role in HLA-B27 associated acute anterior uveitis.
- Significantly increased MCP-1 levels are found in patients with mild cognitive impairment and in mild Alzheimer's disease (AD), but not in severe AD patients as compared with controls.
- In heme oxygenase-1 overexpressing cells, VEGF and the prostaglandin transporter were greatly increased while MCP-1 levels were decreased
- MCP-1 and M-CSF, critical for monocyte recruitment, activation, and differentiation, differentially regulate VEGF-A expression and may play an important role in monocyte/macrophage- mediated tumor angiogenesis
- probiotic E. coli Nissle 1917 specifically upregulates expression of proinflammatory genes and proteins MCP-1, MIP-2alpha, and MIP-2beta in human and mouse intestinal epithelial cells.
- A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.
- Increased MCP-1 levels in blood and cerebrospinal fluid is associated with Lyme borreliosis
- The VEGF level was detected in endometrial stromal cell culture media and was increased significantly when E2 or MCP-1 was added to the media, especially in the presence of E2 plus MCP-1
- The AA genotype at MCP-1 -2518 was an independent risk factor for the progression of renal disease in Japanese patients with IgA nephropathy, and was closely associated with renal survival
- The MCP-1 mRNA expression was increased following exposure to calcium oxalate crystals in renal epithelial cell line
- These data suggest that fibrogenic processes in Mo regulated by MCP-1/CCR2 may be novel, therapeutic targets for combating organ fibrosis.
- Our data show that CT-1 induces in a concentration and time dependent manner MCP-1 mRNA and protein in HUVEC.
- data suggest that CCL2, but not other chemokines, plays a key role in infiltration of HIV-infected leukocytes into the CNS and the subsequent pathology characteristic of NeuroAIDS
- MCP-1 may represent a molecular link in the negative cross-talk between adipose tissue and skeletal muscle assigning a completely novel important role to MCP-1 besides inflammation
- Plasma MCP-1 concentration is genetically determined and associated with age and smoking habit and it also correlates with subclinical atherosclerosis in HIV-infected patients
- Induction of HO-1 inhibits MCP-1 mRNA expression in U937 cells.
- Data indicates that no association exists between the -2518A/G polymorphism of the MCP-1 gene and susceptibility to alopecia areata.
- Monitoring cell excretion and mcp1 content may be utilized for early detection of polyomavirus-induced nephropathy after kidney transplantation.
- Central nervous system involvement in acute lymphoblastic leukemia is associated with significantly higher levels of MCP1 in cerebospinal fluid during therapy.
- Stretch-induced CCR2 downregulation may favour MCP-1 paracrine activity in mesangial cells.
- findings show that in type II alveolar cells intrinsic and extrinsic peptide CGRP inhibits IL-1-induced MCP-1 secretion in an autocrine/paracrine mode
- Albuminuria triggers tubular MCP-1/CCL2 expression with subsequent macrophage infiltration.
- Our data suggest that elevated serum MCP-1 levels and increased monocyte CCR2, CD36, CD68 expression correlate with poor blood glucose control and potentially contribute to increased recruitment of monocytes to the vessel wall in diabetes mellitus.
- study identifies significant correlations between MCP-1 in plasma and tissue alterations in all studied regions of deep white matter and basal ganglia of patients with HIV infection.
- MCP-1 -2518 G allele does not significantly alter susceptibility to chronic pancreatitis.
- found relevant markers in the MCP1 gene associated with HCMV reactivation
- CXC chemokine CXCL10 and CC chemokine CCL2 serum levels increase with normal aging
- monocyte chemoattractant protein-1 has a role in carotid atherosclerosis in HIV-infected patients with lipodystrophy
- MCP-1 acts as a paracrine and autocrine factor for prostate cancer (CaP) growth and invasion.
