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Validated All-in-One™ qPCR Primer for PPARGC1B(NM_133263.3) Search again
Product ID:
HQP002750
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ERRL1, PERC, PGC-1(beta), PGC1B
Gene Description:
PPARG coactivator 1 beta
Target Gene Accession:
NM_133263.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha
- role in coactivating the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma
- role in activating orphan nuclear constitutive androstane receptor
- Variation of PGC-1beta may contribute to the pathogenesis of obesity, with a widespread Ala203 allele being a risk factor for the development of this common disorder.
- fatty acids differentially regulated expression of the genes encoding the PGC-1B isoform
- PPARGC1A, PPARGC1B, and EP300 may have roles for familial breast cancer susceptibility
- Acute elevation of plasma non-esterified fatty acd levels downregulates PPARGC1A, PPARGC1B and PPARA expression.
- Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration.
- Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation.
- Study suggests that young carriers of a PGC-1beta 203Pro allele have enhanced insulin-stimulated glucose metabolism and may be protected against an age-related decline in PGC-1beta expression in muscle.
- training caused a decrease in PGC-1beta mRNA levels.
- A novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.
- the association of the 482G/A polymorphism of the PGC-1alpha gene with type 2 diabetes and the quantitative and qualitative binding force changes between the PGC-1alpha domain mutant and MEF2C