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Validated All-in-One™ qPCR Primer for PRLR(NM_000949.6) Search again
Product ID:
HQP015027
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HPRL, MFAB, RI-PRLR, hPRLrI
Gene Description:
prolactin receptor
Target Gene Accession:
NM_000949.6(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Review: Prolactin receptor signal transduction
- results presented are consistent with a role of the PRL-PRLR system in bone/cartilage formation/repair processes
- Genomic regions containing exons for human prolactin receptor, and 5'-flanking and intronic sequences, were determined and their order was established in chromosome 5p14-13.
- Given its apparent widespread expression, this PRLr isoform may contribute to PRL action.
- Plasma prolactin elevated in exercise and correlated with total prolactin-receptor expression per B lymphocyte. Increase in prolactin-receptor per B lymphocyte in response to exercise. Increased circulating B lymphocytes expressing prolactin receptor.
- Results demonstrate a stimulatory effect of estradiol on the expression of human prolactin receptor mRNA species with alternative exons-1, hE1(3) and hE1(N1)in breast cancer cells.
- To evaluate a possible role of prolactin receptor genes in SLE & MS formed an association study of PRLR SNPs was done. No statistically significant difference in the prolactin allele distribution was observed for any of the tested variations.
- the interaction between Cyclophilin A and the PRLR plays a differential regulatory role in the various signaling pathways leading from the PRLR.
- results demonstrate a direct effect of prolactin, via functional prolactin receptors, in reducing the lipoprotein lipase activity in human adipose tissue
- prolactin signaling is attenuated by phosphorylation of the prolactin receptor on Thr391
- expression in hepatocytes was maximum in secondary liver cancer, high in obstructive jaundice, and less in cholelithiasis; expression in cholangiocytes was higher than in hepatocytes and was maximum during obstructive jaundice
- data indicate that the prolactin receptor is a novel SCF(beta-TrCP) substrate and implicate beta-TrCP as an important negative regulator of prolactin signaling and cellular responses to this hormone
- A150C (Leu-->Ile) transversion at exon 6 of PRLR was detected.Polymorphism of prolactin receptors might play a role in mammary carcinogenesis
- transactivation occurs through an indirect interaction between erbB2 and prolactin or leptin receptors
- Data support an "induced-fit" model for prolactin receptor binding where binding of the first receptor to human prolactin induces a conformation change in the hormone creating the second receptor-binding site.
- Prolactin receptor mediates the Vav2 and Nek3 interaction.
- Responsiveness of ovarian carcinomas to prolactin suggest that the prolactin/prolactin receptor system may be a new therapeutic target of ovarian carcinomas.
- prolactin binding initiates limited proteasomal cleavage of its receptor, generating a cell-associated fragment containing the extracellular domain; findings described new potential mediator of prolactin action
- phosphorylation of prolactin receptor on Ser349 is decreased in breast cancer cells lines and primary cancer tissue that exhibit stabilization and accumulation of prolactin receptor
- Prolactin acts on the preformed Long Form homodimer to induce active signal transduction, while Short Form heterodimer lacks cytoplasmic sequences essential for activation.
- a novel Estradiol-regulated non-estrogen responsive element-dependent transcriptional mechanism that mediates hPRLR expression
- The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation.
- An analysis of changes in the the expression of the prolactin receptor in liver fibrosis and liver cirrhosis.
- The data revealed a widespread expresion of PRLR in normal and neoplastic human thyroid tissues.
- residual agonism can be abolished either by further disrupting hormone site 2-receptor contacts by N-terminal deletion, as in Del1-9-G129R-human prolactin (hPRL), or by stabilizing hPRL and constraining its intrinsic flexibility, as in G129V-hPRL
- In this comprehensive analysis covering 59 kb of the PRL locus and 210 kb of the PRLR locus, we found no significant association between common variation in these candidate genes and breast cancer risk or plasma PRL levels.
- Results demonstrate that altered extracellular domain conformation, and not just a change in bulk, produces altered conformation of the intracellular signaling region of the receptors.
- The resulting pattern of findings confirmed the hypotheses of the significance of the genes involved in the development of affiliative behaviors in the manifestation of ASD, the strongest results were obtained for allelic associations with the PRLR genes
- Prolactin promotes phosphorylation of PRLr on Ser349 and accelerates endocytosis of PRLr. Prolactin stimulated PRLr phosphorylation, endocytosis, and degradation in Jak2-null cells reconstituted with wild type Jak2.
- GSK3 beta is a bona fide PRLr kinase that phosphorylates PRLr on Ser(349) and is required for the recognition of PRLr by beta Trcp, as well as for PRLr ubiquitination and degradation
- The results of experiments using forced expression of ubiquitin mutants indicate that PRLr polyubiquitination via K63-linked chains is important for efficient interaction of PRLr with AP2 as well as for efficient internalization.
- Mechanisms controlling PRLR isoform expression in the fallopian tube.
- Prolactin receptor is significantly more expressed in male breast carcinoma than in gynaecomastia, and with different patterns of reactivity, suggesting a role for prolactin in male breast carcinogenesis.
- a heterozygous single nucleotide polymorphism in exon 6 of the PrlR gene, encoding Ile(146)-->Leu substitution in its extracellular domain confers constitutive activity to the receptor variant
- Data indicate that src family kinases are key mediators of ligand-initiated prolactin receptor internalization, down-regulation, and signal transduction in breast cancer cells.