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Validated All-in-One™ qPCR Primer for IFNG(NM_000619.2) Search again
Product ID:
HQP009467
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
IFG, IFI, IMD69
Gene Description:
interferon gamma
Target Gene Accession:
NM_000619.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control.
Gene References into function
- Penicillin conjugates interferon-gamma and reduces its activity
- Interleukin-6, tumor necrosis factor alpha and interferon gamma serum levels in patients with anorexia nervosa.
- effect on cell proliferation and apoptosis in conjunction with TNF-alpha
- responses to Plasmodium falciparum liver-stage antigen-1 peptide
- novel mechanism by which IFN-gamma can regulate IL-13 responses.
- role of Sp1 and Sp3 in interferon-gamma mediated suppression of macrophage lipoprotein lipase gene transcription
- produced by natural killer cell only upon reaching terminal functional differentiation
- Transient exposure of human bronchial epithelial cells to IFNG leads to persistent increased expression of ICAM-1.
- Two new single nucleotide polymorphisms of the promoter, along with their possible regulatory effects
- P. gingivalis membrane vesicles apparently inhibited IFN-gamma-induced MHC class II by disrupting the IFN-gamma signaling transduction pathway.
- IFN-gamma markedly up-regulated CD14 and MyD88 but not TLR4 protein and MD-2 mRNA expression in human gingival fibroblasts.
- Description of three new polymorphisms in the intronic and 3'UTR regions of the interferon gamma gene
- IL-12R beta 1- and IFN-gamma R1 signals co-ordinately regulate IFN-gamma production, but only IL-12 negatively controls IL-4 production. IL-12 and IFN-gamma signals are each sufficient for IFN-gamma production but both are needed for optimal production.
- Those CD8-positive antigen-specific and alloantigen T-cells secreting interferon gamma have greater cytotoxic potential.
- Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control
- S.stercoralis patients with HTLV-I showed a high frequency of expression of interferon gamma, but those without HTLV-I did not.
- The roles of IFN gamma in protection against tumor development and cancer immunoediting
- Candida albicans stimulates IFN-gamma production in an IL-18, IL-12, and IL-1beta dependent manner in human whole blood cultures
- Results suggest that IFN-gamma facilitates TRAIL-induced activation of mitochondria-regulated as well as mitochondria-independent apoptotic pathways in breast tumour cells.
- Vav activates the IFN-gamma promoter via upregulation of AP-1-binding through a Rac1/JNK pathway
- Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections
- Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent
- augmented mRNA and surface expression of TLR4 in monocytes and macrophages
- Up-regulation of inducible nitric oxide synthase and nitric oxide in Helicobacter pylori-infected human gastric epithelial cells: possible role of interferon-gamma in polarized nitric oxide secretion.
- conserved helix C region in the superfamily of interferon-gamma /interleukin-10-related cytokines corresponds to a high-affinity binding site for the HSP70 chaperone DnaK
- role in inhibition of respiratory syncytial virus infection of human epithelial cells affected by 2'-5'-oligoadenylate synthetase
- expressed in multiple sclerosis brain lesions
- Cells from infected subjects cultured with ST-Ag all released high levels of gamma interferon (IFN-gamma) into the culture supernatant
- Production of matrix metalloproteinase-9 in early stage B-CLL is suppressed by interferons alpha and gamma.
- production by different populations of erythroid cells derived from human embryonal liver
- Interferon-gamma-mediated downregulation of cholesterol efflux and ABC1 expression is by the Stat1 pathway.
- identifies BRCA1 as a component of the IFN-gamma-regulated signaling pathway and suggests that BRCA1 may play a role in the regulation of IFN-gamma-mediated apoptosis
- association of polymorphism with acute and chronic kidsney transplantation outcome
- mutational switch of il-6 gives an interferon-gamma-like response
- single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription
- detected a significant positive correlation between TNF-alpha (r=0.55) and interferon-gamma (r=0.54) mRNA expression and the Beck Depression Inventory sum scores during an acute attack in multiple sclerosis patients
- IFN-gamma plays a critical role in the protection of Schistosoma mansoni-infected patients against periportal fibrosis.
- results indicate opposite effects of IFN-gamma and IL-4 on VEGF expression from normal and activated HF and HK
- Considerable expression of mRNA for this protein was detected in trigeminal ganglia of BALB/C mouse brains during acute HSV-1 infection.
- Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma.
- immune restoration of HIV-1-infected children receiving HAART might be related to an increase in INF-gamma production and a decrease in the rate of IL-10 production after virus suppression
- STAT-1, IRF-1, and RAR-beta expression were enhanced by IFN-gamma and ATRA in combination, and to a greater degree in BALM-3 cells than in BALM-1 cells, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis.
- Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients.
- Association of IFNG gene polymorphism with asthma in the Indian population
- Homozygotes for the D allele (DD) of the interferon-gamma gene have an increased chance of developing sepsis after traumatic injury
- identification of TATA-containing core promoter of the type II collagen gene as target of interferon-gamma mediated inhibition
- Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. ). IFN-gamma also enhanced the adhesion of human eosinophilic leukemia-1 cells to endothelial monolayers, and it was inhibited by the presence of lactose.
- is a critical mediator for the development of autologous graft-versus-host disease
- CD57+ T cells augment IFN-gamma production in a one-way mixed lymphocyte reaction.
- expression of mRNA for IL-4, IL-5, TGF-beta1, IFN-gamma in patients with cicatricial pemphigoid
- direct evidence for production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption
- A minimal IFN-gamma promoter contains a T box expressed in a T-bet responsive unit within the -565 to -410 region of the IFN-gamma promoter and is sufficient to confer Th1 selective expression upon a reporter.
- IFN-gamma-induced killing of Coxiella burnetti in monocytes involves two mechanisms: phagosome maturation and late phagosome alkalinization.
- role of IL-12 and IFN-gamma on inducing inflammatory chemokine secretion and down-regulating CCR5 expression in human T cells
- When transfected into hepatocytes, ameliorates hepatic fibrosis in rats and modifies intrasplenic transplantation of syngenic hepatocytes.
- IFN-gamma shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production
- IFN-gamma has a role in the pathogenesis of measles virus (MV), herpes simplex virus (HSV) type 1, and vesicular stomatitis virus (VSV) infections of the CNS [review]
- increased secretion in mucosal leishmaniasis
- produced by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation
- role in modulating thymus and activation-regulated chemokine/CCL17 and interferon-induced protein of 10kDA/CXCL10 release in HaCaT cell line
- IFN-gamma-mediated caspase-3 activation and C. burnetii killing depend on the expression of membrane TNF.
- The presence of high-expression polymorphisms at position +874 of the IFN-gamma gene significantly increases the risk for bronchiolitis obliterans syndrome development after lung transplantation.
- Preincubation of airway epithelial-like tumor cells with IFN-gamma results in a hyperresponsive IL-6 and IL-8 production to TNF-alpha and LPS via an underlying mechanism involving the induction of indoleamine 2,3-dioxygenase.
