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Validated All-in-One™ qPCR Primer for FGF2(NM_002006.5) Search again
Product ID:
HQP005403
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BFGF, FGF-2, FGFB, HBGF-2
Gene Description:
fibroblast growth factor 2
Target Gene Accession:
NM_002006.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq].
Gene References into function
- Alternate protein isoforms arise through the use of AUG and non-AUG (CUG) translation initiation codons.
- Four FGF2 isoforms result from alternative translation initiation from an AUG and 3 non-AUG (CUG) start codons.
- A new FGF2 isoform results from the use of a non-AUG (CUG) translation initiation codon.
- Significant association with poor survival by bFGF.
- Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis
- Snake venom disintegrin significantly suppresses basic fibroblast growth factor-induced human umbilical vein endothelial cell proliferation, but has little effect on normal growth of the cell.
- Expression of basic fibroblast growth factor (bFGF) was significantly associated with increased microvessel density in cutaneous melanomas
- b-FGF serum levels were significantly higher in patients with chronic myeloproliferative disorders.
- bFGF up-regulated UPA in both normal and dystrophic myoblasts.
- Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells
- Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway
- HTLV-I-transformed T cells, but not HTLV-I-negative CD4(+) T cells, secrete biologically active forms of VEGF and bFGF and induce angiogenesis in vitro.
- stress-induced release from endothelial cells mediated by integrin alpha v beta 3
- plasma basic fibroblast growth factor may have a role in progression of multiple myleoma
- level spontaneously secreted by patient CLL B-cells quantified; consistently secreted in all patient samples.
- REVIEW: Association of expression of bFGF with clinical characteristics in human leukemia and lymphoma
- FGF2 binds to heparin-derived oligosaccharides and stimulates phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts.
- Basic fibroblast growth factor may control proteolysis and fibrinolysis in vessel walls by inducing plasminogen activator inhibitor-1 expression in vascular endothelium.
- possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts
- role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction
- Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts
- FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
- bFGF and aFGF may suppress endothelial-dependent monocyte recruitment and thus have an anti-inflammatory action during angiogenesis in chronic inflammation but inhibit the immunoinflammatory tumor defense mechanism
- Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
- expression associated with poor outcome in non-Hodgkin lymphoma
- FGF2 has a role in controlling normal and premature cranial ossification in humans [review]
- results show that Hensen's node and FGFs induce ectopic expression of cardiac lineage markers, and that FGF and TGFbeta family members can modulate early development of the heart
- Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia.
- FGF-2 is a novel modulator of Lef/Tcf-beta-catenin signaling in endothelial cells
- BFGF may sensitively regulate local bone resorption and remodeling through direct and indirect mechanisms that promote angiogenesis and OC recruitment, formation, differentiation, and activated bone pit resorption.
- This protein has a modulating control of the differentiation of human osteosarcoma cells.
- Data show that FGF/FGFR signaling stimulates the DNA-binding and transcriptional activities of Runx2 as well as its expression, and these are largely regulated by the PKC pathway.
- FGF2 and VEGF release by platelets support cell survival and cell growth of vascular endothelium cells in coculture.
- FGF2 is inhibited by glypican 3 in hepatocellular carcinoma cells
- EphA2 does not inhibit endothelial cell survival, migration, sprouting, and corneal angiogenesis induced by this protein.
- The determination of bFGF will be helpful in estimating the size of infarct lesion at acute stage of cerebral infarction.
- Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
- bFGF has a stimulating role in lymphangiogenesis
- umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass
- Fibroblast growth factor-2-induced signaling is mediated through lipid raft-associated fibroblast growth factor receptor substrate 2
- IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma.
- VEGF, but not bFGF, was associated with higher tumor grading of NHL and high-grade transformation of low-grade lymphoma.
