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Validated All-in-One™ qPCR Primer for RORC(NM_001001523.1) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma
- data suggest that RORC cannot explain the linkage of type 2 diabetes in the 1q21-q23 region
- transcription factor driving the development of IL-17-producing T cells
- Review highlights the regulation of IL-17 production by orphan nuclear receptor ROR gamma t, which dictates the differentiation of pro-inflammatory T helper 17 (TH17) cells and is a therapeutic target for intervention of inflammatory autoimmunity.
- Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
- Expression of the transcription factor RORgammat defined a previously unknown subset of NKp46+CD3- lymphocytes.
- the authors identify the upregulation of the TH17 lymphocyte subset transcription factor retinoid orphan receptor gamma T in contact sensitivity