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Validated All-in-One™ qPCR Primer for CHI3L1(NM_001276.2) Search again
Product ID:
HQP001353
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39
Gene Description:
chitinase 3 like 1
Target Gene Accession:
NM_001276.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis
- elevated serum levels in patients with Streptococcus pneumoniae bacteremia and associated with the outcome of the disease
- The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways.
- human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) is upregulated in osteoarthritic cartilage
- HC-GP39 complexed with HLA-DR alpha beta 1*0401 is localized and presented on dendritic cells in the synovial tissue of rheumatoid arthritis patients.
- CHI3L1 has profound effects on vascular smooth muscle cell (VSMC) migration but no effect on fibroblast migration. In addition, CHI3L1 adsorbed to polystyrene surfaces directly promotes VSMC attachment and spreading.
- chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.
- results indicated a predominant role for a single Sp1 binding site in regulating human cartilage-gp39 promoter activity in macrophages
- upregulgated in glioblstoma multiforme.
- High levels of serum YKL-40 reflect aggressiveness of metastatic breast cancer
- the presence of HC gp-39-specific immune responses in healthy individuals may have an inhibitory effect on inflammatory responses in areas where HC gp-39 is present, and the response in rheumatoid arthritis has shifted toward a proinflammatory phenotype
- Down-regulation of YKL-40 is associated with gliomas
- YKL-40 may have role in neoplasm invasiveness; protein could stimulate fibroblast proliferation, promote angiogenesis, and protect cancer and/or stromal cells against apoptosis
- Findings implicate YKL-40 as an important marker of therapeutic response and genetic subtype in glioblastomas and suggest that it may play an oncogenic role in these tumors.
- induction and continued secretion of CHI3L1 in chondrocytes require sustained activation of NF-kappaB
- The YKL-40 expression was associated with the expressions of p-MAPK, p-mTOR, and p-p70S6K (all P < 0.02), with a trend toward association with p-Akt expression (P = 0.095).
- This article reviews the studies of YKL-40 with focus on a possible role of YKL-40 in insulin resistance, endothelial dysfunction and atherosclerosis.
- Once-weekly intranasal treatment with Org39141 was well tolerated, and no serious or severe AE were reported.
- High YKL40 is associated with high-grade gliomas
- CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play roles in the predisposition to schizophrenia.
- YKL-40 may be used as a sarcoidosis disease marker, but it is unsuitable as a marker to predict the course of the disease.
- conformational comparison of MGP40 and HUMGP39
- YKL-40 has a role in success of hormonal treatment for metastatic prostate cancer
- Data suggest that measuring YKL-40 in nipple aspirate fluid may improve the identification of women at increased breast cancer risk.
- A candidate autoantigen in rheumatoid arthritis found in synovial fluid cells.
- YKL-40 release by intervertebral disc culture may better clarify its role in the pathophysiology of discal degeneration and inflammation and its relationships with COX-2 and NO in disc tissue culture.
- YKL-40 is associated with cell proliferation, differentiation, and tissue morphogenesis during development of the human musculoskeletal system
- High serum levels of YKL-40 is associated with squamous cell carcinoma of the head and neck
- concentration in cord serum significantly higher in pre-eclamptic pregnancies but no significant difference in maternal serum levels between the case and control groups
- High levels of CHI3L1 is associated with glioblastoma
- YKL-40 protein may not have a role in progression of primary breast cancer
- potential role for YKL-40 in myeloma-related bone disease must be considered
- High serum YKL-40 levels in patients with primary prostate cancer indicate that YKL-40 may have a function in the progression of malignant diseases.
- YKL-40 does not seem to have a role in liver fibrosis in children with chronic hepatitis B
- We show that elevated YKL-40 levels are not correlated with the severity of subarachnoid haemorrhage and cannot be used as a serological marker of inflammation in patients with an aneurysm rupture.
- We identified significant association with the same risk allele at the promoter single nucleotide polymorphism (SNP) associated in the original study (rs10399805; p = .018) and with another SNP at intron 7 of CHI3L1 (rs2275351; p = .008).
- CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
- serum concentrations of YKL-40 (chitinase 3-like 1) are greatly increased in AMI patients with and without thrombolytic therapy
- involved in the enhancement of chitin binding protein-expressing bacterial adhesion to colonic epithelial cells
- YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast.
- Plasma YKL-40 was significantly increased in patients with STEMI and stable CAD
- Plasma YKL-40 was identified as an obesity-independent marker of type 2 diabetes
- TNF-alpha suppresses YKL-40 expression in glioma cell lines in a NF-kappaB dependent manner.
- Pretreatment serum YKL-40 level is a possible prognosticator of cervical adenocarcinoma.
- Elevated levels of chitinase-like protein YKL-40 are found in serum and bronchoalveolar lavage fluid, and greater numbers of YKL-40-expressing cells in bronchial biopsies, of smokers with chronic obstructive pulmonary disease.
- Role of YKL-40 as a marker of inflammation in the gradually progressing vascular complications in patients with type 1 diabetes.
- review of CHI3L1 and it's activity in cancer and other diseases [review]
- a functional role of YKL-40 in liver fibrogenesis and should be taken into account when using YKL-40 as a non-invasive fibrosis marker.
- Elevated levels of CHI3L1 mRNA, encoding the secreted glycoprotein YKL-40, are associated with poor survival in glioblastoma.