- reduction of neointimal hyperplasia was observed in autologous vein grafts treated by Sendai virus human-fibroblast growth factor 2; these grafts demonstrated significant restoration of endothelium-dependent vasorelaxation
- IL-1beta, TNF-alpha, TGF-beta, and bFGF are involved in bone remodeling regulation, acting as local effectors, possibly under the control of PTH.
- expression system is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint
- focal sequences of cell surface heparin/heparan sulphate-like glycosaminoglycans from smooth muscle cells and bovine aortic endothelial cells govern, at least in part, the differential activity of FGF2 on these two cell types
- FGF-2, but not VEGF, upregulated the mRNA levels for hTERT and for the hTERT gene transactivation factor Sp1. This restores telomerase activity and maintains the replicative capacity of endothelial cells.
- FGF-2 was expressed in most human leukemia and lymphoma cell lines tested, but only a small amount was released into the media. It may play a role in apoptosis regulation and pathogenesis.
- pituitary tumor transforming gene and fibroblast growth factor-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer
- TSH stimulates FGFR1 but not FGF-2 expression and PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators so increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis.
- Alpha-2 macroglobulin and this protein interact at specific binding sites, involving different FGF-2 sequences.
- pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
- FGF2-stimulated cranial suture closure requires the Erk pathway and activator protein 1
- FGF-2-overexpressing melanocytes exhibited marked proliferation, upwards migration, cluster formation and type IV collagen expression within the epidermal compartment, simulating early radial growth phase melanoma
- Serum levels of both bFGF and TGF-beta1 were found to be significantly higher in chronic lymphocytic leukemia. Significantly higher in patients with progressive disease.
- The determination of the FGF-2 5'-ATR RNA secondary structure by enzymatic and chemical probing experiments showed that the FGF-2 IRES contained two stem-loop regions and a G quartet motif that constitute novel structural determinants of IRES function.
- plasmic degradation of fibrinogen modulates the activity and binding of FGF-2 that involves a site near the carboxyl terminus of the gamma chain
- when FGF-2 was incorporated into fibrin, vascular endothelial cell proliferation was increased 6.5 -fold, equal to growth on a fibrin surface with FGF-2 continually present in the medium
- role of Egr-1 (early growth response-1)in FGF-2 dependent neovascularization, tumor angiogenesis and tumor growth
- FGF-2 clearly enhances cell survival of corneal endothelium after storage at 4 degrees C. Potential future application of FGF-2 as adjuvant to corneal preservation media in order to better maintain endothelial viability during corneal storage.
- Addition of serum to serum-starved cells rapidly induced intracellular FGF-2 clustering under the plasma membrane and into granules that colocalized with patches of the cell membrane with typical features of shed vesicle membranes.
- 5 residues (Phe95, Ser100, Asn102, Arg107, and Arg109) from FGF-2 into the corresponding sites in the third cassette of FGF-1 imparted high-affinity binding with dissociation constants (Kd) of 5.3 nM and 8.6 nM, compared to 1.3 nM for wild-type FGF-2.
- Plasma VEGF and bFGF are elevated in patients with liver cirrhosis depending on age and are predictors of outcome.
- bFGF adds trabecular bone mass through increasing trabecular number and trabecular connectivity.
- Data repropose bFGF as a noninvasive diagnostic tool for breast cancer.
- Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis.
- increased fibroblast growth factor-2 expression and decreased stromal cell compartment turnover in the diabetic placenta might be a compensatory mechanism in response to the altered physiologic milieu of maternal diabetes on placental function
- Recombinant human IGF-2 and IGF-1 synergistically increase the numbers of rat oligodendrocyte progenitor cells recruited into S phase; FGF-2 decreases the levels of cdk inhibitor p27(Kip1) associated with cyclin E-cyclin dependent kinase 2.
- Fibroblast growth factor (FGF) 2 dramatically enhances the association of FGF receptor (FGFR) 1 with heparin and leads to proposal of a model for the stepwise assembly of a ternary FGF-FGFR-heparan sulfate proteoglycan complex on the plasma membrane.
- The proangiogenic action of thyroxine is MAPK dependent and mediated by FGF2.
- Decreased levels of bfgf in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma
- lamellipodial protrusion in smooth muscle cells can be regulated by waves of Rac1 activation, corresponding to the sequential presentation of FGF-2 and remodeled collagen.
- Pulsed electromagnetic field augment angiogenesis primarily by stimulating endothelial transcription and release of FGF-2, inducing paracrine and autocrine changes in the surrounding tissue.
- Results confirmed basic fibroblast growth factor (bFGF) expression in human adult ovarian cortex, and in the isolated follicles a down-regulation of bFGF mRNA was evident as small follicles develop.
- upregulation of telomerase activity by FGF-2 plays a functional role in preventing the early onset of senescence
- A bipartite nuclear localization signal (NLS) was uncovered near the C-terminus of FGF2. The NLS also contains signals controlling the nucleolar localization of FGF2.
- These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells.
- This study demonstrates that Chlamydia pneumoniae activates endothelial cells to produce bFGF, a growth factor which is linked to the development of atherosclerotic plaques.
- fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1.
- No significantly elevated bFGF levels were found in veins draining tumours compared with arterial samples in a patient population, suggesting that serum bFGF levels might also be derived from other sources besides the tumour
- fibroblast growth factor 2 signaling is regulated by IRS-4 and ShcA
- Basic fibroblast growth factor has the ability to induce the trans-differentiation into hepatic lineage cells from bone marrow cells.
- bFGF in plasma and bone marrow stromal cells in idiopathic thrombocytopenic purpura cases are decreased, whereas the production of bFGF remains unchanged.
- Overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF, two major cytokines in mesangioproliferative nephritis(MN). Caveolin-1 expression vector is potential therapy for MN.
- HNRNPA1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA
- These results provide new evidence for the possible involvement of FGF-2 in the regulation of HA production and its appreciable roles in not only homeostasis but also regeneration of periodontal tissues.
- chitosan could potentiate FGF-2 activity by protecting it from inactivations by the interaction between FGF-2 and chitosan molecules
- The IL-6-mediated bFGF upregulation is through activation of JAK/STAT3 and PI3-Kinase/Akt pathways.
- The bFGF expression was evaluated in myomas obtained after surgery.
- bFGF is endogenously positioned to be involved in ongoing neurogenesis in the adult hippocampus.
- Data show that Npn-1 can potentiate the growth-stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins.
- opposite effects of Noggin and bFGF for the neural tube development
- PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells
- A role for FGF2 in cell survival and proliferation of lymphoid and myeloid tumor cells.
- estrogen-dependent vascular endothelial growth factor (VEGF), especially VEGF165, and basic fibroblast growth factor(bFGF) might work on growth via angiogenesis in the human placenta throughout all trimesters of gestation
- Authors show that recombinant human FGF-2 alters osteoblastic expression of bone morphogenetic protein-2 and Msx-2 in vitro to favor cellular differentiation and osteoinduction.
- essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1.
- bFGF, but not VEGF, may havea role in systemic hypoxia and anemia in solid tumor patients
- analysis of complexes of FGF-2 and regioselectively desulfated heparin in aqueous solutions
- Pituitary tumor-transforming gene-1 is up-regulated in human uterine leiomyomas and that the positive feedback loop between PTTG-1 and basic fibroblast growth factor may be pivotal in the growth of leiomyoma cells.
- Recombinant human FGF-2 signaling enhances the intrinsic osteogenic potential by selectively expanding committed chick embryo osteogenic cell populations as well as inversely regulating bone morphogenetic protein 2 (BMP-2) and noggin gene expression.
- combination of noggin and basic fibroblast growth factor was sufficient to maintain the prolonged growth of human embryonic stem cells
- High expression of Hsulf-1 occurs in the stromal elements as well as in the tumor cells in pancreatic cancer and interferes with heparin-binding growth factor signaling
- hrbFGF significantly increased Ki-67-positive cells in colonic epithelium of normal mice and up-regulated gene expression of COX-2, TGF-beta, MUC2, ITF, and VEGF in colon. Rectal administration of bFGF might be treatment for inflammatory bowel disease.
- finding of FGF2 and EGR1 upregulation in endothelial cell microvascular channels within organising thrombus
- Hepatocyte growth factor released FGF-2 in the matrix but did not induce FGF-2 expression in external auditory canal cholesteatoma.
- FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways
- bFGF and vascular endothelial growth factor contribute to a significant proportion of the survival stimulating activity
- abnormally sulfated heparan sulfate in Hurler multipotent progenitor cells perturb critical FGF-2-FGFR1-HS interactions, resulting in defective FGF-2-induced proliferation and survival of Hurler multipotent progenitor cells.
- bFGF was found to bind more strongly to heparin-Sepharose than endostatin, the latter, but not the former, displaced protamine from heparin in solution, which supports the notion that endostatin can compete with bFGF for binding to heparan sulfate
- the MAPK and two PLC pathways are required for FGF-2 to stimulate RGC neurite extension in vitro, but the response of axons to FGF-2 applied asymmetrically to the growth cone depended only on the PLC pathways
- Expression of b-FGF may be associated with promotion of angiogenesis and a good prognostic factor in squamous cell carcinoma of the esophagus.
- Results suggest that the release of bFGF following cell death contributes to enhanced chemosensitivity in Non-Small-Cell Lung Carcinoma (NSCLC) cell lines.
- Not the expression of bFGF in the primary tumour but in its invasion front reflects the aggressiveness of RCC, hereby indicating a different biological potential within both areas.
- TGF-beta1/bFGF and ET-1 have different roles in graft fibrosis in heart failure patients
- bFGF inhibited IR-induced p53 accumulation to some extent in most of these samples and by more than 50% in seven samples from seven patients with chronic lymphocytic leukemia
- Significantly higher expression of TGFbeta1 and bFGF, although lower expression of core protein on the concave side, suggesting possible etiological factor or secondary change in development of adolescent idiopathic scoliosis.
- Using a placental explant model in a fibrin matrix, wtFGF-2 resulted in 2.6-fold more growth over control, and FGF2 binding (to fibrin) mutants increased growth 3.3 -fold. Vessel outgrowth with a nonbinding FGF2 mutant was minimal, comparable to control.
- The expression of basic fibroblast growth factor (bFGF) and its receptors FGFR-2, FGFR-3, and FGFR-4 in human ovaries suggests that bFGF might have a role in early folliculogenesis.
- The reciprocal modulating effects of FGF2 and TGFbeta1 on each other's receptors make the GM-490 cell line a new model for investigating the relationship between these growth factors and their receptors in autocrine loops.
- 18-kDa FGF-2 directly regulates rRNA transcription.
- Fibroblast growth factor 2 (FGF2) regulates rRNA transcription, in part, by localizing to rRNA genes and directly interacting with the upstream binding factor (UBF), an architectural transcription factor, in the nucleolus.
- FGF-2 has a role in esophageal cancer recurrence and mortality
- existence of an HIF-1alpha-bFGF amplification pathway that mediates survival and sprouting of endothelial cells under hypoxic conditions.
- excessive release of bFGF from the cartilage matrix during injury, with loading, or in arthritis could contribute to increased proliferation and reduced anabolic activity in articular cartilage
- MM-LDL and HDL have opposite effects on aortic SMCs: MM-LDL increases both bFGF production and release and SMC proliferation, while HDL decreases both bFGF production and release and SMC proliferation.
- Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane
- Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C.
- These experiments show for the first time that overexpression of basic fibroblast growth factor (bFGF) in developing rodent kidneys can induce the formation of renal cysts in vivo.
