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Validated All-in-One™ qPCR Primer for AGTR2(NM_000686.4) Search again
Product ID:
HQP004525
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AT2, ATGR2, MRX88
Gene Description:
angiotensin II receptor type 2
Target Gene Accession:
NM_000686.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system.
Gene References into function
- AT(2) receptor overexpression is associated with breast disease, further confirming the involvement of the components of the renin-angiotensin system in the aetiology of breast cancer.
- AT(2) receptor inhibits smooth muscle cell migration via fibronectin cell production and binding.
- AGTR2 mutations in X-linked mental retardation; findings indicate a role for AGTR2 in brain development and cognitive function
- explore the relation among myocardial AT(1)-/AT(2)- receptor expression, myocardial remodeling and cardiac function in patients with congestive heart failure
- There is a potential implication of the AT2G+1675A polymorhism in patient with Left ventricular hypertrophy and coronary ischemia.
- Results support the hypothesis that the DRY motif plays a significant role in the binding affinity, structural stability and G-protein recruiting of the angiotensin II type 2 receptor.
- mRNA levels as well as the protein production of angiotensin II receptors of type 2 was monitored during differentiation of primary human preadipocytes in culture and in mature adipocytes.
- Rare polymorphisms in boys with non-specific mental retardation
- Findings may explain the reported antiangiogenic properties of the AT2 receptor.
- Ang II decreases activity of 11beta-HSD2 by AT2 receptor- and MAPK-dependent mechanism. Decreased activity of 11beta-HSD2 increases intracellular availability of cortisol. May be relevant for pathogenesis of hypertension and preeclampsia.
- This analysis showed that the C4599A polymorphism of the Angiotensin-II type 2 receptor gene was associated with hypertension in women (p=0.0058), but not in men.
- Polymorphisms of the angiotensin II receptor, type 2 gene is associated with increased risk of coronary heart disease in hypertension.
- AGTR2 mutations in male patients is associated with mental retardation
- AT(2) enhances expression of p85 alpha PI3K followed by enhanced p70(S6) kinase
- AT1 and AT2 receptors were found within the epidermis and in dermal vessel walls.
- AT2 receptor-mediated vasodilation in the human heart appears to be limited to coronary microarteries and is mediated by B2 receptors and NO. Most likely, AT2 receptors are located on endothelial cells, and their contribution increases with age.
- Comparison between hypertensive subjects with & w/o left ventricular hypertrophy showed an excess of the G_/GG genotype in the group with LVH. The angiotensin type-2 receptor (-1332 G) allele was associated with LVH in hypertensive subjects.
- Polymorphism is not associated with increased risk of developing chronic kidney allograft dysfunction.
- an imbalance of AT1R and AT2R activity in mesangial cells following exposure to pIgA plays a significant pathogenetic role in the inflammatory injury in IgA nephropathy.
- a major role of the AT2R gene in the development of congenital uropathies has been found, at least in Italian children.
- Increased expression in kidney tubule cells after physical exercise.
- The AT2 receptor regulates expression of genes relevant to cell migration, protein processing, intracellular signaling, and DNA repair in both ligand-dependent and ligand-independent manners.
- Taken together, these data indicate that individuals carrying the G allele may express higher levels of AT2 receptor protein.
- Abundant expression of AT2 receptors in all human fibroblasts studied.
- Sequence variations in AGTR2 are unlikely to be associated with X-linked mental retardation.
- CNK1 binds through the sterile alpha motif (SAM) and the conserved region in CNK (CRIC) to the AT2 receptor. CNK1 may play a role in the AT2 receptor-mediated signaling pathways.
- angiotensin II receptor haplotype transmission is distorted in fetal growth restriction
- AT(1) receptor-mediated activation of PI 3-K/Akt cascades occurs at least partially via the transactivation of EGF receptor, which is under a negative control by AT(2) receptor in hypertrophic scar fibroblasts.
- The ATG2 gene may have a gender-specific efefct on kidney function and pulse pressure in type I diabetic patients.
- There was no significant difference in the distribution of A and G-genotypes in any of the patient groups compared to controls. An A-->1675G transition in the AT2R gene seems not to be involved in the pathogenesis of aortic coarctation.
- Mutations were not detected in the AGTR1 and AGTR2 genes in patients with premature adrenarche; however, two polymorphisms were identified in the AGTR1 gene: the C573T (exon 5) and the A1166C (3' untranslated region).
- AT1 an AT2 receptors are developmentally regulated in fetal skin, suggesting theh possible diverse actions that angiotensin II might play in development and maturation of skin
- Data indicate that the angiotensin II type 2 receptor gene A-1332G transition is not associated with the development of human congenital uropathies.
- ANGII signaling occurs primarily via AGTR1 in normal fibroblasts, while AGTR2-mediated effects are dominant on activated (myo)-fibroblasts, a receptor switch that may perturb epithelial-mesenchymal interaction, thereby further perpetuating fibrogenesis.
- Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males
- +1675 G/A angiotensin II type 2 receptor (AT2R) gene polymorphism cannot be considered as a marker of left ventricular hypertrophy in patients with aortic stenosis.
- Although AT2 receptor mRNA is present in human internal mammary arteries, AT2 receptor stimulation does not mediate vasodilation in these arteries.
- Data show that glial as well as neuronal AT2 receptors can mediate the brain's responses to angiotensins.
- These data indicates that the expression of AT1 receptors is altered in adrenal cancer and in pheochromocytomas. The expression of AT2 receptors, in turn, may be connected with the process of tumoral neo-angiogenesis.
- TNF-alpha induces renal tubular cell damage and AT1/AT2 receptor blockers showed cytoprotective effects probably via at least partly different mechanisms.
- In the presence of TIMP-3 and AGTR2, vascular endothelial growth factor-induced human umbilical vein endothelial cell proliferation was additively inhibited.
- AT2-receptor is expressed in human atherosclerotic plaque. Furthermore, we detected no functionally important role of AT2-receptor expression and found no evidence that ARB treatment regulates AT2-receptor expression.
- AT2 receptor may play an important role in the regulation of Ang II induced contractility of placental vascular smooth muscle cells.
- The combination of the genotypes of genes ACE and AT2R (ID+3123C) was met significantly more frequently in male patients with tuberculosis.
- Data show that after silencing HCMV UL83 gene, gene expression of human brain vascular smooth muscle cell AT2 receptor is up-regulated.
- Expression of AT1 and AT2 is associated with high grade of malignancy, increased cellular proliferation, and angiogenesis, and is thus related to poor prognosis.
- analysis of determinants of angiotensin II type 1 receptor functional selectivity [review]
- No association was found between the AGTR2 polymorphism and the development of the metabolic syndrome in subjects screened for stage 1 hypertension.