|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for IGF1(NM_000618.4) Search again
Product ID:
HQP009518
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
IGF, IGF-I, IGFI, MGF
Gene Description:
insulin like growth factor 1
Target Gene Accession:
NM_000618.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Gene References into function
- IGF-1 and IGF-1 receptor may be involved in the pathogenesis of Graves' disease; IGF-1 and IGF-1 receptor act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells.
- transcription is regulated by the PAX3-FKHR oncoprotein
- Hypothyroidism is associated with significant reductions of IGF-1
- induces Pin1 expression in promoting cell cycle S-phase entry
- IGF-I level was significantly lower in the CDGP (constitutional delay of growth and puberty)group
- Protein kinase C-dependent, CCAAT/enhancer-binding protein beta--mediates expression of IGF-I
- Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture.
- lower IFG-I concentrations correlate with higher bone resorption markers values and decreased mineralisation
- Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells.
- role for IGF-I in the regulation of the MDM2/p53/p21 signaling pathway during DNA damage
- Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression.
- study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention
- IGF-I may promote granulocyte functions by increasing granulocyte longevity
- assess the levels of IGF1 during pregnancy and to determine whether or not low concentrations are associated with fetal untrauterine growth retardation
- The insulin-like growth factor-I gene cytosine-adenine polymorphism relates with circulating insulin-like growth factor-I levels and bone mineral density at the lumbar spine and proximal femur.
- IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.
- is essential for normal growth and mutations are associated with extreme growth retardation in mice and humans and the relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question
- Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease.
- Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly.
- plays an important role in the genetic and perhaps nutritional determination of adult stature in humans
- In demonstrating transduction of fascin spike assembly by activation of a peptide growth factor receptor, these novel data reveal a wide role for fascin spikes in cell motility
- Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke
- RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.
- Extravillous cytotrophoblast differentiation requires at least two distinct steps: a column forms as a result of attachment to extracellular matrix, then IGF-I from placental mesenchymal cells stimulates progression to a fully migratory phenotype.
- IGF-1 inscribes a gene expression profile relevant to cancer progression
- cDNA probes were used to analyze the gene expression of IGF-I in luteinized granulosa cells from different-sized follicles after ovarian hyperstimulation.
- determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation
- IGF-I protects the cells from apoptosis by blocking the activation of caspases, which may be responsible for the loss of FAK and Akt.
- Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China.
- results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3
- Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age
- insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch
- IGF1 mediated AKT activation delays radiation-induced apoptosis, allowing the DNA repair mechanism more time to remove cyclobutane thymine dimers.
- A putative functional polymorphism associated with NIDDM, adult height, glucose tolerance and fetal growth
- MGF inhibits terminal differentiation and increase cell proliferation of myoblast (mechano growth factor)
- Elevated levels of IGF-1 is associated with pleural effusions of solid tumors
- is positively associated with benign prostatic hyperplasia risk
- Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
- Autocrine production of IGF-I and IGF-II may via IGF-IR play a significant role in the growth and megakaryocytic differentiation of K562 cells.
- circulating levels of IGF-1 and IGFBP-1 are significantly related to the extent of myocardial injury in patients with hypertrophic cardiomyopathy.
- structural origins of the functional divergence with insulin
- Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old men
- The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain.
- Maternal nitrogen balance in the regulation of circulating levels of insulin-like growth factor-I in human pregnancy.
- improves insulin resistance by GH-dependent and independent mechanisms
- IGF-I does not affect the net increase in GH release in response to arginine.
- The biological relevance of this finding is suggested by the significant association between local IGF-I mRNA levels and microvessel density in the colorectal cancers.
- IGF1 has a role in producing extracellular matrix components in human umbilical cord serum and tissues
- Circulating levels of insulin-like growth factor-I and risk of ovarian cancer
- GH-IGF-I axis in non-obese women with functional hyperandrogenism.
- H358 cells secrete a high level of amphiregulin that, in combination with IGF1, prevents serum deprivation apoptosis
- Insulin-like growth factor I causes nuclear accumulation of cyclin D1 in tumor cell lines
- Intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals.
- Glucose transporter gene expression in the jejunum in response to insulin-like growth factors in rat pups
- Serum levels of insulin-like growth factor-1 and insulin-like growth factor-1 binding proteins after radical prostatectomy
- IGF-1 induces a transient increase followed by a decrease of CCE, and that these effects are at least partly dependent on IGF-1-induced K(+) channel activity.
- Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. IGF-I was an independent predictor of muscle function only in lowest IL-6 tertile.
- analysis of single and double targeted mutagenesis of the gene encoding IGF-I demonstrate its critical role in embryonic development-REVIEW
- Correlation between IGF-I and Mini Mental State Examination in Alzheimer's disease suggests a mechanism involving immuno-somatopause in progression of dementia.
- Above threshold of GH hypersecretion, IGF I levels reach plateau and are no more associated with GH secretion.
- Reduced IGF I secretion in normal elderly subjects not due to alteration of nutritional status.
- IGF I levels within 24 hours from stroke onset significantly and inversely related to poor outcome and death. Lower in acute ischemic stroke than in controls.
- Significant reduction of serum IGF I in centenarians in comparison to normal adults and normal elderly.
- Data suggest role for IGF I in control of blood pressure in obesity.
- Decrease of serum IGF-I level may play a role in the cognitive impairment in patients with obstructive sleep apnea syndrome (OSAS).
- data demonstrate for the first time that serum levels of IGFs (including free fractions) and IGFBPs are not increased in euthyroid Graves' patients with active thyroid eye disease
- REVIEW: from diagnostic to triple-helix gene therapy of solid tumors.
- regulation of signaling in breast cancer by JN kinase
- High resistance exercise resulted in a significant increase in mechano growth factor isoform of IGFI mRNA in young, but not in elderly subjects
- Follicular fluid IGF-1 and IGFBP-3 levels were not significantly different among the groups; however, follicular fluid IGFBP-1 levels were lower in those patients with moderate/severe endometriosis
- A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. In homozygous carriers of the 192 bp alleles of the IGF-I gene an age-related decline in circulating total IGF-I levels.
- Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts.
- results suggest that trunk fat attenuates the hormone replacement therapy-induced increase on growth hormone levels and is a significant determinant of low IGF-1 levels in postmenopausal women
- Inhibition of either phosphatidylinositol 3-kinase (PI3-K) or Mek1/2 signaling pathways completely abrogated the IGF-I-induced increase in VEGF secretion and promoter activity
- IGF-I induces VEGF gene expression and protein secretion in human mesangial cells via a Src-dependent mechanism.
- activates p21 to inhibit UV-induced cell death
- maternal insulin-like growth factor-I levels, especially during late pregnancy, positively influence birth weight
- This study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed, in a prospective study of 3-year cognitive decline in 1318 subjects aged 65-88.
- Poor glycemic control and differences in IGF-I levels and androgens accompany development of microalbuminuria at puberty; differences may account for sexual dimorphism in microalbuminuria risk during puberty and to disease progression
- Levels are altered in diabetic angiopathies.
- IGF-I isoform a expression may be downregulated at the mRNA level during the initial part of recovery from resistance exercise
- combination of low insulin-like growth factor-I and high interleukin-6 levels confers a high risk for progressive disability and death in older women
- results indicate that IGF-I-stimulated migration of WM1341D melanoma cells requires phosphoinositide 3-kinase activation but is independent of mitogen-activated protein kinase/extracellular signal-regulated kinase signaling
- IGF-1 and OP-1 could be key physiological regulators of MMP-13 gene expression
- When IGF-I was added, the reduction in prostate cancer LNCaP cell growth and the induction of apoptosis in medium containing serum alone were reversed.
- The terminal complement complex inhibits apoptosis in vascular smooth muscle cells by activating an autocrine IGF-1 loop.
- Hypertensive subjects who have low IGF-I levels because of a genetic polymorphism in the IGF-I gene are at increased risk of developing atherosclerosis
- IGF-1 plays a critical role in the desensitization of IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization
- possible stimulatory effect of endogenous GH on IGF and IGF-binding protein (IGFBP) levels during fasting.
- free IGF-I plasma levels and human longevity are coregulated by an overlapping set of genes so the impact of the IGF-I/insulin pathway on longevity is a property that has been evolutionarily conserved throughout the animal kingdom.
- IGF-I clearly stimulates telomerase activity in prostate cancer cells through a dual mode of action, including early rapid effects probably involving phosphorylation of hTERT by Akt and later up-regulation of hTERT expression.
- Insulin-like growth factor-1 isoforms in skeletal muscle aging, regeneration, and disease. Review.
- serum concentrations of insulin-like growth factor binding protein-1 are abnormal in antiphospholipid syndrome pregnancies
- Divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in lean body mass in healthy elderly men and women.
- p21CIP/WAF is a positive regulator in the cell proliferation induced by IGF-I in MCF-7 cells
- endurance training may attenuate the aged-related decline in insulin sensitivity and insulin-like growth factor-I
- inactivation of FoxO1 by IGF-I plays a critical role in rat skeletal satellite cell proliferation through regulation of p27Kip1 expression
- during a short-term energy deficit in young men, IGF-I system components differentially respond to a given metabolic perturbation and the relative proportion of IGF-I sequestered in ternary vs. nonternary molecular complexes appears to be well maintained
- insulin-like growth factor 1 promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of bone mineral density levels and rate of bone loss in postmenopausal women.
- The effects of IGF-I are differentiation dependent and restricted largely to the more mature cells of the osteoblast lineage.
- IGF-I promoted maturation of cord blood monocyte-derived dendritic cells (DC)
- IGF-I enhances adhesion via inactivating focal adhesion kinase
- IGF-1 prevents age-related decline in peak intracellular Ca2+ and specific force in a muscle that does not exhibit changes in fibre type composition with senescence.
- role of ERK1 and 2 in mediating IGF-I-stimulated vascular smooth muscle cell proliferation and chemotaxis
- growth disorders in this group of children might be due to a defect in a DNA region regulating expression of the growth hormone receptor and insulin-like growth factor 1 genes or genes involved in their regulation.
- Exercise-associated mechanisms may inhibit increases in IGF-I early in the course of a training protocol, even in overfed subjects.
- IGF-I signals osteoblast mitogenesis and survival through parallel, partly overlapping intracellular pathways involving PI-3 kinase, p42/44 MAPKs, and G beta gamma subunits.
- Recombinant human IGF-I increases gap junction communication and connexin43 abundance in primary astrocyte cultures from 2-day-old rats.
- We conclude that IGF-I plays a dominant role in growth during the perinatal period and that all three studied components of the IGF system are sensitive to liver and kidney function.
- Haplotype analysis in the Swedish short small for gestational age subjects showed that the region of association lay between the promoter and intron 2 of the IGF-I gene.
- IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha
- Review. IGF-1 exerts multiple physiologic effects on the vasculature, including proliferative, hypertrophic, survival, vasomotor, & metabolic effects. IGF-1 & its receptor & binding proteins & involvement of this system in vascular diseases are reviewed.
- IGF-I may be a mediator of steroid effect during precocious maturation of the ileal mucosa.
- study showed decreased levels of serum insulin-like growth factor 1 (IGF-1) and increased levels of growth hormone (GH) in the hypoxic-ischemic (HI) brain of newborns
- Cooperation between CTGF and IGF-I might be involved in glucose-induced matrix accumulation in tubulointerstitial fibrosis and might contribute to pathogenesis of diabetic nephropathy.
- insulin-like growth factor I signaling has a role in neurodegenerative diseases (review)
- A physiologic intrafollicular dose of IGF-I did not stimulate estradiol production but reduced the production of androstenedione and stimulated the production of activin-A, inhibin-A, and VEGF during follicle selection in mares.
- The IGF-1 axis is upregulated in prostate carcinoma cells that have resided in bone.
- progesterone increased local IGF-I bioavailability in malignant breast tissue; this depended on steroid receptor phenotype of breast tissue and was most evident in tissue expressing progesterone receptor
- results establish that tumor necrosis factor alpha targets insulin-like growth factor-I induced E2F-transcription facor 1 synthesis, leading to inhibition of accumulation in cyclin A and hyperphosphorylation of RB protein
- IGF-I-induced activation of the skeletal alpha-actin promoter is regulated by the L-type VGCC and calcineurin but independent of nuclear factor of activated T-cell transcriptional activity as C2C12 myoblasts differentiate into myotubes.
- IGF-1 enhances uncoupling protein 3 expression at transcriptional level, primarily through the phosphatidylinositol 3-kinase-dependent pathway and partly through the MAP kinase pathway.
- Human fat cells protect themselves from apoptosis by IGF-I in an auto-/paracrine manner.
- IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth.
- IGF-I-induced PI3K signaling is responsible for IGF-IR mediated attenuation of antineoplastic agent-induced growth inhibition
- Sserum IGF-II shows positive correlations with myoblast retrieval in control patients that is lost in malignancy.
- IGF-I increases expression of VEGF-A in sarcoma and umbilical vein endothelial cells.
- IGF-I treatment stimulated cell growth and proliferation, but also mildly induces apoptosis in an osteosarcoma cell line.
- "Growth hormone(GH)regulates IGF-1 gene expression in a variety of tissues, including...liver...and skeletal muscles...effects of GH on IGF-1 gene transcription...depend(s)on GH availability, but also on expression of the GH receptor..." p. 1273
- low baseline levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 increase the risk of fatal ischemic heart disease among elderly men and women independent of prevalent risk factors
- IGFBP-3 plays a crucial role in regulating IGF-I bioavailability, promoting cell survival.
- Both first- and second-phase insulin secretion were not significantly different between the various IGF-I or IGF-II genotypes.
- Insulin-like growth factor-I (IGF-I) is sensitive to nutrient supply in hatching chicks, and fasting reduced IGF-I mRNA levels in muscles of older chickens.
- no significant differences between normal and reduced bone mineral density for serum IGF-1
- In human fetuses, IGF-I and IGF-II levels increase longitudinally throughout pregnancy.
- Inhibition of E-cadherin function inhibits both IGF-I-dependent cancer cell migration and invasiveness.
- Data show that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I receptors.
- Recombinant human IGF-I promotes G1 progression in oligodendrocyte progenitor cells by enhancing FGF-2 induction of cyclin D1, activation of G1 cyclin-cyclin-dependent kinase complexes, and hyperphosphorylation of retinoblastoma protein.
- Progesterone down-regulates IGF-I mRNA and protein expression in cultured leiomyoma cells without affecting IGF-I receptor mRNA expression.
- GH and IGF-I can synergize in acute aspects of signaling and IGF-I enhances GH-induced assembly of conformationally active GHRs
- Following severe burn, a shift occurs toward a predominant Th2 phenotype. Exogenous IGF-I/IGFBP-3 treatment partially reverses this response.
- Recombinant human IGF-I increased renal p21 and PCNA expression, but reduced cyclin D1 expression in CDDP-treated kidneys. May ameliorate renal damage, in part by stopping the cell cycle at G1/S phase. Promotes recovery from ischemic renal injury.
- This review outlines the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of peripheral nerves.
- Renal cell carcinoma (RCC) expresses IGF-I and IGFBP-3 and is responsive to exogenous IGF-I stimulation. In metastatic RCC, autocrine IGF-I and IGFBP-3 stimulated and inhibited growth. IGF-I and IGFBP-3 possible treatment in advanced RCC.
- a decrease of insulin-like growth factor 1 along with an increase of hepatocyte growth factor may reflect an underlying biological process that influences cognitive decline as well as carotid atherosclerosis in the elderly
- Transgenic IGF-I promotes proliferation of neural cells in the embryonic central nervous system of transgenic mice in vivo and inhibits neural cell apoptosis during postnatal life of the animals.
- an important role of IGF-I in the pathogenesis and invasiveness of the malignant thyroid neoplasms
- IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi(M) and regulating Bcl proteins.
- P. 445: "The concentration of IGF-I in maternal plasma is correlated to fetal growth."
- the functional epitope of IGF-I for IGF-II comprises residues in the N-terminal L1 domain and residues at the C-terminus of the alpha subunit
- IGF-II:VN and IGF-I:IGFBP-5:VN complexes may be useful in situations where enhanced keratinocyte cell migration and proliferation is required, such as in wound healing and skin regeneration.
- IGF-I-induced cell cycle progression is regulated by 14-3-3sigma
- The C and D domains of IGF-II promote higher affinity binding to the IR-A than the equivalent domains of IGF-I.
- EPO+IGF-I exert cooperative actions that afford acute neuroprotection via activation of the PI3-K-Akt pathway
- IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating mitochondrial membrane potential, possibly by the involvement of UCP3.
- free IGF-II but not IGF-I may have a role in progression of breast cancer
- lower serum IGF-I levels are risk factors for lower bone mineral density in middle-aged Korean men
- Association between high IGF-I and IGFBP-3 levels and increased risk of breast cancer in premenopausal women.
- somatotropin-IGF-I axis contributes to changes in bone density and male reproductive organs.
- The CA-repeat promoter polymorphism in the IGF-I gene is associated with the risk for fragility fracture at old age in women and with bone structure in both genders.
- IGF-I may play a critical role in adipocyte differentiation and lipid accumulation.
- The IGF1 was not associated independently with colon cancer, but there was an association when examined with IRS1. Individuals with an IRS1 R allele and IGF1 non-192 allele were at a 2-fold increased risk of colon cancer (95% CI 1.2-4.4).
- DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling
- Ceramide, derived both from sphingomyelin and de novo synthesis, is a key intermediate by which proinflammatory cytokines impair the ability of IGF-I to promote protein synthesis and expression of critical muscle-specific transcription factors.
- evidence suggests that decreased IGF-1 levels and signaling during early development may modulate longevity in many species--REVIEW
- Insulin like growth factor I polymorphism is associated with increased risk for heart failure in elderly patients.
- In a model of severe undernutrition, rhIGF-I and estrogen individually increase ghrelin levels.
- Long-term use of both conjugated equine etrogens and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio
- IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle.
- common wild-type allele of the IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites
- IGF-1 can regulate RUNX2 DNA binding through sequential activation of the PI3K/Pak1 and ERK1/2 signaling cascade
- Vitreous samples from patients lacking diabetes or other retinal pathology had undetectable or low activities to IGF1
- endogenous expression of SR-BI/CLA-1 was suppressed by exposure to growth hormone or IGF-I in cultured HepG2 cells
- Data confirm the involvement of the insulin-like growth factor binding protein (IGFBP)-binding domain on IGF-1 in binding to IGFBP-2 and IGFBP-3 and support involvement of the IGF-1 receptor-binding domain in IGFBP binding.
- effect on heat shock protein-90 signaling
- Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization.
- Review. IGF-1 protects against endothelial dysfunction, atherosclerotic plaque development, the metabolic syndrome, clinical instability, and ischemic myocardial damage.
- IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM-dependent and LKB1-independent pathway
- Tumor necrosis factor-alpha was more effective at inhibiting differentiation in subcutaneous cells, whereas insulin-like growth factor-I stimulated differentiation more effectively in visceral cells
- contributes toward forming and mineralizing dental tissues as well as in pulp-repairing processes
- Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells
- IGF-I modulates androgen signaling through beta-catenin
- Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1.
- In obese compared with normal-weight healthy subjects, there is a larger increment IGF-I to a single bolus of growth hormone in men amd women.
- IGF-1 may play a role in the selective recruitment of basophils in vivo.
- Recombinant human IGF-I regulates progenitor cell division in the ventricular zone by reducing G1 phase length and decreasing total cell cycle length but increases cell cycle reentry in mouse embryos.
- AIB1 is required for IGF-I-induced proliferation, signaling, cell survival, and gene expression in human breast cancer cells, independent of its role in estrogen receptor signaling
- The effect of serum withdrawal on the autophagy of dysfunctional mitochondria is prevented by the addition of IGF-1.
- Val44 is an essential residue involved in the IGF-IGF-1R interaction, and a a naturally occurring mutant human IGF-I is associated with growth and developmental abnormalities
- Endogenous gonadal steroid secretion appears to result in increased responsiveness to GH in peripubertal girls and boys.
- RACK1 has a scaffolding function and regulates adhesion and insulin-like growth factor I signals that are necessary to regulate Akt activity and to promote turnover of focal adhesions and cell migration
- Systemic administration of IGF-1 improves structure/function of delta-sarcoglycan deficient cardiac muscle in the hamster.
- IGF-I has the characteristics to be a marker for the insulin resistance syndrome.
- Serum IGF-1 levels and IGF-1/Insulin-Like Growth Factor Binding Protein 3 ratios increased with advancing pubertal stages
- increased expression of human IGF-IA in alveolar air spaces does not affect the development of pulmonary fibrosis but promotes premalignant changes in the alveolar epithelium.
- Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis.
- IGF-1 levels decreased significantly six months after the iodine supplementation.
- Serum IGF-1 levels differed significantly between pubertal developmental stages.
- higher serum levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in polycystic ovary syndrome (PCOS) women may be related to the increased vascularity that underlies the increased ovarian blood flow
- The induction of the raf-1/MEK1 pathway blocks IGF-1-mediated intracellular neuroendocrine hormone regulation. This pathway may be a therapeutic target in gastrointestinal carcinoid tumor therapy.
- The expression of IGF-I is significantly altered in renal cell carcinoma
- Megative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects, which is modified by obesity.
- Recombinant human IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of bovine vascular cells via both ERK and PI3K pathways.
- Results indicate that the degree of prematurity, low enteral protein intake, male gender, and slow weight gain are associated with a slower postnatal increase of IGF-I in preterm infants.
- IGF-I deficiency is part of the underlying mechanism of diminished islet growth in GHR(-/-) mice and are consistent with the notion that IGF-I mediates growth hormone-induced islet cell growth.
- Hepatic immunoreactive IGF-I was significantly correlated with serum IGF-I and nitrogen balance.
- High IGF-1 levels are linked to early-onset breast cancer and larger breast volumes.
- AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation.
- Studies in transgenic (OC-IGF-I) mice show that osteoblast-derived IGF-I determines skeletal insulin-like growth factor binding protein 5 (IGFBP-5) abundance, at least in part by inducing its synthesis.
- Effect pf genetic and environmental factors on levels in female twins in puberty.
- The IGF1(70 amino acids) is single-chain polypeptides structurally similar to proinsulin.
- PTEN may inhibit antiapoptotic IGF actions not only by blocking the IGF-IGFR-induced Akt activity, but also by regulating expression of components of the IGF system, in particular, upregulation of IGFBP-3
- IGF)-1 and its receptor are present in the human male genital tract
- Critically ill children are characterized by low levels of IGF-I and -II as well as IGFBP-3 accompanied by elevated levels of GH, probably reflecting the development of peripheral GH resistance.
- IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment.
- response rate of hematocrit to enalapril treatment in patients with post kidney transplant erythrocytosis affects IGF1 levels.
- IGF-I and HGF cooperate to induce migration and invasion of colorectal carcinoma cells, and c-Met and uPA/uPAR are required for IGF-I-mediated migration and invasion.
- Increased IGF-I levels correlated with increased growth, tumor extent, and aggressiveness.
- higher levels of circulating IGF-I may increase risk of several cancers and relatively higher IGF-I levels may reduce the risk of type 2 diabetes and coronary heart disease.
- SHPS-1 functions as an anchor protein that recruits both Shc and SHP-2, whose recruitment is necessary for IGF-I-dependent Shc phosphorylation
- Pituitary gamma-knife surgery in acromegaly is effective in lowering serum IGF-I to normal levels.
- Thus these data suggest that the IGF1 promoter polymorphism may influence the strength response to ST. Larger sample sizes should be used in future studies to verify these results.
- leptin and the IGF system of IGF-I, IGFBP-2, and IGF-I receptor do not interact directly in a cell culture model of neuroepithelioma cells
- The action of insulin-like growth factor-1 might be responsible for elevated luteinizing hormone levels and the consequent hyperandrogenic anovulation observed in normal weight women with polycystic ovary syndrome.
- In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle
- C-domain of IGFBP-2 plays a key role in binding regions of IGF-I and -II that are also involved in binding to the type-1 IGF receptor
- Increased breast cancer risk in women with promoter polymorphisms in IGF1 and IGFBP3 genes, with increased risk for individuals homozygous for both polymorphisms.
- Osterix regulation by IGF-I requires all three MAPK components (Erk, p38, and JNK) in human mesenchymal stem cells
- Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients
- following UV insult the IGF system, including IGF-1 may enhance keratinocyte viability and contribute to a return to epidermal homeostasis
- Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP-1, IGF-I and related metabolic variables such as glucose tolerance.
- insulin-like growth factor-I increased invasion activity in ARK5-mRNA expressing multiple myeloma cell lines
- IGF-I is degraded at its C-terminal D-domain within the endosomal apparatus by cathepsin B.
- Folic acid deficiency could result in reduction of IGF-1 protein levels and might contribute to formation of defects in the skull bone as observed in mengingocele patients
- PAPP-A increased the proliferation and differentiation of myoblasts, its myogenic effect is governed by its proteolytic activity, and it promotes skeletal myogenesis by increasing the amount of free IGFs.
- These studies show IGF-I phosphorylation of FKHR and FKHRL1 via a PI3-K-dependent pathway in neuroblastoma cells.
- IGF-I may act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneration in concert with stromal cell derived factor.
- Age-stratification should be undertaken in larger investigations of IGF-I levels as predictors of postmenopausal breast cancer
- Clustering of family history of diabetes, testosterone and IGF I abnormalities, and high high-sensitive C-reactive protein is associated with metabolic syndrome in Chinese middle-aged men.
- The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells.
- observations demonstrate that leptin directly controls the secretory activity of human ovarian cells and confirm the involvement of insulin-like growth factor (IGF)-I in the regulation of ovarian cells
- IGF-I actions likely depend on cell type, developmental stage, and microenvironmental milieu {REVIEW}
- Review of recent studies shows that IGF-I signals cross-talk at multiple levels with various components of transforming growth factor (TGF)-beta signaling pathway which, depending on context, may function either as tumor suppressor or as tumor promoter.
- IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.
- Regions upstream and downstream of the CWCV motif in IGFBP2 participate in IGF-1 binding.
- Lower serum IGF-I concentration together with higher bone resorption and low bone mineral density reveal involvement of this growth factor in the development of idiopathic decrease of bone mass in children.
- Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults.
- Leptin and the molar excess of leptin receptor are better biomarkers of nutritional status than IGF-I in protein malnutrition children during nutritional recovery.
- results show a local increase in the expressions of IGF-1 and PDEGF in the muscularis propria of the pyloric muscle in children with IHPS, which may have implications to the pathogenesis of the disease.
- IGF-I and IGFBP-3 levels were positively associated with weight gain and height gain from birth to 3 months in small for gestational weight versus appropriate weight children.
- the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer
- The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression.
- Igf-I transduction up-regulated markers of osteoblastic differentiation and in conjunction with recombinant BMP-2-induced matrix mineralization independently of Dex.
- These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms.
- We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction
- variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an abnormal glucose tolerance
- results support the contention that the associations between height and cancer may be mediated by variation in childhood insulin-like growth factor 1
- IGF-I and -II are chemotactic factors for mesenchymal progenitor cells; IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells
- Effect of human IGF-I over-expression on mice skeletal muscles was studied.
- first study to document an association between timing of puberty and adult insulin-like growth factor 1(IGF-I) levels
- The mechanisms by which IGF-I may influence bone metabolism are not fully understood, but as the reviewer points out, they are a predictor of bone mass density and are positively associated with vitamin D concentrations.
- progenitor cells are potent sources of VEGF, HGF, and IGF-I
- IGFBP-1, IGFBP-3 and IGF-I show acute changes following a glucose load and there are marked gender differences in these responses.
- IGF-I and its downstream pathway is a valuable therapeutic approach to overcome Ara-C resistance in AML.
- higher concentrations of neuropeptide Y in constitutional delay of puberty(CDP) girls may be responsible for CDP and reduced levels of insulin growth factor-I(IGF-I)
- overexpression of rtEa4 or hEb transgene in zebrafish embryos disrupts heart development, hematopoiesis, and vasculogenesis by reducing the levels of GATA 5, NKX2.5, GATA 1, GATA 2, and VEGF mRNA
- VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia
- Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response
- Data show that hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.
- The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise.
- IGF-I can augment IL-8 expression through activation of AP-1.
- concurrent administration of tamoxifen and bicalutamide in prostate cancer patients reduces the synthesis and bioavailability of IGF-1
- reduction in bioactive IGF-I may be related to the higher levels of free IGFBP-1 and the faster disappearance of IGFBP-1-bound IGF-I in glucose tolerance test in liver cirrhosis
- findings suggest that this insulin-like growth factor 1(IGF-I) gene polymorphism is associated with an increased risk of diabetic retinopathy
- A decrease in free IGF-I and insulin-like growth factor binding protein 3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications
- IGFs co-activate proliferative and apoptotic pathways in LIM 1215 cells, which may contribute to increased cell turnover.
- The structures reveal the mechanisms of insulin-like growth factor (IGF) signaling regulation via insulin-like growth factor-binding proteins (IGFBP) binding.
- heterotrimeric G protein-dependent ERK1/2 activation is mediated by IGF-1 and IGF-2 by transactivating sphingosine 1-phosphate receptors
- High plasma levels of IGF-1, IGF-2, and IGFBP-3 were associated with good prognosis in patients with advanced NSCLC.
- IGF-1 cell signaling leading to collagen synthesis in fetal lung fibroblasts is mediated by PI3 Kinase acting through NF-(k)B in HFLF.
- IGF-1 is more potent in inducing the survival of vascular smooth muscle cells from asymptomatic patients as compared to that of symptomatic subjects.
- Forced RIZ1 expression in CML-BC cell lines decreases IGF-1 receptor activation
- Low levels of IGF-I may be a useful predictor of abnormal glucose metabolism in patients with acute myocardial infarction.
- Differential expression of insulin receptor, IGF-IR, and IGF-I in adhesion fibroblasts may contribute to pathogenesis of fibrosis in diabetic patients.
- This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production.
- transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2)
- Precise orientation of IGF-I within the IGF-I-IGF-1R complex involving the IGF-I C-domain binding to the IGF-1R CR domain.
- Stromal cell IGF-1 mRNA levels are significantly decreased after castration in non-malignant, but not malignant prostate tissue.
- insulin-like growth factor-1 alters Mdm2-mediated GRK2 degradation, leading to enhanced GRK2 stability and increased kinase levels
- High insulin-like growth factor-1 levels are associated with early-onset breast cancer
- results may indicate that up-regulation of the cardiac IGF-1 system serves as a compensatory mechanism for LV dysfunction
- Platelet factors promote fibroblast growth by activating preotein kinaes, which requires production of IGF-1.
- This review of available data suggests an algorithm of circulating levels of IGF-I, together with evaluation of auxological data, to assess the likelihood of growth hormone deficiency in pre-pubertal children.
- Seems to be an important positive regulator of cartilage oligomeric matrix protein.
- lack of association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb
- These results demonstrate that estradiol positively regulates essential proteins of the IGF signalling pathway.
- Genetic variation in IGF1 is associated with breast cancer risk
- polymorphisms in the IGF-1R and IGFBP3 genes, but not IGF-1 or IGFALS, may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status
- the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis
- GH1/IGF-1 axis polymorphisms may have a role in breast cancer development [review]
- the differences in the IGF-I response to GH between tall obese and short children may reflect differences in the respective anabolic (growth promotion) and metabolic (i.e. insulin action modulation); roles of circulating IGF-I is unknown
- Results indicate that common variation in the IGF1 gene, particularly in the 3' region, may affect prostate cancer risk.
- upregulation of the muscle specific IGF-IEa and MGF isoforms occurs within 2.5h of a single bout of isometric exercise in women
- circulating levels may be lowered in patients with head and neck cancer
- Cerebrospinal fluid levels are lower in motor neuron disease than in normal controls.
- plasma levels of IGF1 and IGFBP-3 vary by ethnic group and have roles in development of obesity
- Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression.
- inhibition of IGF-1 signaling combined with interferon-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own
- Those results reinforce the possibility that the IGF-1Ec isoform may produce an E domain peptide that can act as a cytokine.
- Results suggest a major role of IGF1 system in promoting cholangiocyte survival.
- IGF-1 increases nuclear translocation of liganded estrogen receptor (ER)-alpha in breast cancer cells.
- Individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance.
- study elucidates a mechanism by which insulin and IGF-1 signaling can be matched to the oxygen level that is available to support growth and energy metabolism.
- exposure to hypoxia and acidosis at birth strongly correlated with a fall in IGF-1 and IGFBP-3 levels in cord blood
- the increase in LVM prevalent in human essential hypertension is directly associated with serum GH levels and inversely related to circulating IGF-1
- IGF-1 stimulated EPC differentiation, migration & incorporation into vascular networks in vitro via its receptor, increased telomerase activity & endothelial nitric oxide synthase expression, phosphorylation & activity in a PI-3-kinase/Akt-dependent way.
- 1,25-dihydroxyvitamin D and/or IGF-I may be involved in the regulation of urinary calcium excretion
- alterations in glucose concentrations may regulate the ability of smooth muscle cells to respond to IGF-I
- Circulating levels of total IGF-I were not associated with risk of total coronary events or ischemic stroke among older adults.
- Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c.
- Review provides novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation and its clinical applicability in preventing dysfunction and sodium pump activity in type 1 diabetes.
- Common genetic variation in IGF1 is strongly associated with percentage mammographic density
- IGF-1 induces phosphorylation and an increase of the AP1 complex, which is phosphorylated and binds to the pS2/TFF1 promoter, allowing recruitment of the chromatin remodeling factor Brg1 followed by binding of ERalpha via its interaction with c-Jun
- inhibition of signal transduction pathways common to growth factors such as igf1 appears as a challenge to glioblastoma multiforme inhibition studies. [TRVIEW]
- Bioavailability of IGF-I appears to play a key role in oocyte maturation in patients with polycystic ovary syndrome.
- Mice, transgenic with IGF1, express multiple anti-apoptotic protein in epidermis.
- Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF1 hypothesis of osteochondrodysplasias.
- Presence of two Androgen Receptor response elements within the IGF-I upstream promoter that act in cis to activate IGF-I. expression.
- Our results suggested a potential effect of SNP3 in the IGF1 gene on age at menarche variation in Caucasian women for the first time.
- data confirmed hypothesis that higher growth velocity in the first month of preterm neonates is due to an increased bioavailability of IGF-I
- first study showing the role of the promoter region of the IGF-I gene polymorphism and the level of plasma IGF-I and body composition parameters in Japanese infants; results suggest genetical influence on prenatal growth and serum IGF-I levels
- IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system
- These data point to an interesting relationship between low IGF-1 levels and increased cardiovascular risk factors among chronic kidney disease patients as compared to age-matched healthy control subjects.
- IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms
- Autosomal dominant polycystic kidney disease cells had an increased sensitivity to IGF1 and to cyclic AMP, which required PI3-kinase and the mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) for enhanced growth
- We demonstrated that children with sickle cell anemia have abnormalities in the IGF-I axis, which worsen with age.
- IGF-I synthesis is disturbed in chronic hepatitis C and reflects the severity of the liver fibrosis; may be a biological marker
- IGF-I system is important in the assessment of adaptation to stress imposed by high levels of physical activity and energy/sleep restriction and is more closely associated with losses in body mass and fat-free mass than other nutritional biomarkers.
- IGF-related peptides are most likely synthesized locally and might be involved in the initiation and/or progression of neointimal thickening of primary arteriovenous fistulas.
- IGF-I-immunoreactivity was confined to secretory granules in coexistence with ACTH- or GH-immunoreactivity, respectively, indicating a concomitant release of the hormones.
- Serum testosterone concentration and serum IGF-1/IGFBP-3 molar ratio are the major determinants of bone mineral density in boys at different pubertal stages.
- IGF-I interacts with estradiol to promote the proliferation of breast carcinoma cells via reactive oxygen species-dependent MAPK activation and c-Jun protein expression.
- IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus site
- IGF1-19/-19 genotype was significantly more common among BRCA1 mutation carriers (14.2%) than among non-carriers (4.8%)
- Nordihydroguaiaretic acid inhibits IGF1 signaing, growth, and survival in neuroblastoma cells.
- review of changes during aging which contribute to the decline in GH/IGF-I, including changes in signal to the somatotrophs from growth hormone releasing hormone, somatostatin and other factors such as body composition, exercise, diet and sleep
- Results indicate that positive correlations of maternal, fetal, and neonatal IGF-I levels with customized centiles underline implication of its role in fetal growth.
- the IGF-1 axis is downregulated by curcumin in MCF-7 cells, which inhibits cell growth and induces apoptosis
- IGF-1 expression is activated by hypoxia through STAT5b in human HepG2 cells
- IGF-1 regulates ether-a-go-go channel activity in breast neoplasms, via an Akt pathway to promote cell proliferation.
- seminal vesicle fluid is a local source of IGF-I that provides chronic stimulation of prostate cells
- Upregulates Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein (FLIP) expression in thyroid cells by means of the phosphatidylinositol 3-kinase-dependent pathway that finally leads to activation of NF-kappaB.
- Severely deficient in a case of insulin-resistance syndrome (Rabson-Mendenhall type).
- The results of this study suggest a positive correlation between the increased levels of IGF-1 and colon cancer and are thus consistent with the hypothesis that the level of IGF-1 plays an important role in the development of colon cancer.
- the two systems, TRs and IGF1/IGF1R could be functionally associated.
- The IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer risk in Caucasian postmenopausal women.
- Common genetic variation in IGF1, IGF binding protein 1 (IGFBP1), and IGFBP3 influences circulating levels of IGF-I, IGFBP-1, and IGFBP-3.
- Plasma levels of IGF-I were significantly increased in volunteers with alopecia after oral administration of capsaicin and isoflavone .
- Dichlorodiphenylchloroethylene alters the expression of the ovarian growth factors VEGF and IGF-1 in vitro.
- novel role for autocrine IGF-I signaling in the growth and survival of primary acute myeloid leukemia cells
- large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGF-1:IGFBP-3 molar ratio was related to risk for aggressive prostate cancer in obese men
- These results raise questions concerning the therapeutic value of IGF-1 and indicate that further studies are needed to examine the relationship between methods of IGF-1 administration and its potential therapeutic value.
- AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases.
- Data show that an antenatal course of glucocorticoids elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations.
- Connexin43 expression can be influenced by Ang II and IGF-1 through ERK and p38 pathways and may contribute to the pathogenesis of vein graft disease following coronary artery bypass grafting.
- Strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients.
- hyperglycemic conditions enhance the response of retinal endothelial cells to IGF-I by increasing the association of IAP with SHPS-1 permitting the formation of the SHPS-1-Shc signaling complex, which is required for the proliferative response to IGF-I
- MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.
- Maternal diabetes is associated with significant alterations in IGF-1 blood levels in male newborns.
- IGF-I levels were lower in patients with ectopic neurohypophysis than in those without structural abnormalities of the hypothalamic pituitary axis (n = 25), but patients without structural abnormalities also had significantly lower serum IGF-I levels
- high serum IGF-I levels are associated with goiter
- No significant differences in grade or ethnicity was found in IGF1 repeats and the inverse association with prostate cancer risk
- No significant differences in levels in fibromyalgia patients.
- Exercise-associated mechanisms, such as increased energy flux, regulate IGF-I independently of energy deficit.
- Growth hormone deficiency alone does not account for the high prevalence of reduced IGF-1 in adult beta-thalassemia.
- Low levels of IGF-1 found in obesity may be related to obstructive sleep apnea syndrome.
- Serum levels are indicative of prostate carcinogenesis.
- IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women.
- Recombinant human insulin-like growth factor I therapy could improve glucose disposal by signalling through the IGF-I receptor, whilst reducing the adverse effects of high insulin concentrations.
- IGF-1 plays a role in potentiating platelet aggregation by complementing G(i)- but not G(q)-signaling pathways via PI3-K p110alpha.
- IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses
- 18-repeat genotype is a susceptibility genotype for diabetic retinopathy and its clinical severity in a Southern Indian cohort.
- In a group of older US men, the suggestion of a positive association between IGF-1 and lower urinary tract symptoms was observed.
- polymorphisms identified in the upstream core polyadenylation signal at IGF1 exon 6 do not cause IGF1 deficiency
- Data show that adipose tissue-derived stem cells (ASCs) secrete significant amounts of VEGF (810.65+/-56.92 pg/microg DNA) and IGF-I (328.33+/-22.7 pg/microg DNA).
- variation in the IGF-I gene plays a role in prostate cancer susceptibility by influencing circulating levels of IGF-I (Meta-Analysis)
- Osteopenia is common in children with cerebral palsy and may be associated with lower IGF-1 and IGFBP-3 levels
- IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet.
- IGF-1 plays a role in maintaining muscle GLUT3 expression and basal glucose uptake via the transcriptional factor Sp1.
- PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion
- An impairment of the GH/IGF-I axis might be involved in the biochemical mechanisms determining delayed or failed fracture healing
- Growth hormone may influence luteal function directly or indirectly via IGF-1.
- IGF-I levels determine aortic intima-media thickness in neonates with intrauterine growth retardation and in healthy controls.
- Blocking Hsp90 disrupts IGF-I and IL-6-induced proangiogenic signaling cascades by targeting IGF-IR and STAT3 in pancreatic cancer
- IGF-1 transmits its lipogenic signal in sebocytes through activation of Akt
- Use of a strategy consisting of IGF-1 determination in blood is predictive of growth hormone deficiency.
- study established age- and sex-specific reference ranges for serum IGF-1 and IGFBP-3 levels
- Blood levels are not significantly associated with metabolic syndrome among those with the lowest levels of 25-hydroxyvitamin D in a British cohort.
- IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis.
- Endometrial IGF-I and -II are differentially regulated during decidualization and by human chorionic gonadotropin.
- Expression of IGF-1(des) in mouse prostate epithelium is sufficient to cause hyperplastic lesions in all mice, however the well-differentiated lesions did not progress to adenocarcinoma within a year.
- no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk.
- An inverse significant relationship between IGF-I and both brain natriuretic peptide (BNP) and amino-terminal propeptide of procollagen type III (P-III-P) value in surgically treated acromegaly patients was observed.
- Silent-RNA-mediated downregulation of BRCA1 in primary human breast cancer gland tumor cells triggers upregulation of endogenous intracellular IGF-I in vitro.
- In osteoarthritic cartilage, catabolism was insensitive to IGF-I, but IGF-I exerted a robust stimulation of anabolism at sufficiently high doses.
- Hyperlipidemia is associated with altered levels of insulin-like growth factor-I.
- This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation.
- single nucleotide polymorphisms in IGF-I gene is significantly associated with elevated levels of IGF-I and higher percent breast density.
- MGF splice variant is sensitive to muscle damage-inducing exercise and is differentially regulated compared with IGF-IEa.
- The IGF-I signaling abnormalities in osteoporotic osteoblasts were associated with reduced DNA synthesis both under basal conditions and after stimulation with IGF-I.
- study provides the first mechanistic insights into the action of IGF-I-IGFBP-VN complexes and adds further evidence to support the involvement of VN-binding integrins and their cooperativity with the IGF-IR in the promotion of tumor cell migration
- IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin
- Leptin at the low doses enhanced, whereas at the high dose it suppressed the effect of GH or IGF-I on steroids synthesis in cultured lutein granulosa cells.
- Evidence for association between IGF-i single-nucleotide polymorphisms has been found.
- Data concluded that the higher risk of preterm preeclampsia related to IGF-I increase may reflect placental disease.
- Stimulation of KLF6 expression by IGF-I in a p53-dependent manner may constitute a novel mechanism of action of IGF-I, with implications in normal cell cycle progression and cancer biology.
- These findings suggest that serum levels of IGFBP-3 and possibly IGF-I are associated with the rate of HIV disease progression in women.
- A concurrence of elevated GH levels and decreased IGF-I, IGFBP-3, and total ghrelin levels during the early burn injury period.
- Repeat polymorphism of IGF1 is unlikely to be a major determinant of susceptibility to cancer on a wide population basis.
- Study found significantly lower insulin-like growth factor-1 concentrations in premenstrual dysphoric disorder subjects compared with controls.
- Genetic variants in the IGF-I genes is not associated with breast cancer
- The basis for interactions between tumor necrosis factor and insulin-like growth factor-1 is discussed in this Review with specific reference to clinical consequences for myofiber necrosis of skeletal muscle.
- IGF-1 plasma concentrations do not correlate with alcohol craving in a longitudinal study of 12-weeks abstinent alcoholics.
- IGF-I is involved in ovarian cancer progression; both endocrine and paracrine/autocrine are involved in the regulation of IGF-I activity in ovarian cancer.
- association observed for IGF-I(CA)(19) and malignant melanoma is in keeping with similar results obtained in prostate or breast cancers, suggesting that this type of repeat may be important in controlling cancer induction and its severity
- IGF-1 signaling is an important event in blast crisis transformation in chroni myelogenous leukemia.
- Three of the nine SNPs within evolutionarily conserved regions(rs35455143, rs35765817 and rs3839984) were significantly associated with circulating IGF1 levels.
- Higher early levels of the human milk IGF system might contribute to maturation of the infant gut.
- Signal transduction of IGF1 and cell division may be prevented by lycopene in prostate tumor cells.
- In hyperthyroidism: 1) basal abundance of GLUT3 and GLUT4 on the plasma membrane is increased and 2) the sensitivity of the recruitment of GLUT3 and GLUT4 transporters on the plasma membrane in response to IGF-I is increased
- Measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis.
- There is a novel function of ADAM-12m in chondrocyte proliferation and cloning in osteoarthritic cartilage through enhanced bioavailability of IGF-1 from the IGF-1-IGFBP-5 complex by selective IGFBP-5 digestion.
- analysis of insulin-like growth factor I receptor and HER2 in breast cancer
- Sequence analysis of the IGF1 and IGF1R genes of female centenarians showed overrepresentation of heterozygous mutations in the IGF1R gene among centenarians that are associated with high serum IGFI levels and reduced activity of the IGFIR
- Genetic variation in IGF1 alters IGF-1 concentrations but is not associated with growth, glucose metabolism or type 1 diabetes.
- data suggest that low concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) could be a reliable marker to differentiate benign from malignant ovarian tumors
- No association between IGF polymorphisms and TGCT risk.
- glucose, cannabinoids and insulin-like growth factor-1 have roles in protecting cells from paraquat-induced apoptosis
- IGF1 helps predict disease outcome in GIST patients.
- Authors observed evidence for association of GHRL polymorphisms with circulating IGF-I levels and with breast cancer risk.
- PAPP-A and IGF-1 are elevated in patients with acute coronary syndrome
- first study displaying cardiac expression of insulin-like growth factor-I mRNA and growth hormone receptor mRNA in children with congenital heart disease
- data indicate that strong cooperative cross talk between prolactin and IGF-I augments biological processes associated with neoplastic progression, with implications for therapeutic strategies
- induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity
- in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration
- there was decreased insulin-like growth factor 1 (IGF-I) immunoreactivy in extravillous trophoblasts and increased IGF-I immunoreactivity in cytotrophoblasts and decidual cells of small for gestational age cases
- Plasma levels of Th1/Th2 type cytokine are associated with change of prolactin and GH/IGF-I in hemodialysis patients.
- IGF-I protects against endoplasmic reticulum (ER) stress-induced apoptosis by increasing adaptive mechanisms through enhancement of ER stress-signalling pathways, thereby restoring ER homeostasis and preventing apoptosis
- A low concentration of serum IGF-1 on admission was associated with a poor early prognosis of acute myocardial infarction
- IGF- I exerts a mitochondrial protection in experimental cirrhosis leading to reduced apoptosis and increased ATP production.
- Examine relationship between GH/IGF-1/leptin levels and sleep duration in obesity.
- Relationship between in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density
- activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11
- Former sedentary postmenopausal women submitted to resistance training gained muscle mass and muscle strength significantly associated with insulin-like growth factor 1(IGF-1) increase
- IGF-I, in addition to the C-domain, uses surfaces similar to those of insulin in contacting its cognate receptor
- These data demonstrate that IGF-I modulates proliferation and strongly stimulates migration of glioma cell lines in vitro.
- IGF-I regulates immature testicular cell proliferation, apoptosis and steroidogenesis.
- This study suggests that there is an interaction between leptin, IGF-1, IGFBP-3 and insulin resistance in patients with chronic kidney disease.
- A logistic regression analysis, adjusted for age and sex, has been used to determine the association between tertiles of IGF-1 and IL-6 and metabolic syndrome X.
- an emerging clinical target for improving the clinical manifestations of Alzheimer's disease may be the activation of Growth hormone and insulin-like growth factor-I
- Common IGF1 and IGF1R gene polymorphisms, such as single nucleotide polymorphisms and variable number of tandem repeats, have been investigated with conflicting results with respect to small for gestational age-related outcomes.[review]
- The variant type of the IGF-I promoter region is associated with lower blood pressure but not with left heart dimensions at the age of 2 years.
- Production of PAPP-A by disc cells is important since PAPP-A cleaves IGF-binding proteins, and makes IGF-I, a potent mitogen and antiapoptotic agent, available to cells.
- increased expression 6 months after orthognathic surgery indicates an adequate [masseter]muscle adaptation
- Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation
- the Gab1-SHP2-ERK1/2 signaling pathway comprises an inhibitory axis for IGF-I-dependent myogenic differentiation.
- the association between common genetic variation in the IGF1 genes in relation to circulating IGF-I levels and breast cancer risk
- These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration.
- IGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases
- None of the components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN influence the relation between IRS-1 genotype and prostate cancer risk. Ther is no association between carriage of the variant IRS-1 gene and prostate cancer risk.
- Competitive equilibrium binding assays revealed significantly reduced specific binding to the insulin, IGF-I, and IGF-II and their receptors in both the anterior cingulate and vermis of alcoholic human brains.
- A high IGFI:IGFBP3 ratio was associated with increased benign prostate hyperplasia risk, and high serum IGFBP3 was associated with decreased BPH risk among men with severe symptoms.
- Insulin-like growth factor-I CA repeat is an important modifier of disease onset in hereditary non-polyposis colorectal cancer.
- Independent predictors of Growth hormone deficiency (GHD) were: growth rate < -1 DS (adjusted odds ratio: 3.2; 95% confidence interval [1.3-7.9]), IGF-I concentration < -2 DS (2.8 [1.1-7.3]) and BMI z-score > or = 0 (2.8 [1.2-6.5]).
- Lower insulin-like growth factor 1 is associated with colorectal cancer.
- IGF1 is a common target gene of Ewing's sarcoma fusion proteins EWS-FLI-1, EWS-ERG and FUS-ERG in mesenchymal progenitor cells
- the relatively high IGF1 secretions in elderly patients might be involved in the progression of clinical complications in acromegalic patients
- These results indicate the critical point thymic function regulation by IGF-1 involves thymic epithelial cells expansion regulating thymocyte precursor entry and facilitating thymocyte development.
- A large proportion of rheumatoid arthritis inpatients, mainly women, had rheumatoid cachexia. The muscle wasting was explained by inflammatory activity and physical disability as well as low bioavailable IGF-1.
- Mean blood spot IGF-I levels were significantly higher in the late pubertal stages than in the prepubertal, early pubertal, and postpubertal stages
- phosphatases and pRB have important roles in IGF-I/mTOR-mediated cell survival
- Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
- Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
- klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer
- Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha
- High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk
- dysregulated IGF and steroid hormone receptor signaling is prominent in endometrial benign stages and these alterations could represent clinical indicators for the risk of EnCa (endometrial carcinoma) and also help in development of new therapies.
- The enhanced SULT1E1 activity may have a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of E2.
- IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
- IGF-1 transgene expression induces massive stem cell mobilization via SDF-1alpha signaling and culminates in extensive angiomyogenesis in the infarcted heart.
- we demonstrated that IL-21 induced clonogenicity through an autocrine IGF-1 secretion in human myeloma cell lines and primary myeloma cells
- IGF-1 (insulin-like growth factor 1) levels were higher in patients with diffuse cutaneous SYstemic sclerosis (SSc) than in patients with limited cutaneous SSc; Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis.
- ER alpha mRNA is positively correlated with IGF-I mRNA, which implies that estrogen upregulates the gene encoding IGF-I through ER alpha in leiomyoma.
- Insulin-like growth factor-1-induced activation of the phosphatidylinositol 3-kinase/c-Akt/NF-kappa B signaling pathway is involved in the modulation of endogenous decoy receptor 3 expression in AsPC-1 pancreatic adenocarcinoma cells.
- The IGF1 gene alone or in concert with diabetes increases the risk of pancreatic cancer.
- Low intrauterine IGF-I serum levels may account for thinner and stiffer umbilical arteries in IUGR infants.
- promotes cord blood T cell maturation by means of accessory cells (monocytes) and in part by IL-6
- IGF-1 related gene variations influence susceptibility to multiple myeloma.
- The independent positive association between the plasma ghrelin quartile and the carotid intima-media thicknes was evident in the lowest IGF-I (insulin-like growth factor 1) quartile
- These results suggest that IGF-1 promotes Abeta production through a secretase-independent mechanism involving APP phosphorylation.
- a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas