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Validated All-in-One™ qPCR Primer for ICAM1(NM_000201.2) Search again
Product ID:
HQP009184
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BB2, CD54, P3.58
Gene Description:
intercellular adhesion molecule 1
Target Gene Accession:
NM_000201.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq].
Gene References into function
- A defective expression of ICAM-1 (CD54) on secretory endometrial cells is associated with endometriosis.
- IFN-gamma activates PLC-gamma2 via an upstream tyrosine kinase to induce activation of PKC-alpha and c-Src or Lyn, resulting in activation of STAT1alpha, and GAS in the ICAM-1 promoter, followed by initiation of ICAM-1 expression and monocyte adhesion.
- Premature labor is associated with up-regulation of adhesion molecules in the lower uterine segment
- Role of ICAM-1 in the aggregation and adhesion of human alveolar macrophages in response to TNF-alpha and INF-gamma.
- Transient exposure of human bronchial epithelial cells to cytokines IFNG and TNFA, but not IL1B, leads to persistent increased expression of ICAM-1.
- Incubation of endothelial cells with conditioned media derived from stimulated macrophages modulates ICAM1 mRNA expression. Results suggest TNF-alpha and activation of the NF-kB pathway are involved.
- heat shock decreases endothelial cell ICAM-1 expression via inhibition of IKK activity
- Down-regulation of cell adhesion molecules LFA-1 and ICAM-1 after in vitro treatment with the anti-TNF-alpha agent thalidomide.
- significant increase in plasma levels between day 1 and day 5 of G-CSF-induced stem cell mobilization; possible effect on leukocyte-endothelial cell interactions
- oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1
- ICAM-1 participated in cell attachment to X- and Y-fragments, rather than to intact fibrinogen or late degradation products, fragments D and E.
- Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica.
- raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation
- Elevated soluble CD40 ligand is related to the endothelial adhesion molecules in patients with acute coronary syndrome.
- Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 in shear flow
- Relation between glycemic control, hyperinsulinaemia and plasma concentration in patients with glucose intolerance or niddm
- colocalization of ICAM-1 and B7.1 molecules was demonstrated in Hashomoto's thyroiditis whereas no B7.1 expression was observed in Graves' disease
- CD54 may play an important role in pathogenic process (in COPD)
- expression of ICAM1 in colorectal cancer
- women with stage III and IV endometriosis had higher serum concentrations of soluble VCAM-1, lower serum concentration of soluble ICAM-1
- Prolonged, low dose alpha-tocopherol therapy counteracts intercellular cell adhesion molecule-1 activation
- Blood levels of ICAM1 are low in non-Hodgkin's lymphoma patients
- X-ray doses of < or =5 Gy did not induce ICAM-1 expression, or modulate TNFalpha-induced ICAM-1 expression.
- polymorphism is associated with diabetic retinopathy in type 2 diabetes mellitus
- pregnancy-induced hypertension is accompanied by overexpression of intercellular adhesion molecule-1 (ICAM-1) on peripheral blood and decidual lymphocytes studied "in vitro"
- During leukocyte adhesion VCAM-1, ICAM-1, and activated moesin and ezrin clustered in an endothelial actin-rich docking structure that anchored and partially embraced the leukocyte containing other cytoskeletal components
- the preferential expression of ICAM-1 on the endothelium of femoral and iliac arteries in thromboangiitis obliterans
- that genetic polymorphisms of ICAM-1 might be clinically important in the development and progression of neurodegenerative diseases
- In endothelial cells, ICAM-1 stimulates c-fos and rhoA transcription and up-regulates rhoA expression by a positive feedback pathway after RhoA activation.
- ICAM-1/beta2 integrin interactions mediate monocyte adhesion to human saphenous vein
- infection with cagA+ Helicobacter pylori induces homotypic aggregation of macrophage-like cell by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface and mediates the aggregation via LFA-1
- The TT and TC genotype of the ICAM-1 gene polymorphism in codon 469 is a genetic factor that may determine an individual's susceptibility for CHD and MI.
- modulation of expression in endothelial cells by glucosyltransfease inhibitor
- E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy
- Downregulation of icam-1 is associated with nodal metastasis in breast cancer
- Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), ceruloplasmin (Cp), and transferrin (Tf) in rheumatoid arthritis. Serum Tf levels were significantly diminished and serum levels of sICAM-1 and Cp were significantly increased.
- Depletion of intracellular GTP results in nuclear factor-kappaB activation and intercellular adhesion molecule-1 expression in human endothelial cells.
- may play a role in the development of nephropathy in patients with type 2 diabetes mellitus
- B. pertussis FHA up-regulates ICAM-1 expression on respiratory epithelial cells through interaction of its RGD site with host cell VLA-5 integrin, and that PT impairs this response
- Increased expression in Mycobacterium tuberculosis-infected human macrophages exhibiting enhanced cellular adhesion
- ICAM-1 expression cooperatively facilitates L-selectin-mediated rolling of lymphocytes and neutrophils under physiologic shear flow.
- Circulating ICAM-1, IL-8, and MCP-1 in untreated obstructive sleep apnea were significantly greater than in controls. nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators.
- expression elicited by choline-binding protein A of Streptococcus pneumoniae in alveolar epithelial cells
- expressed in CSF of children with bacterial or viral meningitis
- Expression of ICAM-1 is sufficient to initiate a signal-dependent adhesion of resting NK cells which can be greatly enhanced either by a pulse of IL-2 or IL-15, or by coexpression of LFA-3 or CD48 with ICAM-1, even in the absence of cytokines.
- polymorphisms of the ICAM-1 gene may be clinically important and confirming that inflammatory mechanisms may be crucial in the pathophysiology of neuro-degenerative diseases.
- AP-1 activation calcium-dependent, suggesting the central involvement of this transcription factor in ICAM-1 and RANTES induction after the ligation of ICAM-1.
- The detection of serum sICAM-1 will be helpful in estimating the clinical severity of cerebral infarction.
- the potential associations of ICAM-1 gene polymorphisms with endometriosis and its severity
- serum levels elevated in asthmatic patients during acute attack
- findings demonstrate that the cytomegalovirus transactivators IE2p86 and pp71 are crucial regulatory factors for human cytomegalovirus-induced ICAM-1 upregulation
- the expression of ICAM-1 might involve both p38 MAPK and NF-kappaB activities, whereas the regulation of CD11b, CD18, and ICAM-3 expressions might be mediated through p38 MAPK but not NF-kappaB.
- Expression of CD40, CD54 and HLA-DR were seen in the hair structure including the dermal papilla in alopecia areata.
- Synergistic effect of a polymorphism of interleukin-6 gene and 469 E/K polymorphism of the intercellular adhesion molecule-1 gene in Italian patients with history of ischemic stroke.
- ICAM-1 is induced by TNFalpha in a process that involves IKKbeta
- activation of expression by p53
- Endothelial cells have increased expression of VCAM-1, E-selectin, and ICAM-1 when exposed to sickle blood cells.
- Exposure of epithelial monolayers to the combination of cigarette smoke followed by C5a results in an additive response for ICAM-1 expression and mononuclear cell adhesion compared with smoke or C5a challenge alone
- Chlamydophila pneumoniae-induced ICAM-1 expression in HAECs requires NF-kappaB and PKC activation and NF-kappaB activation is PKC dependent
- the interaction of CD98/LAT2 with ICAM-1, found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE cell monolayers
- IFNbeta-1a is strong regulator of ICAM 1 RNA splicing. IFNbeta-1a over-expression of ICAM 1 isoforms might have an immunoregulatory role in multiple sclerosis.
- In pregnant subjects, a positive correlation between monocyte ICAM-1 expression and a number of markers of vascular/thrombotic disease was observed, and also a significant relationship between monocyte ICAM-1 expression and soluble plasma ICAM-1 levels
- demonstrated that bladder tumor cells express ICAM-1, and that this expression induces a fibrinogen-mediated migration and that ICAM-1/fibrinogen interaction is involved in the extravasation process.
- Extravasated and oxidized LDL in xanthoma adds to foam cell recruitment by activating tyrosine kinase and inducing adhesion of monocytes to dermal microvascular endothelial cells through VCAM-1 and E-selectin.
- combined use of a vector driving the expression of OX40L with three other costimulatory molecules (B7-1, ICAM-1, and LFA-3) both enhances initial activation and then further potentiates sustained activation of nai;ve and effector T cells.
- ICAM1 mutation is associated with BD susceptibility, and is another genetic risk factor for BD among the Korean population.
- effect of PGE2 on the expression of ICAM-1 and B7 in the human mixed leukocyte reaction in the presence or absence of IL-18
- The presence of the cytoplasmic domain of ICAM-1 is essential for transendothelial migration of T lymphocytes as well as ICAM-1-mediated signaling and ICAM-1-mediated activation of Rho GTPase.
- infection with Kaposi's sarcoma-associated herpesvirus leads to the downregulation of MHC class I, CD31 (PE-CAM), and CD54 (ICAM-I)
- Polymorphism in this gene is associated with susceptibility to ocular lesions and vasculitis in Korean patients with Behcet's disease.
- Blood levels do not differ in normal and coronary artery disease patients
- findings show that infection of bronchial epithelial cells by B. pertussis induces the degradation of IkappaBalpha and the subsequent activation of NF-kappaB, which in turn up-regulates ICAM-1 gene and protein expression
- ICAM1 and RANKL are induced by Beta1 integrin/focal adhesion kinase on osteoblasts and in osteoclast maturation
- ICAM-1 plays a role in tumor-mesothelial interactions under steady-state conditions. Tumor-cell binding to a mesothelial monolayer was associated with increased expression of mesothelial ICAM-1 mediated by nuclear factor kappa-B.
- ICAM-1 has a role in SRC tyrosine kinase activation in pulmonary microvascular endothelial cells
- Pterygium epithelium also seems to participate actively in the augmentation of this inflammatory process by expressing ICAM-1 and HLA-DR molecules.
- Adrenomedullin and ACTH induce cell surface expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 on human umbilical vein endothelial cells.
- ICAM-1 is a protective haplotype against multiple sclerosis.
- polymorphism at position c.721G-->A is associated with an earlier age of GD onset and that the c.1405A-->G polymorphism of the ICAM-1 gene could predispose to Graves' ophthalmopathy
- ICAM-1 protein is selectively expressed in cortical tubers, but is only minimally expressed in control cortex, adjacent nontuberal cortex of the tuberous sclerosis complex.
- TNFalpha stimulates binding of nuclear proteins to the nuclear factor kappa beta (NFkappaB) and the CAAT/enhancer binding protein (C/EBP) consensus sites in the ICAM-1 promoter in these cells
- findings indicate that cytochalasin E activates protein kinase C under the depolymerization of actin filament, leading to the induction of interleukin-8 production and the up-regulation of CD54 in HeLa cells
- intercellular adhesion molecule 1 expression was enhanced in the macrophage-derived foam cells
- Vascular endothelium generates microfilament-, microtubule-, and calcium-dependent ICAM-1-enriched-cup-like structures within minutes of binding in vitro to lymphocyte function-associated antigen-1 (LFA-1)-bearing leukocytes.
- Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.
- Increased expression of ICAM1 may affect the development of initial atherosclerotic coronary stenosis, but not re-stenosis.
- minor trauma to skin may induce expression of E-selectin, ICAM-1 and IL-8
- community-circulating strains of Coxsackie virus A21 can infect target cells expressing either ICAM-1 or decay-accelerating factor alone and that such interactions extend tissue tropism and impact directly on viral pathogenesis.
- Basal expression and colocalization of ICAM-1 with E-selectin and CCL17 chemokine in dermal vessels serves to recruit T cells to noninflamed human skin and provides a strong cutaneous immunosurveillance system and model interface with the environment.
- positive marker for precinical type 1 diabetes in children
- study demonstrates that overexpression of RORalpha1 and RORalpha4 inhibits TNF-alpha induced expression of VCAM-1 and ICAM-1 in human umbilical vein endothelial cells by inhibiting the NF-B signaling pathway
- beta2-AR agonists strongly inhibited the expression of ICAM-1 and CD40.
