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Validated All-in-One™ qPCR Primer for ANG(NM_001145.3) Search again
Product ID:
HQP007968
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ALS9, HEL168, RAA1, RNASE4, RNASE5
Gene Description:
angiogenin
Target Gene Accession:
NM_001145.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq].
Gene References into function
- nucleolar localization; nucleolar signal peptide
- Here we report that chANG, an antiangiogenin peptide, binds to the actin-binding site of angiogenin
- Blood levels are elevated in myelodysplastic syndromes and in acute myeloid leukemia.
- role of C-terminal fragment in defining enzymatic potency
- Expression and localization of angiogenin in placenta; enhanced levels at term over first trimester villi
- Distribution of angiogenin and its gene message in colorectal cancer patients has clinical relevance.
- Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia.
- An angiogenin-binding DNA sequence (CTCTCTCTCTCTCTCTCCCTC) has been identified from the nontranscribed region of rRNA gene and characterized as possessing angiogenin-dependent promoter activity that directs the expression of a luciferase reporter gene.
- High serum angiogenin levels were associated with choriocarcinoma
- in umbilical cord plasma, a developmental increase was evident in concentrations of vascular endothelial growth factor(VEGF) and angiogenin during the last trimester of gestation, and VEGF level was lower in term fetuses born to mothers with diabetes
- Compared with controls, patients with multiple myeloma show elevated serum levels.
- The specific localization of angiogenin in peritubular myoid cells suggests that angiogenin plays physiologic roles in the human testis.
- Finb functions as a sequence-specific transcriptional repressor of the hANG gene
- elevated blood levels of angiogenin feature chronic myeloid malignancies, suggesting a role of angiogenin in the pathogenesis of these diseases
- The distribution of ANG was studied in term placenta and by its expression in cultured trophoblastic cells.
- serum angiogenin levels although not increased in comparison with healthy controls, may predict clinical outcome of patients with early chronic lymphocytic leukemia and help to refine Rai's stratification
- The inflammation associated with endometriosis, through increasing levels of peritoneal fluid angiogenin, might promote angiogenesis for progression of the disease and correlate with the extent of the disorder.
- In Irish amyotrophic lateral sclerosis patients, there was a significant allelic association with the rs11701 SNP & a new mutation (K40I) that potentially inhibits angiogenin function.
- Angiogenin-stimulated rRNA transcription in endothelial cells serves as a crossroad in the process of angiogenesis induced by various angiogenic factors.
- The present study demonstrates for the first time, differential expression of mRNA and secretion for angiogenin and VCAM-1 from placental explants and trophoblasts in culture subjected to hypoxia
- Elevated expression of angiogenin is associated with prostate cancer
- Under hypoxic conditions, the ANG and VEGF secreted by renal proximal tubular epithelial cells may modulate angiogenesis and vascular remodeling in the renal interstitium via an increase in the production of HIF-1
- ANG is one of the neovascularization factors of gastric carcinoma and may work in coordination with VEGF, and promote the proliferation of gastric carcinoma cells
- Absence of angiogenic genes not modification in Italian ALS patients.
- in conclusion, we did not detect the association with rs11701-G or with any other newly detected variation in the ANG regulatory region with amyotropic lateral sclerosis
- Our finding supports the evidence that the ANG gene is involved in ALS.
- ANG mutations, identified in ALS patients, are associated with functional loss of ANG activity. Strong ANG expression, in normal spinal cord neurons and endothelial cells confirms plausibility of ANG dysfunction being relevant to pathogenesis of ALS.
- Human ANG variants implicated in amyotrophic lateral sclerosis are characterized.
- In three continental population groups (Asia, Europe, Africa), the angiogenin and RNase 2 genes appear to exhibit markedly less genetic heterogeneity with regard to T195C and A238G (ANG) and C425A (RNASE2) SNPs.
- Results describe significant differences between controls and patients with renal cell carcinoma both pre-operatively and post-operatively in angiogenin, PDGF and MCP-1 serum levels.
- Overall, our findings support the implication of ANG gene mutations as a rare but widespread cause of ALS.
- angiogenin expression is decreased in the eutopic endometrium from women with advanced stage en
- Angiogenin was significantly higher in Chronic heart failure patients compared to controls;Angiogenin is related to worsening heart failure severity (NYHA classification)