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Validated All-in-One™ qPCR Primer for BIRC5(NM_001012270.1) Search again
Product ID:
HQP009099
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
API4, EPR-1
Gene Description:
baculoviral IAP repeat containing 5
Target Gene Accession:
NM_001012270.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Gene References into function
- Relative levels of expression of survivin mRNA and survivin protein increased after low- and high-dose CDDP treatment. Survivin mRNA was not detected in normal gastric mucosas.
- data demonstrate a crucial role of PI3-kinase/Akt/NF-kappaB/survivin signaling in tubular morphogenesis of HCAEC triggered by hypoxic preconditioning.
- Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment
- Survivin was expressed in all thymocyte subsets but its expression level was developmentally regulated.
- expression associated with reduced survival and reduced apoptotic capacity in gliomas
- Data demonstrate that the primary survivin pool in mitotic cells is associated with microtubules and participates in the assembly of a bipolar mitotic spindle.
- expression of alternative survivin splice varients related to gastric tumor progression
- The ratio of survivin to Fas in primary tumors may be used to predict the risk for recurrent disease in patients with neuroblastoma.
- survivin may represent a novel neuroendocrine marker for chromaffin cell tumors, survivin does not appear to reliably distinguish benign from malignant pheochromocytomas/paragangliomas and thus does not identify patients at risk of recurrent disease
- This nuclear shuttling protein is exported actively from the nucleus via the CRM1-dependent pathway.
- Expression in primary glioblastomas.
- survivin expression freqently seen in gastric cancer patients and first-degree relatives; co-expression with cyclooxygenase-2 suggests multiple pathways contributing to apoptosis inhibition in gastric cancer
- expression of functionally different survivin splice variants suggests a role in the progression and clinical behavior of human renal cell carcinomas
- Survivin expression was significantly associated with PCNA-labeling index, clinical stage, histological grade, clinical outcome, and survival rate in ovarian epithelial carcinomas.
- Higher expression level of surviving mRNA in primary leukemic cells from acute leukemia patients may be one of the reasons that leukemic cells are insensitive to chemotherapy.
- Survivin was not likely to be related with an inhibition of apoptosis or induction of telomerase but may have some role in gastric cancer extension.
- comparative study of expression of survivin in primary and metastatic colonic adenocarcinomas
- expression in laryngeal squamous cell carcinomas and its prognostic implications
- studies define a novel p53-survivin signaling pathway activated by DNA damage that results in down-regulation of survivin, cell cycle arrest, and apoptosis
- cellular studies and clinical data suggest a direct link between survivin expression and tumour cell susceptibility to taxol
- survivin not only suppresses apoptosis but also accelerates cancer cell-proliferative activity and plays an important role in tumor progression in hepatocellular carcinoma
- Reovirus-induced apoptosis involves reduction of cellular survivin levels
- findings suggest that activated STAT3 signaling directly contributes to malignant progression of primary effusion lymphoma by preventing apoptosis, acting through the prosurvival protein survivin
- These results indicate that survivin stimulates Aurora-B kinase activity and helps correctly target Aurora-B to its substrates during the cell cycle, thus providing a mechanism as to how survivin exerts its function in human cells.
- Survivin may be actively involved in regulating cell viability during HIV-1 infection
- Suppression of phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
- the determination of nuclear survivin expression could be used to individualise therapeutic strategies in oesophageal squamous cell cancer in the future.
- Survivin expression in astrocytic tumors varies with histologic malignancy and may play an important role in the oncogenesis and progression of astrocytic tumors
- The level of survivin was decreased after thapsigargin treatment in hepatoma cell lines indicating that survivin plays an important role in endoplasmic reticulum stress-mediated apoptosis.
- We conclude that the changes in the level of caspase-3 and survivin play an important role in the transformation from normal gastric mucosa to gastric cancer.
- Survivin is an important inhibitor of apoptosis in colorectal cancer cell lines.
- role in pathological conditions-REVIEW
- Survivin is expressed in embryonic tissues as well as in the majority of human cancers, but is not expressed in most normal adult tissues.
- Survivin-HBXIP complexes, but neither survivin nor HBXIP individually, bind pro-caspase-9, preventing its recruitment to Apaf1, and thereby selectively suppressing apoptosis.
- survivin may play an important role in transition from intraductal papillary-mucinous tumor of the pancreas adenoma to carcinoma in situ
- Data show that mammalian cells lacking survivin are unable to align their chromosomes, fail to recruit Aurora B to kinetochores and become polyploid at a very high frequency.
