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Validated All-in-One™ qPCR Primer for KAT7(NM_007067.4) Search again
Product ID:
HQP001313
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HBO1, HBOA, MYST2, ZC2HC7
Gene Description:
lysine acetyltransferase 7
Target Gene Accession:
NM_007067.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Results show that the isolated TFTC-type histone acetyl transferase complex acts as a third class of coactivator complex for nuclear receptor function.
- inhibition by Set/TAF-1beta inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing
- ordered recruitmenet to thyroid hormone-responsive promoters in vivo
- Hbo1 is a positive regulatory factor for prereplicative complex assembly.
- histone acetyltransferase binding to ORC-1 might play an important physiological role in human progesterone receptor signaling
- reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways
- Hbo1 depletion results in decreased DNA replication and a failure of Mcm complex binding to chromatin, both of which can be partially rescued by the ectopic expression of WT Hbo1 but not Hbo1-S57A
- Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation
- HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin.