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Validated All-in-One™ qPCR Primer for IRF4(NM_002460.3) Search again
Product ID:
HQP009781
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
LSIRF, MUM1, NF-EM5, SHEP8
Gene Description:
interferon regulatory factor 4
Target Gene Accession:
NM_002460.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.
- review article summarizes recent studies on the regulation of IRF-4 and its function in activated T cells, human T cell lymphoma virus (HTLV-I)-infected T cells, and HTLV-I-induced adult T cell leukemia
- Chronic IRF4 expression in human T cell leukemia virus-I-infected T lymphocytes is associated with a leukemic phenotype, driven through activation of the NF-kappa B and NF-AT pathways.
- IRF-4 represents one of the lymphoid-specific components that control the ability of T lymphocytes to produce a distinctive array of cytokines
- IRF-4, by modulating the efficiency of the Fas-mediated death signal, is a novel participant in the regulation of lymphoid cell apoptosis.
- IRF-4 binds to PU.1 and downregulates CD68 expression in lymphoid cells
- MUM1 appears to be a sensitive and specific immunohistochemical stain for melanocytic lesions and may prove to be a useful addition to the current panel of melanoma markers
- in B cells, E47 and PU.1/IRF-4 interact with the E-box motifs and the EICE, respectively, and act synergistically in the activation of CIITA-PIII
- IRF-4 as a potential player in human myeloid DC differentiation and is a target for the immunomodulatory activity of 1,25(OH)(2)D(3).
- IRF4 protein provides a positive feedback signal for its own gene expression in dendritic cells
- The sequence preference of IRF-4 was investigated by nuclear magnetic resonance and fluorescence antisotropy as an example of the indirect sequence recognition.
- MUM1 expression dichotomizes follicular lymphoma (FL) into low-grade FL of CD10+/Bcl-6+/MUM1-/Ki-67low phenotype, and high-grade FL of CD10+/- /Bcl-6+/weak/MUM1+/ Ki-67high phenotype
- Identifies MUM1 mRNA expression as an independent risk factor for poor survival in myeloma, particularly in patients without a deletion of 13q.
- MUM1/IRF4 is expressed in most cases of classical Hodgkin's lymphoma and shows that lack of this expression in a minority of cases may be a potential adverse prognostic factor
- The variability in MUM1/IRF4 staining suggests a level of biologic complexity that is not adequately reflected in the current binary models of CLL pathobiology.
- bortezomib down-regulation of PRDM1beta preceded decreased IRF4 and c-MYC expression
- Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes.
- IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation.