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Validated All-in-One™ qPCR Primer for NR3C1(NM_001024094.1) Search again
Product ID:
HQP008403
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GCCR, GCR, GCRST, GR, GRL
Gene Description:
nuclear receptor subfamily 3 group C member 1
Target Gene Accession:
NM_001024094.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq].
Gene References into function
- The findings show an association between rheumatoid arthritis and a polymorphism in the hGR gene that increased the stability of hGRbeta mRNA.
- The counteracting action of cortisone against cortisol-induced apoptosis may take place partially through intervention of GC-receptors (GC-Rs), but may also be due to unknown pathway(s) different from those mediated by cellular GC-Rs.
- Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene.
- Results are consistent with a dynamic model in which GR first binds to chromatin after ligand activation, recruits a remodeling activity, facilitates transcription factor binding, and is simultaneously lost from the template.
- Glucocorticoid receptor binding in twin pairs is affected by shared environment but not by shared genes
- AUUUA motifs in the 3'UTR of human glucocorticoid receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression
- This study shows that both promoters 1B and 1C are important for the ubiquitous expression of the human glucocorticoid receptor gene.
- Functional interaction between the pro-apoptotic DAP3 and the glucocorticoid receptor
- Corticosteroid receptor beta. CRbeta functions as an endogenous inhibitor of corticosteroids and may play a role in steroid resistance. RA patients have enhanced CRbeta expression in PMBCs.
- There was a significantly higher expression of the GR is untreated RA patients than controls. Glucocorticoid treatment was associated with a strongly decreased GR density.
- The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene. Review.
- Review. The roles of glucocorticoid receptor isoforms alpha and beta in the response to glucocorticoids in asthma are analyzed.
- These findings suggest that JNK-mediated phosphorylation of the GR-Ser226 enhances GR nuclear export and may contribute to termination of GR-mediated transcription.
- We identified a novel heterozygous mutation (C643R) in the ligand-binding domain in P30/OHK cells
- The results of homology modelling of the human glucorticoid receptor (hGR) ligand-binding domain (LBD) based on the ligand-bound domain of the human estrogen receptor alpha (hERalpha) are reported.
- data support the existence of a new pathway involving hSur2 for modulating GR transactivation processes
- Ligand binding induces a conformational change dependent on ligand affinity. This decreases receptor mobility, probably by targeting it to relatively immobile nuclear domains with which it transiently associates. This also blocks immobilization by MG132.
- Association of coronary artery disease with glucocorticoid receptor N363S variant.
- Glucocorticoid receptor activates Bcl-XL during tumorigenesis
- there are non-hormone-binding receptor forms of glucocorticoid receptor in addition to the native heterocomplex
- Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils.
- Data show that differential recruitment of coactivators by progesterone and glucocorticoid receptors determines the assembly of coactivator complexes on target promoters to mediate specific transcription signals.
- REVIEW: pathological and in vitro mutations and polymorphisms
- investigation of dominant negative function of human glucocorticoid receptor beta
- glucocorticoid receptor has a role in regulation of hypoxia-dependent gene expression
- the ligand-binding domain of GR, but not the DNA-binding domain or the N-terminal activation domain, is required for GR-mediated transrepression of TGF-beta transactivation
- Data show that the G allele may be a predisposing gene marker, glucocorticoid receptor gene intron 4 polymorphism contributes to the development of cerebral infarction in females.
- Identification of the novel GRV575M variant in human bronchial epithelial cells using a molecular genetic selection scheme
- GRalpha transcripts containing exons 1A3, 1B, and 1C contribute most to the intracellular level of GR mRNA and may be the most relevant for steroid-mediated apoptosis in T-lymphoblasts
- identified genes transcriptionally activated by GR, in a translation-independent manner, in two human cell lines
- Twelve polymorphisms in the NR3C1 gene were detected, two types of newly found haplotypes were associated with steroid-resistant idiopathic nephrotic syndrome, which might be responsible for steroid-resistance in partial idiopathic nephrotic syndrome.
- promoter has several different steroid-responsive sequences
- the role of Hsp90 in nuclear retention of GR after ligand withdrawal
- Data report the crystal structures of two overlapped fragments of FK506-binding protein 52 and the heterocomplex of glucocorticoid receptors with heat-shock proteins 90.
- Results reveal differential modulatory roles of the protein inhibitor of activated STAT proteins on the transcriptional properties of mineralocorticoid and glucocorticoid receptors.
- a mutation of the glucocorticoid receptor gene may have a role in development of systemic lupus erythematosus
- relaxin acts as GR agonist--a pathway pivotal to its effects on cytokine secretion by human macrophages
- The ER22/23EK polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength in males
- hGRbeta suppresses the transcriptional activity of hGRalpha by competing with hGRalpha for binding to GRIP1, and possibly other p160 coactivators, through its preserved AF-1
- role of GR in glucocorticoid-regulated gene expression
- the interaction between PPARgamma and GR may be responsible for the additive and synergistic inhibition of chemokine expression by PPARgamma agonists, glucocorticoids, and beta(2)-agonists
- an induced-fit mechanism gives structure to the glucocorticoid receptor AF1 domain when it encounters TATA box binding protein
- The inability of GRR488Q to repress NF-kappaB was not related to its inability to activate target genes through a glucocorticoid response element.
- results demonstrate a rational mechanistic basis for UGT1A1 induction by glucocorticoids and PXR activators, showing that activated glucocorticoid receptor enhances CAR/PXR-mediated UGT1A1 regulation with the transcriptional cofactor GRIP1
- GR mRNA expression was reduced in the basolateral/lateral nuclei in schizophrenia and bipolar disorder.
- the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter interact in T-lymphocytes
- Glucocorticoid receptor-induced MPK-1 expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival
- FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor
- Glucocorticoid receptor alpha is expressed in adenotonsillar tissue of children with obstructive sleep apnea
- The molecular basis for the reduced GC sensitivity was elucidated by investigating the influence of the ER22/23EK polymorphism on synthesis of GR-A and GR-B isoforms.
- A possible indicastion for selection of synthetic glucocorticoids for treatment of pathological conditions in which hGR beta modulates the sensitivity of tissues to glucocorticoids.
- glucocorticoid receptor down-regulation and transactivation is mediated by CHIP, an E3 ligase, through the ubiquitin-proteasome pathway
- Carboxyl terminus of the ligand-binding domain is extremely important in conferring transactivational activity by altering multiple functions of this composite transcription factor.
- Relatively frequent SNP Asn363Ser found in Caucasians and African-Americans. Thus, ethnic differences between Japanese and other races are suggested to exist in NR3C1.
- structural analysis of glucocorticoid receptor point mutation V571M
- PPARalpha has a role in CYP4X1 regulation, and the glucocorticoid and progesterone receptors have roles in CYP4Z1 gene activation
- interleukin-5 transcription repression by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment
- discussion of glucocorticoid receptor gene and protein [review]
- Results suggest that cell-type specific glucocorticoid receptor isoforms generate specificity in glucocorticoid control of transcription in different tissues.
- Glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.
- New, alternatively spliced transcripts of glucocorticoid receptor alpha subunit may have physiologically relevant roles that might be manifested in a cell type-specific manner and could potentially affect hormone sensitivity or resistance in leukemia.
- Results identify Hsp90 as a target of HDAC6 and suggest reversible acetylation as a unique mechanism that regulates Hsp90 chaperone complex activity in maturation of the glucocorticoid receptor.
- study suggests that, in men developing obesity early in life, polymorphism of the glucocorticoid receptor gene is associated with less adiposity at a given body mass index, leading to higher insulin sensitivity
- role in transcriptional regulation of CYP2C8
- We conclude that the Gbetagamma complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters.
- In three different cell lines, relaxin induced GR activation, nuclear translocation, and DNA binding as assessed in glucocorticoid response element (GRE)-luciferase assays
- platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands
- The increased expression of GR beta mRNA may be related to the ineffectiveness of glucocorticoids for the treatment of AS.
- When tested in HT29 cells, MPA could only stimulate alpha-ENaC-driven reporter activity when GR was coexpressed, confirming the requirement for functional GR in the transcriptional effect of MPA.
- Review. The presence of multiple GR monomers and dimers in different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic.
- Analysis of the 5' untranslated region of the human glucocorticoid receptor (hGR) has revealed 11 splice variants of exon 1, based on seven exon 1s, four of which were previously unknown.
- There was an association between the BcII polymorphism and salivary cortisol, but no association for obesity.
- MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor
- c-Myb and c-Ets family members (Ets-1/2, PU.1, and Spi-B) control hGR 1A promoter regulation in T- and B-lymphoblast cells
- Spinal glucocorticoid receptor through the cAMP-CREB pathway played a significant role in NMDAR and PKCgamma expression after chronic morphine exposure.
- RNA silencing of GCRbeta mRNA in human BAL macrophages from patients with GC-insensitive asthma resulted in enhanced dexamethasone-induced GCRalpha transactivation.
- Present article reviews the data about a possible role for glucocorticoid receptor beta in the development of glucocorticoid resistance in inflammatory diseases, such as rheumatoid arthritis and septic shock.
- Expresssed in the zona reticularis of the adrenal cortex.
- reduced GRalpha mRNA expression might be trait-dependent and associated with the pathophysiology of mood disorders.
- TBP-GR interaction is functionally significant
- The BclI and ER22/23EK polymorphisms of glucocorticoid receptor were associated with susceptibility to develop major depression.
- Correlation between glucocorticoid receptor number & affinity for ligand, as well as relationship between these equilibrium binding parameters & body mass index, blood pressure, & age were examined in peripheral blood mononuclear cells of healthy humans
- intracellular signaling of GR, AP-1 and JNK are altered in BD and may underly disease aetiopathogenesis and/or reflect the effect of the anti-depressants
- human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5
- results suggest that the N363S variant of the glucocorticoid receptor (GR) gene may play a role in the pathogenesis of bilateral adrenal incidentalomas
- We conclude that, in spite the effect of the ER22/23EK and N363S SNPs on metabolism, these polymorphisms together with the BclI SNP, do not affect the risks of cardiovascular disease and survival at old age.
- persons carrying the glucocorticoid receptor 9beta haplotype seem to have a decreased Glucocorticoid transrepression with normal transactivation
- No compelling evidence that the N363S polymorphism of the GRL gene is associated with either average body mass index or obesity risk.
- Results demonstrate NR3C1 as a potential mediator of chronic fatigue, and implicate variations in the 5' region of NR3C1 as a possible mechanism through which the alterations in HPA axis regulation and behavioural characteristics of CFS may manifest.
- Glucocorticoid receptor is expressed in advanced non-small cell lung cancer
- Importin 13 promotes nuclear occupancy of glucocorticoid receptor to potentiate antiinflammatory effects of glucocorticoids.
- genetic variations of NR3C1 in children with sporadic steroid-resistant nephrotic syndrome & sporadic steroid-sensitive NS; no causative mutations were found; 6 previously identified & 6 novel polymorphisms were detected & 2 novel haplotypes identified
- These data suggest that although LXXLL motifs in helices 1 and 10 appear to lie outside the predicted ligand binding pocket they may contribute to receptor ligand binding affinity.
- Acute effect of glucocorticoids on NHE3 is mediated by a glucocorticoid receptor dependent mechanism that activates SGK1 in a nongenomic manner.
- a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene
- data suggest that the N363S GRL polymorphism may be implicated in the long term response to glucocorticoids in patients with Duchenne muscular dystrophy
- Brg1 and HDAC2 have roles in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease
- Immunohistochemistry (demonstrated no overt difference between CDH, hypoplastic, and control lungs, either in the localization nor the timing of the first expression of glucocorticoid, retinoid, and thyroid hormone receptors
- Role of GR in major depression.
- STAMP is an important new, downstream component of GR action in both gene activation and gene repression.
- no differences in cognitive functioning were observed dependent on the polymorphisms in the MR and GR genes in older adults.
- Hypermethylation was subsequently identified for three of four analyzed genes, ADAMTS1 (85%), CRABP1 (90%), and NR3C1 (35%).
- GR undergoes a phosphorylation/dephosphorylation cycle that maintains steady-state receptor phosphorylation at a low basal level in the absence of ligand.
- the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1
- GRalpha is of significance in meningiomas; however, GRalpha's expression had no obvious effect on the proliferative activity of meningiomas.
- diffusion properties of EGFP-GRalpha and mutants C421G, A458T and I566 in living cells
- Two additional possible first exons are mapped.
- Regulation of splice variants could partly occur through selective use of the multiple promoters.
- Overexpression of TrxR1 markedly increased GR activity in outer root sheath cells cultured in vitro. In addition, thioredoxin reductase 1 protected GR activity against H(2)O(2).
- The ER22/23EK polymorphism was associated with a more aggressive MS phenotype, measured both clinically and on MRI.
- Novel splice variant hGRDelta313-338 represents a glucocorticoid receptor isoform with an altered glucocorticoid-induced transactivation profile.
- For the glucocorticoid receptor (GR), inhibition of proteasome-mediated proteolysis or RNA interference-mediated depletion of specific proteasome subunits results in an increase in gene expression.
- Ginsenoside-Re is an agonistic ligand for the glucocortiod recept which in turn induces rapid calcium influx and nitric oxide production in endothelial cells.
- A profound apoptotic effect of glucocorticoid receptor (GR) in small cell lung cancer (SCLC) cells may explain the low levels of endogenous GR in SCLC cells.
- progesterone and glucocorticoid, but not estrogen receptor mRNA are altered in breast cancer stroma
- Data show that conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block.
- functional assays revealed only minor differences between the wild-type glucocorticoid receptor and N363S receptors in both transiently and stably expressing cell lines
- Results suggest that bombesin-induced expression of SRp30c affects gllucorticoid receptor (GR) pre-mRNA splicing, leading to increased GR beta expression and contributing to glucocorticoid resistance in PC cells.
- evidence presented for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor alpha in HepG2 cells.
- Years 2 to 3 of life were a critical period: the participants whose families owned homes during these childhood years showed higher GR mRNA and lower TLR4 mRNA during adolescence, a profile that suggests better regulation of inflammatory responses
- GR occupancy is a primary determinant of glucocorticoid responsiveness, and core GR binding sequences as well as GRE architecture likely harbor gene-specific regulatory information
- In cases where prednisolone acetate was administered, we found a significant correlation between N363S heterozygosity and steroid-induced ocular hypertension.
- GRalpha may be involved in transcriptional regulation of P-glycoprotein in placental trophoblast. CYP3A4 & CYP2C9 genes are not inducible through GRalpha in placental cell lines, due to lack of HNF4alpha expression
- CTGF is a functional target of aldosterone in mesangial cells, but aldosterone-induced CTGF gene expression is not directly mediated by the mineralocorticoid receptor.
- The mutant receptor hGRalphaF737L causes glucocorticoid resistance because of decreased affinity for the ligand, delay in nuclear translocation, and/or abnormal interaction with the glucocorticoid receptor-interacting protein 1 coactivator
- Results suggest that translational glucocorticoid receptor isoforms can elicit distinct glucocorticoid responses.
- Significant sex specific associations were found between glucocorticoid receptor gene polymorphisms and HPA axis responses to psychosocial stress as well as glucocorticoid sensitivity.
- Carriers of the 23K variant in the glucocorticoid receptor are protected against postnatal growth failure and insulin resistance after preterm birth
- Binding site located in the hippocampal glucocorticoid receptor gene (Nr3c1) exon 1(7) promoter, leads to decreased Nr3c1 expression.
- For the first time, our study suggested the possible role of the GR gene on BMD regulation and sex specificity in the association of GR with extreme BMD in the Chinese.
- GR and C/EBPalpha were involved in cortisol-induced 11beta-HSD1 mRNA expression via binding to 11beta-HSD1 promoter in amnion fibroblasts.
- Breast cancer progression is associated with the accumulation of glucocorticoid receptor in the cytoplasm of tumoral cells and the decrease of COX-2 expression.
- The effect of cell density and inflammatory conditions on the expression, compartmentalization, activation, and the anti-proliferative function of the GR in primary human lung fibroblast cultures, was studied.
- GRbeta is able to act as a transcriptional repressor of cytokine genes, IL5 and IL13 and mediates its function through the recruitment of histone deacetylase complexes.
- The BclI polymorphism may modulate the inflammatory burden in the cystic fibrosis lung and in this way influence progression of lung function.
- The endogenous glucocorticoid receptor exert both ligand-dependent and -independant suppressive effects on surfactant protein A expression via its interaction with NF-kappaB p65 and thyroid transcription factor- 1 bound to the TTF-1 binding element.
- These studies suggest BAF250a is a necessary facilitator of BRG1-mediated chromatin remodeling required for SWI/SNF-dependent transcriptional activation.
- Set/TAF-Ibeta acts as a ligand-activated GR-responsive transcriptional repressor, while Set-Can does not retain physiologic responsiveness to ligand-bound glucocorticoid receptor.
- The significant association between the frequency of the polymorphic BclI allele and ATA stage distribution suggests that this polymorphism of the GR gene may affect clinical manifestations of Graves ophthalmopathy
- The crystal structure of the GR LBD bound to DAC & the fourth LXXLL motif of steroid receptor coactivator 1 reveals that the GR ligand binding pocket is expanded to a size of 1,070 A(3), doubling its size but leaving the coactivator binding site intact.
- both mineralocorticoid and glucocorticoid receptors may be involved in the multiple mechanisms controlling counterregulatory responses to hypoglycemia in healthy man
- Glucocorticoid receptor polymorphism is associated with major depression and greater abdominal obesity
- Distribution of glucocorticoid receptor expression is markedly diverse among tissues of the human digestive system.
- Unipolar depression is associated with DNA variants of the NR3C1 gene in our population; volumetric reductions of the hippocampus may also be mediated by variants in this gene.
- The data suggest that steroids can overcome the restriction on HIV provirus formation by binding to glucocorticoid receptor and thereby increase the reservoir of virus producing cells.
- AngRem104 is involved in the in vivo regulation of GR expression and the activation of NF-kappaB through interaction with GR-EF in human MCs.
- Phosphorylation aids GR sumoylation and that cross talk of JNK and SUMO pathways fine tune GR transcriptional activity.
- Examine response to prednisone in relation to NR3C1 intron B polymorphisms in childhood nephrotic syndrome.
- A homozygous G679S mutation of the GR-alpha gene is associated with severe cortisol resistance, whereas a heterozygous mutation of the same gene can lead to subclinical cortisol resistance.
- GR-alpha may play the major role in the inflammation associated with nasal polyps.
- cases of Cushing's syndrome with putative glucocorticoid receptor dysfunction exist, and we report one such likely case
- HEXIM1 may act as a gene-selective transcriptional regulator via direct interaction with certain transcriptional regulators including glucocorticoid receptor.
- GR occupancy of the GR-binding sequences (GBS) motif correlates with induction but not repression, and GBS conservation alone is sufficient to predict GR occupancy and GRE function at induced genes
- DAX-1 directly modulates GR signaling in addition to affecting glucocorticoid hormone levels
- The lower GR and MR expression and possibly the reduced MR function, may be associated with an impaired function of the HPA axis in fibromyalgia patients.
- GR phosphorylation at S211 and S226 determines GR transcriptional response by modifying cofactor interaction.
- reexpression of wild-type GR restored GRE transactivation, NF-kappaB transrepression, RAFTK phosphorylation, Bim induction, and dexamethasone-induced apoptosis in a dexamethasone-resistance MM1R cell line
- Methylation status of the human NR3C1 gene in newborns is sensitive to prenatal maternal mood and may offer a potential epigenetic process that links antenatal maternal mood and altered hypothalamic-pituitary-adrenal stress reactivity during infancy.
- Association between birth weight in preterm neonates and the BcII polymorphism of the GR gene is reported.
- The human placenta expresses a variety of GR mRNA transcripts
- GR directly bound to the two glucocorticoid-response element-like sequences in the human CALD1 promoter and transactivated the CALD1 gene, thereby up-regulating the CaD protein.
- glucocorticoid resistance could not be attributed to mutations in GR or variations in levels of its expression
- HEXIM1 may participate in tissue-selective determination of glucocorticoid sensitivity via direct interaction with GR at least in certain gene sets including atp1a1 and scnn1a.
- We did not find differences in cardiovascular risk factors between GR haplotypes
- These findings identify a regulatory mechanism, downstream of hormone binding, used by Bag-1M for attenuating GR action in response to its changing cellular levels.
- The presence of the D401H mutation in gccr may predispose subjects to obesity, hypertension, and other manifestations of the metabolic syndrome
- GR-alpha and GR-beta polymorphisms are potentially associated with rheumatoid arthritis susceptibility.
- Results describe a convergence point of the GSK-3beta and the glucocorticoid receptor pathways, and suggest a mechanism by which GSK-3beta activity can dictate how cells will ultimately respond to glucocorticoids.
- Excess heterodimerization with the active GRalpha isoform may reduce glucocorticoid receptor (GR) signaling with subsequent physiological effects on blood pressure regulation.
- A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters.
- No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
- By blocking GR activation, dibutyltin may disturb metabolic functions and modulation of the immune system, providing an explanation for some of the toxic effects of this organotin.
- The genetic information about GRL would be useful for further genetic study of obesity, diabetes, and related metabolic diseases.
- we found no statistically significant relationship between glucocorticoid receptor polymorphisms and IOP (intraocular pressure) elevation following intravitreal triamcinolone acetonide.
- GR-mediated ligand-selective differential interaction with GRIP-1, SRC-1A, NCoR and SMRT is a major determinant of ligand-selective and promoter-specific differences in potency and efficacy, for both transactivation and transrepression.
- dissect the GRIP1:Suv4-20h1 interaction in vitro and in vivo and examine its potential involvement in hormone-dependent transcriptional regulation by GR
- Glucocorticoid receptor inactivation in dopamine receptor 1a-expressing neurons, but not in dopamine-releasing neurons, reduces the motivational properties of cocaine in transgenic mice.
- Post hoc tests show that expression of total glucocorticoid receptor mRNA is significantly reduced in suicide victims with a history of childhood abuse relative to nonabused suicide victims or controls.