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Validated All-in-One™ qPCR Primer for CEACAM5(NM_004363.5) Search again
Product ID:
HQP000593
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD66e, CEA
Gene Description:
CEA cell adhesion molecule 5
Target Gene Accession:
NM_004363.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Inhibition of carcinoembryonic antigen increases apoptotic rate of colon cancer cells and inhibits metastatic tumor growth
- Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer.
- white blood cells express a splice variant of CEA , which hinders detection of tumor cell cDNA in whole blood samples
- results suggest that CEA and CK 20 mRNA identification by RT-PCR appeared to be reliable and may be useful for early diagnosis in peritoneal dissemination of colon cancer
- value of this tumor marker regarding relapse, metastasis and death in resectable non-small cell lung cancer
- the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions
- SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4
- Heterophilic interactions of carcinoembryonic antigen and CEACAM1 inhibit killing by natural killer (NK) cells. The N-terminal domain of CEACAM1 is crucial but not sufficient for both CEACAM1-CEACAM1 homophilic and CEACAM1-CEA heterophilic interactions.
- significantly increased in transformed trophoblast of gestational trophoblastic diseases
- Intensive follow-up by serial assay of CEA and cytokeratins allows early detection of colorectal neoplasm recurrence.
- Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells.
- CEACAM6 expression is elevated in many solid tumors and may be a promising target for antibody-based therapy for cancer.
- CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains
- TNM staging, preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision.
- findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.
- Results show that measurements of AFP, CEA and CA125 are more readily affected by long-term frozen storage compared with frequent freezing-thawing.
- CEA mRNA copy number, not positivity, was significantly associated with postoperative term of recurrent gastric cancer.
- The serum CEA level appears to be closely associated with the presence of EGFR gene mutations in patients with pulmonary adenocarcinomas.
- Cigarette smoking was associated with increased serum carcinoembryonic antigen (CEA) levels in a dose- and duration-dependent manner and association between serum CEA and carotid plaque was significant
- elevated level of CEA has a strong negative prognostic impact on survival in operated early stage of non-small cell lung cancer
- serum MMP-9, SCC-Ag and CEA were not significant for prognosis of esophageal cancer
- possibility of observing many clinical reactions could be shown for CEA652 (9) in cases where positive conversion was observed
- CEA and CD44v cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin at elevated shear stresses.
- Serum samples were investigated for carcinoembryonic antigen (CEA), CA125 and MUC1, alpha-foetoprotein, neuron-specific enolase and CA19.9.
- Elevated carcinoembryonic antigen is associated with recurrence after curative resection of colorectal cancer.