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Validated All-in-One™ qPCR Primer for HOXA10(NM_018951.3) Search again
Product ID:
HQP008981
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HOX1, HOX1.8, HOX1H, PL
Gene Description:
homeobox A10
Target Gene Accession:
NM_018951.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation.
Gene References into function
- regulates hematopoietic lineage commitment, enhancing the monocytic differentiation pathway
- beta3-Integrin expression was directly up-regulated by HOXA10 in the endometrium
- SHP1 has a role in myeloid differentiation and is regulated by HoxA10
- its expression is diminished by hydrosalpinx fluid in the endometrium
- In these studies we identify and characterize the regulation of EMX2 by HOXA10.
- FKHR and HOXA10 interact directly and can function cooperatively to stimulate IGFBP-1 promoter activity in endometrial cells
- HOXA10 expression was repressed by testosterone in vitro; endometrium of patients with polycystic ovary syndrome demonstrated decreased HOXA10 mRNA
- HoxA10 represses gene transcription in undifferentiated myeloid cells by interacting with histone deacetylase 2
- Cell-free media that had contained human embryos cultured to the blastocyst stage contain a soluble molecule that induces HOXA10 expression in an endometrial epithelial cell line.
- Data report novel nucleoporin 98 fusions with homeobox (HOX)A10, HOXB3 and HOXB4, and describe the results of coexpression of these proteins with the Hox cofactor Meis1 in leukemic induction.
- Results show for the first time that SIRT2 interacts with the homeobox transcription factor, HOXA10.
- HOXA10 estrogen response element(ERE)1 therefore demonstrated ligand specificity distinct from the consensus ERE
- The HOXA10 gene cluster is in T-cell malignancies resulting in deregulated HOXA gene expression.
- HOXA10 and HOXA11 expression increases during the menstrual cycle, increasing drastically in the midluteal phase, at the time of implantation.
- HOXA10 is down-regulated in the process of decidualization
- A direct role of vitamin D in the regulation of HOXA10 in primary human endometrium and myelomonocytic cells was identified.
- The aberrant methylation at HOXA10 may be responsible for the aberrant gene expression in the endometrium of women with endometriosis.
- Cytokine-stimulated pathways regulate HoxA10-mediated repression of the CYBB and NCF2 genes in differentiating myeloid cells and in mature phagocytes during the inflammatory response.
- findings reveal a novel role for HOXA10 deregulation in the progression of endometrial carcinoma by promoting epithelial-mesenchymal transition
- The expression of HOXA10 is restricted to primordial and early primary follicles.
- However, the diminished expression of HOXA10 in ectopic endometrium might not allow for normal endometrial development and might contribute to the pathogenesis of endometriosis by creating P resistance.
- synergism between NUP98-HOX and wt-Flt3 is the result of the ability of Flt3 to increase proliferation of myeloid progenitors blocked in differentiation by NUP98-HOX fusions, revealing a direct role for wt-Flt3 in the pathobiology of AML.
- HOXA10 is necessary for implantation.
- HoxA10 is a bifunctional protein that is involved in dynamic regulation of multiple aspects of phagocyte phenotype and function
- No DNA sequence differences were found in either patients with congenital absence of uterus and vagina or normal controls in either of the two protein-coding exons of the HOXA10 gene.
- We sought to understand the role of HOXA10 in megakaryopoiesis better, by investigating its transcriptional regulation by 5' region GATA-1 and Ets-1 sites.
- HOXA10 is differentially expressed in the functionalis and basialis zones of the luteal phase monkey endometrium and is suppressed upon antiprogestin treatment but induced by embryonic stimuli
- Reduction of HOXA10 expression is associated with chronic myelogenous leukemia
- Endometriosis patients with HOXA10 polymorphism were associated with a lower serum cancer antigen-125, a lower American Fertility Society score and less severe obliterated cul-de-sac.
- HOXA10 is actively involved in promoting cell proliferation through the regulation of hundreds of genes.
- the vitamin D(3)/Hox-A10 pathway supports MafB function during the induction of monocyte differentiation.
- constitutive SHP2 activation synergizes with HoxA10 overexpression to accelerate progression to acute myeloid leukemia
- These results indicate that p/CAF is a novel HOXA10 target gene, and HOXA10 promotes human endometrial development, at least in part, through the regulation of p/CAF gene.