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Validated All-in-One™ qPCR Primer for CCND1(NM_053056.2) Search again
Product ID:
HQP016204
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BCL1, D11S287E, PRAD1, U21B31
Gene Description:
cyclin D1
Target Gene Accession:
NM_053056.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq].
Gene References into function
- expression is related to apoptosis in thymus
- TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression
- The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association
- Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1.
- Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas
- TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins.
- Cyclin D1 play important roles in esophageal carcinogenesis.
- This study was conducted to explore the association between the polymorphism and the susceptibility to and disease status of TCC of the bladder in 222 cases and 317 native Japanese controls
- Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4
- cyclin D1 may be a target gene for prolactin in normal lobuloalveolar development, as well as in the development and/or progression of mammary cancer.
- analysis of expression improves differentiation of mantle cells from other lymphoma cells
- Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells.
- A/G polymorphism of CCND1 was associated with the susceptibility to NPC
- expression affected by estrogen receptors alpha and beta
- Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells
- The expression of MIB-1 and prognosis in cyclin D1(CyD1)+ and CyD1- mantle cell lymphoma (MCL)were studied and compared to B-CLL/SLL. The CyD1- group (nodal MCL and CLL/SLL) had a longer median survival time than the CyD1+ group (nodal MCL and MLP).
- Overexpression of cyclin D1 is found to be significantly correlated with increased chromosomal instability in patients with breast cancer.
- The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation (RASSF1A)
- VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
- Cyclin D1 is a candidate oncogene in cutaneous melanoma.
- Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.
- cyclin D1 is a novel ligand-independent co-repressor
- Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.
- The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node.
- Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.
- regulates cell cycle
- Cyclin D1 expression in peripheral blood of 7 mantle-cell lymphoma pts was 1305.4 times higher than in 24 chronic B-cell lymphocytic leukemia pts.
- Data suggest that one mechanism by which INI1/hSNF5 exerts its tumor suppressor function is by mediating the cell cycle arrest due to the direct recruitment of HDAC activity to the cyclin D1 promoter, causing its repression and G(0)-G(1) arrest.
- overexpression of cyclin D1 sensitizes MCF7 cells to treatment with taxol
- These data suggest that PKCdelta attenuates cyclin D1 promoter activity via the regulation of three distinct cis-acting regulatory elements.
- The CCND1 gene was rarely amplified in ILC in spite of showing overexpression of the protein in 41% of tumors. Hence, unlike IDC, increase in gene dosage did not account for the protein excess.
- upregulation of cyclin D1 and Fra-1 in human colorectal adenocarcinomas is driven by abnormally expressed beta-catenin
- Strong cyclin D1 mRNA overexpression was detected in mantle cell lymphomas, hairy cell leukemias,and multiple myelomas. Intermediate transcript levels were found in some multiple myelomas and hairy cell leukemias.
- Amplifications of c-myc and CCND1 are associated with detrusor-muscle-invasive transitional cell carcinoma
- inhibition of GSK3beta activity appears to trigger nuclear accumulation of cyclin D1 and cell cycle progression
- early use of oral contraceptives may be associated with subset of mammary tumors that overexpress cyclin D1
- Marked intratumoral heterogeneity of c-myc and this but not of c-erbB2 amplification in breast cancer
- These results indicate that estrogen-induced cyclin D(1) transcription can occur in HepG2 cells independently of the transcriptional activity of estrogen receptor.
- Oct-1 potentiates CREB-dependent cyclin D1 transcriptional activity by a phospho-CREB and CREB binding protein-independent mechanism
- Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer
- gene expression induced by galectin-3
- CDK-independent transactivation of the estrogen receptor by cyclin D1 is, by itself, not sufficient to cause estradiol-independent growth of breast cancer cells. A vast overexpression of G1/S cyclins D1 A & E is able to do so by capturing CDK inhibitors.
- AA genotype of cyclin d1 polymorphism is associated with increased risk of prostate cancer
- cyclin D1 expression initiates an apoptotic signal inhibited by different levels of cellular Bcl-2 at two points
- Mantle cell lymphomagenesis results not only from direct consequences of inappropriate cyclin D1 expression but also from the ability of overexpressed cyclin D1 to buffer physiologic changes in p27 levels, rendering p27 ineffective as a growth inhibitor.
- PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth
- Clonal aberrations of CCND1 together with high mRNA expression suggest a role for deregulated CCND1 activity in neuroblastoma tumorigenesis.
- The cyclin D1 A allele was associated with a diminished modulation of normal physiologic and treatment-induced decreased expression of cyclin D1.
- cyclin D1 has a role in regulating mitogenic signaling with IKKalpha
- retinoblastoma protein has cyclin D1-inducing activity that is abolished by adenovirus E1A and that involves multiple pocket sequences that are independently involved in cyclin D1 activation
- increases of cyclin D1, cyclin-dependent kinase 4, cyclin E, cyclin A, and Wee1 play an important role in the development of hepatocellular carcinoma from cirrhosis
- gastrin appears to exert its mitogenic effects on gastric adenocarcinoma, at least in part, through changes in cyclin D1 expression.
- Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region.