- could play an important role in the pathogenesis of chronic apical periodontitis and periapical cysts
- Overexpression of bFGF in skin of patients with systemic sclerosis along with normal serum levels suggests that bFGF probably acts in an autocrine or paracrine manner in fibrogenesis.
- bFGF expression upregulates CD13 expression in human melanoma cells and results in enhanced invasive capacity and metastatic behaviour of human melanoma cells.
- A novel mechanotransduction model is proposed in this review that supports a key regulatory role for bFGF in articular cartilage turnover, and highlights its importance as a mechanotransducer.
- altered HSPGs contribute to enhanced signaling of FGF-2 via FGFR1c in gliomas with glypican-1 playing a significant role in this mitogenic pathway
- Study found that a dyad symmetry element (DSE) in the fibroblast growth factor-2 gene promoter exhibited different promoter activities; in HepG2 cells it did, while in U87MG cells it did not, exhibit repressive activity.
- there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region
- analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors
- abnormal expression in cartilage of Kashin-Beck disease
- VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia
- BFGF Is able to increase the migratory activity of Mesenchymal Stem Cells through activation of the Akt/protein kinase B (PKB) pathway.
- Clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells.
- heparanase modifies FGF2 binding, signaling, and angiogenesis in metastatic melanoma cells
- Data suggest that the relative concentrations of Anosmin-1 and FGF-2 modulate the migration of oligodendrocyte precursors during development through their interaction with FGFR1.
- Seminal plasma and PGE(2) can similarly activate FGF2 expression and EP2 receptor signalling in endometrial adenocarcinoma cells.
- Immunohistochemical expression of bFGF in tumors was confirmed by real-time polymerase chain reaction.
- Data suggest role for FGFF2 in ductal integrity during mammary carcinogenesis, with loss of expression corresponding to loss of ductal structure.
- The mRNA levels of BFGF were significantly produced by the megakaryocytes may be associated with the etiology of bone marrow fibrosis in AMM.
- data show that growth plate perlecan binds to FGF-2 by its heparan sulfate chains but can only deliver FGF-2 to FGF receptors when its chondroitin sulfate chains are removed
- FGF-2 transgene plays an important role in the establishment of the proper number of dopaminergic neurons and a normal sized substantia nigra during development.
- Intracytoplasmic sperm injection patients with serum progesterone above 0.9 ng/ml have elevated serum concentrations of basic fibroblast growth factor.
- Real-Time-PCR showed that TGFbeta1 expression is auto-inductive, whereas FGF2 is auto-repressive. The bioavailability of TGFbeta1 regulated by FGF2 may represent part of a negative feedback mechanism controlling stromal growth, differentiation and ECM.
- Inhibition of BFGF with neutralizing antibodies reduced pro-inflammatory gene expression.
- role for PGF(2alpha)-FP receptor interaction in modulating FGF2 expression and signaling using an endometrial adenocarcinoma cell line
- Data Show bFGF was expressed in regenerative hepatocytes, but not in fibroblasts, suggesting its role in promoting oxidative stress produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis.
- Chromatin compaction and cell death by high molecular weight FGF2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria.
- Overexpression of the 18 kDa basic fibroblast growth factor protein can promote autocrine melanoma cell growth and paracrine-driven angiogenesis.
- In cartilage, FGF did not significantly affect ROS levels or antioxidant enzyme activity
- These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression.
- study of cellular mechanisms underlying Apert phenotype, by analyzing effects of FGF2 in cultures of Apert periosteal fibroblasts carrying the FGFR2 Pro253Arg mutation
- FGF2 has a role in tumor angiogenesis associated with haematological malignancies [review]
- Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells
- Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
- expression not different in endometriosis
- TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and is mediated in part through a TbetaRII/Smad3-dependent upregulation of FGF-2 expression and release.
- FGF2 may contribute to the synaptic reorganization after noise damage; it may protect and/or aid recovery of synapses after overstimulation.
- bFGF augments hypoxia induced VEGF release in breast cancer cells mainly through the PI3K pathway and partly depending on HIF-1 activity.
- FGF-2 release from the lens capsule by matrix metallopeptidase 2 is essential to lens epithelial cell viability and survival
- Provide useful information for understanding mechanisms of angiogenesis induced by bFGF and important data for validating a mathematical model of angiogenesis.
- BFGF activates the MAPK and NFkappaB pathways that converge on ELK1 to control production of MMP13 by articular chondrocytes.
- bFGF may promote obviously the healing of orbital implant exposure, particularly it can be the first choice for the treatment of mild degree exposure.
- Fibrin gel-immobiized VEGFA and BFGF efficiently stimulate angiogenesis in the AV loop model.
- alpha-Tocopheryl succinate disrupts angiogenesis mediated by malignant mesothelioma cells by inhibiting FGF2 paracrine signalling
- bFGF does not directly act on p38 nor on the mRNA expression levels of activin receptors but inhibit activin A activation of p38 upstream of p38 in K562 cells.
- Exogenous human FGF-2 increased endogenous FGF-2 promoter activity and protein levels in ovine pulmonary arterial smooth muscle cells.
- endogenously synthesized fibrinogen promotes the growth of lung and prostate cancer cells through interaction with FGF-2.
- Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2): a novel mechanism for the control of FGF-2 and thrombin activity.
- activen A expression is induced by wounding in an FGF-2- and NF-kappaB-dependent manner
- Study demonstrates that the fibroblast growth factor-2 binding site of thrombospondin-1 is located in the type III repeats.
- Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of proliferative diabetic retinopathy.
- IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis.
- We propose FGF-2 negative feedback as potentially important in microvascular remodelling. This is consistent with the absence of a secretory signal sequence in FGF-2, as well as canalicular fragmentation, which is unique to endothelial apoptosis.
- Developed a mathematical model to numerically simulate angiogenesis induced by basic fibroblast growth factor (bFGF) in the corneal pocket assay.
- Basic fibroblast growth factor regulates expression of heparan sulfate in human periodontal ligament ce
- the involvement of FGFR-1 through FGF2 in eliciting PGE(2) angiogenic responses
- Local controlled release of bFGF from the stent-graft significantly accelerated the proliferation of new intimal tissue between the aorta and the stent-graft and within the graft materials.
- REVIEW: FGF2 confers to ASM cells the ability to proliferate in response to different asthma mediators
- bFGF is a mitogen for the rapidly dividing cells (olfactory neuronal precursors and olfactory ensheathing cells), and also a survival factor for both slowly and rapidly dividing cells of the olfactory mucosa.
- FGF2 was among the genes differentially expressed in an in vivo-in vivo comparison between unfused and prematurely fused calvarial tissue.
- In vitro, primary effusion lymphoma -induced angiogenesis is dependent on VEGF and VEGF receptors. However, although PEL cells produce VEGF and bFGF transcripts, they only secrete VEGF in vitro
- Support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability.
- Our data first suggest that JNK participates in bFGF-mediated surface cadherin downregulation. Loss of surface cadherins may affect the cell-cell interaction between endothelial cells and facilitate angiogenesis.
- Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
- FGF-2 expression in malformations of cortical development reflects incomplete differentiation and maturation of dysplastic cells
- Sox2-expressing MSCs showed consistent proliferation and osteogenic capability in culture media containing bFGF
- bFGF differently changes intracellular signals in ECs depending whether it is applied under microgravity or normal gravity conditions
- in angiogenesis,FGF-2(fibroblast growth factor 2)-mediated enhancement of Placental growth factor (PGF) expression was dependent on Vascular endothelial growth factor function
- AT genotype of the 553 T/A polymorphism was associated with PDR in Caucasians with type 2 diabetes.
- potent mitogenic signaling results from heparin-mediated trans-dimerization of FGF2, consistent with the asymmetric model of ternary complex formation
- bFGF immunoreactivity was found to be increased in fibroblasts and in endothelial cells in early oral submucous fibrosis cases, while the expression of bFGF in stroma increased notably in advanced fibrosis.
- identified activin-mediated transforming growth factor (TGF)-beta signaling, platelet-derived growth factor (PDGF) signaling and fibroblast growth factor (FGF) signaling as the key pathways involved in MSC differentiation
- vascular endothelial growth factor A and fibroblast growth factor 2 have effects on chemotaxis and chemokinesis
- VEGF-A and FGF-2 mRNA levels were higher in the outer definitive zone of fetal adrenal gland than in the fetal zone.
- a transient interaction with PI(4,5)P(2) associated with the inner leaflet of plasma membranes represents the initial step of the unconventional secretory pathway of FGF-2
- Document a role for FGF-2 and PDGF-BB in the temporal regulation of coronary artery stem formation and growth of the coronary arterial tree.
- The findings suggest interactive and sequential roles for FGF2 and NT3 on cochlear ganglion development
- beta(2)GPI inhibits VEGF and bFGF-induced proliferation, migration and papillary-like tubule formation of HUVECs
- bFGF has an effect on the proliferation of human adenoid cystic carcinoma ACC-2 cells
- ATP-binding on fibroblast growth factor 2 partially overlaps with the heparin-binding domain
- Nucleostemin expression in cardiomyocytes is induced by fibroblast growth factor-2 and accumulates in response to Pim-1 kinase activity.
- A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.
- Results reveal that platelet-derived growth factor-B-activated fibroblasts play a key role in the recruitment/migration and differentiation of mesenchymal stem cells and implicate a bFGF- and CXCL5-dependent mechanism in mediating these effects.
- Measuring PDGFA, bFGF, and HIF1a expression may contribute to a better understanding of the prognosis of patients with pancreatic cancer.
- bFGF-eluting stents are effective for accelerating organization of the thoracic aneurysm cavity and developing neointima.
- The delivery of bFGF was employed to stimulate proliferation and survival of primary intestinal smooth muscle cells.
- FGF-2 delivery from self-assembling nanofibers facilitated islet transplantation in diabetic mice.
- subconfluent pulmonary artery smooth muscle cells express predominantly S1P2 and S1P3 receptors; S1P1 receptor mRNA levels are significantly up-regulated following bFGF treatment
- bFGF can play an important role in modulating plasticity and neuronal fate of human neural stem cells
- Myometrium conversion into leiomyoma and an increase in its mass is accompanied by a significant increase in aFGF gene expression.
- bFGF, FGFR1, and FGFR2 are frequently overexpressed in squamous cell carcinoma and adenocarcinoma of the lung and may have a role in neoplasm pathogenesis
- HMW FGF-2 inhibits tumor growth in glioma cells by acting on cell-cycle progression and protein translation.
- Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice.
- E22Q and WT peptides suppressed FGF-2 expression while E22G had barely any effect. Phosphorylation of the FGF-2 receptor, FGFR-1, and the survival signal Akt were abolished by E22Q and WT peptides, but not by E22G
- FGF-2 is a new substrate of PRMT5.
- At the early stage of tumor growth bFGF expression play important roles in the regulation of angiogenesis, tumorigenicity and subsequent metastases of human bladder cancer.
- These data further suggest an integral role for visfatin-FGF-2 signaling axis in modulating endothelial angiogenesis.
- These findings showed that HDAC inhibition antagonized FGF2 and IL-1beta induced MMP expression in articular chondrocytes.
- Low plasma bFGF may be a marker for the presence of anti-endothelial cell autoantibodies that may contribute to the need for laser photocoagulation treatment in adult men with advanced type 2 diabetes mellitus.
- a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas