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Validated All-in-One™ qPCR Primer for CCR7(NM_001838.3) Search again
Product ID:
HQP002217
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Gene Description:
C-C motif chemokine receptor 7
Target Gene Accession:
NM_001838.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq].
Gene References into function
- Up-regulation OF CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
- important for migration of chronic lymphocytic leukemia cells into lymph nodes
- Few NKT cells express lymphoid tissue-homing chemokine receptors (CCR7 and CXCR5). A population with homing potential for lymph nodes (L selectin(+) CCR7(+)) exists only within a small subset of CD4 NKT cells.
- PGE2 enhanced the expression of the CCL19/CCL21 receptor CCR7 on the cell surface of monocyte-derived dendritic cells
- Data show that interaction between iC3b-opsonized apoptotic cells and immature dendritic cells down-regulated the expression of CD86 and up-regulated expression of CC chemokine receptor 7.
- Coincident expression of CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis may contribute to their accumulation in nonlymphoid organs such as skin and bone
- Overexpression of CCR7 mRNA in nonsmall cell lung cancer is associated with development of lymph node metastasis
- A striking pattern of early inducible CCR7 expression was seen preferentially on primary T(H)1 cell lines, as compared to T(H)2 cells, and was dependent on the strength and duration of the T cell receptor signal.
- cytomegalovirus infection inhibits dendritic cell migration by impairment of the chemokine receptor switch at the level of the expression of CCR7 molecules
- Premature expression of CCR7 repositions CD4+CD8+ double-positive cells into the thymic medulla of transgenic mice. This repositioning of the thymocytes is accompanied by impairment of their development.
- The expression of VEGF-C and CCR7 is related to lymph node metastasis of gastric carcinoma and both of them may become new targets for the treatment of gastric carcinoma.
- CCR7 induces antiapoptotic signaling in mature DCs
- CCR7 has a role in cell migration induced by CCL21 chemokine in malignant melanoma
- Study of expression of CCR7 and its ligands on dendritic and T cell populations in inflamed central nervous system lesions of multiple sclerosis patients gives insight into pathways for immune cell trafficking and surveillance.
- IL-6 led to inhibition of nuclear factor-kappaB (NF-kappaB) binding activity, regulating CCR7 transcription
- A dose-dependent, mesangioproliferative and antiapoptotic effect of SLC/CCL21 was seen via activation of the chemokine receptor CCR7, constitutively expressed on MC. This suggests involvement in renal inflammation, regeneration and glomerular homeostasis
- specific CC chemokine receptor 7 residues have roles in receptor activation
- MAPK are necessary for haptens to induce CCR7 expression.
- Activation of CCR7 on mesangial cells by SLC/CCL21 enhances the degree and firmness of cell adhesion and increases cell spreading and the formation of cell-cell contacts
- The CC chemokine receptor 7 consists with the known defect in adhesion and migration of CML cells.
- CCR7 may have a role in the synovial recruitment of memory T cells in juvenile idiopathic arthritis, irrespective of the pattern of lymphoid organisation.
- Epigenetic up-regulation of C-C chemokine receptor 7 expression is associated with melanoma
- CCR7 activates two independent signaling modules, one involving G(i) and a hierarchy of MAPK family members and another involving Rho/Pyk2/cofilin, which control, respectively, chemotaxis and the migratory speed of DCs.
- High expressions of CCR7 is associated with differentiated and intestinal-type gastric cancers
- The selective expression of CCR7 in JDM may open new perspectives in the understanding of the pathogenesis of inflammatory myopathies, offering a new tool for the differential diagnosis of these disorders.
- Results suggest that the chemokine receptor CCR7 is a novel biomarker that can predict lymph node metastases in breast cancer.
- we investigated the expression of CC chemokine receptor 7 (CCR7) in oral and oropharyngeal squamous cell carcinomas
- Data show that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulated PEG10 expression and function in leukemic B cells.
- functional and lineage relationships of three distinct memory CD4 subpopulations distinguished by their expression of the cysteine chemokine receptor CCR7 and the TNFR family member CD27
- Chemokine receptor 7 is a new player in regulating apoptosis of CD8+ T cells in cancer patients [editorial]
- CCR7 absence on the majority of CD8(+) T cells in the peripheral circulation of patients with squamous cell carcinoma of the head and neck contributes to apoptosis
- The maturation, in vitro migration and cytokine production of human DC after stimulation with live H. pylori is reported.
- CD62L and CCR7, as well as dendritic cells, are reduced in non-Hodgkin's lymphoma
- expression of CCR7 promotes intrahepatic and lymphatic human hepatocellular carcinoma dissemination
- In systemic lupus erythematosus (SLE) patients, significant increases of CCR7-, CD27- and CCR7-, CD27+ and a reduction of CCR7+, CD27+ CD4 memory T cells were found.
- CD45RA+ CCR7- CD8+ T cells are resting memory cells that, upon antigenic stimulation and then proliferate, lose CD45RA, and transiently acquire CCR7.
- The CCL19,CCL21/CCR7 chemokine system is expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis.
- Rapamycin selectively up-regulates CCR7 and enhances the migration of differentiated dendritic cells to regional lymph nodes.
- Significantly higher CCR7 expression is associated with lymph node metastasis in human cervical cancer
- CCR7 may be regulated by the breast tumor microenvironment and further support the use of endothelin receptor antagonists in the treatment of invasive and metastatic breast cancer.
- Borrelia garinii blocks the up-regulation of CCR7 and CD38, important molecules in DC migration to lymph nodes, thus affecting further immune responses in Lyme borreliosis infection.
- variants of CCR7 gene occur at an extremely low frequency in the German population and that neither Sjogren's syndrome, systemic lupus erythematosus, nor systemic sclerosis are associated with these variants
- High levels of CCR7 expression predicted a poor prognosis.
- role for MMP-9 and CCR7 in B-cell chronic lymphocytic leukemia progression
- We have identified a new three-gene classifier that is independent of and improves on stage to stratify early-stage NSCLC patients with significantly different prognoses.
- This study showed that memory Tregs contain high proportions of inflammatory chemokine-expressing cells and comprise two populations that differ in the expression of the lymphoid chemokine receptor CCR7.
- CXCR4 and CCR7 provide directional migration of uveal melanoma cells toward the liver, the most common site for the formation of uveal melanoma metastases.
- CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion
- CCR7 plays a critical role in mediating chemotactic and invasive responses in colon cancer
- Expression of CCR7 was significantly associated with lymph node metastasis in lung adenocarcinoma
- The survival impact of CCR7 expression on resectable pancreatic cancer may be associated with lymphatic spread.
- results indicate in CRC frequent alternative splicing or post-transcriptional mRNA modification resulting in a CCR7 molecule lacking an intact signal peptide prohibiting membrane translocation
- A CCR7 mutant lacking virtually the complete C-terminus readily bound CCL19 and was internalized, but was unable to activate the G protein and to transmit signals required for cell migration.
- High CCR7 expression is associated with extrathyroidal extension, angiolymphatic invasion, and lymph node metastasis in papillary thyroid carcinoma.
- Independent of arrestin 2 or arrestin 3 expression, CCR7/CCL21 internalize.