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Validated All-in-One™ qPCR Primer for HAVCR1(NM_012206.2) Search again
Product ID:
HQP007375
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1
Gene Description:
hepatitis A virus cellular receptor 1
Target Gene Accession:
NM_012206.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- asthma susceptibility gene
- shedding of KIM-1 in the regenerating kidney constitutes an active mechanism allowing dedifferentiated regenerating cells to scatter on basement membrane and reconstitute a continuous epithelial layer
- Polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population.
- protective effects of hepatitis A virus on atopic disease depends on a common TIM-1 allele
- The exon 4 variation site in human Tim-1 gene is associated with the susceptibility to allergic disease
- Our results strongly suggest that the 5383_5397del variation site of Tim-1 exon 4 might be associated with atopic dermatitis susceptibility.
- Review discusses recent studies demonstrating that the TIM family, particularly TIM-1, plays a critical role in immune responses that regulate the development of atopic diseases.
- is expressed at higher levels in clear cell renal cell carcinoma
- The two polymorphism sites of TIM-1 are not associated with allergic asthma in Chinese children.
- co-immobilized recombinant eTim-1 was able to inhibit T cell activation mediated by CD3 + CD28 mAb
- Kim1 is a novel regulatory molecule of flow-induced calcium signaling in kidney cells
- IgA1lambda is a specific ligand of HAVCR1/TIM1 and that their association has a synergistic effect in virus-receptor interactions
- TIM-1 is a critical component of the human T cell response and provide a mechanistic hypothesis for the role of TIM-1 in disease.
- A variation site in the TIM-1 promoter region is associated with asthma susceptibility in a Chinese Han population.
- Involved in the pathogenesis of systemic lupus erythematosus.
- TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity.
- Urinary excretion of KIM-1 is an independent predictor of long-term graft loss after kidney transplantation.
- identify Kim1 as an endogenous ciliary protein
- The present results suggest that the higher TIM1 expression associated with the protective TIM1 promoter haplotype confers protection against cerebral malaria.
- a pathway from Tim-1 tyrosine phosphorylation to the PI3K signaling pathway appears to be a major effector of Tim-1-mediated T cell activation
- Upregulation of kidney injury molecule-1 (KIM-1), a specific injury marker, is demonstrated in proximal tubular cells in urate nephropathy.
- KIM-1 has a role in the clearance of debris from damaged renal tubules in acute kidney injury.