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Validated All-in-One™ qPCR Primer for NPPB(NM_002521.2) Search again
Product ID:
HQP011897
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BNP, Iso-ANP
Gene Description:
natriuretic peptide B
Target Gene Accession:
NM_002521.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
Gene References into function
- Molecular forms of human brain natriuretic peptide in plasma.
- Clinical significance of blood measurement in the detection of heart disease in untreated outpatients
- Plasma levels in normotensive Type 2 diabetic patients without cardiac disease and macroalbuminuria.
- human bone marrow endothelial cells are a new source of BNP
- A promoter variation of this protein has an association with low bone-mineral density and rapid postmenopausal bone loss.
- Renal function correlates weakly with BNP and influences the optimal cut point for BNP, particularly in those with an estimated glomerular filtration rate less than 60 mL/min/1.73 m2.
- Low BNP levels do not guarantee an uncomplicated hospital course in patients with acute pulmonary embolism, using a cut-off level of 90 pg/mL. A lower cut-off level of <50 pg/mL identifies 95% of patients with a benign clinical course
- Plasma N-BNP (or BNP) and left ventricular ejection fraction are complementary independent predictors of major adverse events on follow-up after myocardial infarction
- BNP can reliably screen diabetic patients for the presence or absence of left ventricular dysfunction.
- data suggest that amniotic fluid concentrations of human brain natriuretic peptide and endothelin-1 were highest in the twins with polyhydramnios and lowest in oligohydramnios, suggesting their importance in the regulation of amniotic fluid volume
- Plasma BNP concentrations were higher in both the judo and marathon groups than in controls, and positively correlated with left ventricular mass as well as with deceleration time.
- a critical role for the metalloproteinase-dependent cleavage event in signaling the strain response
- BNP has a direct effect on cardiac fibroblasts to inhibit fibrotic responses via extracellular signal-related kinase signaling, suggesting that BNP functions as an antifibrotic factor in the heart to prevent cardiac remodeling in pathological conditions.
- natriuretic peptide precursor B prohormone might be a more discerning marker of early cardiac dysfunction than natriuretic peptide precursor B
- In hypertrophic cardiomyopathy, plasma BNP may reflect intraventricular pressure gradient and left ventricular diastolic dysfunction. Plasma ANP reflects left ventricular diastolic dysfunction.
- data suggest that the secretion of Nt-proBNP is increased in type 2 diabetic patients with no overt heart disease, suggesting that type 2 diabetes is associated with a higher prevalence of asymptomatic left ventricular dysfunction than hitherto thought
- BNP testing plays an important role in the screening and diagnosis of left ventricular dysfunction in diabetes
- NT-proBNP, cTnT, or cTnI do not have roles in acute ischemic stroke when other risk factors are considered
- Elevated cirulating levels of this protein is a new independent predictor of the excess overall and cardiovascular mortality in diabetic nephropathy patients without symptoms of heart failure.
- High plasma BNP is a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria.
- hemodynamic implications of BNP in acute ischemic patients
- Elevation in this stress peptide is partly explained by ventriculo-vascular uncoupling in heart transplantation, independent of alterations in blood pressure.
- In humans brain natriuretic peptide is mainly secreted by the cardiac ventricles.
- Predictor of morbidity and mortality in patients with heart failure and also in acute coronary syndrome
- an indicator of chronic renal failure in type 2 diabetes.
- Plasma levels in anthracycline-treated breast cancer patients with drug-induced cardiotoxicity.
- discussion of molecular regulation of the brain natriuretic peptide gene [review]
- the heart releases BNP into the systemic circulation early after subarachnoid hemorrhage
- the kidneys extract BNP and NT-proBNP to a similar extent in healthy young men
- Blood levels are promising markers for the diagnosis, prognosis and follow up of heart failure.
- Plasma concentrations of BNP were higher in children with congenital heart defects with left ventricular volume overload compared with right ventricular volume overload or pressure overload.
- Maternal diabetes and suboptimal metabolic control may affect the fetal heart and predominantly stimulate proBNP secretion in conjunction with perinatal stress
- Increase of BNP is correlated with the extent of myocardial ischemia, age, renal insufficiency, and ventricular dysfunction.
- No support for the hypothesis that the lower BNP levels seen in obesity are driven by enhanced BNP clearance mediated via natriuretic peptide clearance receptor.
- BNP levels parallel changes in pulmonary hemodynamics and functional parameters in pulmonary hypertension.
- Right ventricular dysfunction detected by echocardiography and plasma NT-proBNP determination in asymptomatic or minimally symptomatic tetralogy of Fallot patients.
- Plasma NT-proBNP levels comprise a promising method that could help in the better identification of a patient group with an even higher risk of sudden death.
- Plasma BNP levels were related to cardiac reflex parasympathetic dysfunction in type 2 diabetic patients.
- The release of BNP during and after exercise may not result from myocardial damage but may have cytoprotective and growth-regulating effects.
- proBNP level may not be suitable as a screening test for assessing left ventricular filling pressures in the presence of normal systolic function.
- Anemia is associated with elevated BNP and increased mortality in advanced heart failure.
- Plasma amino-terminal pro-B-type natriuretic peptide blood levels are elevated in hypertrophic cardiomypathy.
- NT-proBNP is a highly dynamic cardiac peptide marker in acute coronary syndrome.
- BNP levels significantly correlated with atrial fibrillation, indicating that the BNP level may reflect early left ventricular dysfunction in this patient population.
- During the first months, a late increase of NT-proBNP value was associated with heart transplant complications, with acute rejection being most frequent.
- Unloading of the left ventricle by a LVAD results in decreased BNP expression in the heart and plasma and may play an important role in the reverse remodeling process of the heart.
- Percentage change in plasma BNP levels from baseline to 3 months was the strongest predictor of long-term response to cardiac resynchronization therapy and may have potential to predict outcome
- This review discusses B-type natriuretic peptide and its precursor N-terminal pro-brain natriuretic peptide (NT-proBNP) in critical illness and their role as markers of severity and prognosis in diseases beyond acute or chronic heart failure.
- Both BNP and NT-proBNP measures obtained from short of breath patients presenting to an emergency department may be predictive of one-year all-cause mortality independently of the baseline diagnosis of acute destabilized heart failure
- BNP is a useful parameter in predicting cardiac death in Chinese patients with acute coronary syndromes
- results show that N-terminal-proBNP plasma levels are significantly elevated in acute ischemic stroke
- in grade 1 hypertension, BNP32 was unchanged & NT-proBNP was significantly reduced; as severity increased with grade 1 to 3 hypertension, both BNP32 & NT-proBNP levels were increased while not being affected by the presence of left ventricular hypertroph
- serial measurements of N-terminal pro brain natriuretic peptide in each individual patient show a significant positive correlation with central haemodynamic parameters and reflect changes in the haemodynamic state over time
- useful for evaluating left ventricular hypertrophy and dysfunction in continuous ambulatory peritoneal dialysis patients. [n-terminal pro-brain natriuretic peptide]
- Systolic blood pressure (BP) and duration of diabetes are predictive of an elevated NT-proBNP.
- NT-proBNP should be included in the risk assessment of acute coronary syndromes to provide guidance for further therapeutic strategies.[N-terminal-pro-brain natriuretic peptide]
- Preload stimulates SERCA expression. BNP antagonizes this mechanism via guanylyl cyclase-A, cGMP, & cGMP-dependent protein kinase. This new BNP action to uncouple preload-dependent SERCA expression may adversely affect contractility in patients with HF.
- BNP and the N-terminal fragment of proBNP (NT-proBNP)plasma levels decrease with increasing age caused probably by age-dependent differences in the metabolic clearance.
- The unexplained variation of BNPis low in chronic heart failure patients, which is a prerequisite for the use of this peptide for monitoring of the disease.
- As a biological marker, provides the best clinical prediction in the secondary-prevention of cardiovascular disease.
- In patients with type 2 diabetes, elevated circulating NT-proBNP is a strong predictor of the excess overall and cardiovascular mortality.
- BNP concentrations are elevated in children with chronic left ventricular systolic dysfunction and predict the 90-day composite end point of death, hospitalization, or listing for cardiac transplantation.
- Both ANP and BNP expression were higher in heart failure than in control samples.
- In chronic heart failure (CHF) patients with and without kidney disease, NT-proBNP provides independent prognostic information.
- BNP testing is more effective than clinical judgment in the diaagnosis of congestive heart failure.
- In heart transplant patients, BNP levels positively correlated with ventricular diameters and a restrictive filling pattern.
- In children with snoring, overnight increase in BNP levels is correlated with severity of disturbance in respiration during sleep, which may indicate presence of nocturnal cardiac strain
- adiponectin and NT-proBNP were related to disease severity, indicating a possible role for assessment of future morbidity and mortality in patients with peripheral arterial disease
- NT-proBNP levels correlate with PCT and CRP levels in septic patients.
- BNP may be a valuable parameter for surveillance of cardiac function in Pompe's disease.
- Level of plasma BNP and the degree of mitral stenosis are significantly correlated, and as mitral stenosis becomes more serious, the plasma BNP level rises.
- There is a discordant expression of NPPB in newborn infants of mothers with type 1 diabetes.
- Moderate/brisk walking induce increases in BNP in coronary artery disease patients.
- Genetic variation in NPPB significantly impacts B-type natriuretic peptide levels after adjustments for clinical/physiologic factors.
- BNP blood levels is not an indicator of heart function in hemodialysis and continuous ambulatory peritoneal dialysis patieents.
- NT-proBNP is influenced by thyroid function among healthy women, as demonstrated by an inverse association between TSH and NT-proBNP
- individuals with -381CC genotype had lower fasting glucose than those with -381TC or -381TT; -381CC genotype was less frequent in individuals with type 2 diabetes; data suggest relatively high BNP expression may protect against type 2 diabetes
- BNP modulates Ang II-induced steroidogenesis in the adrenal gland
- Admission plasma BNP concentrations provide incremental prognostic information in patients with first STEMI treated with pPCI.
- May be used to identify any impairment of left ventricular function in type 2 diabetes.
- Acute heart failure patients with renal failure have higher NT-proBNP levels than those with normal renal function.
- No a useful markers of acute cellular rejection during the first year after heart transplantation, but may be a marker for allograft vasculopathy.
- The 16-repeat allele of the VNTR in the 5'-flanking region of NPPB appears to be a useful genetic marker of essential hypertension in females.
- Polymorphisms are associated with circulaating levels of pro-brain natriuretic peptide but not with prevalent overt diabetic nephropathy.
- there is an association between right ventricular overload,decrease in functional capacity,and cardiac NT-proBNP expression in operated tetralogy of Fallot patients.
- Plasma NT-proBNP levels can be used as a marker in the detection of RV dilatation and dysfunction.
- A biological marker to identify high rish chronic thromboembolic pulmonary hypertension paatients and its rlation to postoperative hemodynamic outcomel.
- Both CA125 and brain natriuretic peptide (BNP) levels are significantly correlated with New York Heart Association (NYHA) class and outcome in patients with aortic stenosis.
- BNP levels are increased in the postoperative course after major pulmonary resection. Cardiac and infectious complications are associated with higher levels and a slower decrease.
- BNP is elevated within 24 h after traumatic brain injury in some patients; it does not originate from the brain and increased NT-proBNP concentrations are not consistently associated with hyponatremia or increased urinary sodium loss
- Results suggest that genetic variation at the primary locus NPPB gene, represented by definition of risk haplotypes, may be an important determinant of plasma BNP levels.
- Thiazolidinediones (rosiglitazone) has no effect on BNP plasma levels in patients with type 2 diabetes.
- hypertensive patients with abnormal diurnal BP variation patterns (nondippers, extreme dippers, and risers) showed higher plasma BNP levels than those with normal circadian BP variation (dippers)
- BNP is a specific HIF-1alpha target gene
- N-terminal pro-B-type brain natriuretic peptide may have a role in cardiac wall stress in women with polycystic ovary syndrome
- N-Terminal-probrain natriuretic peptide (NT-proBNP) may have a role in congestive heart failure
- BNP represents a direct target of SHOX.
- A single NT-pro BNP and cTnT value at 96 hours after onset of symptoms proved useful for estimation of left ventricular ejection fraction and infarct size.
- elevated BNP (brain type natriuretic peptide) plasma levels are closely related to cardiac abnormalities in elderly subjects
- Increased ANP in patients with idiopathic hypertension may indicate the coexistence of complications with types of left ventricular hypertrophy (LVH). High concentrations of BNP may specifically suggest concentric LVH.
- Determined plasma NT-proBNP levels in relation to severity of mitral valve regurgitation.
- Circulating CD34+ cell number was found to significantly correlate with plasma BNP level, a marker of left ventricular dysfunction
- The ratio between early diastolic transmitral velocity and early mitral annular diastolic velocity strongly correlates with NTproBNP.
- NT-ProBNP and cytochemokines mediate the endothelial progenitor cells changes in acute and post-acute response to the inflammatory stimulus of intervention
- Transcardiac gradient of N-terminal proBNP (NT-proBNP) to brain natriuretic peptide (BNP) ratio increases with the severity of left ventricular dysfunction. Plasma NT-proBNP may be more useful than BNP in the prognosis of chronic heart failure patients.
