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Validated All-in-One™ qPCR Primer for EEF1A1(NM_001402.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq].
Gene References into function
- Eukaryotic elongation factor 1A (eEF1A) and tRNA are RanGTP-dependent binding partners of exportin-5 (Exp5). Exp5 stimulates nuclear export of eEF1A and tRNA.
- The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
- TCTP preferentially stabilized the GDP form of eEF1A, and, furthermore, impaired the GDP exchange reaction promoted by eEF1Bbeta.
- analysis of the relationships between EF-Ts and EF-Tu from both yeasts and humans through functional complementation and coexpression experiments
- The potential roles of the PTI-1 protein in carcinogenesis and the origin of the PTI-1 gene in the human genome are discussed.
- Our results indicate that neither EEF1A1 nor IMPG1 could be responsible for RP25 in the studied families due to absence of any pathogenic variants.
- The cytotoxicity of G-rich GT oligomers was shown to be tightly related to their binding affinity for eEF1A protein.
- potential tumor suppressor activity of CCS-3 may be mediated by its interaction with PLZF.
- The interaction between eEF-1A and C-Raf increases eEF-1A stability and induces a survival activity.
- Endogenous HDM2- EF1alpha complex was detected in cancer cells overexpressing HDM2, suggesting a possible role of this interaction in HDM2-mediated oncogenesis.
- identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails
- The expression level of EEF1A1 correlates with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grades.
- Up-regulation of muscle EEF1A1 relates to proteolysis rate, suggesting an involvement of this gene in muscle catabolic response in hypercatabolic traumatized patients.
- both eEF1A and MYPT1 have roles in EGCG signaling for cancer prevention through 67LR
- The ability of eEF1A1 rather than eEF1A2 to interact with calmodulin is predicted by MD analysis and showed experimentally.
- a novel mechanism of regulation of both SK1 and SK2 that is mediated by their interaction with eEF1A.
- These results indicate that the novel gene AngRem104 is involved in the in vivo regulation of GR expression and the activation of NF-kappaB through interaction with GR-EF in human MCs.
- It was demonstrated that the N protein of SARS-CoV induces aggregation of EF1, inhibiting protein translation and cytokinesis by blocking F-actin bundling.
- BPOZ-2 promoted eEF1A1 ubiquitylation and degradation, suggesting that eEF1A1 is a substrate of BPOZ-2.
- eEF1A1 is a novel endothelial nitric oxide synthase 3'-untranslated region binding protein that plays a critical role in mediating tumor necrosis factor (TNF)-alpha-induced decrease in eNOS mRNA stability.
- The cell death was associated with downregulation of eukaryotic translation elongation factor-1 alpha 1 (eEF1A1/EF-1alpha) expression in conjunction with accumulation of its mRNA in processing bodies (P bodies).
- PTI-1 presence parallels Mycoplasma infection suggesting that PTI-1 might not necessarily play a major role in the onset of prostate tumorigenesis.
- EF1A1 regulation of OPN mRNA stability is actin dependent. EF1A1 is a regulatory factor in OPN expression in cancer.