- Percentage of CD4+ T cells expressing IFN-gamma was significantly decreased in atopic dermatitis compared with nonatopic healthy adults.
- IFN-gamma represses IL-4 expression via IRF-1 and IRF-2
- Haplotype analysis of interferon gamma confirms that this multiple sclerosis (MS)associated locus protects males from developing MS according to a recessive or allele-dosage model.
- Downregulation of waf1 mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma.
- The different rates of interleukin-10 production associated with the interleukin-10 polymorphism did not affect susceptibility to tuberculosis.
- role in downregulating CXC chemokine GCP-2/CXCL6
- It was impossible to evaluate whether in vitro cytokine production profiles really can be deduced from a particular cytokine gene polymorphism.
- IFN-gamma gene polymorphisms are associated with disease susceptibility and disease progression in IgA nephropathy in Japanese patients.
- IFN gamma is an important modulator of CXCR4 and CCR5 expression in human fetal astrocytes.
- IFNG treatment of ECV304 cells increased bacterial cell adhesion.
- primarily mediates effects on megakaryocytic cells and platelets rather than on thrombopoietin-producing hepatocytes
- IFN-gamma is an effective inhibitor of ASM cell proliferation by blocking transition from G1-to-S phase by acting at two different levels: modulation of cdk2/cyclin E activation and inhibition of E2F-1 gene expression.
- Membrane-bound form of fractalkine induces IFN-gamma production by NK cells
- relationship between recurrent pregnancy loss and polymorphisms of the genes coding for TNF-alpha (-308 G-->A), IL-10 (-1082 G-->A), IL-6 (-174 G-->C), and IFN-gamma (+874 A-->T)
- In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower.
- IFN-gamma-stimulated p11 expression may serve a counterregulatory role in human epithelial cells
- Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines
- enhanced expression in Helicobacter pylori infection of gastric mucosa; significant association with bacteria load, chronic inflammation and activity
- TNF-alpha and IFN-gamma were significantly overexpressed in stimulated marrow marrow mononuclear cells of Fanconi anemia patients as compared to healthy controls.
- role in genetic susceptibility of tuberculosis
- down-regulation of IFN-gamma-induced gene expression by VIP and PACAP is important for regulation of the inflammatory response in the central nervous system
- In the presence of prolactin, interferon-gamma (IFN-gamma) and interleukin (IL)-12 p70 levels, but not of IL-10 and tumor necrosis factor-alpha (TNF-alpha), increased significantly in whole blood.
- expression of IP-10 in serum and liver highest in chronic hepatitis C and correlates with accumulation of Il-18 and INFgamma mRNA in chronic hepatitis C, but not in hepatitis B nor in nonviral liver disorders
- Measles virus V protein does not block IFNG signaling.
- IFN gamma activates CARD4/NOD1 transcription and regulates innate immune mechanisms in the condition of intestinal mucosal inflammation
- gamma interferon implicated in the pathogenesis of the anemia of chronic disease may exert its effects at least in part through modulation of oxidative stress
- Production of IFNG was reduced after the second T-cell vaccination.
- In all three groups of patients significant correlation was seen between abundance of IL-2 vs. IL-4, IL-5, IL-10, or TNF-alpha, between IL-4 vs. IL-10, and between TNF-alpha vs. INF-gamma
- IFNG -179T is a risk factor for AIDS progression, as measured by CD4 cell count
- IFNgamma strongly blocked the generation of myofibroblasts and moderately inhibited the production of alphaSMA in TGFbeta1-promoted myofibrobasts.
- These two potentially important candidate gene single nucleotide polymorphisms are not associated with susceptibility to idiopathic pulmonary fibrosis.
- Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
- The degree of IFN-gamma promoter methylation correlates with the production of IFN-gamma, which plays an important role during in vitro differentiation of peripheral blood T helper cell subtypes.
- IFNgamma in the presence of GM-CSF and/or TNFalpha differentially regulates monocyte MMPs through induction of TNFalpha and a novel mechanism involving caspase 8 that is independent of apoptosis
- In cultured myotubes from muscle biopsies of patients with sporadic inclusion body myositis, IFN-gamma upregulates the synthesis of monokine induced by IFN-gamma (Mig) and IFN-gamma-inducible protein-10 (IP-10).
- plays an important physiological role during inflammation by down-regulating collagen gene expression and activating major histocompatibility II complex
- interferon gamma has a role in modulating RANKL secretion through interferon gamma/RANKL cross-talk
- Number of CD4+ cells expressing intracellular IFN-gamma (significantly higher in elderly trained than in young. No significant differences in IFN-gamma/IL-4 ratio within CD4+ and CD8+ cells.
- common polymorphisms in the IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to rheumatoid arthritis, by distorting the propensity of female carriers versus male carriers to contract this disease.
- The dermal T cell IFN-gamma responses to the group A streptococcal cell wall extract, which ranged from < 1 to 28%, were significantly higher than that to S. mutans extract (p = 0.0052) and were self-HLA-DR allele restricted
- Tat produced cytotoxicity of brain microvascular endothelial cells, but required IFN-gamma
- identify a highly conserved distal enhancer in the IFN-gamma cytokine locus
- IFN-gamma operates a switch that rapidly regulates signal transducer and activator of transcription (STAT) activation by IL-10 and alters macrophage responses to IL-10.
- Two IFN-gamma polymorphisms (+2109 A/G and +3810 A/G) result in changes in nuclear protein interactions with intronic regions of IFN-gamma, which may play a critical role in the control of periportal fibrosis in hepatic schistosomiasis mansoni infection.
- neonates have an immature interleukin-10 and interferon-gamma response as compared with adults
- No association between interferon gamma single nucleotide polymorphism and risk of Alzheimer disease.
- homozygous for the IFNG +874A allele may have a higher risk of contracting brucellosis
- interferon gamma Stat1 signaling in epithelial cells is disrupted by Helicobacter pylori infection
- IFN-gamma treatment inhibits IFN-alpha-activated signals most probably, at least in part, through the induction of STAT1 protein expression.
- Results describe the effect of CD80 and CD86 inactivation on interleukin-4 and interferon-gamma production in nonatopic asthmatics and healthy subjects.
- peptidoglycan signaling through TLR2 and bacterial CpG DNA signaling through TLR9 are functionally equivalent at synergizing with IFN-gamma in regulating Tap-1 expression in macrophages
- IFN-gamma plays a role in preventing the erythroid progenitor cell apoptosis by affecting Bcl-x expression, thus reducing disruption of mitochondrial transmembrane potential via PI3-kinase pathways that are related to but distinct from the EPO pathway.
- Outward vascular remodeling and intimal thickening, two manifestations of arteriosclerosis with opposing effects on luminal size, result from immune effector mechanisms that are T-cell dependent and interferon (IFN)-gamma mediated.
