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Validated All-in-One™ qPCR Primer for CTSE(NM_001910.3) Search again
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
Summary
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach.
Gene References into function
- These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
- Reduced expression of cathepsin E is observed in erythrocytes of humans with atopic dermatitis.
- crystal structure of an activation intermediate of cathepsin E at 2.35A resolution
- Both cathepsin E message and protein are found in human dendritic cells, but are absent in monocytes.
- Three-dimensional structure of cathepsin-E.
- the human cathepsin E gene is regulated by the constitutive androstane receptor
- cathepsin E differentially regulates the nature and function of dendritic cells and macrophages
- cathepsin E plays a substantial role in host defense against tumor cells through TRAIL-dependent apoptosis and/or tumor-associated macrophage-mediated cytotoxicity
- CatE is important in the processing of tetanus toxin C-fragment in primary human B cells.