- intracellular ascorbate in vitro protects THP-1 cells from oxidative damage and inflammatory responses
- results suggest that MCP-1, under the regulation of NF-kappaB, is involved in the pathogenesis of proliferative diabetic retinopathy
- Results suggest that MCP-1/CCL2 and IP-10/CXCL10 produced by astrocytes may activate astrocytes in an autocrine or paracrine manner and direct reactive gliosis followed by migration and activation of microglia/macrophages in demyelinating lesions.
- MCP-1 markedly enhances CX3CR1 expression on freshly isolated human peripheral blood monocytes or monocytic cell lines and stimulates the adhesion of these cells to immobilized CX3CL1/fractalkine.
- The mRNA expressions of MCP-1 of all post-kidney transplant patients were significantly higher than controls.
- These results suggest that lysophospholipid released by activated platelets might enhance the IL-8- and MCP-1-dependent chemoattraction of monocytes toward the endothelium through an IL-1-dependent mechanism.
- CDK-4/6 modulated the production of MMP-3 and MCP-1.
- A functional polymorphism within the TNF bloc could modulate MCP-1 concentration and seems more likely to be near to the LTA 252A>G polymorphism than to the TNF -308G>A one
- Elevated systemic levels of the chemokines MCP-1, IL-8, and IP-10 precede coronary heart disease but do not represent independent risk factors.
- Polymorphism in the promoter is related to increased susceptibility to pulmonary tuberculosis.
- MCP-1 gene polymorphism might slightly associate with patients with systemic juvnile rheumatoid arthritis
- CCL2 recruits prostate cancer epithelial cells to the bone microenvironment and regulates their proliferation rate
- MCP1 is significantly elevated in the cerebrospinal fluid in HIV-1 infected patients.
- the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and is a risk factor.
- Adiponectin-mediated induction of IL-6, CCL2 and CXCL8 is disturbed in monocytes from type I diabetes patients.
- Elafin inhibits the lipopolysaccharide-induced production of monocyte chemoattractant protein-1 in monocytes by inhibiting AP-1 and NF-kappaB activation.
- Women with endometriosis-associated infertility have a poor IVF outcome.
- C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production
- MCP-1 functions as a chemoattractant to stimulate migration of VSMCs and mesenchymal cells toward ECs
- serum MCP-1 levels are directly correlated, and cell-mediated immunity inversely correlated, with the severity of surgical stress
- genetic markers in the MCP-1 gene do not demonstrate significant genetic associations with the idiopathic inflammatory myopathies and do not discriminate polymyositis from dermatomyositis in a UK Caucasian population
- CCL2 expression by transgenic mouse pancreatic beta cells promotes recruitment of monocytes and dendritic cells into the islets of Langerhans.
- In our cohort of white Spaniards, homozygosity for the variant CCL2-2518GG genotype is overrepresented in HIV-1-infected subjects
- findings show increased permeability & disrupted tight junctions of vascular endothelium cells in dengue haemorrhagic fever/dengue shock syndrome were effected by a mechanism partially dependent on MCP-1 secreted by DV2-infected monocytes & lymphocytes
- HHV-8-induced MCP-1 may play an important role in promoting inflammation and pathogenic angiogenesis typical of HHV-8-associated lesions.
- CCL2-2578G/G genotype could influence melanoma growth
- Serum levels of MCP-1 were increased in Down's syndrome (DS) children and adults, but not in older DS patients.
- frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects
- CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in peripheral blood than peritoneal fluid mononuclear cells of women with endometriosis.
- HOCl-modified albumin acts as a ligand for RAGE and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway
- HGF may facilitate osteophyte development by promoting MCP-1-mediated entry of monocytes/macrophages into the osteoarthritis-affected joint and/or by stimulating macrophage-derived growth factors
- serine proteases can stimulate MCP-1 release from respiratory epithelial cells possibly through a PARs-related mechanism.
- findings show that soluble Entamoeba histolytica proteins (SAP) can induce MCP-1 from intestinal epithelial cells by a unique pathway involving phosphatidylinositol 3-kinase (PI3 kinase) and NF-kappaB p65
- MCP-1 expression and subsequent macrophage/microglia infiltration and activation are critical for retinal detachment-induced photoreceptor apoptosis
- activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha-induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway
- Finding showed that MCP-1*1 haplotype is associated with height.
- A study of CCL2 transport across vascular endothelial cells was done.
- CCL2 mediates fibroblast survival by inhibiting apoptosis through IL-6/STAT3 signaling
- Lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL
- We conclude that PTHrP-induced MCP-1 production by HBME and hFOB cells promotes osteoclast differentiation in vitro and such induction may play a critical role in PCa development in the bone microenvironment.
- The expression of FOUNT-mediated CCL2/CCR2 may have important implications in the pathogenesis of CHF. The CCL2/CCR2 pathway via FROUNT may influence the clinical severity of CHF.
- Inhibition of serine-threonine protein phosphatase activities induces increased MCP-1 production and eventually the aggravated inflammatory response in gastric epithelial AGS cells stimulated by Helicobacter pylori.
- CCL-2 A(-2518)G genotype is a significant risk factor for SLE among Caucasians but not African Americans, suggesting that genetically mandated differences in MCP-1 expression contribute to SLE etiology in the former
- TNF-alpha induces CCL2 transcription in nasal polyp fibroblasts; B-Raf/MEK/ERK signaling cascade and to a less extent the p38 pathway are responsible for c-Fos activation and the subsequent AP-1/DNA interaction leading to CCL2 expression.
- In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases. [REVIEW]
- M-CSF contributes to the pathogenesis of pulmonary fibrosis in mice and in patients with IPF through the involvement of mononuclear phagocytes and CCL2 production
- Psychosine mediates reduced MCP1 production by peripheral immune cells of Krabbe patients.
- Mutations studied in the gene pair CCL2/CCR2 do not play a major role in the outcome and response to treatment for HCV infection in the Spanish population.
- The secreted MCP-1 may affect the production of MMP-9 in fibroblasts and/or macrophages.
- restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis
- The present study demonstrates that the A/A polymorphism of the MCP-1 gene at position -2518 is associated with insulin resistance during glucose loading in non-diabetic Japanese subjects.
- Monocyte chemotactic protein-1 may represent an important factor linking adipose tissue inflammation, obesity and type 2 diabetes [review]
- Data show that Epstein-Barr virus infection of primary human monocytes induced the release of monocyte chemotactic protein 1, and the use of small interfering RNA targeting Toll-like receptor 2 significantly reduced such a chemokine response to EBV.
- Data show that upon experimental and human renal ischemia/reperfusion, microvascular basement membrane (BM) heparan sulfate proteoglycans (collagen 18alpha1, agrin and perlecan) are modified to bind L-selectin and monocyte chemoattractant protein-1.
- IL-18 has a unique role in inducing the secretion of angiogenic SDF-1alpha/CXCL12, MCP-1/CCL2, and VEGF in rheumatoid arthritis synovial tissue fibroblasts, via distinct signaling intermediates.
- Serum of subjects with endometriosis contains significantly higher levels of interleukin-6, monocyte chemotactic protein-1, and interferon-gamma than control women.
- RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms do not have a role in progression of hepatitis B virus infection
- circulating levels of advanced glycation end products (AGEs) and soluble receptor for AGE are independent determinants of serum MCP-1 levels in patients with type 2 diabetes
- MCP-1 expression was increased in glioblastoma specimens.
- CCL2 is secreted in an autocrine manner through the ERK/MAPK pathway, and is up-regulated by the pregnancy-associated hormones, estrogen, progesterone and HCG, which suggests that CCL2 may play an important role at materno-fetal interface.
- A four-marker panel of CA-125, macrophage chemotactic protein-1, leptin, and macrophage migration inhibitory factor could diagnose the presence of endometriosis with 93% accuracy.
- prednisolone suppresses both HIV-1 viral load and CCL2 mRNA expression.
- Results showed there were no associations of MCP-1 and RANTES promoter SNPs with diabetic ESRD in Korean population.
- study is the first to report that MCP-1 serum levels are elevated in association with the HFE H63D mutation and not the C282Y mutation in patients with hereditary hemochromatosis
- Urinary excretion of the monocyte chemoattractant protein-1 (uMCP-1) is a biomarker of the inflammatory activity of the cortical tubulointerstitial area of the kidney, and does not reflect chronic interstitial damage.
- Increased monocyte chemoattractant protein 1 serum level is associated with acute myeloid leukemia
- Monocyte chemoattractant protein-1 (MCP1) may play a role in depression.
- preliminary evidence linking genetic variation in CCR2 to circulating levels of MCP-1
- Results suggest that the role of MCP-1 in metabolism is relevant and that, although new hidden complexities are evident, the function of MCP-1/CCL2 extends far beyond the monocyte chemoattractant effect.
- relationship between monocyte chemoattractant protein-1 gene (MCP-1) -2518A/G polymorphism and acute pancreatitis (AP) in the Han population of Suzhou, China
- The A-2518G polymorphism of MCP-1 is not a major susceptibility factor for bipolar disorder in the Korean population. However, the physiological role of MCP-1 is highly suggestive of its being associated with bipolar disorder.
- Hepatopulmonary syndrome is more common in patients with MCP-1 2518G gene carriage.
- MCP-1 polymorphism does not play a major role in the development of alcoholic chronic pancreatitis but may be associated with disease severity in Koreans.
- Urinary EGF/MCP-1 ratio may be used as a prognostic marker of end-stage renal disease for patients with immunoglobulin A nephropathy.
- Promoter elements responsible for antioxidant regulation of MCP-1 gene expression.
- the MCP-1/CCR2 system has a role in fibronectin deposition in the diabetic glomerulus, providing a new therapeutic target for diabetic nephropathy
- MCP-1 would seem to play a key role in the pathogenesis of XGP by mediating the recruitment of circulating monocytes or by cells resident in the interstitial space.
- MCP-1 Promoter Polymorphism at 2518 may have a role in metastasis of nasopharyngeal carcinoma after treatment
- Hyperhomocysteinemia stimulates MCP-1 expression in the kidney via NF-kappaB activation. Such an inflammatory response may contribute to renal injury associated with hyperhomocysteinemia.
- the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM
- In various renal diseases, l-selectin and MCP-1 binding to interstitial perivascular matrix HSPGs is increased, which is significantly associated with leukocyte influx.
- Beta-amyloid precursor protein (APP) and CCL2 chemokine synergistically enhance aggregated APP clearance by 3 different pathways in mononuclear phagocytes derived from transgenic mouse models of Alzheimer's disease.
- It is shown that human monocytes constitutively express p17Rs and that HIV-1 p17 selectively triggers these cells to produce MCP-1.
- MCP-1/CCR2 system is functionally active in podocytes and may be implicated in the migratory events triggered by podocyte injury in crescentic GN and other glomerular diseases.
- Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients.
- Serum and peritoneal fluid MCP-1 levels and the G (-2518)A MCP-1(monocyte chemoattractant protein-1) polymorphism were found not to be associated with endometriosis in Korean women.
- MCP-1-2518 SNP or a gene located nearby may modify clinical manifestation of sarcoidosis towards Lofgren's syndrome.
- CCL2 and CCL3 induce both immediate and delayed skin reactions in atopics and nonatopics, and evoke a similar profile of local T cell/macrophage and granulocyte recruitment
- GM-CSF regulates MCP-1 expression via Janus kinase-2-Stat5 pathway and by a novel regulatory mechanism of statins to reduce inflammatory reactions by down-regulating the expression of monocytic MCP-1
- These results showed the -2518 MCP-1 polymorphism is related to the susceptibility of plaque type psoriasis.
- Data show that MCP-1 has a synergistic effect on COX-2 and CCR2 protein expression in CD40L-stimulated HUVECs and stimulates VEGF production in these cells.
- the shear stress-induced overexpression of MCP-1 contributes significantly to the development of coronary collaterals during the early phase of acute myocardial infarction
- ACE2 overexpression in the THP-1 attenuates AngII-induced MCP-1 production and that this reduction is likely mediated by increased Ang (1-7) level.
