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Validated All-in-One™ qPCR Primer for IL23R(NM_144701.2) Search again
Product ID:
HQP003495
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PSORS7
Gene Description:
interleukin 23 receptor
Target Gene Accession:
NM_144701.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq].
Gene References into function
- the preferential expression of certain IL-23R spliced variants may be a contributive factor to the pathogenesis of certain cancers
- findings show a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31
- IL12B and IL23R genes play a fundamental role in psoriasis pathogenesis.
- IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.
- This study shows an association between IL23R and all subphenotypes of Crohn's disease with a smaller effect on ulcerative colitis.
- IL23R is a susceptibility gene for inflammatory bowel disease with suggestive epistasis with the IBD5 locus in the Crohn's disease population
- No evidence of positive association of IL23R with Crohn's disease was found in the Japanese population.
- Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
- The data reported provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.
- Variants in the IL23R gene confer a similar magnitude of risk of CD to children as for their adult counterparts.
- Polymorphisms do not appear to play an important role in the susceptibility or severity of systemic lupus erythematosus.
- We conclude that the IL23R gene does not seem to be associated with rheumatoid arthritis predisposition in a Spanish population.
- IL23R gene is one of the genetic factors implicated in the genetics of IBD in the general population.
- IL23R is an established gene locus for Crohn Disease.
- Interleukin-23R Arg381Gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population.
- IL25R R391Q is strongly associated with Crohn's disease in New Zealand Caucasians with inflammatory bowel disease.
- Single nucleotide polymorphism in IL23R gene is associated with ankylosing spondylitis
- IL23R genotypes influence IL-22 serum expression, linking genetic Crohn disease susceptibility to Th17 cell function for the first time
- The IL-23 receptor gene coding variant allele R381Q appears to decrease susceptibility to Crohn Disease in an Israeli Jewish population. We found a trend toward earlier age of onset, but no interactions with CARD15 or modifying effect on disease location
- polymorphism associated with early onset psoriasis
- confirmed the association of IL23R and ATG16L1 with CD susceptibility and also the association of IL23R with UC. We found IL23R and ATG16L1 were not associated with celiac disease susceptibility.
- Variants in the IL-23R gene are strongly associated with Graves' ophthalmopathy (GO). These variants may predispose to GO by changing the expression and/or function of IL-23R, thereby promoting a proinflammatory signaling cascade.
- no strong evidence was present in this study to support a role for the IL12B/IL23R psoriasis-associated SNPs in multiple sclerosis susceptibility; the potential role of other, unlinked SNPs in these genes with a very modest influence cannot be excluded
- No differences were found among 32 SNPS tagging all parts of the gene or haplotypes in patients and controls. It is unlikely that the IL23R gene confers any significant risk for MS.
- These results together with very recent findings strongly suggest that the IL23R gene seems to be one of the genetic markers involved in AS susceptibility and support the hypothesis of a common genetic background for AS and IBD
- CARD15 and IL23R confer susceptibility to CD in the Brazilian population. However, the presence of these variants did not influence disease phenotype.
- Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.
- Our findings also suggest that polymorphisms at IL23R and TNFRSF1A, and possibly HLA and TLR4, loci may account for phenotypic variation in IBD.
- It appears that IL23R is a susceptibility locus for celiac disease and multiple sclerosis.
- case control analysis demonstrates a disease association with the IL-23R (interleukin 23 receptor ) locus and implicates the same polymorphisms associated with Inflammatory Bowel Disease and psoriasis
- Single nucleotide polymorphism in IL23R is associated with inflammatory bowel disease.
- IL23R haplotype variations are associated with Crohn's disease
- IL23R gene is associated with Crohn disease susceptibility in Hungarian patients.
- interleukin23R (IL23R)variants are not associated with rheumatoid arthritis
- ATG16L1, IBD5, and IL23R SNPs were significantly associated with Crohn's Disease
- the 1142G/A variant of the IL23R gene was found to be a risk variant in Barrett's esophagus patients
- This report describes an insertion in the IL-23 receptor and due to consequent early termination within the intracellular region, causing a possible non-responsive receptor isoform.
- Following up on our previous P310L-R381Q haplotype findings, fine mapping of the IL23R-linked region shows variants segregating at IL23R coding and flanking regions significantly associated with psoriasis.
- There is an association of IL23R polymorphisms with inflammatory bowel disease, and ATG16L1 with Crohn's disease, in both adult- and pediatric-onset subsets in our italian study population.
- no association was observed between IL23R genetic variants and SSc clinical phenotypes.
- IL23R polymorphisms may play an important role in the development of osteonecrosis of femoral head.
- variants are not specific risk factors for arthritis, but relevant for susceptibility to psoriasis in general
- IL-23R gene is associated with autoimmune thyroid diseases only in a specific ethnic group.
- Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and psoriatic arthritis
- The IL23R gene variants, rs10889677 C/A and rs2201841 T/C appear to increase susceptibility to Crohn's disease.
- Combined genome-wide significant evidence for association was found on chromosome 6p21 and at the IL23R locus on chromosome 1p31 for ulcerative colitis.
- Expanded catalog of genetic loci implicated in psoriasis susceptibility.
- the first to demonstrate association of IL23R with Crohn disease and ulcerative colitis in Swedish patients; itreports linkage and association of the IL23R region with psoriasis in the Finnish population and linkage of the IL23R region to celiac disease