- An inverse significant relationship between IGF-I and both brain natriuretic peptide (BNP) and amino-terminal propeptide of procollagen type III (P-III-P) value in surgically treated acromegaly patients was observed.
- Admission plasma NT-proBNP may, however, be considered as an additional marker in the diagnosis of AMI, especially in those without RWMA.
- NT-proBNP is linked to disease severity in patients with chronic aortic regurgitation reflecting hemodynamic stress due to volume overload.
- In patients with aortic stenosis there is an association between B-type natriuretic peptide (BNP) and an abnormal blood pressure response to exercise.
- Pulmonary hypertension is associated with NT-proBNP elevation and diastolic impairment in congenital diaphragmatic hernia infants.
- Basal BNP level testing can be recommended in the follow-up evaluation percutaneous coronary intervention, to improve both the detection and the exclusion of asymptomatic re-stenosis.
- Left ventricular hypertrophy and diastolic dysfunction associated with increase in radial augmentation index may be involved in increase in BNP level.
- BNP may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.
- Data indicate that early elevations of NT-proBNP but not cell adhesion molecules are predictive of future death/myocardial infarction.
- Plasmatic B-type natriuretic peptide in hyperacute stroke has no predictive value for CT-evidence of brain edema.
- The frequency of pulses of secretion seems to be unchanged with aging. [review]
- Elevated levels of NT-proBNP are associated with increased left ventricular mass, which are both markers of increased cardiovascular risk in type 1 diabetes.
- in systemic sclerosis patients elevated plasma NT-proBNP (natriuretic peptide precursor B) level reflects the degree of right ventricular overload
- renin-angiotensin system activity had no impact on NT-pro-BNP levels
- N-terminal pro-brain natriuretic peptide is both a sensitive and a specific marker for transfusion-associated circulatory overload and can be helpful in confirming transfusion associated fluid overload
- NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic heart failure patients receiving carvedilol without ACE inhibition.
- During exercise, changes in B-type natriuretic peptide reflect the presence of dynamic changes in both left ventricular dyssynchrony and mitral regurgitation severity in the absence of inducible ischaemia.
- there was significant negative correlation between NTpBNP (natriuretic peptide precursor B) and left ventricular (LV) function in preterm infants
- NT-pro BNP levels tends to be higher in hypertensive subjects with diastolic dysfunction.
- in addition to osteoprotegerin, BNP is also increased during non-ST elevation acute coronary syndrome and more associated to coronary narrowing
- This study confirms the relationship between BNP level elevation and severity of sepsis independent of congestive heart failure.
- IL-6 and TNF-alpha, and the level of an anti-inflammatory cytokine IL-10, but not their gene polymorphisms, provide novel and important prognostic information in patients with ADHF.
- Preoperative, postoperative and 1-year follow-up N-terminal pro-B-type natriuretic peptide levels in severe chronic aortic regurgitation: correlations with echocardiographic findings
- Elevated N-terminal prohormone brain nutriuretic peptide levels are associated with higher risk of cardiovascular disease among blacks with hypertensive kidney disease.
- Sarcoplasmic colocalization of brain natriuretic peptide and chromogranin A is diminished after unloading.
- Patients with impedance cardiography parameters that represent high risk for acute decompensation of heart failure have higher levels of serum BNP and left ventricular end diastolic pressure.
- In this review BNP is discussed in the setting of chronic and acute heart failure (HF), while NTproBNP is a 108-amino acid precursor protein used for diagnosing mild HF or asymptomatic left ventricular dysfunction.
- A correlation exists between magnitude of decrease in BNP and magnitude of improvement in ventricular function during carvedilol therapy.
- After heart transplantation, BNP remained increased despite the normalization of hemodynamic and cardiac systolic and diastolic functions.
- findings show that in patients with nonobstructive hypertrophic cardiomyopathy attributable to an Asp175Asn mutation in the alpha-tropomyosin gene, elevated NT-pro-BNP levels are associated with incipient left ventricular remodeling
- in patients with coronary artery disease, combined use of NT-proBNP (N-terminal-probrain natriuretic peptide ) and hsCRP (high sensitivity C reactive protein) significantly increased predictive value for future cardiovascular events
- A glycosylated form of the cardiac hormone NPPB is an intrinsically unstructured monomeric protein.
- Obese and nonobese patients with essential hypertension show similar N-terminal proBNP plasma levels.
- B-type natriuretic peptides strongly predict mortality in patients who are treated with long-term dialysis.
- Conclude that BNP may be a useful noninvasive tool for the assessment of left ventricular filling pressures in patients with acutely decompensated heart failure and inconclusive tissue Doppler indexes.
- BNP was a significant independent predictor of adverse outcomes in chronic heart failure
- Assessment of plasma NT-proBNP allows for stratifying patients with functional MR regardless of their degree of valvular incompetence. Even in case of only mild or moderate MR, but increased NT-proBNP, patients have to face poor outcome.
- Patients with SLE have increased concentrations of NT-proBNP (natriuretic peptide precursor B), but this is not explained by atherosclerotic burden, augmentation index, or inflammatory state
- Discuss role of BNP in diagnosing and treating heart disease.
- NT-proBNP and hsCRP can independently predict all-cause mortality in a non-dialysis CKD population and may have a useful role in risk stratification.
- C-reactive protein levels are linearly associated with levels of N-terminal-probrain natriuretic peptide in cross-sectional and longitudinal analyses of patients with rheumatoid arthritis.
- Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients.
- Perioperative plasma brain natriuretic peptide and cardiotrophin-1 measured in off-pump coronary artery bypass.
- Report BNP/NT-proBNP levels in chronic kidney disease.
- The synergistic combined effect of anemia with high plasma levels of B-type natriuretic peptide significantly predicts an enhanced risk for major adverse cardiac events.
- Report effects of N-terminal pro-B-type-natriuretic peptide and C-reactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty.
- In patients with reperfused acute myocardial infarction and LV dysfunction, hypertension was not associated with a different pattern of serum procollagen release (serum BNP, PICP, ICTP, and PIIINP) and ventricular remodelling at 6 months of follow-up.
- Elevated BNP levels are also significant predictors of death and/or complicated clinical course in acute pulmonary embo
- The plasma adiponectin level increased along with an increase of plasma BNP in healthy subjects independently of other confounding factors, demonstrating that adiponectin reflects cardiac function.
- NT-ProBNP levels may have predictive power in non-ischemic dilated cardiomyopathy.
- Advanced cirrhosis is associated with advanced cardiac dysfunction, and N-terminal pro B-type natriuretic peptide levels has predictive value for concomitant cardiac dysfunction and cirrhosis progression
- Plasma BNP levels increased progressively with the extent of coronary artery disease.
- Serial determinations of N-terminal pro-brain natriuretic peptide and classification into few categories of changes according to threshold levels may be a superior strategy for risk stratification of patients with chronic and stable heart failure.
- During conditions of extreme physical stress such as prolonged endurance running, brain natriuretic peptide may assist its better known companion hormones (arginine vasopressin and atrial natriuretic peptide) in the regulation of fluid balance.
- NT-proBNP was excellent predictor of left ventricular ejection fraction value (p<0.05).
- Data show that brain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions.
- NT-proBNP levels can be used to diagnose right ventricular dysfunction in patients with coronary artery disease and abnormal left ventricular wall motion.
- A diagnostic tool incorporating the values of matrix metalloproteinase 9, brain natriuretic factor, d-dimer, and S-100beta into a composite score was sensitive for acute cerebral ischemia.
- These data showed that BNP and NT-proBNP are very sensitive and specific predictors of CVE in dialysis patients.
- The plasma BNP level transiently increased in patients with large artery atherosclerosis independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke
- Baseline BNP levels are closely associated with the risk of hypertension in individuals with normal blood pressure, but the prediction of hypertension with BNP is largely dependent on baseline blood pressure
- Elevated plasma B-type natriuretic peptide may be useful in diagnosing inferior myocardial infarction with right ventricular involvement.
- Cutoff values of NT-proBNP for the prediction of low functional capacity, decreased ejection fraction and cardiovascular events in patients with heart failure.
- Site-directed mutagenesis enabled us to ascertain the unique suppressing role of T71-bound O-glycan in proBNP processing
- diagnostic accuracy of Nt-proANP was equivalent to BNP and Nt-proBNP in the present cohort of patients admitted to emergency department with dyspnoea and/or chest pain
- N-terminal pro-brain natriuretic peptide levels may have a role in development of left ventricular systolic function in patients with chronic kidney disease
- Preliminary data suggest that N-terminal pro-BNP levels higher than 500 ng/L could serve as indicator of the burden of pulmonary embolism and perhaps as a predictor of death.
- The combination of comprehensive echocardiography and plasma B-type natriuretic peptide levels elucidates the presence of cardiac damage in patients with Parkinson disease using ergot derivative dopamine agonists.
- Accuracy of N-terminal pro-brain natriuretic peptide in the identification of left ventricular dysfunction in high-risk asymptomatic patients.