- No evidence was found of an association between TLR4, CCR2, and CCL2 and AMD (age-related macular degeneration)
- A significant increase was noted for the risk of late acute rejection in renal allograft recipients who were homozygous for the MCP-1-2518G polymorphism
- These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis.
- results suggest that MCP-1 polymorphism is moderately associated with the genetic susceptibility to systemic lupus erythematosus in Mexican individuals.
- PC-PLC activation through CCR5 is specifically induced by gp120, since triggering CCR5 through its natural ligand CCL4 (MIP-1beta) does not affect PC-PLC cellular distribution and enzymatic activity, as well as CCL2 secretion
- lack of association of SDF-1 3'A, MCP-1 (-2518), CCR5-Delta32 polymorphisms with death and hepatocellular carcinoma occurrence in cirrhotic hepatitis C-infected patients
- Upon MCP-1 stimulation, iPLA(2)beta is recruited to the membrane-enriched pseudopod; in contrast, cPLA(2)alpha is recruited to the endoplasmic reticulum.
- present study showed a significant but not independent association between the -2518G/A polymorphism of the MCP-1 gene (presence of G allele) and myocardial infarction in the Tunisian population
- 15d-PGJ2 and ciglitazone down-regulate TNF-alpha-mediated osteoclast differentiation in human cells, in part via suppression of the action of MCP-1
- Inflammation-activated microvascular pulmonary endothelial cells regulate expression of MCP-1 in alveolar epithelial cell line (A549).
- Insulin increased MCP-1 gene and protein expression significantly more in the insulin-resistant than in the insulin-sensitive subjects
- Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2.
- Polymorphism in the human CCL2 gene is associated with progressive kidney failure in type 2 diabetes.[REVIEW]
- Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in intrauterine growth restriction
- Findings suggest that IL-8 and MCP-1 may be involved in the pathogenesis of endometriosis.
- An increase in adiponectin level due to a decrease in estradiol results in a reduction in monocyte chemotactic protein-1 level in postmenopausal women
- study concludes that chronic stable angina pectoris in Slovak patients is linked to MCP-1-2518 (A/G)single nucleotide polymorphism
- MCP-1 and CD40L had a synergistic effect on COX-2 expression and subsequent VEGF production in gastric cancer.
- Genetic polymorphisms within CCL2 gene are associated with susceptibility neither to systemic sclerosis nor to specific disease phenotypes.
- This study demonstrates an interplay between TGFbeta1, IL-13 and CCL2 in idiopathic pulmonary fibrosis with a usual interstitial pneumonia histological pathology, where these three mediators feedback on each other, promoting the fibrotic response.
- MCP-1 are involved in the pathogenesis of intractable epilepsy.
- The thrombin-induced monocyte/endothelial cell cross-talk mediated by increased CX3CL1 expression potentiates the CCL2 chemokine generation that might contribute to the recruitment of monocytes into inflamed areas.
- The overall current information suggests that CCL2 and CCL5 are inflammatory mediators with pro-malignancy activities in breast cancer.
- These data support the idea of an activator function of c-Jun that is executed by multiple mechanisms, including phosphorylation-dependent interaction with p65 NF-kappaB and HDAC3 at the level of chromatin.
- The expression of MCP-1 mRNA in LI90 cells as well as its secretion into the culture medium was significantly increased in response to AGEs.
- CCL2 and CXCL8 synergize in calcium signaling in peripheral blood monocytes.
- There is a correlation between glomerular expression of MCP-1 and PGM1 and worsening renal prognosis in paediatric lupus nephritis.
- Factors apart from ROS, IL-8 and MCP-1 may be involved in the pathogenesis of reflux esophagitis in children.
- Mechanisms that induce expression of MCP-1 in the brain and the role that it plays in recruitment of mononuclear cells from blood to brain and in the activation of inflammatory processes in HIV-dementia.
- There are elevated concentrations of the chemokines MDC, eotaxin, I-TAC, and MCP-1 in malignant pleural effusions.
- Adiponectin downregulated MCP-1 production by proximal tubular cells.Urinary adiponectin is present in proteinuric patients, and has the potential to activate AdipoR within the nephron
- CCL2 plays a role in the spreading of tumoral cells to the lymph node in oral cavity squamous cell carcinoma.
- The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population.
- The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes.
- CCL2 protects prostate cancer PC3 cells from autophagic death via the phosphatidylinositol 3-kinase/Akt/survivin pathway
- MCP-1, MIP-1beta, and IL-8 play important roles in the pathophysiology of Hemophagocytic lymphohistiocytosis (HLH). In addition, the serum concentrations of these chemokines may be sensitive markers for assessing disease activity in patients with HLH.
- CCL2 stimulation of prostate cancer cells activates the small GTPase, Rac through the actin-associated protein PCNT1.
- MCP-1 -2518 A>G polymorphism is not associated with premature coronary artery disease in Turkish patients.
- TNF-alpha can play a crucial role in the immunopathogenesis of nephritis by the induction of CCL2, ICAM-1 and VCAM-1 expression via the activation of the intracellular MAPK signaling pathway, which may contribute to macrophage and lymphocyte infiltration
- MMP-12 truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists
- Heme oxygenase-1 expression decreased LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha at both 4 and 24 h in murine and human macrophages
- Data show that basal level of MCP1 is higher in Parkinson's disease patients than in healthy control subjects.
- MCP-1 (monocyte chemoattractant protein-1) was higher in pregnant women than in nonpregnant women; MCP-1 was elevated in patients with gestational diabetes mellitus in the third trimester compared to healthy pregnant women
- High CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinemia and chronic hepatitis c(MC); CXCL10 in MC + autoimmune thyroiditis is significantly higher than that in MC.
- The function of survivin in the control of autophagy and the interaction between CCL2, survivin and autophagy in the complex program of tumor progression is discussed.
- CCL2 has the capacity to render a large population of lymphocytes more susceptible to HIV-1 late in the course of infection.
- observations support a major tumor-promoting role for co-expression of the chemokines in breast malignancy, and agree with the significant association of joint RANTES and MCP-1 expression with advanced stages of breast cancer.
- Results describe significant differences between controls and patients with renal cell carcinoma both pre-operatively and post-operatively in angiogenin, PDGF and MCP-1 serum levels.
- AMCase induced epithelial cell production of CCL2, CCL17, and CXCL8.
- mRNA levels of MCP-1 in the perifollicular stroma increased from the preovulatory to the late ovulatory phase and declined during the postovulatory phase.
- MCP-1 levels were significantly higher in Caucasians as compared to African-Americans.
- MCP-1 -362C was associated with resistance to tuberculosis in the case-control studies.
- The increase of Trx expression and activity inhibited Hcy-induced ROS production and MCP-1 secretion.
- activation of MCP-1/CCR2 axis promotes PCa growth in bone.
- demonstrate for the first time an association between the polymorphism in the regulatory region of the MCP-1 gene and susceptibility to cardiovascular disease in hemodialyzed patients
- The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).
- MCP-1 expression in papillary thyroid carcinoma may stimulate the aggressive behavior of this tumor or it may be a marker for aggressive behavior.
- No overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.
- CCL2/MCP-1 polymorphism of the donor has no impact on the allograft outcome during the first year after kidney transplantation
- hepatocyte-derived MCP-1, induced by bile acids, results in hepatic stellate cell recruitment in diverse causes of cholestatic liver injury.
- High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells.
- MCP-1 single nucleotide polymorphisms were not associated with increased Common carotid intima-media thickness.
- CCL2 induces selective and significant expression of ICAM-1
- CCL2 mediates the interaction between tumor-derived factors and host-derived chemokines acting in cooperation to promote skeletal metastasis of pancreatic cancer.
- mutant huntingtin-induced proteasomal dysfunction can up-regulate the expression of MCP-1