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Validated All-in-One™ qPCR Primer for MCAM(NM_006500.2) Search again
Product ID:
HQP011099
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD146, HEMCAM, METCAM, MUC18, MelCAM
Gene Description:
melanoma cell adhesion molecule
Target Gene Accession:
NM_006500.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Increased expression of MUC18 is implicated to play an important role in developing and malignant progression of human prostate cancer.
- Acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18.
- The 28mer peptides are structural equivalents of the MAd18-5D7 epitope of Mel-CAM.
- MCAM and akt protein are reciprocally regulated.
- sCD146 circulates in the plasma of healthy subjects; significantly increased levels of sCD146 in blood and CD146 in kidney endothelial cells of patients with chronic renal failure were observed.
- endothelin-1 (ET-1) upregulates MCAM protein in primary human melanocytes
- Elevation of adiponectin may be a defense mechanism against endothelial damage, reflected by elevated CD146 and thrombomodulin.
- When cell surface glycoprotein gp130 was purified and analyzed by peptide mass fingerprinting, we could demonstrate that it is MUC18 (Mel-CAM, CD146)
- CD146 is a new marker of activated lymphocytes, not just an adhesion marker of endothelial cells
- results demonstrate that CD146 plays a key role in vascular endothelial cell activity and angiogenesis
- Our data indicate a correlation between MUC18 expression and the invasiveness of uveal melanoma cells.
- M-CAM is a marker of early relapse and poorer outcome in epithelial ovarian cancer
- Results identify melanoma cell adhesion molecule as a novel marker for myogenic progenitors in human fetal muscle and confirm that downregulation of this protein promotes myoblast fusion.
- MCAM expression doees not correlates with progression to advanced-stage melanoma.
- These data provide the first evidence that CD146 dimerization occurs in living cells and is regulated within the tumor microenvironment, implying that dimerization of CD146 may be associated with malignancy.
- Plasma levels may be involed in the development of vascular complication in end stage of diabetic nephropathy.
- CD146(an endothelial cell marker)is also expressed on lymphocytes,implicating its role in T cell adherence and activation to vascular endothelium
- Vasculature in tumours and in retina and choroid of all melanoma-affected and normal eyes showed intense MUC18 immunostaining. observations further suggest a role for MUC18 in uveal melanoma growth.
- CD146 and platelet-derived growth factor-receptor beta are expressed in colony-forming endometrial stromal cells which may be mesenchymal stem cells, and have roles in the cells' cyclical growth
- MCAM might be involved in the recruitment of activated T cells to inflammation sites.
- Elevated adiponectin correlated to CD146 may be the expression of a counterregulatory response aimed at mitigating the consequences in endothelial damage and increased cardiovascular risk in renal failure.
- A decrease in serum adiponectin levels and an increase in serum CD146 may be closely associated with the development of arteriosclerosis obliterans, regardless of renal function.
- The immunoreactivity of the polyclonal CD146 antibody (Abcam, ab28360) is prognostic of PSA-relapse in prostate cancer patients
- Reflux laryngitis is associated with down-regulation of mucin gene expression.
- A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction.
- CD146(+) cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation
- CD146 might be a novel marker for RTECs, correlating with cell proliferation and cell-cell conjunctions. High glucose up-regulates both CD146 and sCD146 expression.
- Identification of MCAM/CD146 as the surface antigen bound by one of the mesothelioma-targeting human single chain antibodies in cultured tumor cells.