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Validated All-in-One™ qPCR Primer for HLA-C(NM_002117.5) Search again
Product ID:
HQP008851
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1
Gene Description:
major histocompatibility complex, class I, C
Target Gene Accession:
NM_002117.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
HLA-C belongs to the HLA class I heavy chain paralogues.
Gene References into function
- Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8. HLA-A2, -Cw4, and -Bw46 alleles, or HLA-G1 leads to NK cell apoptosis.
- This is the major genetic determinant for psoriasis. The HCR gene at this locus is the putative susceptibility gene for psoriasis.
- identification of new allele, Cw*0408
- Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208.
- An association between young age of onset of psoriasis and HLA-Cw*0602 is confirmed in patients with psoriatic arthritis.
- Elongation of the cytoplasmic domain, due to a point deletion at exon 7, results in an HLA-C null allele, Cw*0409 N
- results indicate that the HLA-Cw*0409N allele may produce a putative long HLA-Cw4 heavy chain that is not expressed on the cell surface
- Molecular diversity of the HLA-C gene identified in a caucasian population
- Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus
- Psoriasis is associated with a SNP haplotype of the corneodesmosin gene. A psoriasis susceptibility locus has been mapped to the HLA region in the proximity of the HLA-C locus.
- the HLA-C locus may play a role in liver graft alloreactivity or allotolerance and, therefore, may be useful to avoid acute rejection and to achieve graft acceptance, resulting in a better final outcome in liver transplantation.
- Cloning and sequencing of full-length HLA-C genes
- Our results confirmed the published linkage with the PSORS1 locus, as well as the PSORS2 locus, which has not been previously shown in the Chinese population.
- HLA-Cw*1507 association with HIV infection reported for the first time in Maharashtra, India
- Based on the observations that HCR is detected in cancers of epithelial origin in Ki67-negative areas and that interferon-gamma downregulates its expression, it may have an antiproliferative function.
- a relation between HLA-Cw7 and differentiated thyroid carcinoma
- protective gene telomeric to the HLA-C locus in psoriasis vulgaris
- results show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection
- The data suggest that the microsatellite instability (MSI) and loss of heterozygosity (LOH) of HLA class I gene might participate in the carcinogenesis of cervical carcinoma.
- A strong asociation between the HLA Cw*04 haplotype and persistent hepatitis C virus infection was observed (p = 0.006).
- an endogenous retroviral dUTPase constitutes a candidate gene for the PSORS1 mutation.
- PSORS1 is not a major inherited risk factor in the pathogenesis of late onset psoriasis
- CTGGAC haplotype is a single-point score haplotypes telomeric to HLA-C and gives a 1 df, chi2 of 50.27 (p<0.0001).
- CTGGAC haplotype is a single-point score haplotypes telomeric to HLA-C and gives a 1 df, chi2 of 50.27 (p<0.0001).
- we have identified a novel gene, PSORS1C3, and characterized it with regard to psoriasis
- analysis of novel allele HLA-Cw*0208
- analysis of novel allele HLA-Cw*160102
- An examination of the association between HLA-C (Ala-73 and Asp-9) and susceptibility to psoriasis among Saudi patients.
- new HLA class I alleles found in Caucasian population: A*3012, B*270505, B*3541 and Cw*0716
- analysis of novel allele HLA-Cw*1210 and confirmation of HLA-Cw*080102
- defined Cw alleles in 91 individuals from the Maratha community of Mumbai, Maharashtra, western India
- Guangdong Han population in China has twelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles and a total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes.
- HLA-Cw*010203 is a novel HLA-Cw*01 allele identified by sequence-based typing
- preferential association of L31-reactive, beta2m-free H chains with calnexin in beta2m-defective cells, and with calreticulin and TAP in beta2m-expressing cells
- HLA-Cw allele frequency distributions were consistent with the Hardy-Weinberg equilibrium in a group of indigenous Hans in Shenyang, China.
- study of the HLA-C locus revealed that the analysis of the dimorphism at position 80 in the alpha1 helix may help to evaluate the risk and prognosis of melanoma in a Spanish population
- Identification of two novel HLA-C alleles, HLA-Cw*1217 and HLA-Cw*030404
- Carrying a Cw*0801 HLA allele is a risk factor for SARS-CoV infection susceptibility [Cw*0801 HLA]
- Intrathecal production and fluctuations in CSF and serum concentrations of sHLA-I were reciprocal in multiple sclerosis.
- The HLA-Cw4 allele can act as a protector against the development of MG, as it occurs less frequently in the population with MG, and those with this allele develop smaller goiters with no intrathoracic component.
- HLA-C mismatch is associated with inferior survival after myeloablative unrelated donor (URD) hematopoietic stem cell transplantation in hematologic cancers.
- These results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.
- These results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.
- Two novel HLA-C alleles Cw*070105 and Cw*1403 were reported.
- results for antigens and allele frequency of various HLA Loci in vitiligo patients and control subjects suggested that HLA-B7, Bw6, Cw6, Cw7, and DRB4*010101 could be susceptible to vitiligo
- The level of expression of target cell HLA-C determines the extent to which it segregates from ICAM-1 at the immune synapse.
- HLA-Cw*07 allele carried by the liver transplant recipient is negatively associated with acute rejection development and could be considered a predictive factor for liver graft acceptance.
- the HLA-Cw*1609 allele differs from the closest Cw*1602 by only one nucleotide (C --> G) at position 244 in exon 2
- The genetic distance (GD) estimated according to HLA-A, -B, and -C allele frequency indicates that Mongolian and Hui have the closest relationship.
- While the previously reported association between TNF*-238A and psoriasis seems to primarily reflect linkage disequilibrium with PSORS1, TNF*-857T may represent a risk factor for psoriatic arthritis that is independent of the PSORS1 allele.
- evidence of a primary association of HLA-C, and to a lesser extent HLA-B, with Graves' disease
- study showed that Cw*0602-positive patients had some obvious clinical differences from Cw*0602-negative patients in a Han Chinese population, which provides evidence for an HLA-Cw*0602-associated phenotype in psoriasis
- HLA-Cw*08 correlates with low cytotoxic T lymphocyte immune response in human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis patients.
- Our results confirm no association between HLA-C alleles and LOP in the northern Polish population. The lack of this association supports the hypothesis about different genetic backgrounds of early- and late-onset psoriasis.
- Maternal KIR/fetal HLA-Cw gene combinations that are involved in the fetomaternal tolerance do not appear to play a role in the HPA-1a alloimmunization.
- Two new HLA-C alleles, Cw*0333 and Cw*0217, identified in a black South African population appear to have arisen by missense mutations, respectively, from the HLA-B*5801-Cw*0302 and B*080101-Cw*0205 haplotypes.
- HLA-Cw*0220 sequence alignment with classical and nonclassical HLA class I alleles shows that histidine-169 is shared by HLA-E and -G alleles.
- polymorphisms in some alleles of B and C in HLA class I genes are associated with Kawasaki disease in Korean children.
- The novel HLA-Cw allele HLA-Cw*0751 was reported.
- This report describes the unknown exon 4 sequence of the rare human leukocyte antigen-Cw*0716 allele, identified in a Caucasian renal transplant recipient from Italy.
- Study show additional risk loci for rheumatoid arthritis are present SNP alleles found on the conserved A1-B8-DR3 (8.1) haplotype show the strongest evidence of positive association (P ~ 0.00005) clustered in the region around the HLA-C locus.
- By performing family-based association analyses of haplotypes as well as an exclusion analysis of recombinant haplotypes, we refined the PSORS1 gene to a small critical region where HLA-C is a strong candidate to be the PSORS1 susceptibility gene.
- N-linked glycosylation selectively regulates the generic folding of HLA-Cw1
- Co-occurring HLA alleles across loci seem to be more important than individual allelesin squamous cell cervical cancer risk.
- The HLA-Cw*0701 allele and KIR haplotype AA are associated with AMD. This genotype combination suggests that natural killer cells have a role in the pathogenesis of AMD.
- Tightly regulated HLA-C surface expression via the activity of an internalization and lysosomal targeting signal facilitates immune surveillance and allows HLA-C to serve a specialized role in macrophages.
- Data suggest that in spite of HLA-Cw heterogeneity, remarkable similarities may exist between Han populations in China at the combinational level of HLA-Cw and KIR2D, which are characterized by preponderant inhibitory signal pathways.
- selective up-regulation of maternal killer Ig-like receptor has functional consequences because uterine NK cells show increased binding of HLA-C tetramers compared with blood NK cells
- HLA-Cw6, overweight and higher waist-hip ratio are material risk factors of psoriasis vulgaris, especially the combined effects of HLA-Cw6 and BMI, WHR on psoriasis vulgaris in Chinese population.
- Tissue donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation.
- HLA-C molecules associate with HIV gp120 and increase the infectivity of both R5 and X4 viruses.
- Soluble HLA-C serum level is significantly increased in allergic rhinitis patients with pollen allergy.
- Present results suggest that there is a significant relationship between nasal polyposis and HLA-Cw allele frequency among the Turkish population.
- Data demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease.
- These data suggest that HLA-C is involved in the attachment of HCoV-HKU1 to A549 cells and is a potential candidate to facilitate cell entry.
- LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis.
- Expanded catalog of genetic loci implicated in psoriasis susceptibility.