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Validated All-in-One™ qPCR Primer for ESRRA(NM_004451.4) Search again
Product ID:
HQP005003
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Gene Description:
estrogen related receptor alpha
Target Gene Accession:
NM_004451.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq].
Gene References into function
- ERRalpha1 can play a critical role in the etiology of some breast cancers
- directly associates with PGC-1(ALPHA) and has a similar pattern of expression
- ERRalpha has a role in the induction of fatty acid oxidation enzyme MCAD by PGC-1 in human cells
- interacts with a conserved domain of EBNA-LP (Epstein-Barr virus nuclear antigen-leader protein) that is critical for Epstein-Barr virus-induced B-cell immortalization
- VEGF-A is an estrogen responsive gene and modulation of this gene expression by estrogen is biphasic and can be mediated through ER-alpha dependent pathway.
- ERR alpha 1 has a potential role in the regulation of eNOS expression and may stimulate NO production by endothelial cells
- an interdependent ERRalpha/PGC-1alpha-based transcriptional pathway targets the ESRRA23 element to dictate ERRalpha expression level; regulatory polymorphism studied may provide differential responses to ERRalpha/PGC-1alpha-mediated metabolic cues
- ERRalpha possibly modulates the expression of ERE-containing estrogen-responsive genes, and ERRalpha immunoreactivity is a potent prognostic factor in human breast carcinoma.
- study of the crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha
- ERRs, which are coexpressed with ERs in prostatic cells, could regulate cell growth and modulate ER-mediated pathways via interference on ERalpha transcription in prostatic cells.
- Data demonstrate that the multi-hormone response element of the estrogen-related receptor-alpha (ERRalpha) gene is a target for ERRgamma transactivation, which is enhanced by peroxisome proliferator-activated receptor-gamma coactivator-1alpha.
- a polymorphism of ESSRA may have a role in regulating lumbar spine bone mineral density
- A single nucleotide in an ERRalpha binding site can determine specific configuration to the receptor and productive interaction with the coactivator PGC-1alpha.
- Up-regulation of estrogen-related receptor alpha is associated with endometrial adenocarcinoma
- analysis of estrogen receptor-related receptor-alpha-cofactor interactions
- enhanced expression of ERRalpha might play a role in the development of human prostate cancer and serve as a significant prognostic factor for the disease
- Our results indicate that EFP functions as a cofactor for ERalpha-mediated transcription.
- Our results indicate an essential role for ERRalpha as a key regulator of oxidative metabolism.
- Although ERRalpha is not directly related to growth of ovarian cancer, ERRalpha is a candidate for prognostic factors for ovarian cancer.
- analysis of human estrogen-related receptor alpha in complex with a synthetic inverse agonist
- ERR alpha can be deactivated by the synthetic molecule XCT790. Here we demonstrate that this compound also induces a proteasome degradation of ERR alpha
- 17beta-estradiol induces ERRalpha gene expression in MCF-7 cells through active recruitment of co-activators and release of co-repressors when ERRalpha and AP1 bind and ERalpha is tethered to the multiple hormone-response element
- ERRalpha (estrogen-related receptor alpha estrogen receptor-like 1) mRNA levels decreased from normal vagina of the pre-menopausal women to atrophic vaginal tissue in post-menopausal women
- These findings reveal a new function for TNNI2 as a co-activator of ERRalpha.
- Receptor estrogen-related receptors alpha, beta and gamma physically interact with HIF and stimulate HIF-induced transcription in tumor cells cultured under hypoxia.
- Results describe the mapping of the nucleosome positions of the estrogen-related receptor alpha gene promoter and examine the changes of histone acetylation in response to peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
- ERRalpha activates the expression of androgen response elements (ARE)-containing promoters, such as that of the prostate cancer marker PSA, in an ARE-dependent manner.
- The importance of ERRalpha for adaptive energy metabolism suggest that strategies targeting ERRalpha may be useful in fighting metabolic diseases.
- results confirm a role for ERRalpha in breast cancer growth and highlight it as a potential therapeutic target for estrogen receptor-negative breast cancer
- Kaempferol is an estrogen-related receptor alpha inverse agonist.