- Human lung fibroblasts stimulated with IFN-gamma show a marked decrease in CD154 protein expression, for both the normal and fibrotic strains of lung fibroblasts tested.
- interferon-gamma upregulates urotensin II receptor
- genetic polymorphism of the first intron of the promoter gene of IFN-gamma may be an important risk factor to develop oral lesions of lichen planus
- Frequency of IFN- gamma -producing T cells in patients with chronic Chagas disease is associated with history of recent exposure and with the clinical status of the patient.
- In human monocytic THP-1 cells stimulated by IFN-gamma, mRNA abundance of interferon regulatory factor-1 (IRF-1) increases far more than transcription rate, but less than the transcription rate in THP-1 cells infected by Mycobacterium tuberculosis.
- A novel role is shown for IFN-gamma in foam cell formation through upregulation of CXCL16/SR-PSOX.
- up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
- the presence of a combined association between DR beta 1 major histocompatibility complex and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and Lofgren's syndrome patients
- an IFNgamma-dependent signaling cascade activated downstream of the phosphatidylinositol (PI) 3'-kinase, involving the mammalian target of rapamycin (mTOR) and the p70 S6 kinase
- IFN-gamma gene polymorphism at position +874 (intron 1) does not play a dominant role in alcoholic chronic pancreatitis
- The CA repeat polymorphism of the IFN-gamma gene might be associated with the outcome of anti-thyroid drug treatment.
- JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes
- significant effect of IL-18 on IFN-gamma release in vitro
- IFNG CA-repeat polymorphism is associated with susceptibility to endometriosis in a Japanese population.
- findings indicate that T-cell populations rather than malignant B cells are the source of interferon-gamma in B-cell chronic lymphocytic leukemia patients
- IFNgamma CA polymorphism is associated with coeliac disease
- IFN-gamma promoter activity is suppressed by GATA-3 independently of binding to cis-regulatory elements
- IFN-gamma + 874 SNP might be important in determining an individual's susceptibility to development of intrauterine hepatitis B virus (HBV) infection.
- identification of locus in interferon-gamma for epigenetic remodeling and transcriptional regulation by interleukin-2
- FN-gamma regulates IL-4- and STAT6-dependent signaling and gene expression in airway epithelial cells by multiple mechanisms
- Polymorphic in pancreatitis.
- Actinobacillus actinomycetemcomitans (Aa) and Aa lipopolysaccharide (LPS) induces dendritic cells IL-12 p70 and natural killer cells IFN-gamma production
- IFG responses to Plasmodium falciparum LSA-1 and TRAP develop in response to age and/or repeated exposure; and IFG response to LSA-1 as measured by ELISA correlates with protection against uncomplicated malaria morbidity.
- no evidence for IFNG as a predisposing gene in celiac disease, despite its enhanced expression in patients with total villous atrophy (a 240-fold higher expression) and in patients in complete remission
- the synergistic induction of IFN-gamma by interleukin-12 and IL-18 in natural killer cells is mediated at least in part by p38-dependent and 3' UTR-mediated stabilization of IFN-gamma mRNA
- TNFa, IL-1b and ifn-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK
- role of IL-13 in the skin and IFN-gamma in the liver in protective immunity against schistosomes [review]
- exposure of human mast cells to IL-4, IL-5, and IFN-gamma during growth and differentiation generally down-regulated mast cell number and function
- IFN-gamma is a central mediator of vascular dysfunction and, through dysregulation of NOS expression, links early dysfunction with late arteriosclerosis.
- HSV-2 antiviral effect of type II interferon and TNF-alpha is dependent on indoleamine 2,3-dioxygenase (IDO) activation
- tumor cell lines expressed cell surface IFN-gamma receptors, and when cultured for 2 days in the presence of IFNG, all exhibited a significant increase in expression of Fas receptors and exhibited intracellular fragmented DNA as a marker of apoptosis
- interleukin 12 and interferon gamma are involved in inhibition of cytotrophoblastic cell invasion
- gene polymorphisms of cytokines playing a major regulatory role in the inflammatory response do not affect life expectancy in the Sardinian population.
- Peripheral blood leukocytes (PBL) from individuals with specific IFNG genotypes differ in their ability to rapidly develop high-penetrance, Epstein-Barr virus driven-lymphoproliferative disease in the human PBL-SCID mouse model.
- Genetic polymorphism of the interferon-gamma gene is associtated with cervical carcinogenesis. This polymorphism correlates with HPV infection in a disease- and type-specific manner
- The frequency of IFN-gamma-producing cells expressing CXCR3+ CD3+ cells is significantly increased in patients with Behcet's disease
- IFN-gamma enhances TRAIL-induced apoptosis through IRF-1
- mTOR may play a major role in IL-12-induced IFN-gamma production by activated T cells
- Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and inhibits the expression of adenylate cyclase
- The presence of allele 2 (12 CA repeats)in the human IFN-gamma gene was consistently associated with increased duration of survival after confirmation of nonresectable pancreatic carcinoma.
- IFNgamma-induced apoptosis is p53-independent
- In pre eclampsia IFN-gamma expression mimicked that in early placental development.
- In the presence of IFN-gamma, TNF-alpha increased GTPCH I mRNA in a manner dependent on nuclear factor-kappaB. IFN-gamma and TNF-alpha exert distinct but cooperative roles for BH4 biosynthesis in endothelium.
- Here we report that while CDIR does not alter the response of cells to Fas or TRAIL, it significantly modulates IFN-gamma-induced sensitization of HeLa cells to these death-inducing ligands.
- Expression in CD8+ T cells of patients with advanced solid tumors in response to influenza and vaccinia antigens.
- Upregulation in the colonic mucosa of patients with ulcerative colitis.
- IFN-gamma accelerates differentiation of targeted human stem and progenitor cells, demonstrating that IFN-gamma can negatively affect self-renewal of human hempoietic stem cells.
- Among host genetic factors contributing to H. pylori disease outcome, IFN-G +874 AA genotype favors cagA positive infections.
- IFN-gamma plays a role in regulating T helper 1-type immune responses in neonates born to mothers with placental falciparum malaria at delivery.
- IFN-gamma may contribute to the inflammatory cascade of familial mediterranean fever
- IFN-gamma can prime intestinal epithelial monolayers to respond to TNF-alpha by disrupting tight junction morphology and barrier function via MLCK up-regulation and MLC phosphorylation
- IFN-gamma is not only involved in tumorigenicity but also involved in neurogenesis by regulating cell proliferation and differentiation
- p27Kip1 inhibits hTERT mRNA expression and telomerase activity through post-transcriptional up-regulation by IFN-gamma/IRF-1 signaling
- predominant presence of high-producing IL-6 alleles together with low-producing IL-10 and IFN-gamma alleles in G6PD-deficient individuals with ancestry from malaria-endemic regions
- These data indicate that IFN-gamma mediates the recruitment of lymphocytes into the lung via production of the chemokine CXCL10, resulting in Tc1-cell alveolitis and granuloma formation.
- Natural Killer cells produce high levels of IFN-gamma when stimulated with a combination of Helicobacter pylori antigen and IL-12.
- results suggest that autophagy 5-like Atg5 plays a crucial role in interferon-gamma-induced autophagic cell death by interacting with Fas-associated protein with death domain (FADD)
- increased levels in HPV16+ cervical biopsies, decreased levels in HPV18+ biopsies, increased levels in HIV-/HPV16+ biopsies, and decreased levels in HIV-/HPV18+ biopsies.
- IFN-gamma produced in the prostate by basal cells and, under proinflammatory conditions, by infiltrating lymphocytes could support neuroendocrine cell differentiation and play a role in differentiation of tumor cells in hormone-refractory prostate cancer
- transepidermal water loss was suppressed by TNF-alpha and IFN-gamma, and these effects were also inhibited by IL-4.
- Significantly higher interferon, gamma levels are associated with serous adenocarcinoma
- Cytotoxic T-lymphocyte precursor frequency can be determined by the granzyme B and interferon gamma marker for determining donor-specific cytolytic activity after clinical organ transplantation.
- increased frequency of (CA)12 allele (P<0.001) and decreased frequencies of (CA)15 (P<0.01) and (CA)>15 (p<0.001) alleles in sporadic breast cancer patients as compared to controls
- effect of IFN-gamma on the mechanisms responsible for the circadian organization of pituitary hormone release
- IFN-gamma-induced enzyme Indoleamine 2,3-dioxygenase (IDO) plays an important antiviral role in Measles virus infections of epithelial, endothelial, and astroglial cells
- results of this study indicate that IFN-gamma may contribute to the development of type 2 diabetes, based on a combination of molecular and immunological observations
- IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response
- Transgenic interferon-gamma induces alveolar epithelial cell DNA injury and apoptosis via a novel murine cathepsin S-dependent pathway, a critical event in the pathogenesis of alveolar remodeling, emphysema and inflammation.
- CIITA promoter pIV is IFN-gamma inducible in B cells and the GAS and IRF-E sites are necessary for full induction. DNA binding of IRF-1 and IRF-2 was up-regulated in B cells in response to IFN-gamma and increased the activity of CIITA pIV.
- IFN-gamma effects are modified by dexamethasone in normal human bronchial epithelial cells
- EBV LMP1 could activate downstream molecules ERK and interferon-gamma (IFN-gamma)
- IFN-gamma sensitizes KB cells for apoptosis induction by facilitating death-inducing signaling complex (DISC)-mediated caspase 8 processing.
- The effects of IFN-gamma on immature erythroid cells depend on multiple interactions between tumor necrosis factor (TNF) family members and their receptors.
- IL-12 and IL-18, which synergise to stimulate NK cells to produce interferon-gamma, are produced following the Chlamydia trachomatis infection of dendritic cells and epithelial cells
- findings demonstrate that interferon-gamma binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin
- all-trans-retinoic acid, an RARalpha ligand, regulates IFNgamma-induced IRF-1 by affecting multiple components of the IFNgamma signaling pathway, from the plasma membrane to the nuclear transcription factors
- Data show that frequencies of CD4 IL-10 and CD4/CD8 IFNgamma-secreting memory T cells specific for RSV or influenza were not significantly different between young and elderly, but the ratio of IL-10/IFNgamma was significantly reduced in elderly RSV.
- IFN-alpha increased IFN-gamma production
- IFNG T874A, IFNGR1 C-56T and IFNGR2 A839G genotypes were not associated with the incidence of angiographic and clinical restenosis (P>0.23).
- Data suggest that acquired defects in the interferon-gamma pathway may explain unusual susceptibility to intracellular pathogens without underlying, genetically determined immunological defects.
- IFN-gamma may be responsible for acute lung injury in the late phase of severe acute respiratory syndrome (SARS) pathology.
- IFNG priming enhances migration to inflammatory chemokines; IFN-gamma-inducible gene expression is attenuated by high levels of Stat1; physiological regulation of the relative abundance of Stat1 and Stat3 impacts on gene expression
- IFN-gamma attenuates epithelial wound closure by microtubule-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of focal adhesion complexes and cell migration.
- Compared to the control group, there was lower expression of IFN-gamma mRNA in CD4+ cells at the time of lymphoma diagnosis; this may be one of the pathogenetic mechanisms of impaired immunity in these patients
- Short-time incubation with protein kinase C activators or phosphatase inhibitors down-regulate DNA methylation activity in a dose-dependent manner. This inhibition correlates with the induction of the interferon-gamma gene.
- Data from a prospective twin study suggest that signature cytokines (e.g., IFN-gamma) and IFN-gamma signaling events of T helper type 1 (Th1) rather than Th2 cells are genetically determined.
- results demonstrate that the conserved Leu-724 residue is a key residue that controls the maximal transcription activities of Stat1 in IFN-gamma signaling
- The IL-12/IL-18 axis does not induce IFN-gamma production in human endotoxemia.
- Keratinocytes are capable of synthesizing factor H and that this synthesis is regulated by IFN-gamma.
- TNF-alpha and IFN-gamma regulate gene transcription mediated by NF-kappaB-Stat1 interactions
- Changes in IL-10 and inteferon-gamma blood levels in leishmaniasis patients following treatment are reported.
- IFN-gamma, which induces HLA-DR antigens on the cell surface, also suppresses c-myc expression in situ, and is a possible non-immunological mechanism involved in the better long-term survival of colorectal cancer patients
- Loss of interferon gamma production indicates an inadequate immune response to viral progression in the liver transplant recipient with relapsing hepatitis c virurs infection.
- Review. IFN-gamma triggers barrier dysfunction and bacterial translocation in intestinal epithelial cells.
- CTLA-4 on regulatory T cells up-regulates indole 2,3-dioxygenase expression on decidual and peripheral blood dendritic cells and monocytes by the induction of IFN-gamma production.
- Taken together, these results demonstrate that an intact mTOR pathway is critical for IFN-gamma-induced suppression of pY-STAT3 and apoptosis.
- ISG15 as the critical component in IFN-mediated inhibition of HIV-1 release
- Interferon gamma polymorphisms and their interaction with smoking are associated with lung function
- In conclusion, incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs, an effect partially mediated by NO.
- the interaction of IRF-8 with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-gamma and TLR signal pathways
- IFN-gamma may play a key role in the regulation of ocular surface inflammation and immunologic reaction in cystic fibrosis (CF) patients. The tear level of IFN-gamma may be a candidate marker for evaluation of the clinical status of CF and eye disease.
- folding of interferon-gamma in the endoplasmic reticulum is regulated by multichaperone complexes
- Understanding the mechanism by which IFN-gamma exerts its effect will be important in the utilization of this cytokine as a therapy for postoperative adhesion and tissue fibrosis.
- demonstrated production of IFN-gamma by human dendritic cells on the single cell level, identified toll-like receptor 2 as a pattern recognition receptor involved in this process
- CD4+ lymphocytes remain the predominant producers of interferon gamma.
- epidermal caspase-3 cleavage correlated with the numbers of dermal interferon-gamma expressing CD4+ and CD8+ lymphocytes in skin lesions of acute atopic dermatitis
- Within the IFNG gene, two promoter variants showed evidence of novel tuberculosis association: -1616GG and +3234TT.
- IFN-gamma gene polymorphism might be important in determining individual's susceptibility to intrauterine HBV infection
- IFN-gamma primes VSMCs to Fas-induced apoptosis, in part by relocation of Fas to the cell surface, a process that involves PI3K, Akt, and Jak-2/Stat1
- An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.
- Interferon (IFN)-gamma and its receptor subunit IFNGR1 bind to the IFN-gamma-activated sequence (GAS) response element in the promoter region of IFN-gamma-activated genes. This binding results in enhanced activation of IFN-gamma-induced genes.
- T-cell-derived IFN-gamma and IL-10 may be key regulators of production of mucosal antibody to pneumococcal protein antigens in the nasopharynx and may play an important role in local protection against pneumococcal infection in children.
- IL-10 significantly decreased RANKL+ Th1-associated alveolar bone loss and expression of IFN gamma.
- kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1
- Response to Th1 cytokines suggests they may play a significant role in modulating NKCA following a strenuous bout of aerobic exercise when carbohydrate is consumed.
- lipopolysaccharides inhibit interferon gamma-induced gene expression of secretory phospholipase A2 type IID in human monocyte-derived macrophages
- IL-32 is a cell-associated proinflammatory cytokine, which is specifically stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma.
- mu-opioid receptor expression is down-regulated in SH SY5Y neuroblastoma cells by IFN-gamma
- Higher percentages of Gr-1 expressing NK and T cells, poorer ability in controlling bacteria growth, and higher IL-18 could be the factors contributing to IFN-gamma hyperproduction in BALB/c mice
- no statistically significant association with susceptibility to persistent HBV infection was observed with the IFN-gamma, IFNGR-1 and 2, and IRF-1 gene polymorphisms under the codominant, dominant, and recessive models
- Both early interferon-gamma and interleukin-2 production independently predict subsequent memory responses at 3 months in malaria-naive volunteers, but only IFN-gamma predicts memory in malaria-exposed volunteers.
- An association is indicated between IFN-gamma-producing genotype TT (thymine) and Hashimoto's thyroiditis, whereas in Graves' hyperthyroidism the IFN-gamma association is observed to be stronger with the low producing allele A (adenine).
- The ratio of IFN-gamma/IL-10 producing cells is the best tool to discriminate between nonrejecting patients and rejecting patients after kidney transplantation.
- IFN-gamma differentially regulates constitutively expressed and cytokine-induced TGF-beta1 and TGF-beta2 mRNA levels and secretion of TGF-betas by retinal pigment epithelial cells.
- IL-21 differentially regulates IL-4-induced IgE production, via its growth- and differentiation-promoting capacities on isotype- committed B cells, & via its ability to induce IFNg production; the outcome depends on the presence of a IL-21R polymorphism.
- Alopecia areata might be induced by an aberrant expression of IFN-gamma in individuals whose PBMC produce low amounts of IFN-gamma and TGF-beta1
- No association is found for IFNgamma single nucleotide polymorphisms in patients with increased susceptibility to bronchiectasis.
- Thus, sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma.
- Our results suggest that haplotype AG containing +874A and +2109G may be a crucial risk factor of genetic susceptibility to HBV infection in the Chinese population.
- IFN-gamma has a role in regulating the lytic infection of BK virus by inhibiting the expression of viral genes.
- Improved yield of recombinant protein in chromatographic purification promises to enhance the development and therapeutic application of this biologically potent molecule.
- Natural killer (NK) cell-produced IFN-gamma mediates T-independent resistance and granulocyte function in M. tuberculosis infection, a response which could serve as an important barrier in individuals with compromised CD4+ T cell function.
- Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients.
- Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of IFN-gamma
- There is an association between expression of Th1/Th2 transcription factors and cytokines (T-bet, GATA-3, IFN-gamma, IL-4,IL-18) in systemic lupus erythematosus.
- Differential regulation of IFNgamma promoter methylation in T cells may be an important contributory factor in atopy development in childhood
- no associations occurred between IFNG polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan
- Decidual NK (dNK) cells exerted contact-independent inhibition of normal cytotrophoblast migrationd, which was partially reversed by neutralizing Abs against IFN-gamma.
- proof of principle that it is possible to differentially modulate the IFN-gamma-induced expression of the HLA-E and HLA-A genes; Stimulation of HLA-A expression by IFNgamma requires nuclear export of HLA-A mRNA by chromosome maintenance region 1 (CRM-1).
- inhibition of insulin-like growth factor 1 signaling combined with IFN-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own
- Results show natural killer cells produce interferon-gamma in response to Plasmodium falciparum-infected red blood cells (iRBCs). It's dependent upon contact-dependent and cytokine-mediated signals from monocytes and myeloid dendritic cells (mDCs).
- Activation of the IFN-gamma axis is not associated with acute coronary syndromes, but portended increased morbidity and mortality.
- Positive CD3+ cells stained for TNF-alpha and IFN-gamma were significantly higher in peritoneal fluid cells compared with peripheral blood mononuclear cells.
- This study failed to observe a significant difference in the +874IFN-gamma single-nucleotide polymorphism between chronic periodontitis patients and controls.
- high-IFNG-producing alleles in intron 1 of the IFNG locus are associated with high [tsIgE] in asthmatic children from Niue and with natural immunity to the HBV in Polynesian women
- IFN-gamma promoter Single Nucleotide Polymorphism -764G/C is functionally important in determining viral clearance and treatment response in HCV-infected patients
- HNP enhanced the interaction between A549 cells and CD4+ lymphocytes by increasing cell adhesion and release of IFN-gamma, IL-2, and IL-8. This was attenuated by using an alpha1-proteinase inhibitor to neutralize HNP.
- These data suggest a mechanism of IC-mediated inhibition of IFN-gamma signaling, which requires the ITAM-containing FcgammaRI, as well as the ITIM-dependent phosphatase SHP-1, ultimately resulting in the suppression of STAT1 phosphorylation.
- using choriocarcinoma cells, it is shown that tyrosine phosphatase mediated suppression of IFN-gamma-inducible JAK and STAT-1 and select IFN-gamma-inducible gene expression in trophoblast cells may contribute to fetal maintenance
- No significant association between episodes of acute rejection of kidney transplantation and single nucleotide polymorphisms.
- In this study, interleukin 18 (IL-18) levels were higher during early HIV infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon gamma levels.
- IFN-gamma activates Stat1 in A549 non-small cell lung adenocarconima cells but, by itself, did not induce apoptosis.
- In a Turkish population, the interferon-gamma 874T-A polymorphism is associated with tuberculosis disease and affects the magnitude of the interferon-gamma response.
- IFN-gamma upregulates the activity of CIITA in multiple myeloma
- Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4
- Intestinal epithelial cells activate CD4+ T-cells to secrete interferon gamma in inflammatory bowel disease.
- In this review, signature T-helper type 1 cytokine interferon (IFN)-gamma is a key effector in graft arteriosclerosis and part of a positive feedback loop for T-cell activation, differentiation, and recruitment referred to as the IFN-gamma axis.
- in most MM plasma cells, B7-H1 expression was increased or induced by IFN-gamma and Toll-like receptor (TLR) ligands
- Parkinson's disease patients express significantly elevated levels of IFN-gamma in their blood plasma.
- In this study, Wnt signaling activity directly demonstrated in human astrocytes is markedly reduced by interferon (IFN)-gamma treatment. By inhibiting transcription factor 4 (TCF-4), IFN-gamma regulates TCF-4 repression of HIV replication in astrocytes.
- Genetic markers in the IFN-gamma gene demonstrate significant allelic associations with the IIMs in a UK Caucasian population.
- This study demonstrated a significant association between CSF levels of IL-1beta, Il-6, and IFN-gamma and the severity ot EV71 brain stem encephalitis in.
- Our results suggest that IFNG +874T/A polymorphism was not associated with either susceptibility or severity to leishmaniasis but can influence IFNG production.
- L. major counteracts the IFN-gamma response in macrophages, particularly expression of genes in innate immune response, cell adhesion, proteasomal degradation, Toll-like receptor expression, signaling molecules, and matrix metalloproteinases.
- IFN-gamma exerts a tissue-specific action in rodents and humans, having glyceroneogenesis and the PEPCK-C gene as selective targets to intensify fatty acids release from adipocytes
- This study identifies alpha2 beta1 integrin as an important regulatory pathway of IFN-gamma expression and provides novel insights into the signaling mechanisms of integrin costimulation in T cells.
- IFN-gamma T874A polymorphisms might be the genetic factor for the risk of asthma in the Chinese population
- No observed statistically significant differences in INFgamma gene expression between studied group and control for cardiac syndrome X
- Data suggest that individuals who have IFN-gammaAA genotype are more susceptible, and those who carry IL-4CC genotype are more resistant to brucellosis.
- Serum of subjects with endometriosis contains significantly higher levels of interleukin-6, monocyte chemotactic protein-1, and interferon-gamma than control women.
- IL-4 and interferon gamma have opposite effects on the expression of claudin-2 and the physiology of the tight junction
- In human mesenchymal stem cells, interferon- gamma-induced major histocompatibility complex (MHC) class II expression occurs at highest levels in low-density cultures, via effects on class II transactivator CIITA expression.
- Neutrophils can produce macrophage chemoattractant protein-1 (MCP-1) in a T helper type 1 (Th1) cell microenvironment, which potentially amplifies the development of Th1 adaptive responses.
- These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.
- the interferon-gamma +874(A/T) and IL-4 VNTR in intron3 polymorphisms are not responsible for genetic susceptibility to ITP
- Proarteriosclerotic effects of interferon gamma are associated with mammalian target of rapamycin raptor complex (mTORC1) and PI-3 kinase activiation.
- The levels of intralesional expression of mRNA of tumor necrosis factor-alpha, interferon, interleukin-10, RANTES, and indoleamine-2,3-dioxygenase in Mediterranean spotted fever are reported; levels of inducible nitric oxide synthase are also reported.
- Role of IFN-gamma +874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects
- IFN-gamma UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP-HCV+ve (oral lichen planus-chronic hepatitis c) patients compared with OLP-HCV-ve that approached the statistical significance
- expressed IFNgamma and IFNgamma-Ralpha together with the nuclear localization of IFNgamma-Rbeta, could be a tumoral cell response
- Study found that among pleural fluid lymphocytes, natural killer cells are a major source of early IFN-gamma upon M. tuberculosis stimulation and Toll-like receptor 2 and 4 agonists activate NK cells but do not induce IFN-gamma like M. tuberculosis does.
- the +874 intron polymorphism of IFNG may have a role in systemic lupus erythematosus susceptibility with arthritis in the Thai population
- interferon-gamma-induced apoptosis in prostate cancer cells
- there is a strong association between the maintenance of highly functional CD4 T cells producing IFNgamma, IL-2, and TNFalpha and control of HIV-1
- IFNgamma production in response to C. hominis gp15 was noted in both CD4(+) and CD8(+) cells
- A significant distribution difference of IFN-gamma +874 A/T was not observed between those with persistent and self-limiting HBV infections..
- SET expression is essential for suppressing protein phosphatase type 2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma
- secretory leukocyte protease inhibitor can inhibit interferon-gamma-induced cathepsin S production by macrophages
- CD4+ cells may facilitate the early clearance of bacteria by regulating neutrophils function possibly through an IFN-gamma-dependent mechanism
- In in vitro PHA activated PBLs IL-6 was the most induced with a maximum increase of 1110-fold after 4 h of PHA stimulation, followed by TNF-alpha and IL-1beta as well as interferon-gamma (IFN-gamma).
- Regulation of adaptive immune responses by vascular cells through IFN-gamma-inducible expression of indoleamine 2,3-dioxygenase in vascular smooth muscle cells prevents T cell activation and clonal expansion in response to allogeneic endothelial cells.
- Host-derived factors (IFN-gamma and TLR4 ligand) and viral factors (TLR2 ligand) act in tandem to induce and maintain monocyte/macrophage activation, thus favoring persistent inflammation in patients with cHCV infection.
- The regulation of inteferon gamma production during tuberculosis by CD31 and signaling lymphocytic activation molecule-associated protein interactions is reported.
- n-3 PUFAs treatment effectively prevented the redistribution of occludin and ZO-1 and distortion of TJ morphology, reduced transepithelial electrical resistance induced by IFN-gamma and TNF-alpha
- In sarcoidosis patients with severe, treatment-requiring disease, IFN-gamma was strikingly elevated and PPARgamma gene expression was deficient.
- there are two proposed mechanisms for severe hRSV disease: reduced local IFN-gamma response and SP mediated inflammation
- These findings demonstrate for the first time that IRF-1 is a novel alternative GRbeta-independent mechanism mediating steroid dysfunction induced by pro-asthmatic cytokines.
- Candida-specific IFN-gamma (interferon- Gamma) production was significantly reduced in chronic mucocutaneous candidiasis patients.
- IFN-gamma production in both NK and NKT cells was decreased in early pregnancy.
- The IFN-gamma gene polymorphism does not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Korean population.
- psoriasin expression is transcriptionally suppressed by IFN-gamma; this effect is likely to be mediated by the activation of the STAT1 signaling pathway
- Possible effects of genetic polymorphisms in the susceptibility to subacute sclerosing panencephalitis.
- IP-10 expression in epithelial cell/PBMC co-cultures is regulated by multiple factors, such as intercellular interactions in addition to IFN-gamma and IL-12 levels.
- interleukin 10 (IL-10) and interferon gamma (IF-gamma) in serum do not appear to play a role in thyroid eye disease
- Increased IFN-gamma level was found in non-treated patients with IPF, Loefgren's syndrome and progressive sarcoidosis.
- acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4
- IFN-gamma-induced MIC molecules participated in monocyte/NK cell interaction and this interaction also involved mIL-15.
- Our results demonstrate that IFNs may increase cell resistance to staphylococcal alpha-toxin via the regulation of lipid metabolism and suggest that interferons play a protective role during staphylococcal infections.
- Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
- Acute lung transplant rejection is associated with decreased intracellular T-cell TGFbeta in blood and increased intracellular IFNgamma and TNFalpha
- RIG1 plays a role in IFN-gamma-mediated therapy by downregulating p185 and its downstream PI3K/Akt/mTOR/VEGF-signaling pathway
- These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production.
- Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation
- Exogenous IL-24 enhanced IFN-gamma expression by increasing expression of IL-12 family cytokines.
- The functional SNP T allele and microsatellite 12 (CA) repeats were found to have a strong linkage disequilibrium, although a genetic susceptibility for the IFN-gamma gene could not be demonstrated among the Japanese Vogt-Koyanagi-Harada disease patients
- it is suggested that tryptophan depletion via IFN-gamma-mediated IDO induction is a major antibacterial, antiparasitic, antiviral and immunoregulatory mechanism in human lung cells.
- Reporter gene assays with PIII and PIV CIITA promoters indicate constitutive expression of PIII in MSCs and a switch to PIV by IFN-gamma, indicating the presence of factors for effect promoter responses.
- The results of the present study suggest that thioredoxin is a direct stimulator of IFN-gamma gene expression in human T cells and that there is a positive feed-back circuit by IFN-gamma and thioredoxin in the regulation of Th1 immune response.
- The results suggest that the interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms may not be associated with the susceptibility of Iranian individuals to periodontitis.
- The roles of BAFF protein and interferon gamma in IgA production of tonsillar mononuclear leukocytes in patients with IgA nephropathy.
- Elite controllers of HIV-1 infection represent a distinct group of individuals who have significantly more CD4 and CD8 T cells that secrete interferon-gamma and interleukin-2
- We report on a frequent ex vivo dissociation of the HIV peptide-induced secretion of perforin, granzymeB and IFN gamma by HIV-specific CD8(+) cells in HIV infection.
- Data show that depressed and anxious mood were both associated with significantly lower ratios of polyclonally-stimulated CD4 and CD8 (+) cells producing IFN gamma (TH(1) cells) vs. IL-4 (TH(2) cells)in ovarian cancer patients.
- As a surrogate of cytotoxic activity, we found markedly increased production of interferon-gamma in most of the neutropenia patients, irrespective of the presence of immunodominant CTL clones.
- Th1 cytokine/IFN-gamma levels in blood are lower in early onset Crohn's disease patients than in healthy children and are directly associated with disease-related clinical parameters.
- probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-gamma than the probiotic Lactobacillus strains
- investigation of possible association between single nucleotide polymorphisms in IL-10 & IFN-gamma genes with nasopharyngeal carcinoma; no association was found either for each SNP studied alone or for combined analysis for IL-10 & IFN-gamma SNPs
- In uveal melanoma patients, elevated serum levels of IFN-gamma correlate with the spread of metastasis and represent a negative prognostic marker.
- IFNG is associated with sex bias in MS susceptibility and with expression of IFN gamma in MS.
- Results showed an epistatic effect between CD28 and IFNG genes in susceptibility to cervical cancer.
- ERK-regulated site in Med1 protein is also essential for up-regulating interferon-induced transcription although not critical for binding to C/EBP-beta
- TTP plasma-mediated apoptosis appears to involve IFNG-induced acceleration of c-FLIP degradation, sensitizing cells to TRAIL-mediated caspase-8 activation and cell death.
- a positive association of IFNG polymorphism with tuberculosis
- our results showed that retinoid induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to IFN-gamma for increasing apoptosis in human glioblastoma cells.
- A single nucleotide polymorphism (A-->G) in intron 3 of IFNgamma gene is associated with asthma.
- TAP1 and TAP2 expression restores both antigen presentation and immunogenicity in A375 melanoma cells and concomitantly increases IL-12 and IFN-gamma production in tumor antigen-specific cytotoxic T lymphocytes.
- stimulation with Mycobacterium tuberculosis antigen ESAT-6 directly induced purified gammadelta T cells to produce IFN-gamma, independent of both antigen-presenting cells and CD4(+) T cells
- Plasma interferon gamma was elevated in multiple sclerosis patients at the end of an 8 week exercise program.
- Interferon gamma allele +874thymine/adenine polymorphism is a genetic marker for resistance to tuberculosis.
- increase of TIM-3 expression on PBMCs, overproduction of IFN-gamma in the sera, and increased galectin-9 in PBMCs was observed in acquired aplastic anemia patients
- intestinal macrophages expressing CD14 contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
- results suggest the existence of a mutually antagonistic relationship between PGE(2) and IFN-gamma, which may represent a fundamental mechanism of immune control in diseases such as Reumatoid Arthritis
- in macrophages of Ankylosing Spondylitis patients differentially expressed genes, 78 were IFN-regulated, with a "reverse" IFN signature where IFN gamma-up-regulated genes were underexpressed and down-regulated genes were overexpressed
- The suppressive effect on IFNgamma-mediated host cell protection is most effective when IFNgamma is added post infection, suggesting that the bacteria establish a permissive environment within the host cell.
- The production of Th1 and Th2 cytokines by naive CD4+ T cells to mycobacterial antigen-pulsed DCs in the group of young, healthy BCG vaccinated volunteers, was investigated.
- ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines Tumor necrosis Factor (TNF)alpha, IL-12(p70) and Interferon (IFN)gamma in Lipopolysacchaide-stimulated human blood
- There was no significant difference in IL-4/beta-actin between the patients with AIH and the healthy controls. In contrast there was a significant difference of IFN-gamma/beta-actin between those two groups.
- The mean serum IFN-gamma level was increased in silica-exposed workers (10.22 +/- 22.68 pg/mL) although it was undetectable in all office workers and even in the workers with silicosis.
- The polymorphisms in the IFNG and IFNGR1 genes were studied with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies.
- Compare interferon-gamma release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients.
- We hypothesize that SOCS1 functions as suppressor of IFN-gamma signaling, not only by inhibiting STAT1 activation but also by sustaining ERK1/2-dependent antiinflammatory pathways.
- NF-kappaB is important in saimiri transformation-associated protein of subgroup C-mediated upregulation of IFN-gamma production
- Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells.
- Levels of IL-23, IL-17, and IFN-gamma are elevated in Behcet disease(BD) with active uveitis. IL-23/IL-17 pathway together with IFN-gamma is associated with active intraocular inflammation in BD patients.
- IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma
- IFN-gamma is associated with protection against peripheral liver fibrosis in Schistosomiasis japonica, which depends more on egg load and egg-associated toxicity.
- reversion of Fas resistance is mediated through CD40/CD40L ligation rather than IFN-gamma stimulation by inhibiting synthesis of c-FLIP
- No significant differences of Interferon gamma (IFG) concentration were observed between patients with active immune thrombocytopenic purpura and the control group
- with progression of HIV-1 infection, interferon-gamma production declines whereas expression of interferon-gamma receptors (R1 and R2) increases
- This is the first report demonstrating the inhibitory and stimulatory effects of IFN-gamma on VEGF-A and sFlt-1 secretion, respectively.
- overexpression of IFN-gamma in peripheral blood T cells contributes to the immunopathogenesis of systemic lupus erythematosus via the induction of sBLyS by monocytes/macrophages
- involvement of IRF-1 in the regulation of SLC26A6 gene expression by IFNgamma in the human intestine
- Myelin cross-reactive T cells produced IFN-gamma, but differed from EBNA1-monospecific cells in their capability to produce interleukin-2.
- IFN-gamma AA carriers had a decreased odds ratio for the individual presence of Aggregatibacter actinomycetemcomitans. IFN-gamma TA predisposed an individual to infection with Prevotella intermedia.
- Data show that basal level of interferon gamma is higher in Parkinson's disease patients than in healthy control subjects.
- INF-gamma selectively increases P2X4-receptor gene expression, leading to an up-regulation of purinergic signaling in vascular endothelial cells.
- Hypermethylation of the interferon gamma gene among tumor-infiltrating lymphocytes is a mechanism of tumor induced immunosuppression.
- Significant IFN-gamma responses to rotavirus (RV) and NSP4 were detected in children during natural RV-infection and in RV-exposed adults.
- strong IFN-gamma responses associated with efficient viral clearance primarily result from Ag-driven selection/survival of HCV-specific T cells expressing high-avidity T cell receptor
- combination IL-2/IL-4 inhibits GCRalpha nuclear translocation in human T cells, and this effect is reversed by IFN-gamma via inhibition of p38 MAPK activation.
- Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling
- The interferon-gamma-mediated inhibition of LPL promoter activity was prevented by expression of dominant negative forms of casein kinase 2 and protein kinase B, a key downstream component of the phosphoinositide-3-kinase pathway.
- Our data suggest that IL17 might play a crucial role mainly in the early phase of MS, while IFNgamma seems to be involved both in the early phase and in the following relapses of the disease.
- T helper type 1 (Th1) cells and interferon (IFN)-gamma are increased in psoriatic blood and lesional skin; IFN-gamma programs myeloid antigen-presenting cells to induce human interleukin (IL)-17-positive T cells via IL-1 and IL-23.
- The mechanism of IFN-gamma-mediated inhibition involves induction of transcriptional repressor activating transcription factor (ATF)-3 and suppression of DNA binding by AP-1 proteins.
- These studies demonstrate a synergistic role between TNFalpha and IL-1 family members, including IL-1beta, in the induction of interferon-gamma production.
- Genotypes AT and AA + AT in interferon gamma gene is associated with cervical cancer
- the TNF-alpha -308 G/A polymorphism was more common in vitiligo patients than controls (P = 0.0004). This difference was only significant between female patients and controls (P < 0.0001)
- SHP2 activation induced by HCMV infection is responsible for the down-regulation of IFN-gamma-induced STAT1 tyrosine phosphorylation.
- sublingual immunotherapy treatment may induce a quick IFN- gamma response
- Interferon-gamma is associated with vascular endothelial dysfunction in patients with rheumatoid arthritis
- IFN-gamma responses to mycobacterial antigens in children were generally comparable to those of adults
- Human fg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via interferon gamma and IL-2 induction.
- IFN-gamma triggers antigen-presenting cells to produce interleukin (IL)-1 and IL-23 and enables them to induce expansion of memory T helper 17 cells via IL-1 and IL-23 in a B7-H1-independent manner.
- IFN-gamma exerted a delayed suppressive effect on K(+) channels by enhancing iNOS expression and an acute stimulatory effect, which was independent of either NO pathways or phosphorylation mediated by PKA, PKG, and PI3K in renal proximal tubule cells.
- These results indicated that oxidative stress induces PKR expression essentially via the IFN-gamma activation signal, and causes apoptosis in Jurkat T cells.
- Specific IFN-gamma responses to Human cytomegalovirus may be employed as a predictive useful marker for the evolution of HIV-1 infection.
- erythroid colony forming units (CFU-Es) from homozygous sickle cell (SS) patients are less sensitive to inhibition by rhgammaIFN than those from healthy controls
- Like IFNgamma, IP-10 also does not distinguish between active tuberculosis (TB) and latent TB infection.
- colon carcinoma cells silence IFN-gamma-activated IRF8 expression through MBD1-dependent and PIAS1-mediated inhibition of pSTAT1 function at the methylated IRF8 promoter
- IFN-gamma, by down-regulating ligand expression, might facilitate escape of MHC class I-negative melanoma cells from NKG2D-mediated killing by NK cells.
- Cervical mRNA expression of IFN-gamma, IL-10, and IL-12, as well as the Treg transcription factor Forkhead box P3 showed diminished IFNG expression.
- radiation induced CatS expression via ROS-IFN-gamma pathways, and this increased expression may be involved in radioresistance
- The pleiotropic cytokine IFN-gamma may control gene expression by regulating endogenous microRNAs.
- Pre-treatment with IL-4 and IL-13, but not IFN-gamma, induced desensitization of the human airway smooth muscle cells to IL-13 as measured by eotaxin secretion and calcium transients to histamine.
- INF-gamma gene variations were not associated with the susceptibility and disease severity of RSV bronchiolitis as well as IFN-gamma and total serum IgE levels.
- These findings establish Prox1 as a new negative regulator of IFN-gamma expression in T cells.
- the transcriptional activity of IFNg in the heart bioptates appeared to be an early and sensitive marker of inflammatory status of patients with myocarditis
- The expression of MxA protein in arteries from patients with polymyalgia rheumatica and temporal arteritis shows that non-inflamed and inflamed vessel walls are influenced by IFN-I.
- IFGN has a key role in the control of bacterial, micotic, viral and parasitic infections. It has a dual role as pro or anti inflammatory cytokine. Review.
- These results suggest the existence of a particular immunoendocrine relation assuring a preserved IFN-gamma production in healthy housemates of tuberculosis patients.