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Validated All-in-One™ qPCR Primer for FUT2(NM_000511.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Gene References into function
- Analysis of mutations and polymorphisms reveals that Taiwan aborigines are of Austronesian derivation.
- Data show the nt357 c-->t mutation in their FUT2 gene of 10 para-Bombay individuals in China.
- Our results suggest a regional allele preference of h-alleles associated with para-Bombay individuals in Taiwan.
- Finds novel tetrameric short tandem repeat (FUT2/01)located 3.8 kb from 3' end of FUT2 coding region in African and European populations
- Higher expression of Lewis y/b was more often found in high grade and poor prognosis tumours compared to good prognosis breast cancers.
- A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
- This study identified 18 sequence variations in the FUT2 gene, and 6 were novel; the frequencies of alleles and genotypes were also determined in Chinese and Caucasian persons.
- analyzed the sequence variations in the proximal promoter region of FUT2 in several human populations
- Molecular genetic analysis of FUT1 and FUT2 gene was performed for seven Chinese Han individuals serologically typed as para-Bombay.
- hybrid allele of Sec1-FUT2-Sec1 was found; DNA sequence suggested the Sec1-FUT2-Sec1 allele contains a 275-bp sequence identical to the FUT2 sequence including a 54-bp FUT2-specific region & that might have been generated by interlocus gene conversion