- Cyclin G1 is frequently overexpressed in uterine leiomyoma in a p53-independent manner and that this abnormality could be attributed to the severe proliferation of human uterine leiomyomas.
- cyclin D1 (G870A) polymorphism is associated with susceptibility to esophageal and gastric cardiac carcinoma
- Cells overexpressing cdk4 or cyclin D1 exhibited nuclear features characteristic of apoptosis.
- These results indicate that the altered expression of beta-catenin, but not cyclin D1, in hepatocellular carcinoma may play an important role in tumor progression by stimulating tumor cell proliferation.
- This study demonstrates that the CCND1 genotype may confer different risks for buccal squamous cell carcinoma (BSCC) and non-BSCC.
- The activation of Stat 3 and the dysregulation of this protein are mutually exclusive events in multiple myeloma.
- Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide
- Loss of von Hippel-Lindau protein causes cell density dependent deregulation of this protein through HIF.
- Cyclin D1 splice variants have differential effects on localization, RB phosphorylation, and cellular transformation
- LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation.
- overexpression inhibits TNF-induced growth arrest
- Presence is associated with high nuclear grade, large tumor size, and poor prognosis for glioma patients.
- ccnd1 polymorphism is associated with early lung cancer and contributes to susceptibility to lung cancer
- cyclin D1 transcription is repressed by p53 through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1
- Deregulation of cyclin D1 is associated with early stages of plasma cell dyscrasia
- Cyclin D1 could be indirectly induced by ErbB signalling through p21. ER-mediated upregulation of cyclin D1 seems to be a possible mechanism of maintaining cell proliferation in DCIS in case of EGFR- and HER-2/neu-negativity.
- COX-2 or VEGF, but not cyclin D1 may play roles in breast cancer with poor prognosis
- Data may suggest a possible role of the overexpression of cyclin D1 in the tumorigenesis of uveal malignant melanoma.
- Results describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene.
- The data are consistent with an oncogenesis model in which a lack of PTEN fuels the cell cycle by increasing the nuclear availability of cyclin D1 through the Akt/PKB pathway.
- The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis
- Up-Regulation of cyclin D1 and p21(Waf1/Cip1) is associated with differentiation of human myeloid leukemia cell lines
- Study revealed a higher prevalence of both aberrant beta-catenin expression and cyclin D1 overexpression in papillary thyroid cancers around the Semipalatinsk nuclear test site than sporadic cases.
- Localized to suprabasal cells of telogen bulge and anagen outer root sheath(ORS). May mediate proliferation of stem cells in bulge to more differentiated transient amplifying cells in the suprabasal ORS.
- our data indicate that mutations of CCND1, which probably render the protein insensitive to degradation, represent a previously unreported mechanism of cyclin D1 overexpression in human tumors in vivo
- the Cyclin D1/E2F1 pathway may be involved in apoptotic death of bone marrow cells in myelodysplastic syndromes
- cyclin D1 expression is regulated by Pak1 in mammary glands and tumors
- cyclin D1, besides growth pattern, is a prognostic marker for local recurrence in DCIS
- transcriptional regulation of the key cell cycle regulator cyclin D1 and roles of both STAT5 and Oct-1 in this process
- stabilized by HSV-1 ICP0 through degradation of cdc34
- significant difference in their biochemical properties between CDK4/cyclin D1 and CDK2/cyclin A affecting regulation of cellular RB function
- These data provide strong evidence that the CCND1 870A allele may be associated with colorectal cancer, and particularly with forms of the disease that result in severe morbidity and mortality.
- CCND1 G870A polymorphism has been reported as a genetic risk factor for some tumour types, it does not appear to be linked to the risk of breast and colorectal cancers.
- The beta-catenin-cyclin D1 pathway might be involved in the growth of endometrial carcinomas.
- In cervical cancers cyclin D3 may compensate for low levels of cyclin D1, whereas in corpus cancers both isoforms may contribute to the neoplastic phenotype.
- The CCND1 A870G polymorphism may increase risk for colorectal neoplasms.
- Moderate amplification of the CCND1 gene in Paget's disease of breast
- cyclin D1 binding to wild type Cdk4 is stimulated by Cdc37
- Cyclin D1 expression was evatuated in cell cycle responses to DNA mismatch repair-deficient cells upon methylation and UV-C damage.
- cyclin D1/Cdk4 complexes are regulated by calcium/calmodulin-dependent protein kinase I
- There was no correlation between human papillomavirus status and cyclin D1 overexpression in human oropharyngeal squamous cell carcinoma.
- cyclin D1 is inhibited by PPARgamma2 activation in hepatocytes via CREB-dependent and beta-catenin-independent pathways
- cyclin D1 accumulation in G(1) phase is regulated by calcineurin
- expression of Egr-1, c-fos and cyclin D1 varies in esophageal precancerous lesions and cancer tissues, suggesting an involvement of these genes in the development of esophageal carcinoma.
- cyclin D1 has a role in tumorigenesis through interaction with C/EBPbeta
- The expression patterns of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease (IBD) may indicate their contribution in epithelial cell turnover and their possible implication in IBD-related dysplasia-carcinoma.
