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Validated All-in-One™ qPCR Primer for KCNA3(NM_002232.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s).
Gene References into function
- role in apoptosis induced by actinomycin D
- distribution of FLAG epitope-tagged Kv1.3 channels (Kv1.3/FLAG) significantly differs from the stochastic Poisson distribution in the plasma membrane of human T lymphoma cells
- manipulation of membrane cholesterol changed both the kinetic properties of Kv1.3 and steady-state parameters of activation by modifying lipid-protein interactions.
- Fas ligand increases Kv1.3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux, cell shrinkage, and apoptosis
- In different glioma samples investigated for expression of KV1.3 potassium channels, no correlation of expression with glioma entities and malignancy grades is evident for KV1.3.
- Of 13 voltage-gated K+ (Kv) potassium channels sought, only Kv1.3 mRNA was present. Kv1.3 sets the resting potential of the cells, but it is not required for Fc receptor-mediated phagocytosis.
- Localization of Kv1.3 channels in the IS might open an unrevealed possibility in the regulation of ion channel activity by signaling molecules accumulated in the immune synapse.
- study of the mitochondrial localization of Kv1.3
- Kv1.3 is highly expressed in postmortem multiple sclerosis brain inflammatory infiltrates.
- functional role of K(v)1.5 and K(v)1.3 on activated human dendritic cells
- T cells with other antigen specificities from these patients, or autoreactive T cells from healthy individuals and disease controls, express low levels of Kv1.3 and are predominantly naive or central-memory (T(CM)) cells
- The influence of extracellular pH and zinc ions (Zn(2+)) on the steady-state inactivation of Kv1.3 channels expressed in human lymphocytes, was investigated.
- Cholesterol depletion causes significant, reversible alterations in the Kv1.3 channel function in Jurkat cells.
- Defective temporal and spatial Kv1.3 channel distribution may contribute to the abnormal functions of T cells in systemic lupus erythematosus.
- Ketanserin acts directly on the open state of the Kv1.3 channel, reducing current flow. Augmentation of extracellular [K] enhances current flow through the channel.
- The Kv1.3 potassium channel, postsynaptic density protein 95, and insulin receptor serine kinase co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb.
- Specific Kv1.3 blockers may be beneficial in autoimmune diseases such as multiple sclerosis in which effector memory T cells are found in the target organ
- The stimulation of CD28 in addition to CD3 strongly inhibits Kv1.3 current and this additive inhibition is mediated by CD45 activation.
- These findings suggest that Bax mediates cytochrome c release and mitochondrial depolarization in lymphocytes, at least in part, via its interaction with mitochondrial Kv1.3.
- The effects of clofazimine provide the first line of experimental evidence in support of a causal relationship between Kv1.3 and calcium oscillation in human T cells.