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Validated All-in-One™ qPCR Primer for KITLG(NM_000899.4) Search again
Product ID:
HQP011204
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DCUA, DFNA69, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, SLF, WS2F
Gene Description:
KIT ligand
Target Gene Accession:
NM_000899.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- important factor for the growth and activation of nasal epithelial mast cells
- Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells.
- Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas.
- There was a powerful and statistically significant synergy for release of IL-8, both at the mRNA level and protein level between adenosine A(2b) receptor agonists and stem cell factor (SCF).
- SCF mRNA is present in K562, HL-60 and CML cells in blast phase
- stem cell factor has "late" effects on fetal hemoglobin modulation during erythropoiesis, related to the expression pattern of CD117.
- the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation.
- several inflammatory cytokines (T helper 1 and 2) and vasoactive intestinal peptide from mast cells and nerve endings are capable of inducing stem cell factor production from epidermal keratinocytes in atopic dermatitis.
- constitutively activated Bcr-Abl kinase pathways in primitive CML progenitors cooperate with growth factors producing a growth response, and, disrupt the normally required synergistic interactions between KL and other cytokines to achieve activation
- SCF up-regulates Bcl-2 and Bcl-X L in erythroid precursors and exogenous expression of these proteins protects erythroblasts from caspase activation and death induced by chemotherapeutic agents.
- SCF correlated negatively with creatinine clearance & positively with glomerular & interstitial CD68+ cells & collagen III. SCF was shown in the vicinity of alpha-SMA+ cells. This shows potential involvement of SCF/c-kit in crescentic glomerulonephritis.
- Kit-ligand has a role in melanocyte development and epidermal homeostasis [review]
- protein CBP/p300 was shown to be essential for EPO- and SCF-mediated STAT5 transactivation
- long-term exposure of primitive human hematopoietic cells to elevated levels of human IL-3, GM-CSF and SF in vivo may deleteriously affect the stem cell compartment, while expanding terminal myelopoiesis.
- findings of co-expression of KIT and/or FMS with their respective ligands implies these receptors might contribute to leukemogenesis in some patients with AML through autocrine, paracrine, or intracrine interactive stimulation.
- "Stem cell factor (SCF) also termed Kit ligand, steel factor or mast cell growth factor is the ligand of the c-kit proto-oncogene product." P. 75
- Gastrointestinal stromal tumors carrying 1530ins6 occur exclusively in the intestinal location, and a great majority of these tumors follow a malignant course
- SCF dose-dependently promoted survival, migration, and capillary tube formation of HUVEC cells. Akt and Erk1/2 should promote survival and capillary tube formation of these endothelial cells at a locus downstream to stem cell factor/c-kit signaling
- the accentuated expression of SCF in lesional skin plays an important role in the mechanism involved in the epidermal hyperpigmentation of lentigo senilis
- acquisition of autonomous growth during uveal melanoma progression may involve the SCF/c-Kit axis
- only Kit ligand stimulated phosphorylation of signal transducer and activator of transcription 5
- c-Kit makes both kinase-independent and -dependent contributions to the proliferative synergy induced by SCF in combination with GM-CSF
- induction of Slug by autocrine production of SCF and c-Kit activation plays a key role in chemoresistance of malignant mesothelioma
- Increased stem cell factor levels are associated with tumorigenesis in neurofibromatosis type 1
- HMGA1 positively regulates the human KL promoter in breast and ovarian cancer cells
- The expression of SCF and its receptor in ovarian tissue from fetuses and women suggests a possible role of SCF in growth initiation of human primordial follicles.
- C-terminal valine defines a specific endoplasmic reticulum export signal in Kitl
- When SCF was added with TNF-alpha, cell growth inhibition was reduced and the apoptotic cells decreased. The activations of caspase 3 and caspase 8 were almost completely blocked by SCF while CDK6 and the FLICE-inhibitory protein (FLIP) were increased.
- HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves
- stem cell factor receptor/c-Kit has a role in signal transduction [review]
- Coculture with murine embryos enhanced the gene expression of SCF in human ovarian granulosa tumor cells and enhanced murine embryo development.
- The SCF is a member of a group of glycoproteins called hematopoietic cytokines (HCs).
