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Validated All-in-One™ qPCR Primer for OLR1(NM_002543.3) Search again
Product ID:
HQP012035
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Gene Description:
oxidized low density lipoprotein receptor 1
Target Gene Accession:
NM_002543.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis.
Gene References into function
- LOX-1 gene expression is regulated through the cyclic AMP signaling pathway and histamine up-regulates LOX-1 expression via the H2 receptor in THP-1 monocytes
- mediates the action of oxidized LDL that induces the decrease in NO release and the increased expression of adhesion molecules, which are typical changes in endothelial dysfunction
- The expression of this receptor activates a variety of intracellular processes that lead to expression of adhesion molecules and endothelial activation. May be relevant in intra-arterial thrombogenesis and myocardial reperfusion injury.
- oxidized LDL receptor expressed in vascular endothelial cells
- LOX-1 is extensively expressed in the proliferated intima of grafted veins and in advanced atherosclerotic carotid arteries. Further, LOX-1 is colocalized with apoptotic cells.
- Scavenger receptors are the main heat-shock-protein binding structures on human dendritic cells and LOX-1 is one of these molecules.
- genetic variation in the OLR1 gene may modify the risk of AD in an APOE*4-dependent fashion
- Results suggest Ox-LDL may be an important factor involved in the regulation of Fas-induced apoptosis via Ox-LDL/LOX-1 interaction in vascular endothelial cells.
- Ox-LDL through its receptor LOX-1 triggers the CD40/CD40L signaling pathway that activates the inflammatory reaction in HCAECs.
- oxidized high-density lipoprotein activates NF-kappa B via binding to oxidized low-density lipoprotein receptor-1 on the cell surface, followed by enhancement of intracellular reactive oxygen species production in endothelial cells
- Data suggest that genetic variation in the OLR1 gene may modify the risk of Alzheimer's disease.
- a role for LOX-1 as mediator of the stimulatory effect of high glucose on monocyte adhesion
- The oxidised LDL receptor 1 is a susceptibility gene for acute myocardial infarction.
- High glucose concentrations enhance LOX-1 expression in human monocyte-derived macrophages & this is associated with foam cell formation. MDMs of patients with type 2 diabetes overexpress LOX-1 supporting its involvement in diabetic atherosclerosis.
- CRP increased, through LOX-1, both human monocyte adhesion to aortic endothelial cells and oxLDL uptake by these cells.
- the experimental evidence has suggested that LOX-1 may contribute to the development of hypertensive organ damage--REVIEW
- Ox-LDL, mediated by LOX-1, enhanced MMP-3 production in articular chondrocytes. Increased ox-LDL with elevated of LOX-1 in rheumatoid arthritis(RA) cartilage indicates specific role of receptor-ligand interaction in cartilage pathology in RA.
- LOX-1 gene variants at 501 found to be inversely associated with the severity of coronary artery disease
- Data suggest a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands based on the arrangement of critical binding residues on the Lox-1 structure.
- The lectin-like oxidized low-density lipoprotein receptor (LOX-1), a recently identified receptor that plays a role in the uptake of oxidized low-density lipoproteins into endothelial cells, has a pivotal role in the pathogenesis of atherosclerosis.
- Induction of LOX-1-related oxidation pathways and increased susceptibility to oxidative stress play a role in promoting vascular injury in old renal transplants independent of the recipient age.
- angiotensin II upregulates LOX-1 and 12-LO and 15-LO expression in human vascular smooth muscle cells
- LOX-1 and CD40 synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
- Upregulation of LOX-1 by linoleic acid may contribute to endothelial dysfunction associated with type 2 diabetes
- OLR1 polymorpism showed significant association with Alzheimer disease in Italian population.
- The essential role of cytoplasmic sequence of LOX-1 for cell-surface sorting is established.
- Serum LOX-1 appears to be a useful marker for early diagnosis of acute coronary syndromes.
- Human LOX-1 recognizes phosphatidylserine, in a Ca2+-dependent manner, both in vitro and in cultured cells.
- The critical role of Oct-1 in ox-LDL-induced LOX-1 promoter activation was further confirmed by mutagenesis assay
- Ox-LDL and the specific receptor LOX-1 are involved in atherogenesis and atherothrombosis. LOX-1 downregulation is associated with the anti-platelet action of atorvastatin. 3'UTR/T LOX-1 polymorphism has been associated with increased risk of CAD.
- Present data suggests that homozygosity for the C allele for OLR1+1073 polymorphism, selectively in individuals without APOE epsilon4 allele, may impair clearance of Abeta, and particularly Abeta40, from the brain across the blood-brain barrier.
- LOX-1 mediates ox-LDL-induced SMC proliferation and plays a role in neointimal formation after vascular injury
- Purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1
- follicular atresia is not under the exclusive control of apoptosis and LOX-1-dependent autophagy represents an alternate form of programmed cell death
- OLR1 gene single nucleotide polymorphism has little effect on an increased risk for ischemic cerebrovascular disease in the Japanese population.
- These results indicate that the functional unit of LOX-1 is an oligomer and that oligomerization of LOX-1 is dependent on the receptor density on the plasma membrane.
- the chimeric structural property of the NECK region may enable clustered LOX-1 on the cell surface to recognize OxLDL
- role in platelet aggregation; expression on platelets increased 1.5- to 2.0-fold after ADP stimulation
- small concentrations of oxLDL promote capillary tube formation by inducing the expression of VEGF via LOX-1-mediated activation of NADPH oxidase- MAPKs-NF-kappaB pathway.
- findings suggest that cigarette smoking is associated with the formation of LDL subfraction L5, which inhibits endothelial progenitor cell differentiation by impairing Akt phosphorylation via the LOX-1 receptor
- Prenatal increased asymmetric dimethylarginine is associated with LOX1 expression.
- Lysophosphatidylcholine upregulates LOX-1, chemokine receptors, and activation-related transcription factors in human T-cell line Jurkat.
- oxidized LDL (oxLDL) receptor LOX-1 showed a maximum induction after 7 hours. Increased LOX-1 protein expression could be blocked by a LOX-1-specific antibody.
- These results demonstrate the first evidence that the ligand activity of the advanced glycation end-products (AGE)-proteins to the scavenger receptors and its pharmacokinetic properties depend on their rate of modification by AGEs.
- CC genotype of OLR-1 G501C polymorphism is associated with susceptibility and serum C-reactive protein concentration in Chinese essential hypertensive population
- LOX-1 polymorphisms could influence statin effectiveness in CAD prevention by induction of sensitivity to antithrombotic mechanisms such as antiplatelet activity.
- Studies suggest that hetero-oligomerization between naturally occurring isoforms of LOX-1 may represent a general paradigm for regulation of LOX-1 function by its variants.
- This review summarizes recent advances related to the role of LOX-1 in atherosclerosis.
- Our results do not support the presence of an association between selected common SNPs in OLR1 and the risk of clinical CAD
- Obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue.
- LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium.
- sLOX-1 level is increased in type 2 diabetes
- Variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women. LOX-1 expressed on vascular cells plays a major role in atherogenesis .
- The localization patterns of LOX-1 in murine and human placentas suggest the possible involvement of LOX-1 in high oxidative stress conditions of pregnancy.
- a conserved and novel cytoplasmic tripeptide motif (DDL) that regulates LOX-1-mediated endocytosis of OxLDL
- LOX-1 serves as receptor for advanced glycation end products which may give some insight into the role of LOX-1 in the pathogenesis of diabetes and related disorders.
- Increased LOX-1 expression in the systemic vasculature of preeclampsia women provides a fundamental insight into the pathology of preeclampsia and likely contributes to the induction and maintenance of vascular oxidative stress.