- Data indicate that weight loss is more important than glycaemic control in regulating circulating levels of ICAM-1 in morbidly obese subjects.
- Mutagenesis of domain 1 of ICAM-1 shows that the binding sites for different Plasmodium falciparum variants overlap to a large extent, but that there are subtle differences between them that correlate with their adhesive phenotypes.
- even a short-term exposure of endothelial cells (ECs) to high glucose concentration leads to their activation associated with increased expression of adhesion molecules such as ELAM-1, VCAM-1 and ICAM-1.
- In patients on continuous ambulatory peritoneal dialysis, carotid atherosclerosis is associated with markers of inflammation, malnutrition and circulating levels of adhesion molecule ICAM-1.
- Expresson is reduced in treatment with methotrexate in bullous pemphigoid.
- Intercellular adhesion molecule-1 immunoreactivity in gray and white matter of the ACC in bipolar subjects was increased compared with control subjects (gray: p =.001; white: p <.001) and schizophrenic subjects (gray: p =.016; white: p =.025)
- Our study in the Spanish population argues against the hypothesis that polymorphism at codon 469 of the ICAM-1 gene is causally related to Alzheimer's disease.
- Live Porphyromonas gingivalis enhanced the expression of intercellular adhesion molecule-1 (ICAM-1) on the surface of human umbilical vein endothelial cells (HUVECs) in a bacterial dose-dependent manner.
- Intercellular adhesion molecule 1 may play a role in asthma.
- intercellular adhesion molecule-1 may play an important inflammation-related role in plaque development.
- 1548 polymorphism modifies inflammatory immune responses by changing cell-cell interaction and then regulating apoptosis
- sICAM-1 was processed distal to Arg441, indicating that MMP-9, docking to ICAM-1, contributes to sICAM-1 shedding and attenuation of the shear stress-induced upregulation of ICAM-1.
- E469E homozygote status for ICAM-1 is associated with protection against primary sclerosing cholangitis.
- Cytomegalovirus IE proteins stimulate ICAM-1 expression on villous trophoblasts by paracrine release of TNF alpha and IL1 beta, as well as by a direct effect on infected cells.
- Data show that MUC1 mucin expressed on the surface of cells can initiate a calcium-based oscillatory signal on contact with intercellular adhesion molecule (ICAM)-1-transfected cells.
- The ICAM-1/LFA-1 association was a more efficient transmission factor for HIV-1 bearing ICAM-1 than combined gp120/DC-SIGN & ICAM-3/DC-SIGN. The involvement of virus-bound ICAM-1 & LFA-1 in virus binding & carriage was confirmed in human lymphoid tissues
- immature DCs owe part of their outstanding Ag-independent T cell stimulatory ability to chemokines and ICAM-1, but not DC-specific ICAM-3-grabbing nonintegrin.
- The ICAM-1 expression in visually normal peritoneal cells from women with endometriosis may play a role in the early implantation of peritoneal endometriosis.
- mean serum level of soluble ICAM-1 in bronchiolitis patients was significantly higher than in the 10 healthy control infants (345.8 +/- 99.7 microg/mL vs 237.1 +/- 81.7 microg/mL; p<0.05).
- cAMP concentration in endothelial cells prevents thrombin-induced ICAM-1 expression by inhibiting p38 MAPK activation, which in turn prevents phosphorylation of RelA/p65 and transcriptional activity of the bound NF-kappaB.
- the specific CD23-engagement on lung endothelial cells cells induced a significant decrease in ICAM-1 expression, an adhesion molecule implicated in Plasmodium falciparum parasitized red blood cell cytoadherence
- findings help clarify the essential requirements for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) binding to ICAM-1
- These data support linkage for Crohn's disease at 19p13 and suggest that the amino acid polymorphisms in ICAM-1 may be associated with IBD.
- LPA and S-1-P enhance ICAM-1 expression at both the mRNA and protein levels in human umbilical cord vein endothelial cells
- ICAM-1, VCAM-1, E-selectin and interleukin-6 expression are enhanced by glucose and regulated by poly(ADP-ribose) polymerase in human umbilical endothelial cells
- Hypoxia alone did not increase either ROS production or ICAM-1 mRNA levels, but a 2.5-fold increase in ICAM-1 mRNA was noted by 30 min of reoxygenation.
- Clustered monocyte cell adhesion correlated with endothelial cells coexpressing intercellular adhesion molecule-1 (ICAM-1) and E-selectin as result of a flow-induced, selective upregulation of E-selectin expression in a subset of ICAM-1-expressing cells.
- A naturally occurring variant of ICAM-1, ICAM-1Kilifi, has altered binding characteristics with respect to different human rhinovirus serotypes.
- The expression of ICAM-1 in lymphatic vessels is beneficial to the judgement of the invasion and metastasis ability of colon cancer.
- transgenic mice were made that express human intercellular adhesion molecule 1, the cell-surface receptor for Coxsackievirus A21; CAV21 administered to these mice via the intramuscular route causes a paralytic condition consistent with poliomyelitis
- In an Irish population, the ICAM-1 K469E polymorphism is not associated with ishemic heart disease.
- results pinpoint ICAM-1 for the first time as a molecule crucially involved in small cell lung carcinoma cell-endothelial adhesion
- Persistent cAMP elevation activating PKA is able to enhance ICAM-1 expression at cell surface of endothelial cells under pro-inflammatory conditions. Combination of activation of gene transcription and membrane targeting may account for this augmentation
- ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol.
- N-Linked glycosylation regulate both conformation and immune related functions of ICAM receptors
- The ICAM-1 is key molecule in immune-mediated and inflammatory processes and are thus critically involved in diverse clinical disorders, ranging from asthma to atherosclerosis.
- role in increased adhesiveness of circulating leukocytes in the pathogenesis of ulcerative colitis
- Cell expression in response to tobacco smoke extract.
- ICAM-1 molecules interacted only with (group B Streptococcus)GBS-III liquor 90356 strain while beta1 integrin interacted with GBS-III liquor 90356 and GBS-V blood 90186 invasive strains
- In myeloperoxidase-ANCA-positive microscopic polyangiitis, higher sICAM-1 and sELAM-1 levels during active phase and their slower decline during treatment period could be prognostic risk factor for chronic renal failure.
- this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype for multiple system atrophy.
- The Binding of monomeric intercellular adhesion molecule-1 (ICAM-1) induced profound changes in the conformation of LFA-1 but did not alter clustering, whereas binding of ICAM-1 oligomers induced significant microclustering.
- NF-kappaB appears crucial in ICAM-1 induction, but p38 activation itself is not sufficient to confer HO-1 expression and may not be involved in HO-1 and ICAM-1 induction in human tumor cells
- PAR2 induces upregulation of cell adhesion molecules such as ICAM-1 in primary human keratinocytes via NF-kappaB activation
- ICAM-1 in oral keratinocytes may have an immunostimulatory role in oral muocsa and skin
- Direct implication of adhesion molecules in the pathogenesis or progression of type 2 diabetic retinopathy cannot be supported.
- ICAM-1 variants may modulate atherosclerosis in humans. Inflammatory gene polymorphisms may influence atherosclerosis independent of plasma levels of their gene products.
- In human renal proximal tubule epithelial cells, CD40 activation upregulates ICAM-1 (and other NF-kappaB pathway genes) expression with concomitant enhanced adhesion of mononuclear cells, which is mediated via the p38 MAPK signal transduction pathway.
- ICAM-1 has a role in mediating the interaction between the parasitised red blood cell and the vascular endothelium in malaria
- K469E polymorphism of the intercellular adhesion molecule-1 (ICAM-1) gene had impact on plasma fibrinogen level independently of other clinical factors in type 2 diabetic patient
- We hypothesize that the biochemical effect of the G241A SNP is masked in schizophrenic patients, indicating a disease-related mechanism leading to reduced levels of sICAM-1 in schizophrenia.
- findings demonstrate that the mature form of Toxoplasma gondii adhesin MIC2 is activated for binding to ICAM-1 on host cells and that this interaction probably facilitates transmigration by the parasite
- causal role of in invasion of metastatic human breast carcinoma cell lines.
- SCF and TNF-alpha acted through ERK and the NF-kappaB pathway to regulate the ICAM-1 expression and elicited the synergistic effect.
- FXR-mediated activation of ICAM-1 could be further enhanced by TNF-alpha cotreatment in hepatocytes
- propose that a positive feedback loop involving ICAM-1 and HTLV-1 Tax protein facilitates the formation of the virologic synapse and contributes to the T-cell tropism of HTLV-1
- Linkage and association studies of ICAM1 in two Senegalese villages located in regions of endemic malaria showed no evidence for a role of ICAM1 variability on the malarial phenotypes studied.
- Data suggest that ICAM-1 gene induction by TNFalpha and IL-6 is mediated mainly via NFkappaB and Stat3, respectively and Rac1 appears to play a central role in modulating cytokine-induced ICAM-1 expression in endothelial cells.
- Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
- productive engagement of ICAM-1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complexes to cytotoxic T cells.
- Insulin enhances leukocyte-endothelial cell adhesion in the retinal microcirculation through surface expression of ICAM1.
- Cytokine/thrombin-enhanced DC IL-8 expression interacts with constitutively expressed ICAM-1 in decidual endothelium to modulate neutrophil trafficking into hemorrhagic and inflamed first trimester decidua
- describes the responses of sICAM-1 levels to nutrients, physical activity, smoke exposure and alcohol consumption
- Cultured endometrial epithelial cells constitutively express significantly more ICAM-1 mRNA and protein than endometrial stromal cells
- There is an association between ICAM-1 gene K469E polymorphism and ischemic stroke, and E allele may be a genetic risk factor of IS among Guangxi Zhuangs.
- the hybrid domain of integrin alphaL beta2 has different requirements of affinity states for ICAM-1 and ICAM-3 binding
- x-ray crystallographic analysis of coxsackievirus A21 and its interaction with ICAM-1
- 241A and 469G codon variants of intercellular adhesion molecule 1 may indicate haplotypes that are associated with reduced risk for asthma.
- An inverse relationship is shown for the first time in the ratio between ICAM1-expressing lymphocytes and transforming growth factor (TGF)-beta 1 serum concentrations during the clinical stages of acute rheumatic fever.
- lymphocyte-induced destruction through adhesion by ICAM-1 and binding of LFA-1-expressing activated lymphocytes takes place not only in bile ductules but also in the canal of Hering in biliary cirrhosis
- Anti-ICAM-1 antibodies are produced after cardiac transplantation, but not to polymorphic residues, which may contribute to the endothelial activation by binding to the endothelium, causing activation of proinflammatory signaling pathways.
- variant frequencies of ICAM1, APOE, PPARA and PAI-1 genes in coronary artery disease patients and healthy blood donors; specific arrangement of polymorphic variants which differentiate both groups
- The process is not associated with genetic variation of K469E ICAM-1 polymorphism in biliary atresia.
- biophysical analysis of how lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow
- The upregulation of ICAM-1 by postprandial LDL may explain part of the proatherogenic effect of high postprandial lipemia.
- both primary and metastatic human uveal melanoma cells express CD54
- ICAM-1 promoter was activated by the C-terminal region of CD30, which activated NF-kappaB signalling
- ICAM-1 may be involved in the pathogenesis of ulcerative colitis (review)
- ICAM-1 and caveolae are required for the invasion of P. gingivalis into human oral epithelial cells.
- Pneumolysin from Streptococcus pneumoniae induces transcription and production of ICAM-1
- Serum levels were measured with enzyme-linked immunosorbent assays over the first 2 years of life in 65 children seroconverting to positivity for autoantibodies and 65 control children, all with susceptibility to type 1 diabetes.
- results suggest that gingival fibroblast are stimulated by monocytes resulting in enhanced expression of MMP-1 and TIMP-1 and that the enhanced MMP-1 expression, in contrast to TIMP-1, is partly mediated by ICAM-1 and the signal pathway p38 MAPK
- Cellular elements controlling the uptake and intracellular trafficking of nanocarriers targeted to ICAM-1.
- rhMIF induced VCAM-1 and ICAM-1 up-regulation in 12 hours via Src, PI3K, and NFkappaB
- ICAM-1 can influence the migration of cells that express endogenous or transfected MUC1.
- analysis of how TACE mediates the ectodomain cleavage of ICAM-1
- Increased ICAM-1 levels are associated with type 1 diabetes mellitus
- These data suggest that the A allele of the ICAM-1 exon 4 polymorphism may protect against the risk of RPS following UTI and may participate in the regulation of the inflammatory response following UTI.
- NTHI (Nontypeable Haemophilus influenzae) adhesion to human respiratory epithelial cells occurs through the interaction of P5 fimbriae with its receptor, ICAM-1, and upregulation of ICAM-1 expression.
- The translocation of ICAM-1 to caveola- and F-actin-rich domains links the sequential steps of lymphocyte adhesion and transendothelial migration and facilitates lymphocyte migration through endothelial cells.
- Single Nucleotide Polymorphisms in intercellular adhesion molecule-1 is associated with cutaneous melanoma
- study does not confirm association between ICAM1 K469E polymorphism and breast cancer risk
- Immunoreactivity of VEGF, p53 and ICAM-1 was found in epithelial, fibroblast and vascular endothelial cells.
- Progressive decrease in sICAM-1 levels during attacks by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks.
- ICAM-1 expression was related to both the degree and the nature of inflammation, the data indicate increased susceptibility of cancer cells to express ICAM-1.
- Analysis of lymphocyte subsets showed that the total number of CD3+, CD4+, CD8+ and CD56+ lymphocytes increased after the intensive protocol before falling below pre-exercise values at 1 h post-exercise.
- The endothelium most likely contributes to increased ICAM-1 in pregnant heavy smokers, but a leukocyte source cannot be ruled out.
- Higher level of ICAM-1 protein in macular choriocapillaris may impart greater susceptibility of macula to immune cell-mediated damage in age-related macular degeneration.
- ICAM-1 is expressed in pulmonary fibroblasts of COPD patients
- support the potential efficacy of an anti-ICAM Ab delivered by lactobacilli for use as an anti-HIV-1 microbicide
- The study concludes that K469KE is associated with paediatric asthma in the German population and the same polymorphism is correlated with serum levels of ICAM1.
- allosteric antagonists work by eliminating breathing motion that leads to the open conformation of the I-domain when LFA1 and ICAM1 bind
- Results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer.
- Polymorphism observed in the ICAM-1 gene is not genetic susceptibility factors for Crohn's disease or ulcerative colitis in Turkey.
- Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer.
- Blood vessels were similarly ICAM-1 immunoreactive, and in some subjects there was a variable number of extravascular patches of ICAM-1-I. The area fraction of ICAM-1-I was higher in the old subjects than in the young subjects.
- Small interfering RNAs directed against ICAM-1 restored the homoassociation of MHC-I without influencing the expression level of MHC-I by eliminating ICAM-1 molecules interspersed in MHC-I clusters
- mutation of the serine phosphorylation site leads to inability of Mac-1 to become activated to bind the cellular ligands ICAM-1 and ICAM-2.
- H. influenzae infection increases airway epithelial cell ICAM-1 and TLR3 expression, leading to enhanced binding of RV and a potentiation of RV-induced chemokine release
- R241 variant mainly confers predisposition to celiac disease occurring during adulthood.
- Signalling via ICAM-1 induces adhesiveness of mononuclear phagocytes.
- Gastrin-releasing peptide upregulates ICAM-1 via FAK promotes tumor cell motility and attachment to the extracellular matrix.
- endothelial ICAM-1 function is altered by clonal senescence
- these studies indicate a control function of the microtubule network on the expression of ICAM-1
- IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.
- Direct interaction of ICAM-1 with cytoplasmic alpha-actinin-1 and -4 is essential for leukocyte extravasation.
- Excess body iron, reflected by elevated serum ferritin and non-transferrin bound iron and decreased total iron binding capacity, is associated with increased plasma level of sICAM-1
- Presence of soluble ICAM-1 in the cerebrospinal fluid of children during the early phase of mumps meningitis may be a useful marker of inflammatory responses in the central nervous system.
- Stimulation of intercellular adhesion molecule-1 (ICAM-1) was blocked by MG-132.
- alpha-synuclein strongly stimulates human alpha-synuclein strongly stimulates human astrocytes as well as human U-373 MG astrocytoma cells to up-regulate both interleukin IL-6 and ICAM-1; mutated forms are more potent stimulators than wild-type
- These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells.
- Tyrosine phosphorylation of cortactin dynamically links ICAM-1 to the actin cytoskeleton, enabling ICAM-1 to form clusters and facilitate leukocyte transmigration.
- data suggest that induction of ICAM-1 expression by gammaIR is associated with catalase; furthermore, catalase, JNKs, and AP-1 activation induce ICAM-1 upregulation through a sequential process
- ICAM-1 engagement by human rhinovirus and cross-linking antibodies enhances its coassociation with Syk kinase and ezrin in airway epithelium.
- The K469E polymorphism of the ICAM-1 gene was not associated with MI in patients with type 2 diabetes.
- high levels of sICAM-1 and sVCAM-1, together with the presence of circulating endothelial cells in dengue hemorrhagic fever patients, provide further evidence of endothelium damage and activation in DHF patients
- there is significant evidence of locus heterogeneity for sICAM-1 on Chromosome 19 in this sample of Mexican Americans
- The present data underscore a novel function for ICAM-1 in modulating GSH metabolism and raise the hypothesis that this adhesion molecule controls endothelial redox status under basal and inflammatory conditions.
- An ICAM-1-mediated mechanism recruits leukocytes to the lymph nodes during inflammation.
- vascular cell adhesion molecules (sICAM-1 and sVCAM-1) and also P-selectin were higher in patients than healthy controls
- Elevated plasma ox-LDL and sICAM-1 levels were associated with increased risk of type 2 diabetes.
- HOSCN induces E-selectin, ICAM-1, and VCAM-1 expression in HUVEC; HOSCN up-regulation of these adhesion molecules is transcriptionally mediated through a mechanism dependent upon activation of NFKB and constitutively suppressed by PI3K-Akt pathway.
- MARCH-IX expression causes ubiquitination and downregulation of ICAM-1
- Soluble ICAM-1 is responsive to acute psychosocial stress.
- Contact activation of the bronchial epithelial cells, involving ICAM-1 via local activation of ERK1/2, is an important mechanism of alteration of the bronchial epithelial permeability.
- Hemoglobin A1C in diabetics is positively associated with ICAM1 levels.
- Moderately elevated ICAM-1 reduces endothelial cell(EC) barrier function. Expressing higher levels of ICAM-1 affects cell junctions and cytoskeleton. Induction of ICAM-1 may contribute to TNF-induced vascular leak and EC shape change.
- VEGF was associated with a defect in ICAM-1 and VCAM-1 clustering at the EC surface; overexpression of caveolin-1 overcame the VEGF-mediated inhibition of adhesion and restored ICAM-1 clustering
- oxidative stress in endothelial cells created by excess of antioxidative agents resulted in the generation of reactive oxygen species, carbonylation and glutathionylation of proteins, inhibition of IKKalpha activity, and up-regulation of ICAM-1
- ICAM-1 in cooperation with VCAM-1 are essential for monocyte adhesion by carbamylated low-density lipoprotein-activated human vascular endothelial cells in vitro.
- In cultured salivary gland cells from patients with Sjogren's syndrome, CD40-ligand enhances the ICAM-1 expression at mRNA and protein level, by activation of NF-kappaB p50
- These findings reveal for the first time that TNF stimulation of adhesion molecules ICAM-1 and VCAM-1 in human endothelial cells occurs through the TNFR1 subtype and is mediated by the NF-kappaB pathway, but not the ERK, p38MAPK or JNK kinase pathways.
- The elevation of plasma levels of sICAM-1 was associated with a status of insulin resistance in patients with SLE
- ICAM-1 expression on conjunctival epithelial cells may be a marker of the inflammatory status in cystic fibrosis patients.
- data indicate that HIV-1 Tat can modulate monocyte adhesiveness by increasing expression of adhesion molecules such as ICAM-1 and VCAM-1 via ROS- and NF-kappaB-dependent mechanisms in astrocytes
- Serum ICAM-1 was higher in patients with breast cancer, and further elevated in the metastatic breast cancer group.
- ICAM-1 may have a role in inflammation in systemic lupus erythematosus patients with lupus nephritis
- higher levels of E-selectin and ICAM-1 were consistently associated with increased diabetes risk in a multiethnic cohort of U.S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes.
- polymorphisms of ICAM1 may confer susceptibility to postmenopausal osteoporosis in women, and that of GJA4 to osteoporosis in men
- Taken together, these results confirm the role of TNF-alpha and the three adhesion molecules in pathogenic processes associated with severe malaria in children, and suggest an association between sICAM-1 and severe malarial anemia.
- Data demonstrate that (507)RKIKK(511) is an essential motif for the microvillus ICAM-1 presentation and further suggest a novel regulatory role for ICAM-1 topography in leukocyte transendothelial migration.
- Data show that low-dose irradiation stimulates TNF-alpha-induced ICAM-1 mRNA expression in human coronary vascular cells.
- ICAM-1 levels were positively correlated with TAG and C-reactive protein levels, indicating that increased level of oxidative stress marker, proinflammatory markers, and their downstream effectors adhesion molecules occur in type 2 DM.
- Cytokine-induced endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressionwas inhibited by tecastemazole in a manner independent of H1 receptor antagonism.
- Patients with primary hypertriglyceridemia as compared with control subjects showed significantly higher plasma ICAM-1 (intercellular adhesion molecule 1)and increases in monocyte and lymphocyte ICAM1 (CD54)
- circulating levels of adhesion molecules in correlated positively with the stage of kidney disease and with C-reactive protein
- soluble ICAM-1 levels are a good indicator of neonatal sepsis.
- The results show that Hcy activated both ERK(1/2)/p38MAPK pathway and NF-kappaB-DNA-binding activity.
- talin induced an intermediate affinity alphaLbeta2 that adhered constitutively to its ligand intercellular adhesion molecule ICAM-1 but not ICAM-3.
- the cytoplasmic tail of ICAM-1 regulates leukocyte transmigration through MT1-MMP interaction
- ICAM-1 469E polymorphism may contribute to an early age of diagnosis of Crohn's disease.
- The study revealed no differences in mean concentration of serum sICAM-1 between patients with seasonal allergic rhinitis and seasonal asthma but significant increase of serum sICAM-1 level during natural allergen exposure in all patients was observed.
- Hyaluronan of intrinsic molecular weight suppresses LPS-stimulated production of proinflammatory cytokines via ICAM-1 through down-regulation of NF-kappaB and IkappaB
- diminished ability of NK cells to kill HTLV-1-infected cells was the decreased ability of NK cells to adhere to HTLV-1-infected cells because of HTLV-1 p12(I)-mediated down-modulation of intercellular adhesion molecule 1 (ICAM-1) and ICAM-2.
- Among women without a history of cardiovascular disease, sICAM-1 levels are predictive of events that reflect coronary atherosclerotic disease progression and vessel narrowing, but not those events associated with acute thrombosis/vessel occlusion
- Nicotine promotes ICAM1 expression on endothelial cells, shifting them toward a proatherosclerotic state.
- Polymorphisms in the exon of ICAM-1 is associated with the development of differentiation syndrome in acute promyelocytic leukemia
- In women with subsequent preeclampsia, sL-selectin and sVCAM-1 concentrations were significantly lower, whereas sE-selectin, sP-selectin and sICAM-1 levels were significantly higher, compared with controls at mid-pregnancy (p<0.05).
- OPG but not OPN stimulated a dose-dependent increase in the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin by endothelial cells in the presence of TNF-alpha
- The ICAM-1 positive expression rate in gastric carcinoma was 58%. There was no statistically significant difference between the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type.
- CD36, ICAM-1, and P-selectin are major contributors to the dynamic process of Plasmodium falciparum-infected red blood cell adhesion by different mechanisms in vivo
- ICAM-1-mediated signaling regulates proteins of the adherens junctions during transendothelial migration (TEM), signals which are required for facilitating junctional disruption during paracellular passage of leukocytes.
- Highly active antiretroviral therapy produces downregulation of ICAM-1 expression in HIV-1 infection.
- These results showed that the binding probability and adhesion force of Mac-1 with ICAM-1 increased upon Mac-1 activation.
- We concluded that role of the ICAM-1 gene polymorphisms in the pathogenesis of multiple sclerosis is still controversial and should be studied further.
- no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of Graves' disease in a Chinese population.
- These results identify a new signaling pathway involving RhoG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte trans-endothelial migration.
- s-FKN is shed from endothelial cells following hypoxia/reoxygenation and acts through CX3CR1 on them to increase ICAM-1 expression and promote neutrophil adhesion through activation of the Jak-Stat5 pathway
- There was no relationship between investigated genotypes or haplotypes of estrogen receptor alpha and levels of sICAM-1 in postmenopausal women.
- Higher levels of plasma ICAM-1 are associated with primary graft dysfunction following lung transplantation.
- Here we demonstrate that leukocyte function-associated antigen 1 (LFA-1), intercellular adhesion molecule 1 (ICAM-1), and ICAM-3 are enriched at the VS and that inhibition of these interactions influences conjugate formation and reduces VS assembly.
- ps20 promoted HIV entry via fusion and augmented CD54 integrin expression
- There were no significant differences in the mean serum intercellular cell adhesion molecule 1(ICAM1) concentration of women who developed pereclampsia and unaffected women.
- This is the first report of a leptospiral protein capable of up-regulating the expression of endothelial cell adhesion molecules ICAM-1 and E-selectin.
- Lys56Met and Gly241Arg ICAM-1 gene variants may have a role in cardiovascular events
- Iron, unlike interferon-gamma, does not appear to be involved in the regulation of ICAM-1 and VCAM-1 expression in cultured endometrial cells.
- Increased blood levels in rheumatoid arthritis are diminished after treatment with methotrexate.
- study investigated the influence of hepatitis C virus infection on serum profile of sICAM-1 and VEGF in patients with hepatitis C and hepatitis C with superimposed hepatocellular carcinoma
- slCAM-1 could be employed as a potential morbidity marker in schistosomiasis mansoni infection.
- crude extract of D. farinae induces ICAM-1 expression in EoL-1 cells through signaling pathways involving both NF-kappaB and JNK
- Findings implicate upregulation of ICAM-1 in decidual endothelial cells in the development of placental bed vascular pathology in diabetic pregnancy.
- L-selectin is defective in the stem cell compartment of MDS and sAML, whereas ICAM1 is overexpressed; the ratio of their expression has a prognostic role; and a ratio <1 significantly predicts progression to overt leukaemia in MDS patients
- Significant linkage was observed on chromosome 19 (LOD=4.0 at 14cM) in whites near the ICAM gene cluster that includes the structural gene for ICAM-1
- No strong relation was found between G241R and K469E polymorphisms and occurrence of coronary artery disease and myocardial infarction in the studied population from Fars province, Iran
- Increased ICAM-1 expression might be an early factor involved in the pathogenesis of blood brain barrier injury in sepsis.
- Investigating a sample of living-unrelated donor kidney transplant pairs, study revealed an association between recipient K469 allele of ICAM1(P = 0.013) and K/K genotype (P = 0.042) with renal allograft acute rejection.
- Mean sICAM-1 value was higher in patients with active giant cell arteritis than in cluster headache patients during the active cluster period.
- Determined kinetic parameters of beta 2-integrin and ICAM-1 bindings bindings between neutrophils and melanoma cells in a shear flow.
- ICAM-1 downregulation could provide a new target for controlling the recruitment of leukocytes at the sites of inflammation in IBD.
- Xenon, isoflurane, nitrous oxide, and morphine prevent TNF-alpha-induced mRNA and protein expression of intracellular cell adhesion molecule 1.
- These findings revealed that TNF-alpha induced VCAM-1 expression via multiple signaling pathways.
- We conclude that ICAM-1 expressed on TRs is involved in PE pathogenesis and is regulated by cytokines
- The ICAM-1 polymorphisms at codons G241R and E469K were associated with the disease susceptibility, and susceptibility to active decompensated cirrhosis is significantly increased in chronic HBV carriers carrying at least one R241-E469 haplotype.
- the polygenotype of VEGF (vascular endothelial growth factor) +405/intercellular cell adhesion molecule (ICAM)-1 +241/IL6 (interleukin6)-174 (C-A-G) conferred an increased risk for Progressive Massive Fibrosis in Coal miners
- ICAM-1 plays an important role in the pathogenesis of nasal polyps
- Urotensin-induced expression of TF and of VCAM-1/ICAM-1 was mediated through the Rho A-activation of the transcription factor, NF-kappaB
- Plasma of pregnant women and women with preeclampsia up-regulated the percentage of ICAM-1-expressing cells after 4 hours and down-regulated the percentage of ICAM-1-expressing cells and MCB after 24 hours
- CD54 expression is substantially and consistently upregulated on antigen presenting cells during culture with a GM-CSF fusion protein
- Has an important role in maintenance of granulocyte-macrophage colony-stimulating factor receptor-mediated signaling in activated human eosinophils.
- G241/E469 genotype of ICAM-1 is associated with greater cell surface expression of ICAM-1, which in turn leads to greater adhesion of leukocytes
- Syk signals downstream of PKC-delta to mediate thrombin induced ICAM-1 expression in endothelial cells by increasing transcriptional capacity of NF-kappaB via a mechanism that relies on tyrosine phosphorylation of RelA/p65
- Data suggest that Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naive monocytes to produce TNF-alpha through cellular cross-talk.
- In rheumatoid arthritis, a high serum level of sICAM-1 was found compared to its level in the synovial fluid.
- Polymorphisms of the ICAM-1 gene are associated with biliary atresia.
- These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation, through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration.
- analysis of ICAM-1 expression in vaginal cells and its role in inflammation
- show for the first time increased ICAM-1 concentrations in Pseudoxanthoma elasticum patients
- TNF-alpha-induced ICAM-1 up-regulation in the airway epithelium is mediated by Rac1-ROS linked cascade via NF-kappaB-dependent manner
- Involvement of MT1-MMP activity in ICAM-1 ectodomain shedding.
- sICAM-1 may play an important role for the pathogenesis of SBI in patients with diabetes mellitus.
- Individuals carrying the A allele of the ICAM1 gene as well as the A/G haplotype may have a higher risk of developing breast cancer.
- Demonstration that MK2 mediates post-transcriptional regulation by p38 MAPK of the TNF-induced expression of ICAM-1 in lung microvascular endothelial cells, and that this regulation by the p38 MAPK/MK2 pathway is dissociated from HSP27 phosphorylation.
- Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-aged men who develop cardiovascular disease during 6.6 years of follow-up.
- SNP rs5498(E469K) presents a high heterozygous index, and the allele G of this polymorphism may confer the decreased risk susceptibility to the development of diabetic nephropathy in female type 1 diabetes
- When human aortic endothelial cells were stimulated with physiologic concentrations of fructose, ICAM-1 mRNA and protein expression increased in a time- and dosage-dependent manner, which was independent of NF-kappaB activation.
- Plays a nonredundant role in T cell receptor-driven formation of transendothelial protrusion and transendothelial migration.
- genetic association studies with 15 single nucleotide polymorphisms (SNPs) around the ICAM1 locus showed none of the polymorphisms were associated with severe malaria phenotypes
- Beryllium exposure produces up-regulation of ICAM-1 in small airway epithelial cells.
- renal expression is upregulated in rapidly progressive glomerulonephritis
- Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease.
- that three SNPs at the ICAM1 (19p13.2)locus are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies.
- NF-kappaB, but not p38, is critical for TNF-alpha-induced expression of ICAM-1, VCAM-1 and E-selectin
- cytokine and intercellular adhesion molecule-1 gene polymorphisms have roles in acute rejection in pediatric renal transplantation
- significant differences between healthy control group & Crohn patients were observed in mutation 1007fs of the NOD2 gene (P = 0.0203; results support previous findings about participation of mutations of NOD2 & ICAM-1 genes in inflamatory bowel disease
- TNF-alpha can play a crucial role in the immunopathogenesis of nephritis by the induction of CCL2, ICAM-1 and VCAM-1 expression via the activation of the intracellular MAPK signaling pathway, which may contribute to macrophage and lymphocyte infiltration
- VEGF, sVCAM-1, sICAM-1 and sE-selectin median levels were higher in hemodialysis patients compared to controls.
- did not find any differences in genotypic or allelic frequencies of the ICAM1 G241R polymorphism between our Celiac disease patients and controls, and no differences were observed when the other SNPs were analyzed
- C/EBPbeta was found to have an important role in epithelial cell ICAM-1 regulation, while the adjacent NF-kappaB sequence binds the RelA/p65 and NF-kappaB1/p50 members of the NF-kappaB family to induce ICAM-1 expression in response to H. influenzae.
- Gb3 induces oxidative stress and up-regulates the expression of ICAM1, VACAM1 and selectin E in Fabry disease vascular endothelial cells.
- associated with both an increased prevalence and severity of aortic valve calcium in a large, multi-ethnic, asymptomatic cohort
- This independent association of postprandial triglycerides with sICAM-1 may indicate a particular impact of postprandial lipid metabolism on endothelial reaction.
- MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells.
- higher sICAM-1 and sVCAM-1 concentrations were independently associated with lower ankle-brachial index and peripheral arterial disease in blacks, but not in non-Hispanic whites
- correlations found between sVCAM-1, sICAM-1 and sELAM-1 and the presence of retinopathy suggest that cellular adhesion and neovascularization may be linked processes
- identifies filamin B as a molecular linker that mediates ICAM-1-driven transendothelial migration
- These results do not indicate a major impact of missense variants on ICAM-1 biological function.
- ICAM-2 is expressed on the bronchial epithelium and, together with ICAM-1, has an essential function in the clearance of T cells from the lung
- Data show that serum concentrations of PLA(2)-IIA, Lp(a), ICAM-1 and PECAM-1 are higher for patients with unstable rather that stable angina and controls, and that high plasma Lp(a) is an independent risk factor for angina.
- EE genotype of K469E polymorphism of ICAM-1 might be risk factor for proliferative diabetic retinopathy in Slovenian population (Caucasians) with type 2 diabetes.
- These results indicate that ICAM-1 and sICAM have a dual effect on bone homeostasis, increasing osteoclast activity while lowering osteoblast anabolic activity.
- Binding to dimeric ICAM-1, and not monomeric ICAM-1, is sufficient to elicit assembly of F-actin and phosphorylation of Src family kinases that colocalize with LFA-1 on adherent neutrophils.
- Association of the ICAM1 rs5498 (exon 6) G allele with increased risk of severe malaria was observed.
- Report downmodulatory effect of the antihistaminic drug bepotastine on CD54 expression in human keratinocytes.
- sICAM-1 as a biochemical marker for oocyte maturation and grading.
- IL-18 and sICAM-1 seem to be involved in the pathogenesis of severe acute pancreatitis, correlate with the disease severity and may be applied as prognostic markers.
- This review aims to further clarify the relationship between ICAM-1 and acute pancreatitis complicated by acute lung injury.
- Serum levels of sICAM and VEGF were significantly higher in juvenile idiopathic arthritis (JIA) patients with capillary abnormalities than in JIA patients with normal capillaroscopy.
- CCL2 induces selective and significant expression of ICAM-1
- Simultaneous carrier-state of MTHFR, IL-6 and ICAM1 genes increased the risk of Coronary artery disease.