- survivin is upregulated by oncogenic c-H-Ras in tumor cells
- survivin plays an important role in the onset of gastric carcinoma and that high survivin expression is an early event of gastric carcinoma.
- survivin has a role in the dedifferentiation of thyroid carcinoma
- Expression of non-destructible beta catenin mutants increased survivin expression and protected against ultraviolet-B-induced apoptosis.
- All bladder tumor tissues expressed survivin mRNA.
- Survivin is essential for cell cycle progression in leukemic cells
- survivin is required to maintain a critical anti-apoptotic threshold in prostate cancer cells
- adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters
- survivin has separable checkpoint functions at multiple phases of mitosis and in the control of mitochondrial-dependent apoptosis.
- abnormally low levels of expression of the nuclear form of this protein may be a marker of more aggressive disease or higher morphologic grade in ependymal and choroid plexus tumours.
- Stabilization of survivin may contribute to the apoptosis resistance effect of COX-2 in non-small cell lung cancer.
- PML-induced apoptosis by down-regulation of Survivin.
- phosphorylation of survivin at threonine 117 by aurora-B may regulate targeting of survivin
- Hsp90, a molecular chaperone that is central to the cellular stress response, associates with survivin, an apoptosis inhibitor and essential regulator of mitosis.
- Data suggests that survivin expression may identify cases of oral squamous cell carcinoma with more aggressive and invasive phenotype.
- Substitution of single amino acid converts Survivin to proapoptotic agent.
- Through induction of survivin by IL-11 in a human transplant model, evidence is given that survivin can protect cells from T cell-mediated graft injury.
- NO inhibited the expression of survivin, which was down-regulated by the p38 MAP kinase pathway
- Survivin up-regulates Fas ligand (FasL) expression in colon cancer cells by augmenting DNA binding of transcription factor specificity protein 1 (Sp1) to the FasL promoter.
- STAT3 signaling supports gastric cancer cell survival in association with survivin expression.
- High expression of survivin is associated with esophageal cancer
- higher level of expression of survivin is associated with Colonic Neoplasms
- Testicular survivin was found in infertile men.
- new insights into the regulation and function of survivin and implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases and cancer
- survivin, p53, and bcl-2 are elevated in breast carcinoma but not ductal intraepithelial neoplasia
- An important role is suggested for survivin in progression, recurrence, and treatment of hepatocellular carcinoma
- Changes in the turnover of survivin at centromeres influence the stability of kinetochore-microtubule attachment and signaling of the spindle checkpoint.
- the high level of survivin in some cancers is, at least in part, due to a genetic defect in the promoter region of the human survivin gene, which causes derepression of survivin transcription apparently due to the mutated repressor binding motifs.
- Overexpression of survivin plays an important role in the development and progression of pancreatic cancer
- may enhance tumor cell survival upon radiation exposure such as regulation of double-strand DNA break repair and tumor cell metabolism
- survivin-2B variant is a proapoptotic factor and its expression is upregulated by p53
- Survivin is a special tumor marker independent of histopathological characteristics and may play an important role during human colorectal tumorigenesis by inhibiting apoptosis.
- the high level of survivin in some cancers is, at least in part, due to a genetic defect in the promoter region of the human survivin gene, which causes derepression of survivin transcription
- survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells
- possible role of survivin in gastric cancer invasiveness and metastasis
- depletion of survivin caused defects in cell division, followed by an arrest of DNA synthesis
- results show that survivin exists in a novel mitochondrial pool in tumor cells; mitochondrial survivin orchestrates a novel pathway of apoptosis inhibition, which contributes to tumor progression
- survivin may have a role in promoting aberrantly increased cell viability and contribute to the altered homeostatic balance between cell growth and cell death in leukemia
- Inhibition of Cdc2 activity and the subsequent downregulation of survivin and XIAP by subtoxic doses of rottlerin contribute to amplification of caspase cascades.
- Survivin does not act to inhibit Smac-mediated apoptosis
- survivin may play an important role in tumor progression of hepatocellular carcinoma.
- G(1) cell cycle arrest sensitizes breast cancer cells to TRAIL at least in part by reducing levels of the anti-apoptotic protein survivin: ectopic expression of survivin partially suppresses apoptosis induced by TRAIL
- Our results suggest that the different forms of survivin may have different roles in apoptosis in breast cancer.
- involvement of Survivin (and the associated events) in UV-B response in vitro and in vivo in experimental models regarded to have relevance to human situations
- The homodimer interface of this protein interacts with Smac/Diablo.
- Protein binding to the 21-bp DNA element in the survivin promoter contributes at least in part to the inhibitory effect of hedamycin on survivin gene transcription.
- Patients with non-Hodgkin's lymphoma presented a high level of survivin expression, it was more pronounced in aggressive than in indolent nHL.
- a role for Survivin as a marker of tumour morphology and clinical outcome in medulloblastoma.
- Survivin expression provides some prognostic information regarding uterine cervical cancer, even though it was not correlated with survival. It could represent a possible new prognostic marker of uterine cervical squamous cell carcinoma patients.
- Use of the adeno-associated virus mediated survivan mutant (Cys84Ala) is a promising strategy in colon cancer gene therapy.
- Targeting specific survivin isoforms, rather than survivin alone, may selectively and effectively destroy tumor cells.
- Survivin is involved in supporting luteal function, and that HCG contributes to this role.
- Our findings suggest that activated NF-kappaB signaling contributes directly to malignant progression of ATL by preventing apoptosis, acting through the prosurvival protein survivin.
- upregulation of Survivin via IGF-1 signaling confers resistance to flutamide in prostate cancer cells
- a novel survivin splice variant designated as survivin 2alpha
- A high level of expression of survivin mRNA indicates a high grade of malignancy, high likelihood of recurrence, and poor prognosis.
- High expression level of survivin and its splice variants have important roles in the progression of human colorectal carcinomas.
- Survivin up-regulates telomerase activity by augmenting gene transcription of hTERT.
- apoptotic defects in pleural mesotheliomas are linked to increased levels of survivin; gene may be important in mesothelial carcinogenesis, and overexpression may be involved in pleural mesothelioma drug resistance
- Survivin-2B specifically expressed in lung cancer tissue and found to specifically elicit a cellular immune response in lung cancer patients
- survivin is expressed in human germ cells and might be involved in apoptosis control during spermatogenesis
- Overexpression of survivin is associated with metastatic melanomas
- Exposure of human neuroblastoma cells to exogenous VEGF results in an increased expression of survivin protein.
- Survivin expression correlates with the differentiation state of testicular germ cell tumors and may be relevant for their tumorigenesis and malignant potential
- Results indicate that the differential p53-regulated expression of survivin at different stages of the cell cycle results in different cellular outputs under the same apoptosis-inducer.
- Up-regulated survivin expression was an independent predictor of high-risk human papillomavirus in cervical lesions
- This is the first study reporting a statistical significant prognostic relevance of nuclear and cytoplasmic Survivin overexpression in pancreatic cancer.
- survivin-2B and survivin-DeltaEx3 play opposite roles in disease relapse and NSCLC cell survival, which is likely through the differential modulation of mitochondrial potential
- Aurora-c is directly associated with survivin and is required for cytokinesis.
- Survivin might be a good predictor of diffuse large B-cell lymphoma and its subtypes.
- studies demonstrate that lower levels of survivin in recurrent metastatic melanomas are associated with significantly improved survival in patients receiving postoperative adjuvant immunotherapy
- Overexpression of survivin in hepatocellular carcinoma(HCC) closely correlated to expression of VEGF. Stronger expression of survivin and VEGF also found in metastasis. Could become new target of gene therapy of HCC.
- Rebamipide significantly downregulates in AGS cell survivin expression, its association with Aurora-B and cell proliferation. Rebamipide-induced downregulation of survivin is at the transcription level and does not involve ubiquitin-proteasome pathway.
- Like survivin, livin may act as a major cancer antigen in breast cancer patients
- Testicular survivin levels in infertile patients were related inversely to the severity of spermatogenic failure (p < 0.001), with a lack of expression in most specimens with pre-meiotic spermatogenic arrest and in all those with germ cell aplasia.
- Whereas survivin expression is essential for megakaryocyte and erythroid progenitors, its down-regulation is required for terminal differentiation of megakaryocytes.
- survivin is downregulated by p53, and that siRNA targeting of survivin increases cell sensitivity to adriamycin and promotes apoptosis
- Survivin is a critical regulator of multiple processes, including proliferation, apoptosis, and angiogenesis, that determine the remodeling response of vein grafts following arterialization
- Survivin variants are differentially expressed in breast cancer according to tumour progression
- IAP-2, XIAP, and survivin may make an important contribution to the resistance to the apoptotic effect of cisplatin in prostate cancer
- Survivin should accelerate tumorigenesis by inhibiting the anti-proliferative effect of p53 tumor suppressor that is activated by aurora B in normal and glioblastoma cells containing intact p53.
- upregulated by Hepatitis B virus X (HBx) protein in in hepatoma tissues, suggesting that HBx and survivin may both be involved in carcinogenesis of hepatocellular carcinoma
- Survivin may have a role in venous or perineural invasion of metastastic pancreatic cancer
- survivin gene expression is negatively regulated by p53 in NSCLC, and survivin expression could inhibit apoptosis and accelerate tumor cell proliferation to produce more aggressive carcinomas
- downregulation of the XIAP or survivin enhances cell death by TRAIL and increases sensitivity against some chemotherapeutic agents in hepatocellular carcinoma cells
- Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP.
- Inhibition of Bcr-Abl by imatinib significantly decreased survivin expression and cell viability in omatinib-resistantchronic myelogenous leukemia cells.
- alternatively spliced variants of survivin do not play a role in mitosis
- SI gene (GenBank accession No.AY830084) might be a novel alternatively spliced isoforms of the survivin gene involved in other functional significances related to tumorigenesis
- thymosin beta-4 increases colon carcinoma apoptosis resistance triggered by FasL and apoptosis inhibitors by downregulating Fas and upregulating Survivin expression
- Espression of survivin dropped in testes with postmeiotic spermatogenic arrest. These findings substantiate results from studies in the rodent testis suggesting a predominant expression of survivin in meiotically dividing germ cells.
- increased accumulation of Survivin in the cytoplasm of more malignant glioma cells may prove to be a selective advantage, thus accelerating progression to a more aggressive phenotype
- Depletion of survivin by small interfering RNAs (siRNAs) increased both the number of microtubules nucleated by centrosomes and the incidence of microtubule catastrophe, the transition from microtubule growth to shrinking.
- Induction of survivin is at least in part responsible for DEC1 antiapoptosis.
- transgenic mice expressing survivin in pancreatic islet beta-cells show no changes in cell proliferation, as determined by islet size or islet number
- combination of gene dosages of MYCN and Survivin and the expression level of BIN1 using the quantitative polymerase chain reaction method was significantly correlated with the clinical stage and the patients' outcome in neuroblastoma
- Survivin expression was associated with cell proliferation in renal cell carcinoma cells.
- Combined detection of survivin and PTEN protein smight be more valuable in the evaluation of malignancy and prognosis in epithelial ovarian tumors.
- Survivin overexpression, by disrupting the balance between cell proliferation/differentiation and apoptosis, may play an important role in chronic myelomonocytic leukemia's pathophysiology.
- Survivin is positively correlated with PTEN expression in gastric cancer and is a molecular marker of lymph node metastasis
- Expression of HIF-1alpha mRNA was closely correlated with the expression of survivin, PCNA, and CD34 proteins in pancreatic cancer.
- A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin.
- analysis of a novel regulatory pathway for the expression of survivin under the control of KLF5 and p53
- Results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished beta-catenin-Tcf/Lef-dependent transcription.
- Results suggest that survivin and splice variant survivin-EX3 may be closely linked to escape from apoptosis and the development of endometriosis.
- In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance
- survivin promoter polymorphism at position 31 may not represent an increased risk for the development of cervical cancer
- Eosinophils of hypereosinophilic syndrome (HES) patients (but not normal eosinophils)express high levels of survivin and inhibit the caspase cascade in HES eosinophils.
- the direct interaction of Survivin and Aurora B was critical for the correct location of Survivin and the function of the Survivin complex in cell division
- RTQ-LDA and RTQ identified survivin as significantly over-expressed in dead-of-disease compared to long-term survival glioblastoma multiforme patients.
- survivin-aryl hydrocarbon receptor-interacting protein (AIP) complex may influence the cellular xenobiotic response to environmental toxin(s) and contribute to subcellular chaperone trafficking during cell death regulation
- Survivin, an inhibitor of apoptosis, is key players in cellular apoptotic mechanisms. High survivin mRNA levels were associated with worse overall survival in children's neuroblastoma.
- High levels of survivin mRNA and protein expression is associated with endometrial adenocarcinomas
- Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells.
- 84% of the examined primary central nervous system lymphoma specimens showed expression of survivin. Tumours expressing survivin co-expressed PDGFRalpha frequently and PDGF-A occasionally.
- TRAIL induces apoptotic cell death in neuroblastoma and survivin inhibits TRAIL induced apoptosis. Neuroblastoma cell sensitivity to TRAIL is governed by the ratio of TRAIL-R to survivin expression.
- All variants of survivin exhibited particular associations with clinicopathologic characteristics of breast cancer patients. Survival analyses suggest a modulating role of survivin 2alpha and survivin-3B on the biological function of total survivin.
- anti-apoptotic and mitotic roles of survivin can be separated through mutation of its nuclear exportation signal
- Nuclear survivin could reflect the different behavior between keratinocyte stem cells in vitro and in vivo, in terms of proliferation.
- Survivin gene promoter-driven stathmin siRNA expression vector may have potential use in tumor gene therapy with targeted tumor gene silencing effect.
- CD3/CD46-induced T regulatory cell 1-like cells die through a process of abortive proliferation
- a novel pathway regulating angiogenesis through Survivin DeltaEx3 and a novel mechanism for Rac1 activation during angiogenesis
- This suggests that the balance between cellular Smac/DIABLO and Survivin levels could be critical for cellular destiny in taxane-treated cancer cells.
- A dominant negative mutant of survivin (surDN) was expressed in colorectal tumor cells. Its expression induced by RU486 was dose- and time-dependent. surDN suppressed tumor cell growth and had a synergistic effect with antineoplastic agents.
- findings suggest that a predominant nuclear localization of Survivin increases the sensitivity for pro-apoptotic stimuli, whereas nuclear export enables Survivin to fulfill its inhibitor of apoptosis function
- Molecular data based on gene transcriptional profiles of a 3-gene set (GPC3, LYVE1, and survivin) allow a reliable diagnosis of early hepatocellular carcinoma.
- functional relationship between TEL/AML1, HSP90, and survivin provides the rational for targeted therapy
- Survivin gene RNAi not only could inhibit the proliferation of human cervical carcinoma cells (HeLa), but also could enhance the radiosensitivity of those cells. RNAi-targeted survivin gene strategy is an approach to radiosensitization therapy
- Our report shows the functional significance of the Survivin-Crm1 interface and provides a novel link between the mitotic effector Crm1 and the CPC.
- results indicate that Ad-PTEN exerts its tumor suppressive effect on bladder cancer cells through inhibiting survivin and upregulating caspase-related proteins
- Results suggest an active role of Survivin in normal and in myelodysplastic hematopoiesis.
- A review of the roles of survivin including its role in the mechanisms of tumor invasion and metastasis.
- COX-2 and beta-Catenin may have roles in regulating intracellular Survivin levels in mouse and human colon cancer
- Patients with meningiomas and malignant gliomas mount a high-titer IgG immune response against the 'universal' tumor-associated antigen survivin.
- Nuclear Survivin expression was found to be an independent predictor of progression-free survival.
- indicate a role for c-myc in the transcriptional regulation of survivin in breast cancer
- The degree of survivin staining was significantly higher in the high grade refluxing ureters compared to low grade reflux and to the bladder wall in the same patients.
- overexpression of survivin mRNA is a common feature in medulloblastoma, may contribute to their anti-apoptosis properties and clinical behaviours
- Survivin is a critical modulator of atherosclerotic macrophage apoptosis under dual control by growth factors and oxidized lipids accumulating in atheroma.
- The presence of the inhibitor of apoptosis protein survivin is a highly significant independent predictor of shorter duration of survival of patients with poor prognostic features, and merits investigation as a marker in other prognostic groups.
- CD8+ T cells react against survivin antigen in patients with multiple myeloma
- Sensitization towards TRAIL was due to the transcriptional downregulation of survivin
- Survivin expression is a bad prognostic indicator in cases with acute leukemia especially in AML. Survivin negativity and EPR-1 positivity show good clinical outcome in acute leukemias
- Cell hypoxia promotes an antiapoptotic phenotype in brain endothelial cells by activating survivin via the PI3-kinase/Akt pathway.
- Review highlights how better knowledge of the role of survivin in tumor versus normal cells will be instrumental for the design of optimal strategies to selectively disrupt survivin in cancer.
- Review highlights the role of survivin as a subunit of the chromosomal passenger complex and its export as a novel strategy to antagonize survivin's activity.
- Intracellular delivery of survivin or Survivin DeltaEx3 by fusion with protein transduction domain would enhance skin flap survival through accelerating revascularization.
- Changes of survivin mRNA and protein expression during paclitaxel treatment in breast cancer cells are reported.
- Downregulation of survivin results in significant inhibition of tumor growth in vitro.
- Phosphorylation by aurora-B negatively regulates survivin function during mitosis.
- survivin expression was up-regulated in cervical carcinoma associated with humanpapillomavirus (HPV) infection
- Survivin-DeltaEx3 plays a key role in the inhibition of caspase-3 activity, and in the control of the mitochondrial checkpoint of apoptosis.
- Survivin may be used as an indicator of the success of in vitro fertilization-embryo transfer.
- GM-CSF-stimulated CD34(+) cell proliferation is regulated by the JAK/STAT3/survivin signaling pathway.
- XIAP and Survivin are not involved in the cytoprotective effect of HGF against antineoplastic agents.
- findings suggest that survivin is involved in tumor cell apoptosis and proliferation and may play a role in critical steps of cancer progression in NSCLC
- Nuclear presence of survivin may be an independent biomarker for disease recurrence and overall survival in patients with Stage I and II melanoma.
- Ehe expression of survivin was potently inhibited by quercetinin non-small cell lung cancer cells.
- mRNA levels of survivin and its splice variants in liver tumour tissue were significantly higher than in paired non-tumour tissue.
- Survivin is a potentially significant protein in the diagnosis, prognosis and treatment of gastric tumors.
- Survivin isoforms are unlikely to modulate survivin in trans in cancer patients.
- Chromogranin A can increase prostatic cancer cell survival through sutvivin up-regulatoin.
- subcellular localisation of survivin was significantly correlated with the lymph node involvement indicating its value in predicting the aggressiveness of tumour cells, since it increases the resistance to apoptosis and promotes cell proliferation
- XAF1 mediates Survivin down-regulation through a complex containing XIAP, supporting dual roles for XAF1 in apoptosis
- the direct interaction of survivin with the nuclear export receptor Crm1 is critically involved in its intracellular localization and cancer-relevant functions [review]
- PIN1 down-regulates BIRC5.
- This review discusses the possible connections between viral infection, survivin expression, and subsequent joint inflammation in rheumatoid arthritis.
- Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels
- Elevated expression of cell-cycle regulators p16(INK4A), p21(CIP1), and cytoplasmic/nuclear beta-catenin correlated with increased colorectal cancers risk, as did elevated expression of survivin and human telomerase reverse transcriptase.
- Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin.
- Survivin expression in bladder cancer cell line can be markedly inhibited by the application of siRNA-survivin, that could also induce apoptosis and inhibit the growth of the tumor.
- Heavy ion beams induce survivin expression in human hepatoma cells more effectively than X-rays.
- prognosis of stage I-IIIA non small cell lung cancer may be linked to the cellular pattern of distribution of survivin.
- Survivin expression is associated with progression of ovarian carcinoma.
- survivin expression was detected in 53 of the cases with NHL, and is associated with aggressive histology and shorter overall survival.
- Survivin contains a monomer-specific NES and that dimerization modulates cytoplasmic access of the protein
- The present review is a summary of survivin's functions, focused on its role in cell division in normal and cancer cells, as well as introduction to discussion about anticancer therapies based on survivin depletion.
- Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells.
- Survivin levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer.
- We concluded that As(2)O(3) induced the apoptosis of Hep-2 cells via down-regulating the expression of survivin mRNA.
- Survivin and its splice variants might be involved in the pathogenesis and development of cervical carcinomas.
- The survivin protein concentration in hepatocellular carcinoma cells was increased by the combination of hypoxia and anti-cancer drugs.
- mitotic regulator Survivin binds as a monomer to its functional interactor Borealin
- survivin was not expressed in normal bladder urothelium; survivin was overexpressed in 53% of non-muscle-invasive bladder tumors; overexpression of survivin was associated with greater tumor grade
- Compared with survivin, PLK1 seems to be a better independent prognostic factor for diffuse large B-cell lymphoma.
- Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle.
- survivin -31C>G polymorphism influences survivin expression, thus contributing to the genetic susceptibility to lung cancer.
- Inhibition of Survivin expression and/or function has been shown to impede tumor cell proliferation, and markedly induce spontaneous or chemotherapy induced apoptosis.
- The antiapoptotic isoform of survivin which was decreased during differentiation, was re-induced by GM-CSF in neutrophil-like, differentiated HL60.
- Radiation-induced apoptosis of tumor cells is increased by inhibition of the interaction between Survivin and Smac/DIABLO.
- survivin may be of importance for renal pathophysiology and pathology
- Data show that in both HeLa cells and chondrocytes, Cartilage oligomeric matrix protein induced survivin mRNA by 5-fold. Thus survivin is the first gene identified to be up-regulated transcriptionally by COMP.
- expression is negatively regulated by Egr-1
- Survivin expression was observed in 29 (91%) surgical malignant peritoneal mesothelioma (MPM) specimens; transfection of MPM cells with the survivin siRNA inhibited survivin protein expression and cell growth, and enhanced drug-induced apoptosis.
- tumor vaccine consisted of a cell-penetrating peptide of Tat(49-57), a CTL epitope peptide survivin(85-93) and a plasmid encoding murine interleukin-15 (IL-15)could effectively mediate the expression of the gene and presentation of the tumor antigen
- These data shed more light on the molecular biology of meningioma cells and suggest that survivin and proteins of the RB pathway could play a determinant role in the development and the treatment of meningiomas.
- Survivin mRNA positive cases are associated with bladder tumour recurrence
- survivin in the cell nucleus has reduced stability and is not cytoprotective
- Downregulation of survivin causes changes in mitosis and apoptosis, which may be related to changes in TNF receptors and NF-kappaB signaling.
- Survivin may play an important role in progression of hepatocellular carcinoma by promoting cell proliferation, and may be positively correlated with high risk of disease recurrence and poor prognosis.
- IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin
- Survivin expression is induced as an early event in lung carcinogenesis.
- Our findings suggest an important role of survivin to promote trophoblast cell survival and proliferation during placentation, thus maintaining pregnancy.
- Survivin and VEGF co-expression is an independent prognostic survival factor for patients with advanced nasopharyngeal carcinoma.
- Increased expression of COX-2 and survivin in ovarian cancer is associated with adverse clinicopathologic parameters, including reduced survival.
- Up-regulation of of BIRC5 is associated with breast carcinomas
- -survivin expression might be a prognostic factor for non-small cell lung cancer
- methylation status of the survivin promoter and occurrence of these SNPs within the promoter region of the survivin gene appear to be of minor importance in leukemogenesis
- Survivin and caspase-3 expression correlate with poor prognostic parameters (higher histologic grade and high proliferation), but not with outcome, in breast carcinoma patients.
- identify leptin/STAT3 signaling as a novel pathway for survivin expression in breast cancer cells
- Wild-type survivin mRNA expression level is significantly associated with docetaxel-resistance in gastric cancer.
- survivin levels were correlated with activity scores in chronic liver disease.Increased Survivin levels were correlated with high tumor grade and vascular invasion. Tumor recurrences were more frequent in patients with high survivin levels.
- Survivin immunohistochemical staining can be a useful adjunct tool for the grading of challenging cases of papillary urothelial carcinoma.
- survivin has a role in proliferation of leukemia cells
- EBV uses its latent protein, LMP2A, to activate the NF-kappaB-survivin pathway to rescue EBV-infected epithelial cells from serum deprivation
- Hyperexpression of Survivin is associated with gliomas
- In human cardiomyopathy, survivin was potently induced in the failing heart and downregulated again after hemodynamic support by a left ventricular assist device. Its expression positively correlated with the mean cardiomyocyte DNA content
- we believe the elevated expression of survivin might play an important role of development in nasal polyps
- survivin and its spliced isoforms have associations with PCa cell proliferation and aggressive phenotypes
- Survivin shRNA effectively inhibits survivin gene expression in Hep-2 cells leading to growth suppression and apoptotic induction in Hep-2 cells.
- The expression of survivin gene may play some roles in the pathogenesis of nasopharyngeal carcinoma.
- Survivin, Smac, and PKC alpha might play important roles in the inhibition of apoptosis by FGF-2 in human small cell lung cancer cells.
- Immunohistochemical assessment of both Survivin and CD44v6 status in negative surgical margin may be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer
- survivin is expressed in Merkel cell carcinoma
- Report effect of antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancers.
- Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly
- Smac/DIABLO interacts in a similar way with both XIAP and survivin through its amino terminal residues.
- Inhibition of survivin function by dominant-negative approaches showed that this inhibitor of apoptosis family member is critical to cell survival.
- in breast cancer, increased nuclear, but not cytoplasmic, survivin was associated with reduced overall survival (OS) & disease-specific survival; high cytoplasmic-to-nuclear ratio of survivin was associated with improved OS & disease-specific survival
- Genetically programmed cell death is related to the p27, cathepsin and survivin pathways in Fuchs' dystrophy and to the p21 and p27 pathways in pseudophakic bullous keratopathy.
- These data suggest that the apoptotic response of infected intestinal epithelial cells is actively suppressed by C. parvum via upregulation of survivin, favoring parasite infection.
- Chemically synthesized human survivn does not inhibit caspase 3.
- Silencing survivin gene expression promotes cell apoptosis mediated by translocation of the mitochondrial apoptosis inducing factor, while no changes were observed in caspase-3 activation and Bid cleavage.
- p21 could be a potential mediator of survivin suppression at the transcriptional level
- tumor-shared survivin does not appear to be the target of immune tolerance in healthy donors and cancer patients and is a relevant candidate for cancer vaccine
- Survivin is a novel effector of Ran signaling, and this pathway may be preferentially exploited for spindle assembly in tumor cells.
- A novel molecular mechanism of how NO signaling may contribute to therapy resistance in ovarian cancer by modulating survivin expression.
- ER- breast cancer cells become dependent on Notch-survivin signaling for their maintenance, in vivo.
- overexpression of survivin in endothelial cells serves as a protective mechanism that defends the vasculature from drug cytotoxicity.
- CCL2 protects prostate cancer PC3 cells from autophagic death via the phosphatidylinositol 3-kinase/Akt/survivin pathway
- survivin expression in non-small cell lung cancer was significantly higher than in normal tissues; survivin mRNA was up-regulated in tumors of 42 patients (66%); survivin overexpression did not correlate with survival of lung cancer
- survivin greatly enhances the activity of an oncolytic adenovirus in the presence of low-dose radiotherapy
- Up-regulation of survivin is associated with oral squamous cell carcinoma.
- Results suggest that survivin appears to participate in the multidrug resistance mechanism of H460/cDDP lung cancer cells.
- BIRC5 expressing circulating cancer cells are associated with metastasis and recurrence in gastric and colorectal cancer.
- T-cell survivin in prostate or colorectal neoplasms has a role in response to radiation therapy
- survivin gene acts as a critical mediator of AML1/ETO-induced late oncogeneic events.
- survivin is an important predictive factor for effectiveness of neoadjuvant chemotherapy with TE regimen in locally advanced breast cancer
- Survivin expression was markedly downregulated after the siRNA expression vector against HIF-1 alpha was transfected into the LS174T cells.
- BIRC5 is a novel target of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
- chromosomal binding of the mitotic regulators such as survivin is essential for mitotic progression.the localization of survivin was altered in cells.
- The function of survivin in the control of autophagy and the interaction between CCL2, survivin and autophagy in the complex program of tumor progression is discussed.
- Survivin was down-regulated in the growth inhibition of hepatoma cells induced by a selective Cyclooxygenase 2 Inhibitors , N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide , in a concentration- and time-dependent manner.
- survivin may have a role in progression of lung cancer
- Adenoviral activity is facilitated by abrogation of multiple cell cycle checkpoints and can be enhanced by expression of survivin within the nucleus.
- The main purpose of this study was to compare (in the same cells) survivin expression driven by chromosomal survivin promoters (endogenous survivin) with survivin expression from plasmids driven by recombinant survivin promoter.
- Akt2 down-regulation sensitizes ovarian cancer cells to paclitaxel-induced apoptosis, and inhibits survivin expression
- the increase of level of survivin in tumor tissues is not the result of decrease in content of its inhibitors SMAC and PML, as their content in tumor and normal cells is the same.
- the phosphorylation of survivin on Thr34 critically regulate survivin and plays an important role during the malignant transformation of oral submucous fibrosis
- Survivin has a dual role in mitosis & in apoptosis resistance. It plays an important role in development, but is absent in differentiated adult tissues. Aberrant survivin expression is found in most human cancers (Review)
- silibinin induced apoptosis of laryngeal squamous carcinoma cells by a mechanism involving decreased survivin expression, which suggests the possibility that silibinin may be an effective treatment of laryngeal cancers.
- Patients with low survivin expression had statistically significant better survival rates than patients with high survivin expression (p < 0.05).
- Mutation within a putative Sp1 binding site in BIRC5 promoter led to a sharp decrease of promoter activity.