- Serum levels of early hemopoietic cytokine stem cell factor (SCF) correlate with disease activity in Langerhans cell histiocytosis and are relatively higher in patients with bone lesions.
- The effect of THPO on HuMCs in the presence of rhSCF varies, depending on the relative concentration of each growth factor, while THPO alone or in combination with rhSCF supports a unique population of CD117low/CD110+ HuMCs.
- The SCF gene was cloned into baculovirus transfer vector pVL1392 under the control of polyhedrin promoter and expressed in the Sf9 cells (Spodoptera frugiperda).
- KIT expression is a hallmark of oncocytoma and chromophobe renal cell carcinoma.
- Neuroprotective role for SCF in cortical neurons, an effect mediated by Akt and ERK, as well as NFkappaB-mediated gene transcription. SCF represents a novel therapeutic target in the treatment of neurodegenerative disease.
- SCF/c-Kit interactions are likely to be involved in mediating islet cell differentiation and proliferation during human fetal pancreatic development, and that phosphorylated Akt may have a role downstream of SCF/c-Kit signaling.
- Stem cell factor is an important cytokine in neurofibromatosis type 1 skin, but that additional (growth) factors and/or genetic mechanisms are needed to induce NF1-specific CALM hyperpigmentation.
- SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain
- Mutations in the coding regions of the KITLG gene appear not to be a common cause of 46,XX spontaneous premature ovarian failure in North American women.
- stem cell factor and clusterin may have roles in azoospermia
- SCF and Kit are expressed in bronchial biopsies from lung transplant recipients irrespective of the clinical status of the graft; role for these factors in tissue repair following lung transplantation is hypothesised
- Our data indicate that the KIT/KITLG system may be involved in a low sperm count trait in humans.
- antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation in leukemic cells
- influence of the extent of liver resection on levels and kinetics of serum growth factors.
- In patients with urticaria pigmentosa, the mutation of the c-kit Asp-816-Val was detected in 38% of the adults and 25% of the children.
- A potential role of the c-Kit/mbKitL interaction in pathological settings is sustained by the expression of the membrane-bound KitL on endothelial cells lining intraplaque neovessels.
- SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway.
- Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
- SCF can be introduced to rescue cells from the damage caused by certain antineoplastic agents.
- Early myeloid cells expressing GNNK+ or GNNK-c-KIT show different responses to stem cell factor.
- The highest density of CD117-positive cells was found at the ureteropelvic junction, however the differences in between the segments were minimal.
- we report that SCF acts as a potent regulator in the fate determination of human gonocytes.
- These experiments suggest that regulatory changes in Kitlg contribute to natural variation in vertebrate pigmentation, and that similar genetic mechanisms may underlie rapid evolutionary change in fish and humans.
- The effects of activin on germ cells are indirect and include mediation by the kit ligand/c-Kit pathway, rather than being an autocrine germ cell effect.
- Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes.
- Hypoxia and epidermal growth factor receptor signal coexisted in the tumor microenvironment and might promote angiogenesis through HIF-1 alpha-mediated upregulation of SCF and other angiogenic factors.
- loss of repopulating activity during KIT-ligand stimulation is counteracted by Oncostatin M through the downregulation of ERK pathway signaling
- stem cell factor expression would be a useful marker for tumor proliferation.
- Airway smooth muscle cells maintain human lung mast cell survival in vitro by a direct cooperative interaction between the two cell types via a mechanism dependent upon stem cell factor, interleukin-6 and cell adhesion molecule (CADM)1.
- SCF activated the RAS/MAPK and PI3K/AKT pathways, followed by downregulation of the pro-apoptotic factor BIM and upregulation of the anti-apoptotic factor MCL1
- These data suggest a novel mechanism of SCF/c-Kit signaling in angiogenesis and tumor progression.
- Co-expression of KIT and SCF in a high percentage of MCC tumors hints to an autocrine mechanism. KIT and SCF expression in primary tumors and in metastases suggests an early event in Merkel cell transformation.
- This study provides therefore a direct link between MSK1-mediated phosphorylation of Ser276 p65 of NF-kappaB, allowing its binding to the SCF intronic enhancer, and pathophysiological SCF expression in inflammation.