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Validated All-in-One™ qPCR Primer for IL13RA2(NM_000640.2) Search again
Product ID:
HQP009702
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD213A2, CT19, IL-13R, IL13BP
Gene Description:
interleukin 13 receptor subunit alpha 2
Target Gene Accession:
NM_000640.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq].
Gene References into function
- novel mechanism by which IFN-gamma can regulate IL-13 responses.
- IL-13Ralpha(345-354) (WLPFGFILI) induced a CD8(+) T-cell line that specifically produced IFN-gamma in response to HLA-A2+ T2 cells pulsed with the relevant peptide and lysed these cells.
- interleukin-13 receptor possibly plays an important part in the early inflammatory process of psoriasis; however, its function is lost in the psoriatic keratinocytes.
- IL-4/IL-13-induced IL-13Ralpha2 expression is potentiated by TNF-alpha
- The 5' flanking region of IL-13Ra2 has been isolated and cloned and the gene control region functionally characterized.
- analysis of binding between interleukin-13 and interleukin-13 receptors IL-13Ralpha1 and IL-13Ralpha2
- TGF-beta1 production and fibrosis require IL-13 signaling through the IL-13alpha2 receptor
- The inhibitory effects of the IL-13 receptor alpha 2 subunit on IL-13 signaling are dependent on both the level of expression of the receptor and the concentration of IL-13.
- Immunohistochemical analyses revealed that 83% of ovarian cancer specimens express IL-13Ralpha2, whereas normal ovary samples expressed none or very low levels.
- data suggest that IL13RA2 gene polymorphisms may be involved in susceptibility to systemic sclerosis
- A polymorphic variant of IL-13 (R110Q) was demonstrated to have altered binding affinity to IL-13 receptor alpha2.
- Highly variable expression of IL13Ralpha2 protein both within and across specimens of glioblastoma multiforme.
- IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas
- RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell's ability to respond to IL-13.
- soluble form of IL-13Ralpha(2) may therefore modulate mucus overproduction by IL-13 through the pathway including IL-13Ralpha(1) in normal human bronchial epithelial cells
- IL-13R alpha 2, EphA2, and Fra-1 are attractive therapeutic targets representing molecular denominators of high-grade astrocytomas. One hundred percent of GBM tumors overexpress at least one of these proteins.
- Humans only express the membrane bound form of the IL-13 receptor alpha 2
- 13Ralpha2 protein and mRNA are expressed to significantly higher levels in brainstem glioma than in normal brain tissue
- The feasibility of MRI to visualize different phases of immune response when IL-13Ralpha2-specific CTLs are administered directly to the glioma tumor bed.
- IL-13Ralpha2 is expressed by both primary bronchial epithelial cells and fibroblasts as an intracellular protein with a diffuse cytoplasmic distribution; in vivo, IL-13Ralpha2 is expressed in the airway mucosa mainly by bronchial epithelial cells
- analysis of cDNA clone and prokaryotic expression of human interleukin-13 receptor [alpha]2 chain
- study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo
- Hepatic stellate cells in sinusoidal lesions of liver from patients with nonalcoholic steatohepatitis express high levels of high-affinity IL-13R (IL-13 receptor alpha2), whereas fatty liver and normal liver specimens do not express IL-13Ralpha2.
- Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo.
- Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN.