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Validated All-in-One™ qPCR Primer for WWC1(NM_015238.2) Search again
Product ID:
HQP005956
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Gene Description:
WW and C2 domain containing 1
Target Gene Accession:
NM_015238.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Data describe the isolation of a cDNA coding for a novel protein, KIBRA, possessing two amino-terminal WW domains, an internal C2-like domain and a carboxy-terminal glutamic acid-rich stretch
- identification as novel substrate for protein kinase C zeta and regulation of cellular function by same enzyme
- the DLC1-KIBRA interaction is essential for ER transactivation in breast cancer cells
- gene expression studies showed that KIBRA was expressed in memory-related brain structures; KIBRA allele-dependent differences in hippocampal activations during memory retrieval were detected
- The impact of KIBRA on memory is most likely of high relevance in elderly subjects as it is in young.
- The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
- KIBRA may play a role in how the reproductive state influences the mammary epithelial cell to respond to changing cell-context information, such as experienced during the tissue remodeling events of mammary gland development.
- KIBRA T-->C polymorphism contributes to modulate episodic memory amongst community-dwelling older adults free of dementia
- No association is found between Kibra and memory performance in multiple memory tasks.
- the KIBRA genotype could affect memory performance in a different way in those that complain of memory deficits compared to those that do not.