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Validated All-in-One™ qPCR Primer for EPAS1(NM_001430.4) Search again
Product ID:
HQP004903
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
Gene Description:
endothelial PAS domain protein 1
Target Gene Accession:
NM_001430.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- hypoxic induction of the COOH-terminal transactivation domain (CAD)occurs through abrogation of hydroxylation of a conserved asparagine in the CAD
- enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex
- expression related to increased angiogenesis in endometrial adenocarcinoma
- HIF-2alpha and Ets-1 binding is required for transcriptional activation of Flk-1 in endothelial cells
- MAPK signaling facilitates HIF1a and HIF2a activation through p300/CBP
- HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase gene expression in vascular endothelial cells.
- HIF2A is upregulated in rheumatoid arthritis and osteoarthritis.
- Hypoxia-inducible factors 1alpha and 2alpha have roles in vascular endothelial growth factor expression and in nodular malignant melanomas of the skin
- hypoxic gene induction in cells expressing HIF-2alpha but not HIF-1alpha
- HIF-2alpha PAS-B binds the analogous ARNT domain in vitro
- HIF2alpha has a role in regulating pVHL-defective tumor growth
- trans-regulation between HIF-1alpha and HIF-2alpha during hypoxia likely conveys target gene specificity
- HIF-2alpha/EPAS1 is expressed in most of hepatocellular carcinoma with capsular infiltration and portal vein invasion, which indicates a possible role of HIF-2alpha/EPAS1 in HCC
- deregulation of hypoxia-inducible genes in VHL-/- cells can be attributed mainly to deregulation of HIF and validate HIF as a therapeutic anticancer drug target
- role of EPAS1 and Sp1 in the hypoxic response of cancer cells
- siRNA targeted degradation of HIF-1alpha and HIF-2alpha results in decreased hypoxia-induced PHD3 expression
- EPAS1 may contribute to the construction of mature vessels by modulating the coordinated expressions of VEGF, Flt-1, Flk-1, and Tie2.
- HIF-1alpha and HIF-2alpha in renal cell carcinoma harboring VHL mutations do not have a major role in radiosensitivity
- the complete EPO enhancer displayed dependency on HIF-2alpha regulation, indicating that additional cis-acting elements confer HIF-2alpha specificity within this region
- HIF1a and HIF2a are regulated by PHD1, PHD2, and PHD3
- The HIF2A is a transcription factor that plays a key role in the response of cells to oxygen levels.
- HIF-2alpha protein is selectively present in human fetal week 8.5 SNS paraganglia. HIF-2alpha was detected in hypoxic and in well-oxygenized neuroblastoma cells and tissue, presumably reflecting their embryonic features.
- Results describe the specific interaction of hypoxia-inducible factors (HIF)-2alpha, but not HIF-1alpha, with the NF-kappaB essential modulator (NEMO).
- Enhanced expression of HIF2A suppressed HIF1A and vice-versa.
- Overexpression of HIF-2alpha in glioma tumors enhances angiogenesis but reduces growth of these tumors, in part by increasing tumor cell apoptosis.
- DNA variants in EPAS1 influence the relative contribution of aerobic and anaerobic metabolism and hence the maximum sustainable metabolic power for a given event duration
- The role of HIF-1alpha and HIF-2alpha on cell migration and proliferation in fibroblasts during hypoxia is reported.
- androgen receptor is involved in VEGF and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
- HIF-1alpha and HIF-2alpha mRNA levels are transiently increased in untrained human skeletal muscle in response to an acute exercise bout, but this response is blunted after exercise training.
- In the normal, fully developed kidney, HIF-1alpha is expressed in most cell types, whereas HIF-2alpha is mainly found in renal interstitial fibroblast-like cells and endothelial cells
- hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment are regulated in a cell-specific manner
- High HIF-2alpha expression is associated with head and neck cancer
- HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors
- knockdown of the HIF-2alpha gene demonstrated that HIF-2alpha regulates VEGF production, expression of which is essential in renal cell carcinoma
- Results describe the differential recruitment of HIF-1alpha and HIF-2alpha to common target genes in neuroblastoma, and show that HIF-2alpha promotes an aggressive phenotype.
- MT1-MMP is a major mediator of tumor cell invasiveness and type I collagen degradation by VHL RCC cells that express either MT1-MMP or HIF-2alpha
- HIF2alpha C-terminal transactivation domain, in contrast to the HIF1alpha C-terminal transactivation domain, is relatively resistant to the inhibitory effects of FIH1 under normoxic conditions
- Overexpression of the HIF-2A is associated with astrocytomas
- discovery of a conserved, functional iron-responsive element (IRE) in the 5' untranslated region of the messenger RNA encoding EPAS1
- The late expression of HIF-2alpha in the Barrett's carcinogenesis sequence and its high expression in adenocarcinoma suggest it as a morker of disease progression.
- The role of protein expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1) in patients with colorectal adenocarcinomas.
- There may be a hormonal and hypoxia-independent regulatory mechanism coordinating the expression of HIF-1alpha, HIV-2alpha, VEGF, the androgen receptor, and FOXP1 in prostate tumors.
- HIF-2alpha was strongly expressed in both the epidermis and in capillary endothelial cells of the dermis in psoriasis.
- Quantitative differences with respect to HIF deregulation are sufficient to account for the differential risks of kidney cancer linked to VHL mutations.
- cytoplasmic expression of HIF-2alpha in ovarian carcinomas was higher than that in benign and borderline tumors; cytoplasmic expression of HIF-2alpha was significantly higher in stage III and IV tumors than stages I and II
- hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha in prostate cancer has been confirmed
- both HIF-1alpha and HIF-2alpha play important and similar roles in hypoxia-mediated stimulation of PAI-1 expression in HTR-8/SVneo cells
- high levels of the hypoxia regulated proteins HIF1alpha and CA9 in HNC predict resistance to platinum based radio-chemotherapy.
- we provide the first evidence that HIF-2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype via SOX9
- HIF-1 and HIF-2 are detected in the endothelium and macrophages. Hypoxia-inducible factors in endothelial cells may induce VEGF, thereby contributing to the development of choroid neovascularization.
- HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells
- new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha
- The ratio of the HIF-2alpha positive cell in tumor infiltrative macrophages may be a new predictive indicator for prognosis before radiation therapy for uterine cervical cancer.
- Data show that the specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
- HIF-2alpha differentially binds and regulates transcription under hypoxia.
- the region between -3 kb and -1 kb is required for the minimal skeletal tissue-specific expression of Runx2, and that the region between -155 bp and -75 bp is important for its basal transcription, which may be in part mediated by HIF2A in bone tissues.
- the HIF2A(M535I) gene mutation could induce hereditary erythrocytosis at a young age
- an angiogenic signal-ETS1/HIF-2alpha axis regulates the VEGFR1 chromatin domain to induce VEGFR1 transcription in endothelial cells and in differentiating embryonic stem cells
- HIF-2 alpha plays an important role in the regulation of Epo production.
- Poorer survival of HIF-2 alpha and CA9 stromal-positive CRCs was associated with wild-type TP53, but not with BNIP3 methylation
- expression of hypoxia-inducible factors 1 alpha and 2 alpha is dependent on mTORC1 and mTORC2
- This study offers novel evidence supporting redox status regulation of HIF-2alpha accumulation under hypoxic conditions.
- Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer.
- LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to factor HIF1alpha and HIF2alpha expression. LDH5 expression is linked with activated VEGFR2/KDR expression
- HIF-1alpha and HIF-2alpha have divergent roles in colon cancer
- Data show that EPAS1 and VEGF, but not HIF1alpha, are overexpressed in pancreatic carcinoma.
- crystal structures of the heterodimer formed by the C-terminal PAS domains from the HIF2alpha and ARNT subunits of the HIF2 transcription factor, both in the absence and presence of an artificial ligand