- results indicate an effect of gene dosage as an alternative mechanism of cyclin D1 deregulation in MM
- overexpression may be involved in the formation of the giant cells and the pathogenesis of central giant cell granuloma
- The authors found a correlation between CCND1 genotype and the age of onset of hepatoblastoma.
- Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation
- Up-regulation of cyclin D1 is observed early in tumor formation, implying a possible role in tumor initiation.
- Presence in bone marrow cells indicated diagnosis of multiple myeloma.
- results suggest a model where RNA polymerase II bound at IgH regulatory sequences can activate the cyclin D1 promoter by either long-range polymerase transfer or tracking
- cyclin D1-positive tumors tend to have perineural invasion more frequently.lymph vessel invasion is another factor related to cyclin D1 reactivity of the cells.
- The CCND1 variant A allele may recessively increase the risk of carcinoma in situ incidence in patients with superficial bladder cancer.
- Data show that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha/progesterone receptor complex to the tetradecanoyl phorbol acetate-responsive element of the gene.
- Cyclin D1, p53, and p21Waf1/Cip1 have roles in progression of serous epithelial ovarian cancer
- Data suggest that cyclin D1-Cdk2 complexes mediate some of the transforming effects of cyclin D1 and demonstrate that the cyclin D1-Cdk2 fusion protein is a useful model to investigate the biological functions of cyclin D1-Cdk2 complexes.
- Review of Cyclin D1 overexpression in squamous cell head and neck neoplasms resulting from abnormalities in chromosome 11q13.
- Synthesis is regulated by combined activity of ErbB2 and FGFR-4 that involves S6K1-mediated translation.
- regulation by SNIP1
- Tumor growth inhibition might be due to apoptosis caused by reduced cyclin D1 expression as revealed by immunohistochemical analysis of tumor samples.
- Expression levels of CCND1 predict the cellular effects of mTOR inhibitors in ovarian carcinoma.
- C-terminal sequences direct cyclin D1-CRM1 binding
- cyclin D1 binding to the androgen receptor NH2-terminal domain inhibits activation function 2 association
- estrogen receptor mediates cyclin D1 expression and growth of tamoxifen-resistant tumors.
- CCND1 gains are early events in ovarian tumorogenesis.
- CCND1 alternate transcripts encode proteins with differing functions: CCND1(tra) encodes protein involved in regulating mitogen responsive, anchorage-dependent progression; CCND1(trb) modulates ability of cell to grow in anchorage-independent manner
- overexpression of FAK promoted exit from G(1) in glioblastoma cells, enhanced expression of cyclins D1 and E while reducing expression of p27(Kip1) and p21(Waf1), and enhanced the kinase activity of the cyclin D1-cyclin-dependent kinase-4 (cdk4) complex
- In colorectal cancer, the CCND1 copy number increase was neither associated with the tumor phenotype (stage and grade) nor with the tumor localization (colon, rectum or sigmoid colon).
- Cyclin D1 central domain could be exploited to develop novel prostate cancer therapeutics.
- Cyclin D1 protein is upregulated in epithelioid sarcoma, suggesting a role in the pathogenesis of epithelioid sarcoma and appears to be regulated by translational and/or post-translational mechanisms.
- Endogenously released IGF-I leads to constitutive cyclin D1 expression in human neuroendocrine tumour cells.
- expression level of cyclin D1 RNA in bone marrow cells is predictive of the phase evolution in Chronic myeloid leukemia
- Cyclin D1 may play a role in the early stage of gallbladder carcinoma.
- experiments suggest that both catalytic and non-catalytic functions of cyclin D1 can collaborate to inactivate pRb-mediated cell cycle exit
- Cyclin D1 may be a potential target for molecular intervention in patients with oropharyngeal squamous cell cancer.
- We expressed cyclin D1 in the beta-cells of mice and islet hyperplasia developed in a time-dependent manner.
- activation in breast cancer cells is mediated by mayven
- An associative interaction between XPD protein and CCND1 genetic polymorphisms, tobacco exposure, and cancer risk.
- Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM tumors despite their low proliferative capacity
- marked expression in high-grade tumors supports its role in proliferative activity
- data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression
- cyclin D1 overexpression is associated with non-small cell lung cancer
- Bcl-1 staining was similar in all benign keratoses.
- AA genotype does not affect breast cancer risk.
- Amplification of Bcl-1 is associated with the development of uterine cervical carcinoma
- To explore the potential prognostic value of cyclin D1 in invasive breast cancer
- CCND1 polymorphism is associated with an increased risk of endometrial cancer.
- TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G(1)-to-S-phase progression
- exposure of cells to cadmium chloride results in cytotoxicity and cell death due to enhanced ubiquitination and consequent proteolysis of eIF4E protein, which in turn diminishes cellular levels of critical genes such as cyclin D1
- Identification of mantle cell lymphoma with low cyclin D1 3'UTR is important because it seems to be associated with shorter overall survival.
- PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2
- cyclin D1 was localized in cell nuclei
- levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism
- cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300.
- Atypical teratoid/rhabdoid tumor can be misdiagnosed as a variety of tumors, including ependymoma that potentially harbors LOH 22q. Our data indicate that cyclin D1 is a target of hSNF5/INI1in primary tumors.
- Increased cyclin D1 expression seen when earlier and later stage esophageal carcinomas stages compared
- Cyclin D1 expression was significantly associated with tumour size and lymph node metastases in thyroid papillary microcarcinoma.
- cases of cyclin D1-negative mantle cell lymphoma (MCL) do exist and are part of the spectrum of MCL
- an activating mutation of the beta-catenin gene affected regulation of the cyclin D1 gene, resulting in the generation of intrathoracic sporadic desmoid tumor
- the Wnt signaling pathway plays an important role in carcinogenesis in intrahepatic cholangiocarcinomas through overexpression of its target genes, particularly cyclin D1
- STAT5b may mediate the transcriptional activation of cyclin D1 after hypoxic stimulation.
- cyclin D1 nuclear localization has a role in cancer [review]
- SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex
- The binding of STAT5 to the cyclin D1 promotor might up regulate cyclin D1 expression in oral squamous cell carcinoma.
- expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis
- p38 kinase activation is linked temporally with cyclin D1 expression after PH and appears to exert cell cycle control in the adult liver.
- integrin-dependent signal transduction events regulate the expression of cyclin D1 during G1 phase [review]
- Cyclin D1 expression may be a useful biomarker for assessing the risk of developing esophageal cancer.
- Hypermethylation of cyclin d2 is asspciated with prostate tumorigenesis
- data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of colorectal cancer in our Indian population
- level of cyclin D1 negatively correlates with the proliferation properties of leukemic cells
- TIMP-1-mediates cell-cycle arrest via cyclin D1 downregulation & p27KIP1 upregulation.
- These studies indicate that the altered AR regulatory capacity of cyclin D1b contributes to its association with increased prostate cancer risk and provide evidence of cyclin D1b-mediated transcriptional regulation.
- an association with alcohol consumption and the CCND1 gene or protein levels, in both esophageal and gastric cancers
- This study demonstrates for the 1st time the involvement of MAPK-cyclin D1-p21(cip)machinery during cell growth inhibition and apoptosis of human vascular smooth muscle cells induced by cysthationine gamma-lyase overexpression.
- we identified ZONAB-responsive elements in cyclin D1 promoter, cyclin D1 expression is regulated by ZONAB
- Cyclin D1 overexpression alters the proliferation and differentiation behavior of HaCaT skin keratinocytes in organotypic co-cultures.
- Our study suggests that the effect of cyclin D1 gene polymorphism on colorectal cancer risk is only observed in males and AA/AG genotype of cyclin D1 gene is associated with a higher risk of colorectal cancer
- expression is repressed by SUMO modification of Sam68
- the subtype 2 receptor-mediated antiproliferative effect of SRIH on TT cell proliferation may be exerted through a decrease in cyclin D1 and cdk4 levels
- Cyclin D1 expression was not significantly different in normal cervix and in cervical cancer.
- These findings suggest heterogeneous abnormalities of CCND and RB in cutaneous T-cell lymphomas, in which dysregulated CCND and RB1 may lead to impaired cell cycle control.
- Differences in oncoprotein expression between endometriotic and adenomyotic tissues provide further evidence that the pathogenesis of endometriosis is different from that of adenomyosis.
- glucocorticoid receptor (GR) represses cyclin D1 via Tcf-beta-catenin
- ionizing radiation is able to enhance cyclin D1 transcription induced by B[a]PDE, and NFAT3 is involved in the regulation of cyclin D1 transcription by B[a]PDE or B[a]PDE plus ionizing radiation
- Mantle cell lymphoma should be very sensitive to targeted therapy aimed at functional inhibition of the cyclin D1/CDK4 complex.
- Results indicate that individuals carrying the CCND1 GG genotype have increased risk for the development of nasopharyngeal carcinoma.
- ERK1/2, JNK1/2 and p38 mapk pathways are all required for B[a]P-induced G1/S transition
- Cyclin D1 promotes cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.
- Cav-1-deficient mammary acini displayed increased ERalpha levels and enhanced sensitivity toward estrogen-stimulated growth, with specific up-regulation of cyclin D1
- Cyclin D1 is often mutated in esophageal cancer. The mutations disrupt phosphorylation at Thr-286, causing its nuclear accumulation. An acidic residue in the C-terminus is needed for recognition & phosphorylation by glycogen synthase kinase-3 beta.
- cyclin D1 expression is deregulated in idiopathic pulmonary fibrosis through a RhoA dependent mechanism that influences lung fibroblast proliferation
- Study evaluated associations odds ratios and 95% confidence intervals in polymorphisms of seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls, the cyclin D1 splice variant G870A (rs603965) increased NHL risk.
- When the combinations of the variables were assessed in two separate multivariate models, the combined variables p21/Ki-67 or p21/cyclin D1 expression were independent predictors for overall survival.
- CCND1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma.
- Pin1 expression is correlated with cyclinD1 expression and may have a role in esophageal squamous cell carcinoma
- association between this CCND1 genotype and colorectal cancer risk in the Singapore Chinese Health Study.
- telomerase reverse transcriptase has a novel role in the modulation of cyclin D1 expression
- novel signaling pathway links BRCA1-IRIS to cellular proliferation through c-Jun/AP1 nuclear pathway; finally, this culminates in the increased expression of the cyclin D1 gene
- High levels of cyclin D1 expression is associated with salivary adenoid cystic carcinoma
- Cyclin D1 overexpression is associated with endometrial carcinoma
- Cyclin D1 or cyclin D3 are differentially used in the distinct mitogenic stimulations by growth factors or TSH.
- Expression of p27Kip1 in melanoma is regulated via cyclin D1 control of Cks1/Skp2-mediated proteolysis.
- HBx and NF-kappaB2/BCL3 mediated-cyclin D1 up-regulation might play an important role in the HBx-mediated HCC development and progression
- The suppression of cyclin D1 levels during S phase is regulated by cell cycle position rather than signaling activity.
- Curcumin treatment inhibited cyclin D1 mRNA expression in K562 chronic leukaemia cells.
- DACH1 repressed cyclin D1 through a novel mechanism via a c-Jun DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin.
- After adjustment for age, sex, and smoking status, the AG genotype was associated with an increased risk for overall lung cancer
- Alternatively spliced cyclin D1 mRNA isoforms a and b are expressed in mantle cell lymphoma (MCL) and multiple myeloma (MM). Cyclin D1b proteins are present in MCL, rarely in MM.
- subcellular localization is modulated by GSK-3beta and DYRK1B by phosphorylation of Thr(288)
- Cyclin D1 expression was not significantly different among 20% of esophageal dysplasia, 53% of esophageal squamous cell carcinoma and 20% of normal mucosa.
- cyclin D1 overexpression is not a consequence of, but rather a pivotal element in the process of malignant transformation in the lung and other tissues. [REVIEW]
- SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1.
- Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors.
- cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1 [review]
- XRCC1-01, XRCC3-01, and CCND1-01 may be predictive of survival outcome in patients with metastatic breast cancer treated with DNA-damaging chemotherapy
- findings suggest that CDK4 cooperation with CCND1 may be involved in the progression of laryngeal tumors
- p53 and Ki-67 were expressed with increasing frequency, and bcl-2, p21, and mdm-2 with decreasing frequency in thyroid carcinoma progression. p27 and cyclin D1 were expressed in <15% of cases, with a trend toward decreasing expression.
- By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP-1 in spontaneously regressing keratoacanthoma and squamous cell carcinoma, the changes in the expression of these proteins to specific stages of skin carcinogenesis, is defined.
- eIF4E, along with VEGF and cyclin D1, has a role in translational regulation of proteins related to angiogenesis and growth
- cyclin D1 has a role in progression of germ cell tumors
- the p38 MAPK/NF-kappaB/cyclin D1 signaling pathway might participate in the oncogenesis of extramammary Paget's disease
- All grade II/III meningiomas showed increased expression of cyclin D1 and high proliferative activity, suggesting the combined expression of cyclin D1 and proliferation may define subgroups of meningiomas with a more aggressive biological behavior.
- deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli
- Data suggest that trisomy 11 does not appear to directly cause CCND1 gene overexpression.
- genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that may have a role in progression of mantle cell lymphoma
- These findings uncover specific residues conferring ubiquitination of cyclin D1 and provide a mechanistic basis for proteasomal degradation of cyclin D1.
- There was a highly significant positive association between p27(KIP-1) and estrogen receptor/progesterone receptor (ER/PR) status and with p27(KIP-1) and cyclin D1 expression. A trend between cyclin A and PR status was also identified.
- Cyclin D1/cdk4-mediated phosphorylation of BRCA1 inhibits the ability of BRCA1 to be recruited to particular promoters in vivo.
- CYCLIN D1 may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms involve activated Stat3
- Interaction of MUC1 with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms.
- BCAR3 induces anti-estrogen resistance and augments transcription of the cyclin D1 promoter.
- PTEN/PI 3-kinase signaling and cyclin D1 control a novel pathway that regulates assembly of the SCF(SKP2) complex.
- findings suggested that the G870A polymorphism of cyclin D1 may contribute to susceptibility to gastric cancer in Korean men
- cyclin D1 expression in human tumoral parathyroid cells is regulated by calcium sensing receptor activation
- Amplification of CCND1 is associated with recurrence and tamoxifen resistance in postmenopausal breast cancer
- The function of cyclin D1b in cell cycle regulation was investigated, by generating B-cell lines displaying conditional expression of isoform b.
- a frameshift mutation (G base deletion) at nucleotide 82 of codon 28 in exon 4 of the cyclin D1 gene in a case of glioblastoma multiform (WHO Grade IV) sample.
- Our results indicate that the down-regulation of CCND1 is an essential step for DBC2's growth suppression of cancer cells.
- Taken together, our data suggest that Apr3 should play an important role in ATRA signal pathway.
- There are significant differences between Ki-67 indices and CCND1 expression among melanocytic lesions.
- Overexpression of cyclin D1 is associated with head and neck squamous cell carcinomas
- a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21WAF1/Cip1 transcription, p21WAF1/Cip1-cdk4-cyclin D1 assembly and intimal thickening.
- There appears to be an influence of CCND1 870AA genotypes on esophageal cancer phenotype, particularly with regard to tumor location, which supports the theory of prevalence of site-specific genetic alterations
- a significant proportion of pancreatic ductal adenocarcinomas is characterized by simultaneous protein alterations regarding p16 & cyclin D1 genes; this mechanism of genetic deregulation in cell cycle potentially explains in part the aggressive phenotype
- This study provides a molecular basis to support the correlation of IL-8 expression with that of cyclin D1 in human prostate cancer and suggests a mechanism by which this chemokine promotes cell proliferation.
- Suberoylanilide hydroxamic acid caused a rapid decrease of cyclin D1 in mantle cell lymphoma by blocking the translation of cyclin D1 by inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/eIF4E-BP pathway, probably by PI3K inhibition
- Cyclin Dl over expression was evident among all cases of mantle cell lymphoma and few cases of large B-cell lymphoma
- RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC.
- that an O(2)(*-) signaling pathway regulates NAC-induced G(1) arrest by decreasing cyclin D1 protein levels and increasing MnSOD activity
- Predominance of the Delta3'UTR mRNA was associated with higher cyclin D1 levels in cases with t(11;14), but did not correlate with the proliferation rate, suggesting a different role of this isoform in MM.
- strong correlation between CCND1 amplification and its protein expression in breast cancer
- Levels of cyclin D1 gene expression were significantly higher in malignant thyroid tumours (papillary thyroid carcinoma, medullary thyroid carcinoma) compared to macroscopically unchanged thyroid tissue, follicular adenoma and/or nodular goitre groups.
- Ki-67 antibody and cyclin D1 overexpression seem to parallel each other, supporting the concept that cyclin D1 serves as a cell cycle activator in squamous cell carcinoma of the penis.
- mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1
- in angiosarcoma, significant correlation was seen between phosphorylated-STAT3 and cyclin D1 but not between phosphorylated Akt and cyclin D1
- Temporal control of cyclin D1 subcellular localization and proteolysis is critical for maintenance of homeostasis within the mammary epithelium of transgenic mice.
- The tumor-promoting activity of cyclin D1 may be tissue specific.
- p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma
- A431 cells expressing SIP1 along with exogenous cyclin D1 were highly invasive
- Review of cyclin D1 and cyclin G and CDK acitivty and their roles in cancer pathogenesis, and their proteosomal degradation pathways as targets for cancer therapy
- ZO-2 down-regulates cyclin D1 transcription by interacting with the c-Myc/E box element and by recruiting histone deacetylase 1
- role for D-type cyclins in the excessive basal-cell proliferation and perturbed keratinocyte differentiation in the psoriatic epidermis
- CCND1 polymorphism may be an early event in tumorigenesis, but it is not a reliable prognostic criterion.
- Cyclin D1 showed significantly higher median expression in thyroid cancer patients with netastatic papillary microcarcinoma compared to those without, indicating a correlation to tumour aggressiveness.
- This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
- A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma
- CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation
- Alteration of CCND1 in Chinese patients with breast carcinoma and its correlation with Ki-67, pRb, and p53.
- roles for cyclin D1 in the development of PA and for cyclin D1 in the progression ofpleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) of parotid gland
- specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1-positive and - negative MCL may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL.
- p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells.
- that Rac1 is an essential player for mediating the induction of cyclin D1 and p21(Cip1) by HRG in breast cancer cells
- Report a potential association of variants in the CCND1 and CDH1 genes with familial colorectal cancer using a unique study design with phenotypic extremes.
- Nuclear accumulation of CCND1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.
- HSPB8 is a candidate CDK-independent cyclin D1 target that can mediate its effects
- high cyclin expression may contribute to deregulation of the cell cycle in bone and soft tissue tumors
- polymorphic variant of Aurora A does not appear to be associated with variation in colorectal cancer risk in HNPCC, whereas there is a more complex relationship between the Cyclin D1 polymorphism and disease risk in HNPCC
- CCND1 G870A polymorphism makes a significant contribution to breast cancer with the preponderance of breast cancer in young women
- Tissue expression of cyclin D1 or E1 seems not to add independent prognostic value to standard features in patients with nonmuscle -invasive urothelial cell carcinoma of the bladder.
- cyclin D1 reactivity is a considerably better marker of replicative senescence than senescence-associated beta-galactosidase activity.
- CCND1 polymorphisms stand-in as cis-acting regulatory elements modulating its expression and cyclin D1 genotype and phenotype could provide valuable additional information regarding prognosis of oral cancer patients.
- PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation
- investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas
- The Wnt pathway target gene cyclin D1 was found to be up-regulated specifically in the nonfunctioning pituitary tumors compared with controls at both mRNA and protein level, supportive of activation of the Wnt-beta-catenin pathway
- alternatively spliced cyclin D1 modulates p27KIP1 binding and cell migration
- The A allele and AA genotype of CCND1 G870A polymorphism have a significant association with an increased risk of the uterine leiomyoma in obese Korean women.
- Rac signaling to cyclin D1 is a crucial pro-proliferative effect of E-cadherin-mediated cell-cell adhesion
- The CCND1 G870A polymorphism is not associated with the risk of CRC in the German population.
- The results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect.
- metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
- polymorphic alleles of HER2 and CCND1 may not play an important role as genetic markers for breast cancer risk, but presence of Val allele may be useful for tumor prognosis.
- These studies suggest the endogenous cyclin D1 promoter BRG-1 binding site functions as a molecular scaffold in the context of local chromatin upon which coactivators and corepressors are recruited to regulate cyclin D1.
- Cyclin D1 may mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer.
- present study did not demonstrate a significant association between CCND1 genotype and oral squamous cell carcinoma
- Expression of cyclin D1 is accelerated independently of beta-catenin in ameloblastomas.
- Only FIGO stage, cyclin D1, p27 (Kip1) and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients.
- Analysis of the pattern of expression of these biomolecules showed increased p16-positive phenotypes and decreased cyclin D1- and pRB-positive phenotype among the invasive tumors compared to low-grade CIN lesions
- Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases.
- tumor cell incubation with pioglitazone results in increased levels of p53 and p27 and decreased levels of cyclin D1
- up-regulation of cyclin D1 by inflammatory factor-1 (AIF-1) pathway
- A certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas exist that have structural aberrations at the CCND1 locus, including the t(11;14).
- Cyclin D1 expression is an independent poor prognostic factor in women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen-based therapy.
- The CCND1 A870G polymorphism had consistent associations with survival outcomes in head and neck neoplasms.
- The results indicate that the waiting time for onset of oncogenic virus-associated neoplasia in patients homozygous (GG) for CCND1 genotypes (52 years) was 12 years earlier in comparison with patients carrying AG or AA genotypes (60 years).
- a reliable marker of gene aberration in plasma cell myeloma
- Report overexpression of cyclin D1, D3, and p21 in renal carcinomas with Xp11.2 TFE3-gene fusion.
- Nerve growth factor induced the cyclin D1 promoter via Sp1, nuclear factor-kappaB, and cAMP-response element/activated transcription factor sites.
- DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells
- Cyclin D1 as a very useful proliferative marker in meningiomas.
- Cyclin E and cyclin D1 expression distinguishes non-BRCA1/2 tumors from both sporadic and BRCA1- and BRCA2-associated tumors and may reflect different predisposition and pathogenesis in these groups.
- gene copy numbers of CCND1 in breast cancers
- 11q23 deletion along with relatively strong CCND1 expression was common in uremic hyperparathyroidism
- Thus, an acidic environment triggers cytoplasmic localization and proteasomal degradation of cyclin D1.
- miR-34a reduces both mRNA and protein levels of cyclin D1 (CCND1) and cyclin-dependent kinase 6 (CDK6).
- EWS-FLI1 directly stimulates cyclin D1 gene transcription.
- Genomic aberrations of Cyclin D1 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.
- Id1 may contribute to early breast cancer by promoting excessive proliferation through cyclin D1.
- Data demonstrate that RNA interference of genes encoding cyclin D1 and cyclin D2 (CCND1 and CCND2, respectively) inhibits proliferation and is progressively cytotoxic in human myeloma cells.
- Cyclin D1 is induced in HaCaT+ by BARF1 and is overexpressed in EBV-associated gastric cancer indicating an interaction of viral BARF1 and cyclin D1.
- SOX2 and beta-catenin act in synergy in the transcription regulation of CCND1 in breast cancer cells
- GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased cyclin D1 by down-regulation of activation protein-1 signaling.
- ADAM17 mediates the EGFR/AKT/cyclin D1 pathway and cell cycle progression to the S phase induced by UVA radiation
- miR-16-1 regulates CCND1 mRNA expression; role of miR-16-1 in the regulation of CCND1 in MCL
- Loss of p16/Rb protein expression and overexpression of cyclin D1/CDK4 were observed in 49%/40% and 37%/37% of gastric carcinomas, respectively.Cyclin D1 and CDK4 overexpession was inversely associated with lymph node metastasis and depth of invasion.
- Estrogen and progesterone lower cyclin B1 AND D1 expression, block cell cycle in G2/M, and trigger apoptosis in human adrenal carcinoma cell cultures.
- A significant elevation in expression of CCND1 in oral squamous cell carcinoma cells was seen in carbon and neon-irradiated cells.
- These findings suggest that CCND1 (G870A) polymorphism may be associated with increased risk of squamous cell carcinoma of the uterine cervix in north Indian women.
- hnRNP A1 has a role in mediating rapamycin-induced alterations of cyclin D1 and c-myc IRES activity in an Akt-dependent manner and provide the first direct link between Akt and the regulation of IRES activity
- Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.
- cell cycle exit is preceded by p27-dependent inhibition of cyclin A-Cdk1/2, cyclin D1 downregulation and reduced pre-mitotic pRb pocket protein phosphorylation
- CCND1870 GG genotype is associated with an increased risk for non-cardiac gastric cancer in patients in a high-risk area of China.
- we here propose that reactive oxygen species-mediated cyclin D1 degradation contributes to tumor growth retardation in hypoxic environments
- Overexpression of cyclin D1 is associated with cholangiocarcinoma.
- cyclin D1 gene targeted cell lines lost the translocated chromosome (t(11;14)) and the nonrearranged cyclin D1 locus reverted from CpG hypomethylated to hypermethylated
- cyclin D1b protein is aberrantly regulated and could contribute to therapeutic failure in the context of ER-positive breast cancer
- Results describe the effects of estradiol on cyclin D1, PS2, and c-fos gene expression by measuring levels of RNA polymerase II on DNA templates, levels of nascent transcripts associated with RNA polymerase II, and levels of RNAs.
- beta-TrCP-dependent degradation takes part in controlling cyclin D1 turnover when cancer cells undergo glucose starvation, which endows physiological relevance to this novel mechanism.
- Overexpression may reflect early genetic events during the progression of Barrett esophagus-associated carcinogenesis.
- FGFR1-IIIb and FGFR1-IIIc are coexpressed, and the FGFR1-III isoforms are differentially regulated by growth factors and cyclin D1.
- Alterations of transcriptional regulators in disease may lead to splicing alterations.
- These studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclin D1 induces miR-17-5p/miR-20a.
- cytosolic cyclin D1 is able to regulate apoptosis by interaction with Bax in LDIR-induced adaptive resistance.
- These results demonstrate that ERKs and JNKs are responsible for the decrease of cyclin D1 and CDK4 expression levels in human embryonic lung fibroblasts induced by silica.
- The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells.
- The present data support a role for p27 in the assembly of D-type cyclin-Cdk complexes and indicate that both cyclin D1-Cdk4-p27 assembly and kinase activation are regulated by p27 phosphorylation.
- Results show that VRK1 activates CREB and regulates cell cycle progression in the DNA replication period by inducing cyclin D1 (CCND1) expression.
- Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients.
- two mechanistically distinct phases of Rac-dependent cyclin D1 expression and emphasize that the acquisition of Rac/ERK co-dependence is required for the mid-G1 phase induction of cyclin D1 associated with S phase entry.
- Cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.
- Activated STAT3 may take effect on promoting transcription of its downstream target gene CyclinD1.
- Inhibition of PI3-K/Akt induces a 40% decrease of cyclin D1 half-life as a result of accumulation of the dephosphorylated/active form of GSK-3beta within the nucleus, where it can phosphorylate cyclin D1 on Thr286 thereby promoting its nuclear export.
- Overexpression of Cyclin D1 is associated with lymph node metastases in laryngeal squamous cell carcinoma.
- The p16INK4a/cyclin D1/pRB pathway was altered in gastrointestinal tract endocrine tumors.
- Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer.
- We detected a cyclin D1 overexpression exclusively in bone marrows infiltrated with Mantle Cell Lymphoma (MCL), including minimal residual infiltration.
- results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer
- GG genotype of CCND1 is associated with oral premalignant lesions.
- The chimeric mRNA is a bicistronic transcript of post transcriptional origin that independently translates the Cyclin D1 and Trop-2 proteins in cancer cells.
- Polymorphisms and expression of CCND1 might modify the level of DNA damage in vinyl chloride exposed workers.
- NDRG2 modulates intracellular signals to control cell cycle through the regulation of cyclin D1 expression via phosphorylation pathway and down-regulation of AP-1
- CK7, bax, CCND1, and HER2 represent marker proteins and frequently amplified genes in carcinomas of the ampulla of Vater.
- cyclin D1 has a role in cisplatin chemosensitivity in oral squamous cell carcinoma
- TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells
- Cyclin D1 activation is associated with Microsatellite instability and inversely with p21 loss in colorectal cancers.
- These results support the hypothesis that STAT3 and CREB play an important role in leptin signaling pathway that leads to the proliferation of Ishikawa cells, thus establishing a direct association between obesity and endometrial tumorogenesis.
- CCND1 amplification showed no relationship with tumour relapse.
- Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma.
- Proliferation parameters of differentiating cells correlate with the activity and structure of cyclin A/E-CDK2 but not of cyclin D-CDK4/6-p27 complexes.
- the G/A870 polymorphism in the CCND1 locuw does not correlate with patient; however, total D1 expression seems to be associated with esophageal adenocarcinoma patient survival. survival
- The findings suggest that a thalidomide-based regimen may overcome the poor prognosis associated with a cyclin D1-negative or fibroblast growth factor receptor 3-positive phenotype.
- These data indicate that communication between ATM and cyclin D1 may be required for maintenance of genomic integrity achieved by rapid arrest of the cell-cycle, and that disruption of this crosstalk may increase susceptibility to cancer.
- UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer
- These results showed that the expression of cyclin D1, p21 and p27, alone or in combination, are early events in gastric tumorigenesis and may serve as a candidate molecular marker for the early gastric carcinoma.
- Levels of cyclin D1 mRNA were specifically reduced and binding of RNA Polymerase II to the CYCD1 promoter was decreased in Mcm7-depleted cells.
- Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity.
- Out of 710 SNPs in 120 candidate genes, the most significant association was CCND1 SNP rs3212879 in estrogen receptor-negative breast cancer.
- JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones
- These findings support CD1 genotype and protein expression as important risk markers for laryngeal cancer
- either p57Kip2 "apice" or p27Kip1 "apice" inhibitors bound to cyclin D1/cdk4 complex, thus, suggesting that they cooperated to inhibit the activity of cyclin D1/cdk4.