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Validated All-in-One™ qPCR Primer for IL10(NM_000572.2) Search again
Product ID:
HQP009685
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CSIF, GVHDS, IL-10, IL10A, TGIF
Gene Description:
interleukin 10
Target Gene Accession:
NM_000572.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.
Gene References into function
- Individuals carrying the IL10-5'-592A promoter progress to AIDS more rapidly than homozygous -592 C/C carriers. About 25-30% of long-term nonprogressors (no AIDS for 10 + years) can be attributed to the IL10-592 C/C genotype.
- In mice, expression of the human anti-inflammatory protein IL-10 in a recombinant adenoviral vector drug-delivery system was used prophylactically in acute experimental inflammatory syndromes to suppress the underlying inflammatory process.
- The IL10 -1082 G/C SNP is associated with immune function and hepatitis B vaccination results in end-stage renal failure patients
- A MnlI restriction site polymorphism in the interleukin-10 gene promoter.
- CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
- Heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) had no effect on the release of IL-1ra, IL-10, and IL-12p40 from neutrophils or peripheral blood mononuclear cells.
- +1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10.
- Mechanism by which hIL-10 added to murine macrophage cells inhibits nitric oxide biosynthesis and iNOS expression involves suppression of CAT-2 transcription.
- This study documents for the first time that Wegener's Granulomatosis is associated with IL-10.G in the IL-10 gene.
- Polymorphisms in the promoter region of IL-10 were analyzed for possible gender-specific association with longevity.
- A novel PCR-rFLP assay for the detection of the single nucleotide polymorphism at position -1082 in the human IL-10 gene promoter.
- IL-10 promoter polymorphisms were associated with the production of anti-CA II ab in patients with endometriosis, suggesting a role in the genetic susceptibility for endometriosis.
- The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL-8, IL-10 and IL-12 production and apoptosis in vitro.
- Th1 and Th2 cytokine modulation by IL-10/IL-12 imbalance in autoimmune hemolytic anemia.
- regulates CCR5 and CD4 expression and HIV-1 replication in human macrophages and microglia
- These data could partly explain the abnormal secretion of IL-10 occurring in schizophrenic patients in response to infections or different stressors and suggest a potential role of IL-10 as a candidate gene for susceptibility to schizophrenia
- Polymorphism associated with herpes zoster susceptibility
- polymorphism at position -819 does not confer susceptibility to major depression and schizophrenia in Korean study population
- Secretion levels of sIL-2R, IL-6, IL-8, IL-10, and TNF-alpha, but not IL-4 and IL-12, are elevated in activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders.
- The interleukin-10-1082 G/A promoter polymorphism: allele frequency in different populations and functional significance
- induction of IL-10 is due to effects of H-ferritin on adherent antigen-presenting cells (APCs) in blood and monocyte-derived dendritic cells (MoDCs).
- conserved helix C region in the superfamily of interferon-gamma /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK
- Low-dose endobronchial transfer to the donor of the gene for human interleukin 10 ameliorated ischemia-reperfusion injury in rodent lung transplantation by improving graft oxygenation and reducing neutrophil sequestration.
- production by different populations of erythroid cells derived from human embryonal liver
- IL-10 can inhibit TNF-alpha expression in primary macrophages by targeting either the 5' promoter or the 3' untranslated region, indicating involvement of both transcriptional and posttranscriptional mechanisms.
- Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis.
- association of polymorhpism with acute and chronic kidney transplantation outcome
- Endogenous expression in nasopharyngeal carcinoma cells
- Increased IL-10 production and HLA-DR suppression in the lungs of injured patients precede the development of nosocomial pneumonia.
- Decreased IL-10 production coupled with a sustained IFN-gamma presence was noted in missed abortion compared with elective termination.
- Lactic acidosis after cardiac surgery is associated with polymorphisms in interleukin 10 gene.
- Mycobacterium bovis-mediated upregulation of IL8 in human monocyes is down-regulated by IL10.
- reduction in the capacity to produce IL-10 may be a characteristic of G6PD-deficient monocytes. An attenuated IL-10 production may be a contributing mechanism in the augmented inflammatory response in G6PD-deficient trauma patients
- Altered IL-10 signaling in lymphocytes of systemic lupus erythematosus patients is characterized by persistent mitochondrial hyperpolarization and increased production of reactive oxygen intermediates.
- Promoter polymorphism in multiple sclerosis is associated with disease progression.
- increased IL-10 production during spontaneous apoptosis of monocytes
- IL-10 to regulate the progression of sepsis and control the onset of irreversible septic shock and mortality
- IL-10 gene expression in esophageal squamous cell cancer specimens was significantly correlated with VEGF121 gene expression. The results suggested that IL-10 stimulates angiogenic factor gene expression.
- IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes
- There is a protective effect from prednisone poor response in patients with the IL-10 G/G genotype. No association of the risk of relapse and IL-10 genotype was found. IL-10 genotype might influence prednisone response in patients with childhood ALL.
- The IL10 -1082 G/A SNP is associated with cardiovascular morbidity in hemodialysis patients
- IL-10 causes anemia in patients with inflammatory bowel disease which may be referred to the induction of imbalances in iron homeostasis by the cytokine.
- immune restoration of HIV-1-infected children receiving HAART might be related to an increase in IFN-gamma production and a decrease in the rate of IL-10 production after virus suppression
- Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia.
- Respiratory syncytial virus induces IL-10 generation in antigen presenting cells
- Data show that IL-10 completely inhibits LPS-induced dendritic cell maturation, resulting in altered DC-T-cell interactions and reduced T-cell responses.
- REVIEW: role in limiting proinflammatory activation in humoral responses in uremia
- ATPgammaS synergized with LPS and sCD40L, but not TNF-alpha, to stimulate IL-10 production.
- ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells.
- Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells.
- Review. The role of IL-10 in autoimmune diseases and its beneficial effects in cellular-based autoimmune diseases such as multiple sclerosis (MS) or its involvement in humoral-based autoimmune diseases such as systemic lupus erythematosus are discussed.
- IL-10 reduced monocytes and T lymphocytes migration across endothelium stimulated by LPS & decreased endothelial production of chemokines in response to LPS & Borrelia burgdorferi in a manner that is selective with respect to stimulus & effector response
- Autoimmune response in Sjogren's syndrome appears to be mediated by IL-10 levels and there is a linkage with IL-10 gene polymorphism.
- is a critical mediator for the development of autologous graft-versus-host disease
- When incubated with peroxynitrite, IL-10 has enhanced activity to inhibit IL-1 production of stimulated peripheral blood mononuclear leukocytes.
- a total of 19 genes are up-regulated in response to IL-10 in human monocytes
- Upregulation of IL-10 by G-CSF-mobilized leukocytes prolongs heart transplantation survival.
- Glucocorticoids and IL-10 stimulated macrophage production of GILZ, which displayed activities related to anti-inflammatory and immunosuppressive effects.
- investigated polymorphisms are not associated with periodontal disease
- Antigen-presenting cell derived IL-10 can exert a major inhibitory effect on control of Mycobacterium avium infection by a mechansism involving suppression of macrophage effector function and apoptosis
- decreased secretion in mucosal leishmaniasis and reduced ability to modulate Th1 type response
- role in rendering CD25(-)CD4(+) T cells anergic and differentiation into Tr1 cells
- A relationship exists between tumor necrosis facotor-alpha and interleukin-10 promoter polymorphisms and the development of paucibacillary leprosy
- The IL10.G microsatellite remains to date the only IL10 marker associated with systemic lupus erythematosus in this Italian population.
- the level of basal as well as cAMP-stimulated IL-10 transcription depends on the expression of C/EBP alpha and beta and their binding to three motifs in the promoter/enhancer region
- The dual role of IL-10(review)
- IL-10 inhibits TNF-alpha and IL-1 beta production by lipopolysaccharide-stimulated choriodecidual membranes and is also involved in the suppression of prostaglandin production.
- IL-10 stimulated the rapid translocation of IL-10E1 to the cell nucleus and the activation of TMP-1.
- Effect of monocyte adherence on monocyte responses to interleukin-10
- A genetic defect in the production of interferon-gamma in individuals homozygous for the (+874) A allele could contribute to their increased risk of developing tuberculosis.
- In addition to SOCS3 expression, IL-10 induces SOCS1 up-regulation in all cell lines tested, including murine Ba/F3 pro-B cells, MC/9 mast cells, M1 leukemia cells, U3A human fibroblasts, and primary mouse CD+ T cells.
- It was impossible to evaluate whether in vitro cytokine production profiles really can be deduced from a particular cytokine gene polymorphism.
- IFN-alpha2b increases the expression of this interleukin in primary activated human CD8+ T cells.
- Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese.
- IL-10 promoter polymorphisms have no significant effect on susceptibility to ankylosing spondylitis, but may play a minor role in determining age of disease onset and disease severity.
- overproduction of IL-10 and attenuated inflammatory response may account for the persistence of Bartonella quintana in homeless people
- relationship between recurrent pregnancy loss and polymorphisms of the genes coding for TNF-alpha (-308 G-->A), IL-10 (-1082 G-->A), IL-6 (-174 G-->C), and IFN-gamma (+874 A-->T)
- In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower.
- STAT3 activation induced by IL-10 in primary human macrophages is affected differentially compared to STAT3 activation by IL-6, by mechanisms that suppress the Jak1/STAT3 pathway, despite the ability of the two cytokines to signal via similar pathways.
- Constitutive levels of IL-10 (mRNA and serum protein) displayed remarkable interindividual variations, which are genetically controlled by polymorphic variants at the cytokine gene promoter.
- p38 MAPK activation is central to IL-10 production of cells from patients with schistosomiasis and the difference in the levels of activated p38 MAPK may explain the difference in the amount of IL-10 produced from intestinal and hepatosplenic patients.
- individuals with interleukin-8-251TT and interleukin-10-819TT, a combination presumably causing mild inflammation, have a higher probability of the continuing Helicobacter pylori infection, especially among current smokers.
- infection with cytomegalovirus was found to elicit the production of CXCL10 from primary microglial cells but not from astrocytes; CXCL10 production was regulated by human and viral interleukin-10
- Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development.
- Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells.
- Endometriosis is associated with with an elevated level of IL-10 in the peritoneal fluid: cells resident in the peritoneum are a major source of IL-10.
- Results describe the time course of human interleukin (hIL)-10 gene expression after transtracheal administration of adenoviral (Ad)hIL-10 and its effect on the early adenoviral proinflammatory cytokine response and on post-transplant lung function.
- reduction in the frequency of GG homozygotes in the octo/nonagenarian age group and a higher serum IL-6 level associated with CC homozygotes with reciprocal changes for the anti-inflammatory cytokine IL-10.
- reduction of IL-10 -1082A/* carriers was found in tuberculosis patients
- Polymorphisms in the IL-10 promoter region do not increase the risk of developing Alzheimer's disease.
- Proinflammatory genotypes of IL-10 was associated with more than doubling of the risk of noncardia gastric cancer.
- enhanced expression in Helicobacter pylori infection of gastric mucosa; significant association with bacteria load, chronic inflammation and activity
- A novel polymorphism is identified affecting the efficiency of protein translocation and signal peptide cleavage resulting in lower levels of IL-10 protein secretion.
- A critical role fis suggested for the immunomodulatory cytokine IL-10 in the orchestration of CpG-ODN-induced responses in B lymphocytes.
- Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.
- Certain specific cytokine genotypes for TGF-beta1, IL-10, and TNF-alpha are not associated with chronic allograft dysfunction.
- In the presence of prolactin, interferon-gamma (IFN-gamma) and interleukin (IL)-12 p70 levels, but not of IL-10 and tumor necrosis factor-alpha (TNF-alpha), increased significantly in whole blood.
- Results suggest that interleukin-10 (IL-10) is a potent inhibitor of lipopolysaccharide-stimulated release of IL-8 and MIP from neutrophils of the newborn via a mechanism not involving nuclear factor-kappa B activity.
- Role in the control of autoimmunity. Review.
- Role in autoimmunity. Review.
- Role in systemic lupus erythematosus. Review.
- IL10 has a role in endothelial cell damage and platelet adhesion
- Data report the location and level of interleukin (IL)-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases.
- elevated IL-10 is a physiological consequence of normal healthy pregnancy
- Immunocytochemical localization in oral mucosa and lymph nodes of patients with paracoccidioidomycosis
- no association between genotype and/or blood level and incidence of kidney transplantation rejection
- results demonstrate a decreased frequency of the -863CC TNF-alpha promoter genotype and an increased frequency of the -1082GG IL-10 promoter genotype in patients recovered from hepatitis C virus infection
- The -2849 IL-10 promoter polymorphism is associated with autoantibody production and subsequent joint damage in RA.
- Production of IL10 was reduced after thew second T-cell vaccination.
- In all three groups of patients significant correlation was seen between abundance of IL-2 vs. IL-4, IL-5, IL-10, or TNF-alpha, between IL-4 vs. IL-10, and between TNF-alpha vs. INF-gamma
- the effect of proteasome inhibition on IL-10 activation of the IL-10E1 pathway
- IL-10 production following whole-blood stimulation is increased in first-degree family members of patients with non-paraneoplastic Lambert-Eaton myasthenic syndrome.
- IL-10 is one of the cytokines up-regulating the GM-CSF expression in non-small cell lung cancer.
- up-regulated to a greater extent in patients with influenza-associated encephalopathy than in those without neurologic complications
- The IL-10 gene -627 "A" allele is an associated risk factor of developing atopic asthma
- A continuous rise of IL-6 and a transient elevation of IL-10 during liver cancer surgery.
- Single Nucleotide Polymorphism in interleukin 10 gene is associated with AIDS progression
- IL-10 inhibited cytokine production and survival of immunostimulatory-sequence-activated plasmacytoid dendritic cells. IL-10 regulated PDC activation but did not inhibit the subsequent T-cell-priming ability of PDCs already activated by ISS.
- possible associations between common serological markers of celiac disease with the -1087 IL10 and -308 TNFA polymorphisms
- IL-10 expression in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway and a possible reduction of deleterious inflammatory effects of cytokine following by using pharmacological agents.
- Bifidobacterium genomic DNA induced secretion of the antiinflammatory interleukin-10 by PBMC and total bacterial DNA from feces collected after probiotic administration modulated the immune response by an increase of interleukin-10.
- IL10 production is regulated by different molecules in AILIM/ICOS- and CD28-costimulated T-cells
- results suggest that in pulmonary alveolar proteinosis, GM-CSF synthesis is deficient and associated with negative regulation by IL-10; IL-10 gene expression is elevated in patients not responding to recombinant GM-CSF therapy
- Autocrine production of IL-4 and IL-10 promotes thyroid tumor cell progression and resistance to chemotherapy through the up-regulation of antiapoptotic proteins.
- a mechanism whereby reduced cytoplasmic levels of AUF1 in MNT1 melanoma cells may lead to IL-10 overexpression, with deleterious consequences for tumor surveillance and rejection
- HLA-G and IL-10 may play roles in the evasion of immunosurveillance in cutaneous lymphomas
- An infant with an unfavorable interleukin 10 (IL-10) genotype may exhibit aberrant IL-10 production, which leads to imbalance in immune response.
- neonates have an immature interleukin-10 and interferon-gamma response as compared with adults
- Levels of CFP32 protein in TB patient lung sputum were positively correlated with levels of IL-10 in the same sputum sample suggesting a role for IL-10 in the pathogenesis of active tuberculosis
- The -627C-->A substitution in the IL-10 promoter represents a silent or neutral variant in subjects with family history of asthma.
- We found significantly reduced frequency of the genotype and haplotype responsible for high production of interleukin-10 in kidney transplanted patients.
- IL10 polymorphisms influence IL10 production and incidence and outcome of diffuse large B-cell lymphoma. Increased serum levels of IL-10 were associated with adverse prognostic factors
- It is suggested that IL-10 is an inhibitory factor for the remodeling of the extracellular matrix during wound healing.
- IL-10 has a role in adaptive immunity [review]
- IL-10 and IFNgamma genotypes do not have a role in predisposition to the development of Hodgkin lymphoma
- Association between IL-10 production and the modified Th2 response coupled with activation of chain 2 of cat allergen Fel d 1 epitope-specific T cells during immunotherapy support a role for IL-10 in tolerance to cat allergen.
- Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women.
- IL-18 is required for facilitating neutrophil-dependent hepatic ischemia/reperfusion injury through suppressing anti-inflammatory cytokine expression (IL-4 and Il-10).
- After CD40-activation, acute lymphocytic leukemia cells released substantial amounts of interleukin-10 (IL-10) but were unable to produce bioactive IL-12.
- IL-10 and IL-6 induce decorin mRNA transcription, but additional signals from the extracellular matrix are necessary for its translation.
- TNF-alpha and IL-10 gene polymorphisms are related to the risk of death among patients with acute renal failure who require dialysis
- There was no relationship between mother and infant IL-10 genotype and spontaneous preterm birth.
- minor role of in risk of autoimmune diabetes
- IL-10 gene promoter polymorphism at position -1082 does not play a dominant role in alcoholic chronic pancreatitis
- Macrophages produce neither IL-23 nor IL-12 but predominantly secrete IL-10.
- IL-10 is related to the intractability of Graves' disease, but not to the severity of Hashimoto's disease.
- Patients homozygous for CC at SNP -33IL4 (low IL-4 producers) and HLA class I mismatched (regardless of matching for class II) are protected from chronic rejection.
- 2849 AA genotype is protective against pre-eclampsia
- In end-stage renal disease on long-term hemodialysis, single nucleotide polymorphisms in promoter of IL-6, TNF-alpha, and IL-10 show strong association with indices of comorbidity and function, and biological and nutritional markers.
- combined production of the immunosuppressants IL-10 and TGF-beta, as well as coexpression of TGF-beta RI and RII (required for cellular response to TGF-beta), may act to down-modulate host anti-Mycobacterium tuberculosis immunity
- effects of mosaics of genetic elements in the promoter on the capacity of leukocytes to produce IL-10 depend on the agent inducing IL-10 expression
- the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with hepatotoxicity susceptibility.
- The association of increased levels of IL-10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease
- promoter variants influence the adaptive immune response
- activated CD4(+) T cells (characterized by a high CD25 expression) might contribute to the tolerogenic immune response toward an antigen, such as cow's milk, through the production of IL-10
- the nt -1082 polymorphism had no influence on the early phase of cervical carcinogenesis but may determine different susceptibilities to cervical abnormalities unrelated to HPV infection
- concetration in children with acute lymphoblbastic leukemia after chemotherapy
- Significantly higher levels were found in soluble egg antigen-stimulated PBMC from schistosomiasis mansoni patients with degree III hepatic fibrosis compared to patients with degree I or II fibrosis, and in patients untreated for 1 year.
- data suggest a possible link between the genotype of the -592 single nucleotide polymorphism and significantly higher mean multiple organ dysfunction scores
- Review article concludes that IL-10 exerts its antipsoriatic activity by immunoregulatory effects on cell populations including antigen-presenting cells and T-helper cells, but not through direct effects on keratinocytes.
- tumor-derived MUC-1 profoundly affects the cytokine repertoire of monocyte-derived DC and switch them into IL-10(high)IL-12(low) regulatory APCs with a limited capacity to trigger protective Th1 responses
- B7-H3 enhances T lymphocyte proliferation and IL-10 secretion when expressed in E. coli in vitro
- the presence of epistasis between MHC with humoral systems, such as IL-10, could be underlying the susceptibility/resistance to Chagas' disease
- In cytokine il-10 a high mutation rate was found when Terena were compared with the general Brazilian population.
- Our results suggest that IL-10 gene G-1082A polymorphism is an important marker of progression in patients with IgA nephropathy and focal segmental glomerulosclerosis.
- No difference in serum level of normal and hemodialysis or peritoneal dialysis patients.
- Only CD4(+) T cells from IL-10(-/-) animals leave Rag mice susceptible to NSAID-induced, Th1 colitis. Lamina propria T cells normally make large quantities of IL-10, suggesting that IL-10 from T cells may be protective.
- Serotype III Group B Streptococci strain stimulated significantly greater interleukin-10 (IL-10) (P < 0.05) production than did serotype VIII strain in A549 epithelial cells
- Fetal membranes can exhibit opposing responses to IL-10, depending on whether inflammatory insult occurs at maternal or fetal face. Inflammatory reactions are negatively regulated by IL-10 in choriodecidua. Pro-inflammatory reactions may promote labor.
- Interleukin-10 promoter polymorphisms is associated with systemic lupus erythematosus
- Haplotypes for IL-10 defined by three SNP positions (-3575, -2849 and -2763) captured significant differences between controls and leprosy patients (P=0.04).
- Polymorphic in pancreatitis.
- After acute brain injury, serum IL-10 in adults is detectable independent of CNS lesion type; its systemic release is strongly individualized; serum IL-10 may have some prognostic value to predict development of infection in patients with CNS lesions
- significant association between the IL-10 -592*A allele and Sudden Infant Death syndrome, consistent with the earlier findings. This study lends support to the hypothesis that IL-10 genotype is related to the susceptibility of babies to SIDS.
- In this study, we determined the ethnic distribution of IL-10 promoter SNPs and their haplotype rates among Hispanics, African Americans, and Caucasians from Texas and Ashkenazi Jews from New York
- chronic active Epstein-Barr virus infection T-cells are activated to transcribe IFN gamma, IL-10, and TGF beta excessively, and the latter two genes are expressed preferentially in the EBV-infected subsets
- MBL significantly augmented IL-10 production after stimulation with LPS- Neisseria meningitidis
- IL-10 is likely more important than transforming growth factor regarding the immunosuppressive properties of septic patients' plasma
- IL-6 and IL-10 polymorphisms act synergistically, with a fivefold decreased risk of AD being found in subjects who concomitantly carry the (-174) IL-6 C/C and the (-1,082) IL-10 A/A genotypes.
- gene polymorphisms of cytokines playing a major regulatory role in the inflammatory response do not affect life expectancy in the Sardinian population.
- IRAK1 is essential for lipopolysaccharide-induced interleukin-10 gene expression
- High production of interleukin 10 thus is protective for acute myocardial infarction and a determinative parameter for longevity
- results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway
- results showed that PKC beta(II) and delta isozymes are essential for the activation of IL-10 production in human monocytes following stimulation by HIV-1 Tat protein
- No association was found between the polymorphisms in IL-10 studied and Graves' disease.
- In monocytes IL-10 has a dual function: to inhibit pro-inflammatory cytokine production and to suppress spontaneous apoptosis.
- IL-10 has an immunosuppressive role in circulating dendritic cells in patients with hepatocellular carcinoma
- IL-10 has roles in atherosclerosis, possibly contributing to plaque stabilization
- neutrophils in UVB-exposed skin express IL-10
- IL-10 enhanced mRNA levels of cell activation/cytotoxicity-related genes and increased the expression of cell migration-related genes in natural killer (NK) cells.
- gene expression regulation induced by interleukin-10 is modified by adherence
- induced by R5 HIV-1 infection of fetal thymic organ culture (FOTC) which in turn induced CCR5 expression
- elevated IL-10 levels are detectable in the saliva of Sjogren's syndrome patients and correlate with the severity of the disease
- Here we demonstrate that the soy isoflavone genistein, a tyrosine kinase inhibitor, rapidly decreased IL-10 secretion followed by upregulation of IFNgamma and inhibition of cell proliferation with pre-dominantly G2 arrest.
- the G/A mutation at position -1082 of IL-10 promoter gene region might be one of the factors participating to the pathogenesis of LADA diabetes
- The increased frequency of the low producer IL-10 haplotype (-1082 /-819 A/T) suggest that the carriage of this haplotype might predispose to pemphigus or the high and intermediate producer haplotypes may be protective factors
- Among host genetic factors contributing to H. pylori disease outcome, IL-10 -819 TT genotype favors intestinal metaplasia and non-cardia gastric cancer.
- interleukin-10 polymorphisms have a role in susceptibility to psoriasis
- IL-10 plays a role in regulating T helper 1-type immune responses in neonates born to mothers with placental falciparum malaria at delivery.
- In the frequency of IL-10 promoter 1082 genotypes consisting of AA, A/G and GG, the allele frequency of G in the SLE patients was significantly higher than that in the healthy controls.
- IL-10-G1082A polymorphism might not be used as a stratification marker to predicate the risk of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma development in North China.
- The results suggest an influence of IL-10 promoter polymorphisms on interferon treatment response in multiple sclerosis.
- predominant presence of high-producing IL-6 alleles together with low-producing IL-10 and IFN-gamma alleles in G6PD-deficient individuals with ancestry from malaria-endemic regions
- IL-10 potentiates CD14-dependent engulfment of apoptotic Burkitt's lymphoma cells and production of B cell survival factor (BAFF)by macrophages in vitro.
- the functional polymorphisms of the IL-10 gene act as a risk factor for AD.
- role of c-Maf in the transcriptional regulation of IL-10 and the underlying molecular mechanism in macrophages
- Results suggest that insufficient interleukin-10 production may contribute to hypogammaglobulinemia in X-linked lymphoproliferative disease.
- This anti-inflammatory cytokine may play important roles in the development of T cell imbalance, cardiovascular disease and wasting in the uremic milieu. (review)
- increased levels in HPV16+ cervical biopsies and increased levels in HIV+/HP16+ biopsies
- IL-10 -592C > A promoter polymorphism may be associated with a reduced breast cancer risk
- iC3b interferes with monocyte-derived dendritic cell differentiation and IL-12 and IL-10 production is mediated via an ERK MAPK-dependent mechanism
- direct implication of IL-10 in humoral hyporesponsiveness, particularly in compartments where the T-B cell interplay determines the subsequent immune response
- S. mansoni and HIV-1 coinfection is associated with decreased Gag-specific CD8+ cytolytic T cell responses and increased number of Gag-specific IL-10 positive CD8+ T cells.
- A study of 54 SNPs and haplotypes in the IL10 region indicate that IL10 and IL19/IL20 may be involved in natural clearance of HCV in the African Americans while no significant associations were detected in European Americans.
- These data are consistent with the theory that IL10 plays a role in the severity of RSV infection in infants.
- The interleukin-10 Gly15Arg mutation is rare in patients with Crohn's diseases, and is not associated with the disease in the Netherlands.
- Allergen-specific T cell lines induced in the presence of salmeterol and fluticasone proprionate inhibited IL-5 and IL-13 production by allergen-specific Th2 cell lines in an IL-10-dependent manner
- autocrine loop between HLA-G5/sHLA-G1 and IL-10 expression in activated PBMCs, which may result in higher IL-10 levels in +14/+14 bp HLA-G genotypes
- PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction
- involvement of IL-10 in TLR tolerance induction seems to be a more general phenomenon as shown by experiments using different toll-like receptor-agonists in IL-10(-/-) macrophages
- levels of IL-12 in patients having complex lesions tended to be higher than in those having simple lesions and levels of IL-10
- a polymorphism in the promoter region of il-10 does not have a role in response to drug therapy in diffuse large B-cell lymphoma [letter]
- No significant associations between five informative IL10 SNPs and severe malaria was identified.
- Levels in circulating dendritic cells after kidney transplantation.
- No differences in haplotype distribution were detected between cases and controls for preterm birth. For SGA carriers of the ATAhaplotype had lower risk
- This Th2 cytokine is possibly involved in the modulation of lung graft transplantation tolerance.
- There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with gastric cancer and peptic ulcer diseases and control group
- Genotype frequencies of interleukin-10 polymorphisms were not found in coeliac disease.
- model of the ternary complex of interleukin-10 with its soluble receptors
- the IL1A and il10 genesw are substantially related to the development of cat exposure-induced allergy
- Both systemic and local effects of IL-10 provide important protection of arteries against inflammatory stimulus. IL-10 decreases iNOS-mediated impairment of vasorelaxation after LPS.
- IL-10 produced locally by intestinal mesenchymal fibroblasts is critically involved in the survival of T cells in the intestinal mucosa
- IL-10-1082G plays an important role in the susceptibility of acute severe pancreatitis patients to septic shock.
- Positive correlation between il-10 levels and whole body insulin action in normal individuals.
- IL-10 polymorphism contribute to susceptibility to Crohn disease in Spanish population.
- IL-10 single nucleotide polymorphisms, including -2849, do not play a major role in the susceptibility of distal interphalangeal osteoarthritis
- B-cell IL-10 functions as an autocrine growth factor in AIDS-associated B-cell lines
- Data show that frequencies of CD4 IL-10 and CD4/CD8 IFNgamma-secreting memory T cells specific for RSV or influenza were not significantly different between young and elderly, but the ratio of IL-10/IFNgamma was significantly reduced in elderly RSV.
- The polymorphisms of IL-10 genes were significantly associated with the occurrence of non-small cell lung cancer
- The IL-10 haplotype - 592C/734G/3367G is associated with increased mortality and organ dysfunction in critically ill patients with pulmonary sepsis.
- The genetic determination of the defense mechanisms in Crohn's disease appears to be not associated with the polymorphism of the interleukin 10.
- IL-10 may induce the abnormally activated T cells to trigger apoptosis via the Fas-FasL pathway
- NF-Y and HMG-I(Y) may play an important role in regulating the IL-10 promoter activity in B cells.
- The novel inhibitory function of apoA-I on DC differentiation and function may facilitate the development of new therapeutic interventions in inflammatory diseases.
- IL-10, but not TNF-alpha, TNF-beta, or IL-6 polymorphisms are associated with lung cancer
- GG homozygosity of the IL-10 promoter -1082 polymorphism is associated with elevated IL-10 levels in apparently healthy subjects, but this cannot account for the IL-10-related specific disease features observed in Sjogren's syndrome.
- The results suggest that IL10 gene -627 polymorphisms are not associated with an increased risk of CHD, but it might assume a role in IL10 gene expression.
- Administration of vitamin D3 to healthy individuals and glucocorticoid resistance asthmatic patients enhanced subsequent responsiveness to dexamethasone for induction of IL-10.
- In comparison with controls, the frequency of -1,082*G alleles was lower in IgA nephropathy and the frequencies of -592*C and -819*C were lower in focal segmental glomerulosclerosis, respectively.
- Changes in IL-10 and inteferon-gamma blood levels in leishmaniasis patients following treatment are reported.
- Interleukin-10 -1082 promoter polymorphism is associated with schizophrenia in a Han Chinese.
- Patients carrying the -592 C allele had a higher risk of diffuse proliferative glomerulonephritis, indicating the genetic influence of the IL-10 gene polymorphism in the renal lesions of lupus nephritis
- Our present study suggests that serum IL-6 and IL-10 levels are related to fever, and the CSF IL-6 level, myoclonic jerks, in SSPE patients in PNG.
- Our study suggests that PE (Preeclampsia)is associated with IL-10-(1082) polymorphism.
- The A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis
- We analyzed single nucleotide polymorphisms (SNP) in the IL-10 gene among 344 HBV carriers and 208 patients with hepatocellular carcinoma (HCC). The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection.
- These findings suggest that IL-10 expression, seen mainly in macrophages, was possibly upregulated with oxLDL, and was inversely correlated with T-lymphocytic function in atherosclerotic coronary intimas.
- This review discusses recent knowledge about the effects of cytokines of the IL-10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory disease.
- Polymorphisms of IL-10 promoter in HBV and HCC patients may be associated with HBV infection and HCC development.
- Antimalarial downregulation of TNFalpha levels in systemic lupus erythematosus is influenced by polymorphisms at IL-10 and TNFalpha promoters. May identify patients likely to benefit from antimalarials.
- Data show strong expression of interleukins (IL)-4, IL-10, and IL-13 in different non-leukocytic cell types, especially in endothelial and epithelial cells in the rat, with strong similarity of expresion in humans.
- IL-10 gene polymorphism could lead to high or low inflammatory process and consequently, to atherosclerosis. IL-10 genotyping can define a high-risk group for atherosclerosis among HD patients.
- Impaired cell-mediated response to C trachomatis is associated with IL-10 genotype in subjects with high IL-10 producing capacity.
- Increased IL-10 and Foxp3 induction in cord blood mononuclear cells of non-atopic compared to atopic mothers, may indicate an increased capacity to respond to microbial stimuli.
- IL-10 polymorphisms are not associated with celiac disease in the Spanish population.
- IL-10 gene promoter polymorphisms significantly influence the mode and sequel of HBeAg seroconversion in patients with chronic HBV infection.
- The IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T SNPs may alter risk for sepsis in ventilated VLBW infants
- Polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance but not with type 2 diabetes in a large sample of Italian Caucasians.
- found relevant markers in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease
- The study suggests that IL-10 genetic polymorphisms may play a specific role(s) in determining diabetic susceptibility, but do not seem to be important in the clinical manifestations of diabetes.
- sIL-2R and IL-6, but not IL-2, IL-4, or IL-10, may have a role in preventing progression of aggressive non-Hodgkin's lymphoma
- IL-10 or TNF-alpha expression variation is not associated with alterations in HCV clearance or ALT levels, but TNF-alpha polymorphisms may be associated with hepatic fibrosis
- This study finds that polymorphism in the 5' upstream regulatory region (5'URR) of the HLA-G gene may also be implicated in differences in IL-10 secretion.
- Microsatellite polymorphism and promoter deleteriously affect outcome in bone marrow transplantation.
- significant correlation of the IL-10 microsatellite polymorphisms with mortality after unrelated stem cell transplantation.
- Lower antibody titer to influenza A virus was observed in elderly individuals, and the seroconversion factor was found to be correlated inversely with IL-10 production and correlated directly with TNF-alpha production.
- 'large' molecular weight molecules, the most important of which appears to be TGFbeta(1), make a significant contribution to immunosuppression by human seminal plasma
- IL-10 promoter gene variants may contribute, but to a minor extent, to disease susceptibility in juvenile type 1 diabetes.
- Antigen-presenting cell (APC)-derived, rather than T-regulatory cell-derived, IL-10 is responsible for B7-H4 induction in APCs.
- No evidence of association of IL-10 polymorphisms with IgA deficiency in the Spanish population.
- Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis. Furthermore, IL-10 G10 allele is more frequent in recurrent disease.
- IL-10 deficiency protects against LPS-induced bronchial hyperreactivity, and is associated with higher nitric oxide synthase, and airway nitrate levels
- The carriers of the -592A allele in the IL-10 promoter have higher risk of persistent HBV infection.
- Asbestos may affect the human immune system through activation of IL-10 expression.
- IL-10 may contribute to the inflammatory process by facilitating monocyte differentiation into TNF-alpha-responsive macrophages in the presence of M-CSF in rheumatoid arthritis.
- T-cell-derived IFN-gamma and IL-10 may be key regulators of production of mucosal antibody to pneumococcal protein antigens in the nasopharynx and may play an important role in local protection against pneumococcal infection in children.
- IL-10 significantly decreased RANKL+ Th1-associated alveolar bone loss and expression of IFN gamma.
- The higher frequency of IL-10 -1082 G allele in preeclamptic patients compared to controls may be considered as a genetic susceptibility factor for the development of PE.
- Serum adiponectin levels are associated with interleukin 10 levels nd may be associated with metabolic syndrome X>
- Data show it is possible that genetic polymorphisms of IL10 promoter region are not associated with both susceptibility of HBV infection and HBV-DNA replication after infected HBV in Chinese Han population.
- during chronic lung allograft rejection there was a significant decline of T(IL-10) cells with concomitant expansion of collagen type V-specific IFN-gammaproducing Th1 cells
- a genetically programmed imbalance between serum levels of tumour necrosis factor and interleukin-10 exists in patients with poly- or dermatomyositis and this imbalance is related to the presence of disease-associated autoantibodies
- Data suggest that RANTES and IL-10 are secreted from mesenteric adipose tissue and creeping fat and that the elevated RANTES secretion from creeping fat in Crohn's disease is caused by steroid treatment.
- intracellular HIV-Tat induces IL-10 transcription by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation
- OX40 ligand (OX40L) completely inhibited the generation of IL-10-producing CD4(+) type 1 regulatory T (Tr1) cells from naive and memory CD4(+) T cells induced by the immunosuppressive drugs dexamethasone and vitamin D3.
- The frequences of IL-10-1082 G-allele and GG high expression genotype increased significantly in cystic fibrosis patients.
- an interleukin 10 promoter polymorphism has a role in gender susceptibility to chronic hepatitis C virus infection
- Balancing selection has played a role in the evolution of polymorphisms in the IL10 promoter region.
- promoter polymorphisms could have an active role in the pathogenesis of gingivitis in Caucasian children
- Intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control.
- The two marker 'A-T' haplotype confers an odds ratio of 2.24 for systemic juvenile idiopathic arthritis suggesting an important role for these cytokines in pathogenesis
- Data show that the gene expression for interleukin-8, IL-10, and IL-1Ra, but not IL-6, is increased in blood leukocytes taken from athletes following 2 hours of intensive cycling and is not influenced by carbohydrate compared with placebo ingestion.
- supernatants from HPV-transformed cell cultures contained IL-10 and TGF- beta1.
- An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations.
- The ratio of IFN-gamma/IL-10 producing cells is the best tool to discriminate between nonrejecting patients and rejecting patients after kidney transplantation.
- We found a 60% increase in risk of intestinal metaplasia (IM) and dysplasia combined (OR 1.62, 95% CI: 1.10-2.38) among the carriers of the IL10-1082 low activity allele.
- expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production
- Expansion of T IL-10 cells during col-V stimulation in vitro involved CTLA-4 on Tregs
- The -592C/A & -819C/T alleles were associated with exclusively early but not exclusively late recurrent spotaneous abortion, where negative association for both was noted. IL-10-592C/A & -819C/T polymorphisms are inherited risk factors of idiopathic RSA.
- The high IL-10 production, due to IL-10(-1082GG) genotype, influences the clinical expression of the HCV infection by increasing susceptibility to develop NHL and might contribute to the indolent form of the disease.
- There is an association between the -2849 AA genotype of IL-10 and a decreased fertility and fecundity in females.
- The early induction of IP-10 and IL-2, as well as the subsequent over-production of IL-6 and lack of IL-10 production, probably contribute to the main immuno-pathological processes involved in lung injury in SARS.
- haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding
- result demonstrated that ACC haplotype of IL-10 gene & FcgammaRIIa R131 polymorphism can be used as marker for genetic susceptibility & severity to systemic lupus erythematosus in Thai population, particularly individuals carrying both specific genotypes
- Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients.
- The -592 C/A promoter polymorphism of the IL-10 gene is associated with susceptibility to giant cell arteritis.
- The T cell costimulatory potential of human umbilical vein endothelial cells is markedly suppressed by IL-10 due to up-regulation of immunoglobulin-like transcripts 3 and 4 (ILT3/ILT4), without involving induction of regulatory T (Treg) cells.
- Interleukin-10 overexpression under control of the constitutive ubiquitin C promoter ameliorates acute rejection and preserves lung graft function for a prolonged time.
- Polymorphisms at -819 and -592 sites in IL10 promoter and their protein production are associated with endometriosis risk.
- Our data indicate that the IL-10 gene polymorphism is a candidate genetic marker to screen for AD.
- results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II-dependent p38 MAPK
- IL10 promoter polymorphism seems to be associated with susceptibility of herpes zoster in Korea
- CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in peripheral blood than peritoneal fluid mononuclear cells of women with endometriosis.
- This study failed to observe a significant difference in the -1082IL-10 single-nucleotide polymorphism between chronic periodontitis patients and controls.
- The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.
- positive specific IgE and IgG are associated with decreased IL-10 level in allergic reaction to penicillins; distributions of genotype and frequency of allele at the -1082 G/A position may be associated with the production of both specific IgE & IgG
- IL-10 is associated with Treg function. Some have suggested that IL-10-secreting Tregs do not express foxp3.
- IL-10 promoter activity was ablated by mutating two nonpolymorphic binding sites for the AP-1 transcription factor, and in primary human T cells, SDF-1 costimulation enhances AP-1 binding to both of these sites
- constitutive expression of IL-10 by lung inflammatory cells is associated with the risk for bronchopulmonary dysplasia.
- No significant association between episodes of acute rejection of kidney transplantation and single nucleotide polymorphisms.
- IL-10 inhibits inflammation-induced endoplasmic reticulum stress response mechanisms by modulating ATF-6 nuclear recruitment to the grp-78 gene promoter
- No significant differences were observed among colorectal cancer patients and controls for IL-10 -1082G/A; -592C/A genotype frequencies.
- although CD4+ CD25+ T regulatory cells induced by IL-10 seem to contribute to aspects of sepsis-induced lymphoid immune suppression, the oblation of CD25+ cells does not provide a survival advantage or disadvantage
- High adiponectin levels and a relationship between adiponectin/IL-10 in newly diagnosed non-hodgkin;s lymphoma patients suggests a role for both in the immunodysregulation in ghis cancer.
- the risk of respiratory distress syndrome is significantly lower in preterm infants with an IL-10 -1082 GG/GA genotype than in those with an AA genotype [odds ratio (OR) = 0.48
- results provide evidence that IL-10 -1082(AA) genotype is associated with resistance to develop invasive pulmonary aspergillosis (IPA); allele frequency of IL-10 -1082A allele was weakly associated with susceptibility to develop IPA infection
- Cells from First Nation subjects had a reduced production of IL-10 in response to HCV core protein, suggesting that reduced susceptibility of FN immunity to virally induced IL-10 synthesis might contribute to enhanced HCV clearance.
- polymorphisms of interleukin-10 and its receptor have roles in lung function in COPD
- polymorphism at position -597 seems to be associated with severe generalized chronic periodontitis
- The polymorphism of IL-10 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.
- Data showed that the frequencies of IL-10 (A-1082) alleles are more than 0.95 and the haplotype frequency of the high-producer-type GCC in IL-10 gene is 0.05.
- Chronic morphine treatment diromg demdritic cell development from monocytes decreased il-10 secretion.
- the IL-10 haplotype and genotype associated with high IL-10 production may alter the susceptibility to systemic sclerosis
- implicate Interleukin-10-producing CD25(-)Foxp3(-) T cells in the pathogenesis of human visceral leishmaniasis
- IL-10 can regulate thrombin generation and endogenous IL-10 regulates TF expression and release of active TF-bound microparticles by a negative feed back loop through IL-10 receptor alpha.
- Results suggest that in the Chinese Han population, the polymorphism at position -1082 in the promoter region of IL10 gene may be associated with the serum HDL-C level and TG level.
- the ATA haplotype was identified as a favourable prognostic factor for T-cell non-Hodgkin lymphoma compared to non-ATA haplotype (P = 0.037, hazard ratio 2.1); IL10 polymorphism may affect the survival of T-cell non-Hodgkin lymphoma patients
- Up to 1% of PBMC constitutively produce IL-10; determined the surface phenotype of circulating PBMC constitutively producing IL-10
- findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in Kawasaki disease
- Our results indicate that IL10 polymorphisms may be involved in the risk of developing AD.
- balance between TNFalpha and IL-10 seems to determine the occurrence of post-operative complications
- analyzed candidate genes related to TNFalpha regulation and found that interleukin (IL)-10, interferon-gamma receptor 1 (IFNGR1), and TNFalpha receptor 1 (TNFR1) genes were linked and associated to both tuberculosis and TNFalpha
- IL10 [TCATA] haplotype, identified by the presence of the IL10 -592A-allele, may exert a protective effect against retinal artery occlusion
- interleukin-10 gene promoter single nucleotide polymorphisms have roles in developing coronary and cerebrovascular events
- Intermittent hypoxia increases IL-10, improving aerobic fitness and minimizing the risk of thromboimflammation.
- when exposed to inflammatory or microbial signals, M-CSF-conditioned DC precursors can participate in the modulation of inflammation and immune response by rapid release of IL-10.
- HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer
- In Hodgkin's lymphoma Carriers of the IL-10-592AA genotypes had a significantly lower probability of freedom from treatment failure
- Some cytokine gene alleles reflecte stable graft function among kidney transplant recipients.
- Interleukin-6 (IL-6) was expressed in monocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T cells from patients with active disease.
- interleukin-10 expression by tumour-associated macrophages, but not by tumour cells, may play a role in the progression and prognosis of nonsmall cell lung cancer
- Higher levels of IL-10, IL-8 and TNF-alpha were found in fibromyalgia patients than in controls.
- Heterozygocity for the gene polymorphisms did not occur more often in preeclamptic women compared with controls (TNF-alpha: 29.0% versus 24.3%, p>0.05; IL-6: 46.7% versus 51.4%, p>0.05; or IL-10: 49.5% in each).
- These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease.
- Il-10 is produced by memory CD45RA- CD8+ T cells during development of infections with Leishmania guyanensis.
- Findings suggest that individuals higher in trait positive emotional style show decreased in vitro production of the early inflammatory mediators interleukin-10 in response to stimulation with endotoxin.
- The results suggest a potential implication of IL-10 -1082 promoter polymorphism in susceptibility to giant cell arteritis in Northwestern Spain.
- The study shows for the first time an association between IL10 gene promoter polymorphism and its haplotype may contribute to genetic susceptibility to nasopharyngeal carcinoma in a Chinese population.
- The IL-10 G-1082A and CYP3A5()3 polymorphisms may influence the interindividual variability of tacrolimus pharmacokinetics in Chinese liver transplant patients.
- ATA haplotype carriage appears to increase the susceptibility to melanoma. This is not a significant prognostic factor in localized melanoma, but in advanced disease, it implies longer survival.
- There was no evidence of a statistically significant association in the allelic distribution of IL4, IL10, IL16 and TNF polymorphism that were tested,nor in the haplotype frequencies in patietns with CD.
- The -1082A allele of the IL-10 gene may be important in increasing susceptibility in both the newly-diagnosed and recurrent pulmonary tuberculosis groups.
- In patients with ST-segment elevation acute myocardial infarction, the serum IL-10 level is a major independent predictor of 30-day mortality and should be used for early risk stratification following acute myocardial infarction.
- IL-10 was elevated in colostrum of mothers of neonates with jaundice.
- Results describe a contact-dependent mechanism by which mesenchymal stem cells modulate IL-10 and TGF-beta gene expression in T cells.
- Predisposition to rheumatic heart disease is influenced by cytokine gene polymorphisms esp. composite polymorphism (TNF-alpha(-308 )A/A and IL-10(-1082) A/A) and (TNF-alpha(-308 )A/A and IL-10(-1082) G/G).
- There was no association between IL-10 and CD14 polymorphisms and myocardial infarction occurrence
- The GG genotype of the IL-10-1082 A>G SNP was inversely associated with antibody response to tetanus vaccine.
- polymorphisms are unlikely to influence colorectal adenoma recurrence and cannot be used to identify individuals who derive benefit from aspirin interventio
- Serum IL10 levels correlated with inflammatory proteins, but not with adiponectin. IL10 positively associated with adiponectin especially in the subjects with MetS. IL10 might be involved in the inflammatory network of MetS in relation to adiponectin
- These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.
- IL-6 and IL-10 genotypes may be useful in predicting disease severity in autoantibody-positive and autoantibody-negative rheumatoid arthritis patients, respectively.
- The levels of intralesional expression of mRNA of tumor necrosis factor-alpha, interferon, interleukin-10, RANTES, and indoleamine-2,3-dioxygenase in Mediterranean spotted fever are reported; levels of inducible nitric oxide synthase are also reported.
- IL10 polymorphisms influence the clearance of infection with high-risk HPV types.
- IL-10 gene polymorphisms were not related to oral lichen planus development.
- Results revealed that TNF-alpha could increase cholesterol content by down-regulating ABCA1 expression, IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression.
- IL-10 reflects a proinflammatory state in patients with ACS and therefore suggests that IL-10 is as effective a biomarker for the risk prediction of future cardiovascular events as other markers of systemic inflammation.
- IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency.
- Polymorphisms in two key anti-inflammatory cytokines, IL-10 and TGF-beta, are associated with susceptibility to EBV-associated posttransplant lymphoproliferative disorder.
- molecular evidence presented that the differential apoptotic cell-induced IL-10 gene expression in individuals with the GCC or ATA promoter haplotypes is determined at the level of transcription mediated by PARP-1
- IL-10 concentration was associated with an increased risk for future cardiovascular events in post-menopausal women with established coronary atherosclerosis
- -1082 and -819 polymorphisms not associated with psoriasis in Korean population
- IL-10 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan.
- septic plasma permanently suppressed the production of IL-6 and IL-10 in stimulated whole blood.
- -819 T allele may increase risk of gastritis and lymphoid follicle formation
- Overexpression of interleukin-10 in sentinel lymph node is associated with breast cancer
- Our data suggest that P. brasiliensis induces regulatory DCs in susceptible mice, which promotes IL-10 production and contributes to the susceptibility of mice to P. brasiliensis infection.
- TCR-stimulated interleukin-10 synthesis may play an important role in HSV pathogenesis.
- first evidence that variation in the IL10 gene that promotes high IL-10 responses is associated with reduced risk for atopic reactivity in children living in Africa
- IL-10 gene G-1082A polymorphism is not a major risk factors in renal transplantation
- Has a general role in activating monocytic scavenger functions, which are at least partly mediated by CD14.
- role of CYP3A5, MDR1 and IL-10 genetic polymorphisms in the variability of tacrolimus population pharmacokinetic parameters
- IL-10 gene polymorphisms and erythropoetin dose requirements in chronic haemodialysis patients
- This is the first report of a significant increase of plasma IL-10 levels in Pb-exposed workers.
- study shows the IL-10-1082 'A' allele is associated with abdominal aortic aneurysms (AAA), although this association is likely to be secondary to an association between IL-10-1082 genotype & other markers of cardiovascular disease rather than AAA per se
- The IL10-1082 A/A genotype contributed to protection from the recurrence of acute otitis media after pneumococcal vaccination
- Expression of IL-10 in lung macrophages stimulated by LPS depends on concomitant activation of MAP kinases, which control downstream signalling to Sp-1 transcription factor. Sp-1 is a key signalling pathway for IL-10 expression in lung.
- Plasma IL-10 levels were associated with the presence of anti-AChR antibody and response to treatment suggesting a critical role for IL-10 in juvenile myasthenia gravis pathogenesis.
- Cereal grains have strong innate immunomodulatory effects by inducing marked production of IL-10 from CD14+ monocytes in vitro.
- IL10 polymorphism is not a risk factor of sporadic Parkinson disease in a Polish population.
- there is an association between SNPs in the promoter of the human IL-10 gene and susceptibility to rheumatoid arthritis
- IL -10 (-1082 G/A) and IL -12B 3'UTR (Taq I) (A/C) gene polymorphisms were not associated either with susceptibility or resistance to pulmonary tuberculosis in the south Indian population.
- results show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria
- These findings provide a plausible functional explanation for the observed genetic association, and support the hypothesis that an excessive IL10 response to C. trachomatis infection is a risk factor for scarring and blindness.
- Candida-specific T cell IL-10 (interleukin -10) production was markedly higher in chronic mucocutaneous candidiasis patients
- production of TGF-beta1 within the BM microenvironment of chronic idiopathic neutropenia patients results in downregulation of IL-10 and reduction of myeloid progenitor cells
- IL-10 (-1082, -819, -592) GCC/ATA haplotype seems to be a potential risk factor for breast cancer. The IL-10ACC/ATA haplotype may be protective.
- the polymorphic nucleotide A at position -1082 of the IL-10 gene is not associated with generalized aggressive periodontitis in the Iranian population
- Single nucleotide polymorphisms in the IL10 gene, notably those associated with high IL-10 production, may play a role in the susceptibility to Epstein-Barr virus-positive Hodgkin lymphoma development.
- IL-10 gene plays an important role in the development of oral cancer
- study did not support an important role of the proximal IL-10-1082, IL-10-819, IL-10-592 polymorphisms in increased risk of developing follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma
- the IL10 -819 TT and -592 AA low expression genotypes are associated with increased risk of prostate cancer and with high-grade disease in this population
- IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio
- IL-2 selectively enhanced production of IL-10 in HOZOT primarily through activation of STAT5, which synergistically acts with NF-kappaB/NFAT activation, implying a novel regulatory mechanism of IL-10 production in Treg cells.
- Lymphoma patients with the IL-10-(3575T>A) genotype had a better overall survival. atients with the IL10(-1082GG) genotype had a better median overall survival
- interleukin 10 (IL-10) and interferon gamma (IF-gamma) in serum do not appear to play a role in thyroid eye disease
- production of human interleukin-10 (IL-10) and IL-4 partially contributed to HSV-1-induced KSHV replication.
- Canges in IL-10 expression may serve as an immunologic-based surrogate for predicting outcome for stage IV patients after surgical resection.
- CF airway PMNs released spontaneously high level of IL-8 that was neither further enhanced by microbial activators nor inhibited by recombinant human IL-10.
- These findings demonstrate that LMP1 uses both p38 and PI3K activation for maximal up-regulation of IL-10.
- acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4
- study indicates that the Interleukin-10 gene may play a significant role in the etiology of vitiligo among Saudis
- 1082 G/A alleles or haplotypes containing these alleles may play a role in tuberculosis (TB) susceptibility and increase the risk of developing TB.
- Il-10 levels were assessed in chronic liver diseases as possible marker to assess severity of disease/response to treatment.
- This study supports immune activation as a driving force in HIV pathogenesis and indicates a protective role of IL-10 -1082G that should be evaluated in other cohorts.
- the -2763A allele and the extended AAGC haplotype can be used as a genetic marker for susceptibility to late-onset psoriasis in a Thai population.
- Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.
- We found that carriers of the high-Interleukin-10-producing-GCC haplotype had significantly higher risk of colonization with Pseudomonas aeruginosa
- Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia
- CD4(+) T cells are the most frequent producers of IL-10 in human filarial infections , many of which are skewed toward a type 2 phenotype and most of which are not CD25(+).
- high IL-10-expressing haplotype of IL-10 promoter may be a risk factor for photocarcinogenesis
- changes in IL-10 production observed due to the -571 genotype depend on both cell type and stimulus.
- Regulatory function is impaired in patients with multiple sclerosis.
- IL-10 (-1082) AA homozygosity and IL-10 ACC genotype were found to be associated with unfavourable prognosis in patients with non-Hodgkin's lymphoma.
- Preinduction thoracic epidural anesthesia reduced serum IL-10. Preinduction with glucocorticoid and thoracic epidural anesthesia+steroids increased serum IL-10.
- Exposure of human monocyte-derived dendritic cells (DC) to cell culture-grown HCV genotype 1a or 2a significantly inhibited DC maturation and was associated with the production of IL-10.
- IL-10 gene polymorphism of PCOS patients has no effect on inflammatory markers, metabolic parameters (fasting insulin, fasting glucose, HOMA-IR), carotid intimae media thickness and Ferriman- Gallwey scoring
- Melanoma patients with a low-producing IL-10 polymorphism appear to have a wors prognosis after melanoma vaccination.
- The haplotype ATA, which is known as a 'low interleukin-10 producer' is a putative risk indicator for generalized aggressive periodontitis.
- An altered pattern of IL-10 release was observed in trauma patients treated with catecholamines.
- regulation of PPAR gamma by Enterococcus faecalis results in elevated DNA binding and transcriptional activation of downstream target genes, including IL-10
- The risk of progression and chronic course of viral hepatitides in Caucasian population was associated with alleles of promoter regions -330G and -592A in the IL-2 and IL-10 genes
- IL-10 -1082 genotype may be a risk marker for development of acute respiratory failure after trauma.
- IL-10 silenced dendritic cells produce more IL-12 and also generate a better cytolytic T cell response against the human melanoma associated epitope, MART-1(27-35), in vitro.
- in an animal model of diet-induced fatty liver disease, the inhibition of IL-10 promotes the increased expression of inflammatory cytokines, the worsening of insulin signaling and the activation of gluconeogenic and lipidogenic pathways.
- Il-10 was a primary predictor for overall stages of oral squamous cell carcinoma
- There is a trend to increase in TNF alfa and IL-10 values in Alzheimer's disease.
- Set-association analysis did not reveal an independent or an interactive effect of IL-10 on the PD risk.
- Studies of passive systemic anaphylaxis in IL-10-transgenic mice show that IL-10 overexpression reduces the immunoglobulin E (IgE)-mediated anaphylactic response.
- Subjects carrying both the aromatase (5 -UTR) GG and the IL-10 (-1082) GG genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR = 0.17, 95% CI = 0.04-0.77, P = 0.02).
- The distribution of IL-10 and TNF-alpha genotype did not differ among patients with or without access failure.
- Higher FoxP3 expression at diagnosis predicted worse future glycemic control while higher mean numbers of IL-10 cells were associated with better future glucose control.
- No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls
- investigation of possible association between single nucleotide polymorphisms in IL-10 & IFN-gamma genes with nasopharyngeal carcinoma; no association was found either for each SNP studied alone or for combined analysis for IL-10 & IFN-gamma SNPs
- expression in chronic periodontitis lesions is associated with a distinct genotype
- These results demonstrate that Siglec-9 enhances the production of the anti-inflammatory cytokine IL-10 in macrophages.
- IL-10 may play a key role in maintenance of Tregs and explains the immunosuppressive state of cervical cancer patients.
- the expression of IL-10 in normal pancreas tissues and pancreatic carcinoma
- IL-6 and TNF-alpha, and the level of an anti-inflammatory cytokine IL-10, but not their gene polymorphisms, provide novel and important prognostic information in patients with ADHF.
- A new mechanism of dsRNA signaling pathway that triggers the expression of IL-10, which acts as an autocrine growth factor in BL cells.
- P-selectin-PSGL-1-induces TF and IL8 expression through Lyn phosphorylation, and part of the inhibitory effect of IL10 depends on reduced phosphorylation
- study suggests polymorphisms of IL10, TNFalpha & TGFbeta1 do not have major independent role in acute rejection (AR)& hepatitis B virus(HBV)recurrence after liver transplantation & may not be risk factors of AR & HBV recurrence after liver transplantatio
- IL-10 -1082 G/A polymorphism is not a genetic marker for identifying women at increased risk of common pregnancy complications.
- Findings suggest that the high expression G allele of the -1082A/G polymorphism of the inflammation and angiogenesis-related IL-10 is strongly associated with increased risk for oral cancer.
- HCV-specific IL-10 Tr1 responses may play a dual role in HCV infection, dampening effector T-cells to promote viral persistence in acute infection but also protecting against progressive fibrosis in chronic infection.
- Although IL-10 production by regulatory T cells is not required for the control of systemic autoimmunity in Foxp3 transgenic mice, it is essential for keeping immune responses in check at environmental interfaces such as the colon and lungs.
- the concentration of cerebrospinal IL-10 and TNF-alpha was below the sensitivity of the measurements in cervical spondylotic myelopathy
- High levels of IL-1beta, IL-10, IL-17 and TNF-alpha (in the serum and synovial fluid) were observed in arthritis compared to the healthy controls.
- data suggest that the IL-10 promoter haplotype that produces higher levels of cytokine is associated with systemic lupus erythematosus in patients from Canary Islands
- In this review IL-10 is a regulatory cytokine with a pleiotropic role in the immune system, operating primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens.
- The interleukin-10 promoter gene polymorphism was found not to be associated with acute graft-versus-host disease in patients after an allogeneic peripheral blood stem cell transplant.
- Though not significant, IL10 -1082guanine/adenine single nucleotide polymorphism presents a trend towards protection from tuberculosis (TB) when only studies with pulmonary TB patients are considered.
- an important role for IL-10 in skin lesions in humans infected with L. braziliensis, and identify circulating monocytes and Tregs as principal sources of IL-10 in these patients.
- IL-27 activates monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
- Foxp3 mRNA as well as Foxp3 protein was detected in all tumor cell lines, correlating with the expression levels of IL-10 and TGFb1
- The -592C>A IL10 polymorphism is not related to the risk of ALC. Nevertheless, our study shows that alcoholism is associated with an excess of allele A carriers in alcoholic patients.
- This study suggests that the genotypes related with a low production of IL-10 may be associated with the occurrence of toxoplasmic retinochoroiditis.
- findings suggest that dust mite allergen levels modify the effect of IL10 SNPs on allergy and asthma exacerbations
- genotype contributes to the progression of periodontal disease
- Results describe the association of haplotypes of interleukin-10 gene with the risk of cancer.
- results suggest that IL10 and IL20 gene variants influence hepatitis B virus infection outcome
- in diffuse large B-cell lymphoma patients, pretreatment elevated levels of IL-10 (interleuking 10) were associated with worse survival and more adverse disease
- IL-10, IL-4 and TNF-alpha genetic polymorphisms were not related to the risk of developing drug induced liver injury
- TGF-beta suppressed iNKT cell activation and proliferation and IFN-gamma production while IL-10 was identified as a cytokine involved in stimulating the activation and expansion of iNKT cells that could subsequently suppress NK cell and T cell responses.
- data indicate that cysteinyl leukotriene-induced activation of human monocytes and dendritic cells may be specifically inhibited by IL-10, suggesting a direct link between the 5-lipoxygenase proinflammatory pathway and IL-10 regulatory mechanisms
- IL10 -1082 G/A allele frequency in systemic sclerosis (SSc) patients was higher than that in control and significant association was found between SSc and -1082 G/A
- Production of both TNFalpha and IL-10 in COPD lung tissue following exposure to bacterial LPS may have important biological implications for both episodes of exacerbation, disease progression and amelioration.
- the IL10 -3575/-1082/-592 TAC haplotype, part of the extended ancient haplotype IL10.2, was highly significantly associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosis
- According to the results higher frequency of C alleles at positions -592 and -819 of IL-10 in patients may be considered as genetic factors for susceptibility to brucellosis
- IL-10(-1082(G-->A)) G/G genotype may be contributing factor in susceptibility as well as in severity of asthma among Egyptian children
- serum IL-10 is useful to predict treatment response to IFN-beta particularly in combination with a panel of other IFN-beta dependent parameters.
- Data describe the role of PKC-delta and p38 MAP kinase in HIV-1 Tat protein-induced IL-10 production by an alternative TNF-alpha-independent pathway in monocytes.
- findings suggest that selective induction of IL-10 in uninfected individuals and especially in HIV-monoinfected individuals plays a role in establishing chronic hepatitis C virus infection
- IL-10 gene variations could be associated to the clinical course of aggressive non-hodgkin's lymphoma.
- Travelers from the US genetically predisposed to produce high levels of IL-10 were more likely to experience symptomatic ETEC travelers diarrhea.
- IL-10 is associated with protection against central liver fibrosis in Schistosomiasis japonica, because of its anti-inflammatory and antifibrosis effects.
- IL-10 could be one of the factors participating in the regulation of trophoblast invasion during gestational process.
- IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.
- no associations of IL-10 promoter polymorphisms with the susceptibility to Sjogrens syndrome were found;production of IgA anti-alpha-fodrin antibodies is associated with polymorphisms within the IL-10 promoter region
- Among non-Hispanic Caucasian patients treated with peginterferon and ribavirin after failing previous treatment with interferon, homozygosity for the ACC IL10 promoter diplotype was associated with sustained virological response.
- Results point to possible tumour promoting role of IL-8 and potential protective role of IL-10 in sporadic colon cancer.
- The frequency of homozygotic infants for IL10 haplotypes in SIDS was higher than the control groups.
- The IL-10 genotype may balance the effects of inflammatory cytokines on the myocardium and may be a determinant of left ventricular function in hemodialysis patients
- No association was detected between the TGFB1, IL10, TP53, and HMOX1 genes and DGF. The G allele of the TNF polymorphism rs3093662 was associated with DGF in an adjusted analysis.
- recombinant activated protein C-mediated up-regulation of IL-10 reduces tissue factor in circulating monocytes
- Heme oxygenase-1 expression decreased LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha at both 4 and 24 h in murine and human macrophages
- Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide.
- results demonstrated that the production of IL-10 from PBMC depended on both -1082A*G in IL10 and +16974A*C in IL12B polymorphisms
- findings would support the concept of contribution of TNF-alpha and IL-10 gene polymorphisms in the pathogenesis of pre-eclampsia in this Iranian population
- Single nucleotide polymorphism in IL-10 promoter lower levels of TIMP-3 and osteoprotegerin expression with periodontal disease.
- IL10 levels were significantly higher in remitting clinically isolated syndromes and in relapsing remitting multiple sclerosis patients than in secondary progressive MS patients and controls.
- Significantly lower plasma levels of both sHLA-G and IL-10 were found in psoriatic group compared to controls; findings could indicate that low sHLA-G levels may contribute to susceptibility to psoriasis.
- Clear relationship between IL-10, human papilloma virus and stage of cervical cancer diseasem which could contribute to the immunosuppressive micro-environment in the tumor site.
- These findings strongly suggest that defective IL10 function is central to the pathogenesis of the ulcerative colitis subtype of inflammatory bowel disease.
- Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells.
- Fluvastatin therapy might lead to an increase in plasma IL-10 levels in patients with chronic heart failure.
- mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta.
- Finds lack of association between functional polymorphisms in IL-10 at positions -1,082, -819 and -592 and silicosis and pulmonary tuberculosis in Chinese iron miners
- study provides evidence that IL-10 release requires stronger triggering of TLR4 than TNF release; lower number of responsive TLR4 receptors on monocytes of heterozygous carriers of Asp(299)Gly polymorphism may explain why only IL-10 release is affected
- common IL-10 promoter haplotypes condition susceptibility to severe malarial anemia and functional changes in circulating IL-10, TNF-alpha, and IL-12 levels in children with falciparum malaria
- Children with the higher IL-10/IL-5 ratios appeared to have lower risks for virtually all of the four categories of respiratory infections in each of the five 1-year periods spanning the study.
- Results suggest that rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals.
- HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells.
- role of IL10 in immune responses and in Hodgkin lymphoma
- IL-10 overexpression modulates some catabolic features of TNF-alpha in chondrocytes
- IL-10 gene G-1082A polymorphism was associated with an increased recurrence rate.
- The present study suggests that Chlamydia pneumoniae may modulate the expression of IL-6 and IL-10 by human gingival fibroblasts.
- These results suggest that the inhibitory effect of cAMP on IL-10 production by normal peripheral T lymphocytes is cell type and stimulus specific, exerted on multiple levels and involves MEF2 transcription factor.
- interplay of sex hormones and IL-10-819C/T polymorphism may lead to the susceptibility of gallstone-mediated gallbladder carcinogenesis.
- in patients with ovarian cancer, IL-10 levels correlate statistically significantly with the tumor grade, with lower IL-10 levels observed in well-differentiated and higher IL-10 levels in undifferentiated or only poorly differentiated tumors
- Dtaa show that the cytokine profile of neonatal toxic shock syndrome-like exanthematous disease (NTED), with its high IL-10 level, is clearly different from that of the other bacterial infections.
- we have found modest differences in genotype distribution for two functionally significant polymorphisms, IL-6 +174 and IL-10 -592, between patients with decompensated ALD and heavy-drinking controls.
- The present study established increased risk for major depressive disorder related to the IL10 haplotype
- Cervical mRNA expression of IFN-gamma, IL-10, as well as the Treg transcription factor Forkhead box P3 showed diminished IL-10 expression.
- The IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
- IL-10 has a profound effect on myeloid differentiation-2 (MD-2) and CD14 mRNA and protein levels in monocytes; IL-10 may be a driving force for increased release of MD-2 and CD14 during systemic inflammation.
- Interleukin-10 (IL-10) -592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis and lower levels of highly-sensitive C-reactive protein.
- S100A8 and S100A9 were induced in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic and was IL-10 dependent