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Validated All-in-One™ qPCR Primer for CXCR1(NM_000634.2) Search again
Product ID:
HQP009679
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Gene Description:
C-X-C motif chemokine receptor 1
Target Gene Accession:
NM_000634.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq].
Gene References into function
- Data show that CXCR1 is expressed in neutrophils in inflamed human stomach and gut tissues.
- Identification of a signal transduction switch in this receptor
- Phagocytosing neutrophils down-regulate its expression
- CXCR1 and CXCR2 internalization and recycling are tightly regulated by receptor domains and by actin-related kinases.
- Level of expression of the adhesion molecule/complement receptor CD11b/CD18 and the chemokine receptor IL-8 receptor-A was also higher after vaginal delivery.
- Neutrophil recruitment to inflammatory sites is mediated by two related receptors: CXCR1 and CXCR2. Both receptors share two ligands, interleukin-8 (CXCL8) and GCP-2 (CXCL6).
- The specific distribution and regulation of chemokine receptors CXCR1, CXCR4, CCR5, and CCR2b in endometrial epithelium and blastocyst suggest a role for these receptors in the apposition and adhesion phases of human implantation.
- Subjects with atopic disease are found to have higher numbers of CXCR1+CD4+ T cells in peripheral blood and in T cell populations expanded from nasal mucosa tissue.
- the data suggest that constitutive expression of CXCR1 and CXCR2 play an important role regulating the IL-8-mediated metastatic phenotype in human malignant melanoma cells.
- neutrophil migration in response to CXCR1 or CXCR2 agonists is not dependent on endocytosis of CXCR1 or CXCR2
- Role of N-terminal domain in ligand selectivity and affinity of chemokine receptor CXCR1
- extra- and intracellular CXCR1 and CXCR2 are differentially expressed and regulated on T lymphocytes and mast cells
- CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation.
- IL-8 and CXCR1 participate in the altered megakarocyte growth that features myeloid metaplasia with myelofibrosis
- Activation of neutrophils and down-regulation of CXCR1 were predominantly caused by IL-8
- CD38 is stimulated by sequential activation of IL8 receptor, IP(3)-mediated Ca(2+) rise, and cGMP/protein kinase G and plays an essential role in IL8-induced migration of LAK cells
- CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway
- In eutopic endometrium of women with endometriosis, significant increase in both proliferative and secretory phases for epithelial CXCR2 expression, and in proliferative phase for CXCR1 expression. May be involved in pathogenesis of endometriosis.
- Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling.
- The expression of CXC chemokine receptor 1 mRNA was significantly more increased than in controls.
- the relative expression levels of CXCR-1 and -2 mRNA were rather lower than expected in the affected esophageal mucosa of patients with reflux esophagitis
- Proliferating NK cells were simultaneously positive for CXCR1 in all aggressive NK cell leukemia patients examined.
- CXCR1-CXCR2 heterodimers are as likely to form in cells co-expressing these two chemokine receptors as the corresponding homodimers.
- Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy.
- the complete coding region of the CXCR1 gene in worldwide human populations and five representative nonhuman primate species; results indicate accelerated protein evolution in the human lineage
- In CXCR1-expressing cells FAK phosphorylation was adhesion-independent.Overall, several aspects of CXCL8-induced FAK phosphorylation and migration are regulated in a receptor-specific manner.
- Intrinsic abnormalities concerning IL-8 and its receptor system may be present in eutopic endometrium of women affected by adenomyosis. IL-8 receptors may be involved in pathogenesis and/or pathophysiology of adenomyosis.
- CXCR-1 and CXCR-2 chemokine receptors of synovial fluid neutrophils may have diverse functions in the course of inflammatory arthritides
- No association is found for chemokine (C-X-C motif) receptor 1 (CXCR1) single nucleotide polymorphisms in patients with increased susceptibility to bronchiectasis.
- no association of polymorphisms with melanoma susceptibility
- data herein indicate that the second extracellular loop (2ECL) of the receptors CXCR1,CXCR2, and CXCL8 is critical for the distinct rate of internalization of each
- An interaction between this cytokine and glial cells may help explain the pathophysiological mechanisms leading to cognitive impairment in our study group.
- Mesenchymal stem cells express chemokine receptor CXCR1 and migrate upon stimulation with IL-8.
- A haplotype of the human CXCR1 gene is protective against rapid disease progression in HIV-1+ patients, probably acting through modulation of CD4 and CXCR4 expression.
- RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms do not have a role in progression of hepatitis B virus infection
- Findings indicate that beta-endorphin and Met-enkephalin are contained in primary granules of PMN, and that CXCR1/2 ligands induce p38-dependent translocation and release of these opioid peptides to inhibit inflammatory pain.
- The development of a model for the structure of the IL-8/CXCL8 receptor CXCR1, using a combination of homology modeling and a molecular dynamics simulation was pesented.
- Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites
- Cyr61 promotes interleukin-8-dependent chemotaxis, transendothelial migration, and intravasation by induction of CXCR1/CXCR2 through integrin alphavbeta3/Src/PI3K/Akt-dependent pathway.
- CXCR1 cleavage on neutrophils disables bacterial killing in cystic fibrosis lung disease
- Data show that CXCL8 stimulation leads to paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors (CXCR1 and CXCR2) mediate CXCL8-induced paxillin phosphorylation.