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Validated All-in-One™ qPCR Primer for ROS1(NM_002944.2) Search again
Product ID:
HQP016380
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
MCF3, ROS, c-ros-1
Gene Description:
ROS proto-oncogene 1, receptor tyrosine kinase
Target Gene Accession:
NM_002944.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity.
Gene References into function
- Results show that c-ros expression in the human epididymis differs from that in mice and suggest that the unusual morphology of the human epididymis may reflect species differences in gene expression along the excurrent duct.
- inactivation of Ros by SHP-1-mediated dephosphorylation plays a role in the regulation of complex stability
- bcl2 and ROS1 oncogene expression in meningiomas are not concurrent and neither can be ascribed to any histologic subtype or grade of tumor.
- the G --> A polymorphism of ROS1 genotype was independently associated with in-stent restenosis in a Japanese population
- These results suggest that polymorphisms of ABCA1 and ROS1 are determinants of blood pressure and the development of hypertension in Japanese individuals.
- Data show that genotypes for the G-->A (Asp2213Asn) polymorphism (rs529038) of ROS1 was associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.